Alpha-tubulin N-acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBQ9_LEIDO

TriTrypDb:

LdBPK_251190.1 , LdCL_250017500 , LDHU3_25.1520

Length:

246

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	12
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3Q8IBQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBQ9

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	12
GO:0006475	internal protein amino acid acetylation	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018205	peptidyl-lysine modification	6	12
GO:0018393	internal peptidyl-lysine acetylation	8	12
GO:0018394	peptidyl-lysine acetylation	7	12
GO:0019538	protein metabolic process	3	12
GO:0032886	regulation of microtubule-based process	4	12
GO:0033043	regulation of organelle organization	5	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043543	protein acylation	5	12
GO:0044238	primary metabolic process	2	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051128	regulation of cellular component organization	4	12
GO:0051493	regulation of cytoskeleton organization	6	12
GO:0065007	biological regulation	1	12
GO:0070507	regulation of microtubule cytoskeleton organization	5	12
GO:0071704	organic substance metabolic process	2	12
GO:0071929	alpha-tubulin acetylation	9	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008080	N-acetyltransferase activity	6	12
GO:0016407	acetyltransferase activity	5	12
GO:0016410	N-acyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0019799	tubulin N-acetyltransferase activity	4	12
GO:0034212	peptide N-acetyltransferase activity	7	12
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	179	181	PF00675	0.255
CLV_NRD_NRD_1	3	5	PF00675	0.642
CLV_NRD_NRD_1	44	46	PF00675	0.639
CLV_NRD_NRD_1	56	58	PF00675	0.291
CLV_PCSK_KEX2_1	2	4	PF00082	0.651
CLV_PCSK_KEX2_1	44	46	PF00082	0.628
CLV_PCSK_PC7_1	40	46	PF00082	0.619
CLV_PCSK_SKI1_1	112	116	PF00082	0.248
DEG_COP1_1	15	28	PF00400	0.692
DEG_Nend_UBRbox_1	1	4	PF02207	0.733
DEG_SPOP_SBC_1	224	228	PF00917	0.651
DOC_CYCLIN_RxL_1	215	229	PF00134	0.500
DOC_MAPK_gen_1	57	65	PF00069	0.525
DOC_MAPK_JIP1_4	162	168	PF00069	0.534
DOC_MAPK_MEF2A_6	102	111	PF00069	0.525
DOC_PP1_RVXF_1	172	179	PF00149	0.448
DOC_PP1_SILK_1	104	109	PF00149	0.459
DOC_PP2B_LxvP_1	214	217	PF13499	0.602
DOC_USP7_MATH_1	224	228	PF00917	0.645
DOC_USP7_UBL2_3	108	112	PF12436	0.438
DOC_WW_Pin1_4	186	191	PF00397	0.468
DOC_WW_Pin1_4	215	220	PF00397	0.647
LIG_Clathr_ClatBox_1	124	128	PF01394	0.448
LIG_FHA_1	115	121	PF00498	0.524
LIG_FHA_1	187	193	PF00498	0.553
LIG_FHA_1	230	236	PF00498	0.651
LIG_FHA_1	60	66	PF00498	0.486
LIG_FHA_1	89	95	PF00498	0.503
LIG_FHA_2	204	210	PF00498	0.688
LIG_FHA_2	30	36	PF00498	0.611
LIG_KLC1_Yacidic_2	134	138	PF13176	0.534
LIG_LIR_Gen_1	149	157	PF02991	0.451
LIG_LIR_Nem_3	90	95	PF02991	0.535
