Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBR0_LEIDO

TriTrypDb:

LdBPK_231930.1 , LdCL_230026500 , LDHU3_23.2530

Length:

651

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IBR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBR0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	353	357	PF00656	0.582
CLV_C14_Caspase3-7	421	425	PF00656	0.496
CLV_NRD_NRD_1	17	19	PF00675	0.612
CLV_NRD_NRD_1	193	195	PF00675	0.459
CLV_NRD_NRD_1	319	321	PF00675	0.419
CLV_PCSK_KEX2_1	17	19	PF00082	0.612
CLV_PCSK_KEX2_1	193	195	PF00082	0.459
CLV_PCSK_KEX2_1	319	321	PF00082	0.425
CLV_PCSK_KEX2_1	369	371	PF00082	0.498
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.498
CLV_PCSK_SKI1_1	102	106	PF00082	0.634
CLV_PCSK_SKI1_1	131	135	PF00082	0.575
CLV_PCSK_SKI1_1	181	185	PF00082	0.454
CLV_PCSK_SKI1_1	355	359	PF00082	0.517
CLV_PCSK_SKI1_1	496	500	PF00082	0.564
CLV_PCSK_SKI1_1	567	571	PF00082	0.430
DEG_APCC_DBOX_1	180	188	PF00400	0.467
DEG_APCC_DBOX_1	307	315	PF00400	0.362
DEG_APCC_DBOX_1	32	40	PF00400	0.466
DEG_Nend_UBRbox_2	1	3	PF02207	0.592
DOC_CDC14_PxL_1	613	621	PF14671	0.378
DOC_CKS1_1	499	504	PF01111	0.460
DOC_CYCLIN_RxL_1	573	585	PF00134	0.450
DOC_CYCLIN_RxL_1	628	636	PF00134	0.406
DOC_CYCLIN_yCln2_LP_2	489	495	PF00134	0.363
DOC_MAPK_DCC_7	640	649	PF00069	0.327
DOC_MAPK_MEF2A_6	308	315	PF00069	0.432
DOC_MAPK_MEF2A_6	40	47	PF00069	0.460
DOC_MAPK_NFAT4_5	308	316	PF00069	0.394
DOC_PP2B_LxvP_1	302	305	PF13499	0.406
DOC_PP2B_LxvP_1	9	12	PF13499	0.594
DOC_PP4_FxxP_1	286	289	PF00568	0.420
DOC_PP4_FxxP_1	499	502	PF00568	0.503
DOC_USP7_MATH_1	112	116	PF00917	0.618
DOC_USP7_MATH_1	12	16	PF00917	0.681
DOC_USP7_MATH_1	243	247	PF00917	0.498
DOC_USP7_MATH_1	348	352	PF00917	0.604
DOC_USP7_MATH_1	529	533	PF00917	0.516
DOC_USP7_MATH_1	541	545	PF00917	0.509
DOC_WW_Pin1_4	204	209	PF00397	0.372
DOC_WW_Pin1_4	341	346	PF00397	0.555
DOC_WW_Pin1_4	408	413	PF00397	0.483
DOC_WW_Pin1_4	498	503	PF00397	0.499
DOC_WW_Pin1_4	504	509	PF00397	0.448
LIG_14-3-3_CanoR_1	111	117	PF00244	0.642
LIG_14-3-3_CanoR_1	181	190	PF00244	0.289
LIG_14-3-3_CanoR_1	308	314	PF00244	0.525
LIG_14-3-3_CanoR_1	33	43	PF00244	0.541
LIG_14-3-3_CanoR_1	391	396	PF00244	0.461
LIG_14-3-3_CanoR_1	51	56	PF00244	0.519
LIG_14-3-3_CanoR_1	567	572	PF00244	0.420
LIG_14-3-3_CanoR_1	578	583	PF00244	0.270
LIG_Actin_WH2_2	309	327	PF00022	0.368
LIG_Actin_WH2_2	482	498	PF00022	0.422
LIG_APCC_ABBA_1	43	48	PF00400	0.448
LIG_APCC_ABBA_1	580	585	PF00400	0.393
LIG_APCC_ABBA_1	610	615	PF00400	0.455
LIG_BIR_III_2	538	542	PF00653	0.354
LIG_eIF4E_1	359	365	PF01652	0.504
LIG_eIF4E_1	613	619	PF01652	0.412
LIG_FHA_1	156	162	PF00498	0.606
