rRNA biogenesis protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rRNA biogenesis protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IBQ3_LEIDO

TriTrypDb:

LdBPK_200710.1 , LdCL_200011800 , LDHU3_20.0850

Length:

737

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8IBQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBQ3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.591
CLV_C14_Caspase3-7	438	442	PF00656	0.523
CLV_C14_Caspase3-7	730	734	PF00656	0.645
CLV_NRD_NRD_1	101	103	PF00675	0.447
CLV_NRD_NRD_1	108	110	PF00675	0.414
CLV_NRD_NRD_1	403	405	PF00675	0.533
CLV_NRD_NRD_1	433	435	PF00675	0.568
CLV_NRD_NRD_1	532	534	PF00675	0.406
CLV_NRD_NRD_1	555	557	PF00675	0.386
CLV_NRD_NRD_1	576	578	PF00675	0.431
CLV_NRD_NRD_1	639	641	PF00675	0.491
CLV_NRD_NRD_1	661	663	PF00675	0.429
CLV_PCSK_FUR_1	430	434	PF00082	0.606
CLV_PCSK_KEX2_1	101	103	PF00082	0.450
CLV_PCSK_KEX2_1	403	405	PF00082	0.586
CLV_PCSK_KEX2_1	432	434	PF00082	0.567
CLV_PCSK_KEX2_1	532	534	PF00082	0.344
CLV_PCSK_KEX2_1	54	56	PF00082	0.474
CLV_PCSK_KEX2_1	576	578	PF00082	0.423
CLV_PCSK_KEX2_1	591	593	PF00082	0.298
CLV_PCSK_KEX2_1	596	598	PF00082	0.369
CLV_PCSK_KEX2_1	607	609	PF00082	0.384
CLV_PCSK_KEX2_1	644	646	PF00082	0.481
CLV_PCSK_KEX2_1	713	715	PF00082	0.326
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.478
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.377
CLV_PCSK_PC1ET2_1	596	598	PF00082	0.384
CLV_PCSK_PC1ET2_1	607	609	PF00082	0.399
CLV_PCSK_PC1ET2_1	644	646	PF00082	0.499
CLV_PCSK_PC1ET2_1	713	715	PF00082	0.326
CLV_PCSK_PC7_1	592	598	PF00082	0.374
CLV_PCSK_PC7_1	640	646	PF00082	0.504
CLV_PCSK_SKI1_1	110	114	PF00082	0.444
CLV_PCSK_SKI1_1	386	390	PF00082	0.561
CLV_PCSK_SKI1_1	460	464	PF00082	0.413
CLV_PCSK_SKI1_1	54	58	PF00082	0.405
CLV_PCSK_SKI1_1	566	570	PF00082	0.474
CLV_PCSK_SKI1_1	597	601	PF00082	0.372
CLV_PCSK_SKI1_1	632	636	PF00082	0.340
CLV_PCSK_SKI1_1	673	677	PF00082	0.337
CLV_PCSK_SKI1_1	80	84	PF00082	0.526
CLV_Separin_Metazoa	98	102	PF03568	0.477
DEG_SCF_FBW7_1	237	244	PF00400	0.568
DOC_CYCLIN_RxL_1	51	61	PF00134	0.431
DOC_CYCLIN_RxL_1	692	700	PF00134	0.417
DOC_MAPK_gen_1	106	116	PF00069	0.438
DOC_MAPK_gen_1	556	564	PF00069	0.353
DOC_MAPK_gen_1	576	584	PF00069	0.202
DOC_MAPK_gen_1	607	615	PF00069	0.348
DOC_MAPK_MEF2A_6	109	116	PF00069	0.445
DOC_MAPK_MEF2A_6	577	586	PF00069	0.407
DOC_PP1_RVXF_1	693	700	PF00149	0.419
DOC_PP2B_PxIxI_1	327	333	PF00149	0.336
DOC_USP7_MATH_1	129	133	PF00917	0.575
DOC_USP7_MATH_1	192	196	PF00917	0.525
DOC_USP7_MATH_1	279	283	PF00917	0.634
