Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBQ4_LEIDO

TriTrypDb:

LdBPK_292950.1 , LdCL_290035600 , LDHU3_29.4310

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IBQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBQ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.491
CLV_NRD_NRD_1	227	229	PF00675	0.335
CLV_NRD_NRD_1	88	90	PF00675	0.508
CLV_PCSK_KEX2_1	132	134	PF00082	0.476
CLV_PCSK_KEX2_1	227	229	PF00082	0.355
CLV_PCSK_KEX2_1	88	90	PF00082	0.557
CLV_PCSK_SKI1_1	152	156	PF00082	0.431
CLV_PCSK_SKI1_1	227	231	PF00082	0.301
CLV_PCSK_SKI1_1	38	42	PF00082	0.689
DOC_CYCLIN_yCln2_LP_2	278	284	PF00134	0.323
DOC_MAPK_MEF2A_6	200	209	PF00069	0.411
DOC_USP7_MATH_1	302	306	PF00917	0.504
DOC_WW_Pin1_4	135	140	PF00397	0.376
DOC_WW_Pin1_4	217	222	PF00397	0.450
DOC_WW_Pin1_4	33	38	PF00397	0.533
DOC_WW_Pin1_4	72	77	PF00397	0.517
LIG_14-3-3_CanoR_1	132	137	PF00244	0.475
LIG_14-3-3_CanoR_1	66	70	PF00244	0.641
LIG_BIR_II_1	1	5	PF00653	0.627
LIG_BIR_III_4	276	280	PF00653	0.348
LIG_BRCT_BRCA1_1	259	263	PF00533	0.324
LIG_deltaCOP1_diTrp_1	99	109	PF00928	0.325
LIG_FHA_1	289	295	PF00498	0.433
LIG_FHA_1	34	40	PF00498	0.587
LIG_FHA_1	66	72	PF00498	0.699
LIG_FHA_2	116	122	PF00498	0.388
LIG_FHA_2	252	258	PF00498	0.263
LIG_LIR_Apic_2	135	139	PF02991	0.392
LIG_LIR_Apic_2	172	177	PF02991	0.502
LIG_LIR_Gen_1	190	201	PF02991	0.481
LIG_LIR_Gen_1	214	222	PF02991	0.400
LIG_LIR_Gen_1	245	255	PF02991	0.338
LIG_LIR_Gen_1	273	283	PF02991	0.349
LIG_LIR_Nem_3	190	196	PF02991	0.473
LIG_LIR_Nem_3	214	218	PF02991	0.371
LIG_LIR_Nem_3	245	251	PF02991	0.285
LIG_LIR_Nem_3	260	266	PF02991	0.362
LIG_LIR_Nem_3	273	278	PF02991	0.296
LIG_LIR_Nem_3	94	100	PF02991	0.480
LIG_MYND_1	60	64	PF01753	0.483
LIG_NRBOX	22	28	PF00104	0.346
LIG_PCNA_PIPBox_1	144	153	PF02747	0.407
LIG_Pex14_2	215	219	PF04695	0.393
LIG_PTB_Apo_2	277	284	PF02174	0.385
LIG_SH2_CRK	136	140	PF00017	0.400
LIG_SH2_CRK	193	197	PF00017	0.353
LIG_SH2_GRB2like	174	177	PF00017	0.423
LIG_SH2_GRB2like	193	196	PF00017	0.431
LIG_SH2_NCK_1	136	140	PF00017	0.362
LIG_SH2_NCK_1	174	178	PF00017	0.426
LIG_SH2_SRC	174	177	PF00017	0.423
LIG_SH2_STAT5	136	139	PF00017	0.402
LIG_SH3_3	215	221	PF00018	0.340
LIG_SUMO_SIM_par_1	290	298	PF11976	0.341
MOD_CDK_SPK_2	33	38	PF00069	0.486
MOD_CK1_1	135	141	PF00069	0.557
MOD_CK1_1	208	214	PF00069	0.455
MOD_CK1_1	4	10	PF00069	0.473
MOD_CK2_1	115	121	PF00069	0.393
MOD_Cter_Amidation	86	89	PF01082	0.532
MOD_DYRK1A_RPxSP_1	217	221	PF00069	0.338
MOD_GlcNHglycan	112	115	PF01048	0.441
MOD_GlcNHglycan	244	247	PF01048	0.338
MOD_GlcNHglycan	42	45	PF01048	0.538
MOD_GlcNHglycan	53	56	PF01048	0.479
MOD_GSK3_1	104	111	PF00069	0.453
MOD_GSK3_1	128	135	PF00069	0.601
MOD_GSK3_1	247	254	PF00069	0.297
MOD_GSK3_1	302	309	PF00069	0.522
MOD_N-GLC_1	302	307	PF02516	0.425
MOD_N-GLC_1	4	9	PF02516	0.480
MOD_N-GLC_1	71	76	PF02516	0.418
MOD_NEK2_1	1	6	PF00069	0.674
MOD_NEK2_1	110	115	PF00069	0.439
MOD_NEK2_1	140	145	PF00069	0.391
MOD_NEK2_1	205	210	PF00069	0.446
MOD_NEK2_1	27	32	PF00069	0.540
MOD_NEK2_1	288	293	PF00069	0.382
MOD_NEK2_1	39	44	PF00069	0.582
MOD_NEK2_1	65	70	PF00069	0.690
MOD_NEK2_1	71	76	PF00069	0.511
MOD_NEK2_2	302	307	PF00069	0.337
MOD_PIKK_1	125	131	PF00454	0.342
MOD_PIKK_1	140	146	PF00454	0.387
MOD_PKA_1	132	138	PF00069	0.401
MOD_PKA_2	125	131	PF00069	0.428
MOD_PKA_2	132	138	PF00069	0.433
MOD_PKA_2	30	36	PF00069	0.630
MOD_PKA_2	65	71	PF00069	0.629
MOD_PKB_1	89	97	PF00069	0.474
MOD_Plk_1	302	308	PF00069	0.458
MOD_Plk_1	4	10	PF00069	0.473
MOD_Plk_4	247	253	PF00069	0.321
MOD_Plk_4	302	308	PF00069	0.440
MOD_ProDKin_1	135	141	PF00069	0.370
MOD_ProDKin_1	217	223	PF00069	0.447
MOD_ProDKin_1	33	39	PF00069	0.537
MOD_ProDKin_1	72	78	PF00069	0.519
TRG_DiLeu_BaEn_4	122	128	PF01217	0.482
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.421
TRG_ENDOCYTIC_2	193	196	PF00928	0.383
TRG_ENDOCYTIC_2	97	100	PF00928	0.316
TRG_ER_diArg_1	237	240	PF00400	0.320
TRG_ER_diArg_1	88	91	PF00400	0.541
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z2	Leptomonas seymouri	45%	100%
A0A1X0P8Z8	Trypanosomatidae	27%	92%
A4H3R5	Leishmania braziliensis	64%	100%
A4I4Y4	Leishmania infantum	100%	100%
C9ZKJ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	93%
E9AEE6	Leishmania major	84%	100%
E9ALE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
V5BSV9	Trypanosoma cruzi	37%	100%