LIG_FHA_1	319	325	PF00498	0.433
LIG_FHA_1	449	455	PF00498	0.423
LIG_FHA_1	65	71	PF00498	0.474
LIG_FHA_2	405	411	PF00498	0.542
LIG_GBD_Chelix_1	95	103	PF00786	0.527
LIG_LIR_Gen_1	142	148	PF02991	0.436
LIG_LIR_Gen_1	356	366	PF02991	0.508
LIG_LIR_Gen_1	531	542	PF02991	0.412
LIG_LIR_Gen_1	590	598	PF02991	0.331
LIG_LIR_Nem_3	142	147	PF02991	0.395
LIG_LIR_Nem_3	327	332	PF02991	0.487
LIG_LIR_Nem_3	356	362	PF02991	0.475
LIG_LIR_Nem_3	590	594	PF02991	0.354
LIG_LIR_Nem_3	627	633	PF02991	0.345
LIG_NRBOX	451	457	PF00104	0.454
LIG_Pex14_1	512	516	PF04695	0.433
LIG_SH2_CRK	359	363	PF00017	0.468
LIG_SH2_GRB2like	326	329	PF00017	0.410
LIG_SH2_SRC	422	425	PF00017	0.473
LIG_SH2_SRC	613	616	PF00017	0.428
LIG_SH2_STAP1	256	260	PF00017	0.417
LIG_SH2_STAP1	326	330	PF00017	0.455
LIG_SH2_STAP1	419	423	PF00017	0.423
LIG_SH2_STAP1	516	520	PF00017	0.337
LIG_SH2_STAT5	214	217	PF00017	0.356
LIG_SH2_STAT5	266	269	PF00017	0.367
LIG_SH2_STAT5	326	329	PF00017	0.590
LIG_SH2_STAT5	399	402	PF00017	0.514
LIG_SH2_STAT5	422	425	PF00017	0.344
LIG_SH2_STAT5	607	610	PF00017	0.441
LIG_SH3_1	406	412	PF00018	0.481
LIG_SH3_3	199	205	PF00018	0.365
LIG_SH3_3	406	412	PF00018	0.481
LIG_SH3_3	640	646	PF00018	0.322
LIG_Sin3_3	300	307	PF02671	0.475
LIG_Sin3_3	434	441	PF02671	0.386
LIG_SUMO_SIM_anti_2	451	456	PF11976	0.396
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.510
LIG_SUMO_SIM_par_1	214	221	PF11976	0.353
LIG_TRAF2_1	11	14	PF00917	0.634
LIG_TRAF2_1	137	140	PF00917	0.419
LIG_TRFH_1	171	175	PF08558	0.456
LIG_WRC_WIRS_1	390	395	PF05994	0.496
MOD_CK1_1	115	121	PF00069	0.567
MOD_CK1_1	155	161	PF00069	0.582
MOD_CK1_1	162	168	PF00069	0.456
MOD_CK1_1	176	182	PF00069	0.410
MOD_CK1_1	221	227	PF00069	0.405
MOD_CK1_1	235	241	PF00069	0.352
MOD_CK1_1	411	417	PF00069	0.482
MOD_CK1_1	466	472	PF00069	0.503
MOD_CK1_1	624	630	PF00069	0.406
MOD_CK2_1	134	140	PF00069	0.473
MOD_CK2_1	142	148	PF00069	0.440
MOD_CK2_1	182	188	PF00069	0.284
MOD_CK2_1	203	209	PF00069	0.495
MOD_CK2_1	221	227	PF00069	0.270
MOD_CK2_1	290	296	PF00069	0.591
MOD_CK2_1	404	410	PF00069	0.505
MOD_CK2_1	482	488	PF00069	0.446
MOD_CK2_1	589	595	PF00069	0.544
MOD_CK2_1	7	13	PF00069	0.644
MOD_Cter_Amidation	15	18	PF01082	0.735
MOD_GlcNHglycan	114	117	PF01048	0.564
MOD_GlcNHglycan	13	17	PF01048	0.658
MOD_GlcNHglycan	136	139	PF01048	0.516
MOD_GlcNHglycan	144	147	PF01048	0.413
MOD_GlcNHglycan	154	157	PF01048	0.386
MOD_GlcNHglycan	184	187	PF01048	0.277
MOD_GlcNHglycan	220	223	PF01048	0.442
MOD_GlcNHglycan	239	242	PF01048	0.377
MOD_GlcNHglycan	24	27	PF01048	0.479
MOD_GlcNHglycan	352	355	PF01048	0.631
MOD_GlcNHglycan	475	478	PF01048	0.421
MOD_GlcNHglycan	562	565	PF01048	0.449