DOC_USP7_MATH_1	287	291	PF00917	0.481
DOC_USP7_MATH_1	365	369	PF00917	0.647
DOC_USP7_MATH_1	405	409	PF00917	0.579
DOC_USP7_MATH_1	466	470	PF00917	0.343
DOC_USP7_MATH_1	643	647	PF00917	0.351
DOC_USP7_MATH_1	665	669	PF00917	0.446
DOC_USP7_MATH_1	8	12	PF00917	0.570
DOC_USP7_UBL2_3	596	600	PF12436	0.404
DOC_WW_Pin1_4	237	242	PF00397	0.450
DOC_WW_Pin1_4	378	383	PF00397	0.744
DOC_WW_Pin1_4	451	456	PF00397	0.425
DOC_WW_Pin1_4	624	629	PF00397	0.399
DOC_WW_Pin1_4	702	707	PF00397	0.376
LIG_14-3-3_CanoR_1	139	146	PF00244	0.599
LIG_14-3-3_CanoR_1	204	214	PF00244	0.650
LIG_14-3-3_CanoR_1	41	47	PF00244	0.468
LIG_14-3-3_CanoR_1	55	61	PF00244	0.381
LIG_14-3-3_CanoR_1	576	580	PF00244	0.432
LIG_14-3-3_CanoR_1	695	700	PF00244	0.373
LIG_14-3-3_CanoR_1	714	720	PF00244	0.295
LIG_14-3-3_CanoR_1	80	85	PF00244	0.440
LIG_Actin_WH2_2	580	598	PF00022	0.431
LIG_BIR_II_1	1	5	PF00653	0.760
LIG_BIR_III_4	75	79	PF00653	0.555
LIG_BRCT_BRCA1_1	527	531	PF00533	0.441
LIG_Clathr_ClatBox_1	542	546	PF01394	0.241
LIG_Clathr_ClatBox_1	81	85	PF01394	0.528
LIG_DLG_GKlike_1	695	702	PF00625	0.486
LIG_FHA_1	195	201	PF00498	0.760
LIG_FHA_1	24	30	PF00498	0.416
LIG_FHA_1	261	267	PF00498	0.354
LIG_FHA_1	317	323	PF00498	0.530
LIG_FHA_1	378	384	PF00498	0.539
LIG_FHA_1	42	48	PF00498	0.332
LIG_FHA_1	496	502	PF00498	0.390
LIG_FHA_1	610	616	PF00498	0.364
LIG_FHA_1	667	673	PF00498	0.455
LIG_FHA_1	692	698	PF00498	0.423
LIG_FHA_1	726	732	PF00498	0.522
LIG_FHA_1	81	87	PF00498	0.499
LIG_FHA_2	148	154	PF00498	0.448
LIG_FHA_2	238	244	PF00498	0.444
LIG_FHA_2	359	365	PF00498	0.712
LIG_FHA_2	44	50	PF00498	0.547
LIG_FHA_2	451	457	PF00498	0.597
LIG_FHA_2	596	602	PF00498	0.511
LIG_FHA_2	651	657	PF00498	0.478
LIG_FHA_2	703	709	PF00498	0.424
LIG_FHA_2	716	722	PF00498	0.429
LIG_FHA_2	93	99	PF00498	0.490
LIG_GBD_Chelix_1	52	60	PF00786	0.437
LIG_Integrin_isoDGR_2	630	632	PF01839	0.341
LIG_Integrin_RGD_1	175	177	PF01839	0.524
LIG_LIR_Apic_2	95	99	PF02991	0.449
LIG_LIR_Gen_1	456	466	PF02991	0.400
LIG_LIR_Gen_1	578	587	PF02991	0.348
LIG_LIR_Gen_1	694	702	PF02991	0.357
LIG_LIR_Gen_1	88	97	PF02991	0.455
LIG_LIR_Nem_3	36	42	PF02991	0.490
LIG_LIR_Nem_3	456	461	PF02991	0.397
LIG_LIR_Nem_3	469	475	PF02991	0.429
LIG_LIR_Nem_3	578	582	PF02991	0.332
LIG_LIR_Nem_3	646	652	PF02991	0.325
LIG_LIR_Nem_3	694	699	PF02991	0.347
LIG_LIR_Nem_3	88	93	PF02991	0.473
LIG_PCNA_PIPBox_1	690	699	PF02747	0.427
LIG_PCNA_yPIPBox_3	532	543	PF02747	0.294
LIG_PCNA_yPIPBox_3	687	697	PF02747	0.391
LIG_Pex14_1	394	398	PF04695	0.601
LIG_SH2_CRK	79	83	PF00017	0.395
