Mitochondrial_processing_peptidase_alpha_subunit_ putative/GeneDB:LmjF.13.0870

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial processing peptidase alpha subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBQ6_LEIDO

TriTrypDb:

LdBPK_130760.1 , LdCL_130013000 , LDHU3_13.0960

Length:

528

Annotations

Annotations by Jardim et al.

Proteases, mitochondrial processing peptidase alpha subunit

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Phosphorylation

Promastigote: 161

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IBQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBQ6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004175	endopeptidase activity	4	7
GO:0004222	metalloendopeptidase activity	5	7
GO:0005488	binding	1	22
GO:0008233	peptidase activity	3	7
GO:0008237	metallopeptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0043167	ion binding	2	22
GO:0043169	cation binding	3	22
GO:0046872	metal ion binding	4	22
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.397
CLV_C14_Caspase3-7	434	438	PF00656	0.543
CLV_C14_Caspase3-7	484	488	PF00656	0.423
CLV_NRD_NRD_1	165	167	PF00675	0.617
CLV_NRD_NRD_1	3	5	PF00675	0.538
CLV_NRD_NRD_1	354	356	PF00675	0.475
CLV_PCSK_KEX2_1	165	167	PF00082	0.604
CLV_PCSK_KEX2_1	3	5	PF00082	0.538
CLV_PCSK_KEX2_1	498	500	PF00082	0.406
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.406
CLV_PCSK_SKI1_1	225	229	PF00082	0.411
CLV_PCSK_SKI1_1	355	359	PF00082	0.386
CLV_PCSK_SKI1_1	419	423	PF00082	0.429
CLV_PCSK_SKI1_1	70	74	PF00082	0.364
DEG_Nend_Nbox_1	1	3	PF02207	0.564
DEG_SPOP_SBC_1	108	112	PF00917	0.339
DEG_SPOP_SBC_1	157	161	PF00917	0.454
DOC_MAPK_gen_1	137	146	PF00069	0.307
DOC_MAPK_MEF2A_6	137	146	PF00069	0.320
DOC_PP4_FxxP_1	196	199	PF00568	0.360
DOC_PP4_FxxP_1	396	399	PF00568	0.324
DOC_USP7_MATH_1	130	134	PF00917	0.419
DOC_USP7_MATH_1	158	162	PF00917	0.619
DOC_USP7_MATH_1	245	249	PF00917	0.416
DOC_USP7_MATH_1	46	50	PF00917	0.589
DOC_USP7_MATH_1	471	475	PF00917	0.392
DOC_USP7_MATH_1	488	492	PF00917	0.301
DOC_USP7_MATH_1	79	83	PF00917	0.360
DOC_WW_Pin1_4	286	291	PF00397	0.420
DOC_WW_Pin1_4	29	34	PF00397	0.522
DOC_WW_Pin1_4	395	400	PF00397	0.354
LIG_14-3-3_CanoR_1	123	129	PF00244	0.412
LIG_14-3-3_CanoR_1	419	428	PF00244	0.480
LIG_14-3-3_CanoR_1	70	79	PF00244	0.470
LIG_Clathr_ClatBox_1	118	122	PF01394	0.372
LIG_eIF4E_1	400	406	PF01652	0.314
LIG_FHA_1	157	163	PF00498	0.411
LIG_FHA_1	39	45	PF00498	0.461
LIG_FHA_1	400	406	PF00498	0.393
LIG_FHA_1	420	426	PF00498	0.178
LIG_FHA_1	71	77	PF00498	0.457
LIG_FHA_2	316	322	PF00498	0.425
LIG_FHA_2	332	338	PF00498	0.496
LIG_FHA_2	456	462	PF00498	0.367
LIG_FHA_2	478	484	PF00498	0.420
LIG_LIR_Apic_2	214	220	PF02991	0.369
LIG_LIR_Apic_2	262	267	PF02991	0.327
LIG_LIR_Gen_1	185	196	PF02991	0.328
LIG_LIR_Nem_3	185	191	PF02991	0.314
LIG_LIR_Nem_3	259	264	PF02991	0.293
LIG_LIR_Nem_3	461	465	PF02991	0.324
LIG_PTAP_UEV_1	95	100	PF05743	0.346
LIG_PTB_Apo_2	113	120	PF02174	0.353
LIG_PTB_Apo_2	237	244	PF02174	0.458
LIG_PTB_Apo_2	285	292	PF02174	0.401
LIG_SH2_CRK	93	97	PF00017	0.384
LIG_SH2_GRB2like	286	289	PF00017	0.392
LIG_SH2_NCK_1	93	97	PF00017	0.404
LIG_SH2_PTP2	141	144	PF00017	0.381
LIG_SH2_PTP2	264	267	PF00017	0.303
LIG_SH2_SRC	93	96	PF00017	0.364
LIG_SH2_STAP1	223	227	PF00017	0.434