MOD_GlcNHglycan	567	570	PF01048	0.489
MOD_GlcNHglycan	591	594	PF01048	0.420
MOD_GlcNHglycan	595	599	PF01048	0.474
MOD_GlcNHglycan	9	12	PF01048	0.656
MOD_GSK3_1	102	109	PF00069	0.529
MOD_GSK3_1	115	122	PF00069	0.586
MOD_GSK3_1	155	162	PF00069	0.600
MOD_GSK3_1	217	224	PF00069	0.480
MOD_GSK3_1	228	235	PF00069	0.444
MOD_GSK3_1	385	392	PF00069	0.418
MOD_GSK3_1	404	411	PF00069	0.297
MOD_GSK3_1	446	453	PF00069	0.382
MOD_GSK3_1	498	505	PF00069	0.588
MOD_GSK3_1	90	97	PF00069	0.543
MOD_LATS_1	100	106	PF00433	0.435
MOD_N-GLC_1	309	314	PF02516	0.370
MOD_N-GLC_2	577	579	PF02516	0.317
MOD_NEK2_1	318	323	PF00069	0.417
MOD_NEK2_1	324	329	PF00069	0.433
MOD_NEK2_1	364	369	PF00069	0.438
MOD_NEK2_1	385	390	PF00069	0.399
MOD_NEK2_1	46	51	PF00069	0.537
MOD_NEK2_1	572	577	PF00069	0.497
MOD_NEK2_1	589	594	PF00069	0.280
MOD_NEK2_1	94	99	PF00069	0.453
MOD_NEK2_2	232	237	PF00069	0.387
MOD_PIKK_1	411	417	PF00454	0.552
MOD_PK_1	51	57	PF00069	0.494
MOD_PKA_2	142	148	PF00069	0.435
MOD_PKA_2	2	8	PF00069	0.786
MOD_PKA_2	318	324	PF00069	0.442
MOD_Plk_1	309	315	PF00069	0.371
MOD_Plk_1	404	410	PF00069	0.567
MOD_Plk_1	624	630	PF00069	0.470
MOD_Plk_4	243	249	PF00069	0.447
MOD_Plk_4	309	315	PF00069	0.388
MOD_Plk_4	450	456	PF00069	0.499
MOD_Plk_4	51	57	PF00069	0.534
MOD_Plk_4	529	535	PF00069	0.517
MOD_Plk_4	541	547	PF00069	0.390
MOD_Plk_4	567	573	PF00069	0.451
MOD_Plk_4	578	584	PF00069	0.480
MOD_Plk_4	90	96	PF00069	0.500
MOD_ProDKin_1	204	210	PF00069	0.368
MOD_ProDKin_1	341	347	PF00069	0.565
MOD_ProDKin_1	408	414	PF00069	0.477
MOD_ProDKin_1	498	504	PF00069	0.497
TRG_DiLeu_BaEn_1	615	620	PF01217	0.450
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.473
TRG_DiLeu_BaLyEn_6	614	619	PF01217	0.420
TRG_DiLeu_BaLyEn_6	643	648	PF01217	0.442
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.500
TRG_ENDOCYTIC_2	326	329	PF00928	0.460
TRG_ENDOCYTIC_2	359	362	PF00928	0.513
TRG_ENDOCYTIC_2	607	610	PF00928	0.346
TRG_ENDOCYTIC_2	613	616	PF00928	0.332
TRG_ER_diArg_1	193	195	PF00400	0.442
TRG_ER_diArg_1	318	320	PF00400	0.432
TRG_ER_diArg_1	456	459	PF00400	0.433
TRG_NES_CRM1_1	35	48	PF08389	0.447
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	194	199	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	631	636	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKS3	Leptomonas seymouri	53%	78%
A0A1X0NXC2	Trypanosomatidae	26%	83%
A0A3R7RJS0	Trypanosoma rangeli	28%	82%
A4HD37	Leishmania braziliensis	86%	100%
C9ZNR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	80%
E9AH15	Leishmania infantum	100%	100%
E9AWI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QAY5	Leishmania major	94%	100%
V5BFS5	Trypanosoma cruzi	26%	82%