LIG_OCRL_FandH_1	177	189	PF00620	0.489
LIG_Pex14_2	198	202	PF04695	0.448
LIG_SH2_STAP1	151	155	PF00017	0.534
LIG_SH2_STAT3	188	191	PF00017	0.473
LIG_SH2_STAT5	136	139	PF00017	0.509
LIG_SH2_STAT5	188	191	PF00017	0.468
LIG_SH2_STAT5	95	98	PF00017	0.459
LIG_SH3_3	113	119	PF00018	0.473
LIG_SH3_3	157	163	PF00018	0.553
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.704
LIG_SUMO_SIM_anti_2	62	67	PF11976	0.509
LIG_SUMO_SIM_par_1	123	128	PF11976	0.490
LIG_SUMO_SIM_par_1	164	169	PF11976	0.523
LIG_TRAF2_1	14	17	PF00917	0.731
LIG_UBA3_1	175	181	PF00899	0.534
LIG_WRC_WIRS_1	198	203	PF05994	0.497
MOD_CDC14_SPxK_1	218	221	PF00782	0.689
MOD_CDK_SPxK_1	215	221	PF00069	0.691
MOD_CK1_1	226	232	PF00069	0.613
MOD_CK1_1	29	35	PF00069	0.643
MOD_CK2_1	158	164	PF00069	0.530
MOD_CK2_1	203	209	PF00069	0.633
MOD_DYRK1A_RPxSP_1	215	219	PF00069	0.674
MOD_GSK3_1	114	121	PF00069	0.534
MOD_GSK3_1	225	232	PF00069	0.704
MOD_GSK3_1	75	82	PF00069	0.426
MOD_N-GLC_1	229	234	PF02516	0.634
MOD_N-GLC_1	88	93	PF02516	0.325
MOD_NEK2_1	114	119	PF00069	0.466
MOD_NEK2_1	202	207	PF00069	0.639
MOD_NEK2_1	225	230	PF00069	0.628
MOD_NEK2_1	8	13	PF00069	0.661
MOD_NEK2_2	146	151	PF00069	0.492
MOD_PIKK_1	67	73	PF00454	0.494
MOD_PIKK_1	95	101	PF00454	0.553
MOD_PKA_2	169	175	PF00069	0.473
MOD_PKA_2	29	35	PF00069	0.641
MOD_PKB_1	85	93	PF00069	0.470
MOD_Plk_1	19	25	PF00069	0.683
MOD_Plk_1	202	208	PF00069	0.604
MOD_Plk_1	87	93	PF00069	0.527
MOD_Plk_2-3	203	209	PF00069	0.645
MOD_Plk_4	146	152	PF00069	0.450
MOD_Plk_4	19	25	PF00069	0.631
MOD_Plk_4	197	203	PF00069	0.497
MOD_Plk_4	75	81	PF00069	0.426
MOD_ProDKin_1	186	192	PF00069	0.468
MOD_ProDKin_1	215	221	PF00069	0.650
MOD_SUMO_for_1	155	158	PF00179	0.497
MOD_SUMO_rev_2	54	59	PF00179	0.534
TRG_DiLeu_BaEn_1	209	214	PF01217	0.689
TRG_DiLeu_BaEn_4	16	22	PF01217	0.728
TRG_ENDOCYTIC_2	151	154	PF00928	0.493
TRG_ER_diArg_1	1	4	PF00400	0.659

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K7	Leptomonas seymouri	69%	100%
A0A0S4IKU1	Bodo saltans	50%	75%
A0A1X0NLY3	Trypanosomatidae	60%	73%
A0A422P1Z8	Trypanosoma rangeli	61%	77%
A4HE59	Leishmania braziliensis	81%	97%
A4I1F7	Leishmania infantum	100%	100%
A8XKM2	Caenorhabditis briggsae	29%	94%
B3RNE8	Trichoplax adhaerens	45%	100%
C0H559	Plasmodium falciparum (isolate 3D7)	28%	100%
C9ZK12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	74%
E9AXJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q23192	Caenorhabditis elegans	29%	94%
Q4CQJ5	Trypanosoma cruzi (strain CL Brener)	57%	75%
Q4DTX9	Trypanosoma cruzi (strain CL Brener)	55%	75%
Q4Q9X8	Leishmania major	96%	100%
Q57XX3	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	54%	74%
Q58CX6	Bos taurus	43%	100%
Q5DD96	Schistosoma japonicum	42%	92%
Q5TM63	Macaca mulatta	46%	76%
Q767K7	Sus scrofa	46%	82%
V5BCX4	Trypanosoma cruzi	57%	75%