LIG_SH2_STAP1	25	29	PF00017	0.628
LIG_SH2_STAP1	261	265	PF00017	0.294
LIG_SH2_STAP1	501	505	PF00017	0.318
LIG_SH2_STAT3	223	226	PF00017	0.323
LIG_SH2_STAT5	141	144	PF00017	0.360
LIG_SH2_STAT5	264	267	PF00017	0.278
LIG_SH2_STAT5	317	320	PF00017	0.400
LIG_SH2_STAT5	462	465	PF00017	0.307
LIG_SH2_STAT5	86	89	PF00017	0.289
LIG_SH3_1	93	99	PF00018	0.490
LIG_SH3_3	2	8	PF00018	0.471
LIG_SH3_3	42	48	PF00018	0.611
LIG_SH3_3	93	99	PF00018	0.382
LIG_TRAF2_1	481	484	PF00917	0.502
MOD_CK1_1	160	166	PF00069	0.548
MOD_CK1_1	438	444	PF00069	0.398
MOD_CK1_1	474	480	PF00069	0.478
MOD_CK1_1	506	512	PF00069	0.361
MOD_CK2_1	130	136	PF00069	0.369
MOD_CK2_1	20	26	PF00069	0.565
MOD_CK2_1	315	321	PF00069	0.387
MOD_CK2_1	477	483	PF00069	0.438
MOD_GlcNHglycan	154	157	PF01048	0.507
MOD_GlcNHglycan	272	275	PF01048	0.395
MOD_GlcNHglycan	293	296	PF01048	0.477
MOD_GlcNHglycan	375	378	PF01048	0.540
MOD_GlcNHglycan	96	99	PF01048	0.551
MOD_GSK3_1	152	159	PF00069	0.461
MOD_GSK3_1	395	402	PF00069	0.344
MOD_GSK3_1	431	438	PF00069	0.453
MOD_GSK3_1	473	480	PF00069	0.431
MOD_GSK3_1	503	510	PF00069	0.336
MOD_GSK3_1	94	101	PF00069	0.452
MOD_N-GLC_1	114	119	PF02516	0.408
MOD_N-GLC_1	506	511	PF02516	0.485
MOD_NEK2_1	107	112	PF00069	0.345
MOD_NEK2_1	227	232	PF00069	0.436
MOD_NEK2_1	38	43	PF00069	0.610
MOD_NEK2_1	446	451	PF00069	0.397
MOD_NEK2_2	114	119	PF00069	0.385
MOD_OFUCOSY	463	469	PF10250	0.285
MOD_PIKK_1	160	166	PF00454	0.616
MOD_PIKK_1	32	38	PF00454	0.511
MOD_PIKK_1	446	452	PF00454	0.421
MOD_PKA_1	355	361	PF00069	0.495
MOD_PKA_2	204	210	PF00069	0.393
MOD_Plk_1	114	120	PF00069	0.390
MOD_Plk_1	474	480	PF00069	0.439
MOD_Plk_1	506	512	PF00069	0.286
MOD_Plk_4	114	120	PF00069	0.370
MOD_Plk_4	252	258	PF00069	0.400
MOD_Plk_4	339	345	PF00069	0.380
MOD_Plk_4	361	367	PF00069	0.320
MOD_Plk_4	435	441	PF00069	0.491
MOD_Plk_4	500	506	PF00069	0.336
MOD_Plk_4	507	513	PF00069	0.308
MOD_ProDKin_1	286	292	PF00069	0.428
MOD_ProDKin_1	29	35	PF00069	0.522
MOD_ProDKin_1	395	401	PF00069	0.351
MOD_SUMO_for_1	410	413	PF00179	0.338
MOD_SUMO_rev_2	23	29	PF00179	0.515
MOD_SUMO_rev_2	491	500	PF00179	0.317
TRG_ENDOCYTIC_2	141	144	PF00928	0.381
TRG_ENDOCYTIC_2	501	504	PF00928	0.315
TRG_ER_diArg_1	2	4	PF00400	0.542
TRG_Pf-PMV_PEXEL_1	166	171	PF00026	0.649
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM61	Leptomonas seymouri	40%	100%
A0A0N1PFG1	Leptomonas seymouri	77%	100%
A0A0S4IY11	Bodo saltans	41%	100%
A0A0S4JST8	Bodo saltans	45%	100%
A0A1X0NPP7	Trypanosomatidae	54%	100%
A0A1X0NXN6	Trypanosomatidae	38%	100%
A0A3R7JXS6	Trypanosoma rangeli	37%	100%
A0A3R7MEV0	Trypanosoma rangeli	53%	100%
A0A3S7WWC3	Leishmania donovani	39%	100%
A4H775	Leishmania braziliensis	82%	100%
A4HBN2	Leishmania braziliensis	39%	94%
A4HVL5	Leishmania infantum	100%	100%
A4HZ33	Leishmania infantum	40%	93%
D0A6P1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9APB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AV01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	93%
P43265	Euglena gracilis	24%	100%
Q0P5M8	Bos taurus	22%	100%
Q10713	Homo sapiens	21%	100%
Q4QCI1	Leishmania major	40%	93%
Q4QG67	Leishmania major	96%	100%
Q5R513	Pongo abelii	21%	100%
Q9DC61	Mus musculus	22%	100%
Q9ZU25	Arabidopsis thaliana	20%	100%
V5BB16	Trypanosoma cruzi	54%	95%
V5BQ54	Trypanosoma cruzi	38%	100%