LIG_SH2_GRB2like	514	517	PF00017	0.292
LIG_SH2_SRC	514	517	PF00017	0.385
LIG_SH2_SRC	719	722	PF00017	0.368
LIG_SH2_STAP1	221	225	PF00017	0.512
LIG_SH2_STAP1	398	402	PF00017	0.625
LIG_SH2_STAT3	652	655	PF00017	0.341
LIG_SH2_STAT5	301	304	PF00017	0.402
LIG_SH2_STAT5	470	473	PF00017	0.335
LIG_SH2_STAT5	514	517	PF00017	0.385
LIG_SH2_STAT5	652	655	PF00017	0.341
LIG_SH2_STAT5	719	722	PF00017	0.368
LIG_SH3_1	308	314	PF00018	0.393
LIG_SH3_3	273	279	PF00018	0.365
LIG_SH3_3	28	34	PF00018	0.374
LIG_SH3_3	308	314	PF00018	0.555
LIG_SH3_3	376	382	PF00018	0.619
LIG_SH3_3	449	455	PF00018	0.453
LIG_SUMO_SIM_anti_2	319	325	PF11976	0.466
LIG_SUMO_SIM_anti_2	329	335	PF11976	0.530
LIG_SUMO_SIM_anti_2	612	617	PF11976	0.404
LIG_SUMO_SIM_par_1	261	271	PF11976	0.392
LIG_SUMO_SIM_par_1	583	588	PF11976	0.377
LIG_SUMO_SIM_par_1	80	85	PF11976	0.490
LIG_TRAF2_1	454	457	PF00917	0.434
LIG_TRAF2_1	653	656	PF00917	0.388
LIG_TYR_ITIM	512	517	PF00017	0.293
LIG_UBA3_1	634	641	PF00899	0.410
LIG_WRC_WIRS_1	158	163	PF05994	0.615
LIG_WRC_WIRS_1	696	701	PF05994	0.365
MOD_CK1_1	132	138	PF00069	0.483
MOD_CK1_1	154	160	PF00069	0.709
MOD_CK1_1	2	8	PF00069	0.616
MOD_CK1_1	367	373	PF00069	0.683
MOD_CK1_1	650	656	PF00069	0.305
MOD_CK2_1	358	364	PF00069	0.573
MOD_CK2_1	450	456	PF00069	0.438
MOD_CK2_1	58	64	PF00069	0.531
MOD_CK2_1	650	656	PF00069	0.387
MOD_CK2_1	715	721	PF00069	0.381
MOD_CK2_1	92	98	PF00069	0.615
MOD_Cter_Amidation	589	592	PF01082	0.502
MOD_GlcNHglycan	10	13	PF01048	0.543
MOD_GlcNHglycan	127	130	PF01048	0.616
MOD_GlcNHglycan	153	157	PF01048	0.732
MOD_GlcNHglycan	161	164	PF01048	0.693
MOD_GlcNHglycan	194	197	PF01048	0.657
MOD_GlcNHglycan	246	249	PF01048	0.456
MOD_GlcNHglycan	291	294	PF01048	0.680
MOD_GlcNHglycan	367	370	PF01048	0.735
MOD_GlcNHglycan	371	374	PF01048	0.752
MOD_GlcNHglycan	418	421	PF01048	0.777
MOD_GlcNHglycan	422	425	PF01048	0.719
MOD_GlcNHglycan	527	530	PF01048	0.391
MOD_GlcNHglycan	6	9	PF01048	0.596
MOD_GlcNHglycan	60	63	PF01048	0.421
MOD_GlcNHglycan	684	687	PF01048	0.445
MOD_GlcNHglycan	90	93	PF01048	0.478
MOD_GSK3_1	125	132	PF00069	0.541
MOD_GSK3_1	147	154	PF00069	0.684
MOD_GSK3_1	194	201	PF00069	0.597
MOD_GSK3_1	237	244	PF00069	0.524
MOD_GSK3_1	260	267	PF00069	0.364
MOD_GSK3_1	289	296	PF00069	0.584
MOD_GSK3_1	3	10	PF00069	0.612
MOD_GSK3_1	359	366	PF00069	0.619
MOD_GSK3_1	416	423	PF00069	0.607
MOD_GSK3_1	446	453	PF00069	0.530
MOD_GSK3_1	466	473	PF00069	0.358
MOD_GSK3_1	571	578	PF00069	0.493
MOD_GSK3_1	643	650	PF00069	0.341
MOD_GSK3_1	691	698	PF00069	0.390
MOD_GSK3_1	715	722	PF00069	0.423
MOD_GSK3_1	88	95	PF00069	0.445
MOD_N-GLC_1	228	233	PF02516	0.420
MOD_N-GLC_1	466	471	PF02516	0.339
MOD_N-GLC_1	682	687	PF02516	0.423
MOD_NEK2_1	1	6	PF00069	0.765
MOD_NEK2_1	116	121	PF00069	0.444
MOD_NEK2_1	358	363	PF00069	0.746
MOD_NEK2_1	56	61	PF00069	0.532
MOD_NEK2_1	595	600	PF00069	0.507
MOD_NEK2_1	676	681	PF00069	0.460
MOD_NEK2_1	682	687	PF00069	0.484
MOD_NEK2_1	715	720	PF00069	0.566
MOD_NEK2_1	727	732	PF00069	0.435
MOD_NEK2_2	250	255	PF00069	0.479
MOD_PIKK_1	470	476	PF00454	0.475
MOD_PKA_2	125	131	PF00069	0.626
MOD_PKA_2	138	144	PF00069	0.593
MOD_PKA_2	2	8	PF00069	0.581
MOD_PKA_2	40	46	PF00069	0.416
MOD_PKA_2	575	581	PF00069	0.349
MOD_Plk_1	359	365	PF00069	0.712
MOD_Plk_1	466	472	PF00069	0.355
MOD_Plk_1	523	529	PF00069	0.500
MOD_Plk_1	609	615	PF00069	0.463
MOD_Plk_2-3	575	581	PF00069	0.400
MOD_Plk_4	129	135	PF00069	0.549
MOD_Plk_4	260	266	PF00069	0.389
MOD_Plk_4	293	299	PF00069	0.440
MOD_Plk_4	466	472	PF00069	0.359
MOD_ProDKin_1	237	243	PF00069	0.454
MOD_ProDKin_1	378	384	PF00069	0.737
MOD_ProDKin_1	451	457	PF00069	0.421
MOD_ProDKin_1	624	630	PF00069	0.395
MOD_ProDKin_1	702	708	PF00069	0.371
MOD_SUMO_rev_2	304	310	PF00179	0.423
TRG_DiLeu_BaEn_1	457	462	PF01217	0.383
TRG_DiLeu_BaEn_1	503	508	PF01217	0.466
TRG_DiLeu_BaEn_4	503	509	PF01217	0.238
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.553
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.482
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.426
TRG_DiLeu_LyEn_5	457	462	PF01217	0.397
TRG_ENDOCYTIC_2	514	517	PF00928	0.292
TRG_ENDOCYTIC_2	79	82	PF00928	0.379
TRG_ER_diArg_1	100	102	PF00400	0.449
TRG_ER_diArg_1	430	433	PF00400	0.562
TRG_ER_diArg_1	531	533	PF00400	0.413
TRG_ER_diArg_1	71	74	PF00400	0.503
TRG_NES_CRM1_1	506	518	PF08389	0.300
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	217	222	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	597	601	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	632	636	PF00026	0.340
TRG_Pf-PMV_PEXEL_1	673	677	PF00026	0.337
TRG_Pf-PMV_PEXEL_1	695	700	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	80	85	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9P1	Leptomonas seymouri	71%	100%
A0A0S4J3E1	Bodo saltans	42%	100%
A0A1X0NXS8	Trypanosomatidae	43%	100%
A0A3R7KD39	Trypanosoma rangeli	49%	100%
A4HYP7	Leishmania infantum	99%	99%
C9ZI84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AIC1	Leishmania braziliensis	84%	100%
E9AUK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QCX6	Leishmania major	94%	100%
V5BQT5	Trypanosoma cruzi	50%	100%