LeishMANIAdb
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2OG-Fe(II)_oxygenase_superfamily_putative/Pfam:PF 03171

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
2OG-Fe(II)_oxygenase_superfamily_putative/Pfam:PF 03171
Gene product:
2OG-Fe(II) oxygenase superfamily, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IBQ1_LEIDO
TriTrypDb:
LdBPK_251040.1 , LdCL_250015700 , LDHU3_25.1330
Length:
431

Annotations

Annotations by Jardim et al.

Metal Binding, 2OG-Fe(II) oxygenase superfamily, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IBQ1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBQ1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0016491 oxidoreductase activity 2 12
GO:0043167 ion binding 2 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0051213 dioxygenase activity 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 185 189 PF00656 0.573
CLV_C14_Caspase3-7 417 421 PF00656 0.628
CLV_NRD_NRD_1 139 141 PF00675 0.470
CLV_NRD_NRD_1 159 161 PF00675 0.230
CLV_NRD_NRD_1 289 291 PF00675 0.575
CLV_PCSK_KEX2_1 139 141 PF00082 0.487
CLV_PCSK_KEX2_1 159 161 PF00082 0.230
CLV_PCSK_KEX2_1 248 250 PF00082 0.433
CLV_PCSK_KEX2_1 289 291 PF00082 0.586
CLV_PCSK_KEX2_1 80 82 PF00082 0.626
CLV_PCSK_PC1ET2_1 248 250 PF00082 0.433
CLV_PCSK_PC1ET2_1 80 82 PF00082 0.662
CLV_PCSK_SKI1_1 291 295 PF00082 0.653
CLV_PCSK_SKI1_1 311 315 PF00082 0.417
CLV_PCSK_SKI1_1 381 385 PF00082 0.353
CLV_PCSK_SKI1_1 49 53 PF00082 0.375
CLV_PCSK_SKI1_1 60 64 PF00082 0.305
DEG_APCC_DBOX_1 8 16 PF00400 0.482
DEG_MDM2_SWIB_1 364 372 PF02201 0.312
DEG_Nend_Nbox_1 1 3 PF02207 0.689
DOC_CDC14_PxL_1 347 355 PF14671 0.296
DOC_MAPK_gen_1 159 167 PF00069 0.498
DOC_MAPK_gen_1 266 273 PF00069 0.643
DOC_MAPK_MEF2A_6 344 352 PF00069 0.405
DOC_PP1_RVXF_1 58 64 PF00149 0.360
DOC_PP4_FxxP_1 395 398 PF00568 0.332
DOC_USP7_MATH_1 175 179 PF00917 0.690
DOC_USP7_MATH_1 418 422 PF00917 0.594
DOC_USP7_MATH_1 75 79 PF00917 0.625
DOC_USP7_MATH_2 94 100 PF00917 0.432
DOC_WW_Pin1_4 373 378 PF00397 0.296
DOC_WW_Pin1_4 90 95 PF00397 0.407
DOC_WW_Pin1_4 99 104 PF00397 0.407
LIG_14-3-3_CanoR_1 214 222 PF00244 0.378
LIG_14-3-3_CanoR_1 3 8 PF00244 0.465
LIG_BRCT_BRCA1_1 390 394 PF00533 0.296
LIG_FHA_1 312 318 PF00498 0.370
LIG_FHA_1 323 329 PF00498 0.295
LIG_FHA_1 367 373 PF00498 0.312
LIG_FHA_2 317 323 PF00498 0.335
LIG_FHA_2 48 54 PF00498 0.519
LIG_HCF-1_HBM_1 36 39 PF13415 0.480
LIG_LIR_Gen_1 150 157 PF02991 0.459
LIG_LIR_Gen_1 346 353 PF02991 0.338
LIG_LIR_Gen_1 36 47 PF02991 0.465
LIG_LIR_Nem_3 104 109 PF02991 0.381
LIG_LIR_Nem_3 240 245 PF02991 0.372
LIG_LIR_Nem_3 346 350 PF02991 0.310
LIG_LIR_Nem_3 36 42 PF02991 0.461
LIG_LIR_Nem_3 391 397 PF02991 0.296
LIG_LYPXL_yS_3 258 261 PF13949 0.423
LIG_MYND_3 350 354 PF01753 0.381
LIG_Pex14_2 190 194 PF04695 0.477
LIG_Pex14_2 364 368 PF04695 0.283
LIG_SH2_CRK 110 114 PF00017 0.405
LIG_SH2_CRK 347 351 PF00017 0.412
LIG_SH2_CRK 39 43 PF00017 0.322
LIG_SH2_STAP1 202 206 PF00017 0.382
LIG_SH2_STAT3 142 145 PF00017 0.495
LIG_SH2_STAT3 257 260 PF00017 0.445
LIG_SH2_STAT5 112 115 PF00017 0.413
LIG_SH2_STAT5 153 156 PF00017 0.443
LIG_SH2_STAT5 206 209 PF00017 0.464
LIG_SH2_STAT5 241 244 PF00017 0.418
LIG_SH2_STAT5 39 42 PF00017 0.301
LIG_SH2_STAT5 66 69 PF00017 0.366
LIG_SH3_3 129 135 PF00018 0.439
LIG_SH3_3 221 227 PF00018 0.466
LIG_SUMO_SIM_anti_2 324 330 PF11976 0.296
LIG_SUMO_SIM_par_1 324 330 PF11976 0.417
LIG_WRC_WIRS_1 242 247 PF05994 0.503
MOD_CDK_SPxK_1 373 379 PF00069 0.296
MOD_CK1_1 155 161 PF00069 0.458
MOD_CK1_1 324 330 PF00069 0.312
MOD_CK1_1 388 394 PF00069 0.310
MOD_CK1_1 99 105 PF00069 0.416
MOD_CK2_1 90 96 PF00069 0.414
MOD_GlcNHglycan 103 106 PF01048 0.430
MOD_GlcNHglycan 115 118 PF01048 0.389
MOD_GlcNHglycan 175 178 PF01048 0.625
MOD_GlcNHglycan 24 27 PF01048 0.510
MOD_GlcNHglycan 277 280 PF01048 0.569
MOD_GlcNHglycan 302 305 PF01048 0.714
MOD_GSK3_1 148 155 PF00069 0.500
MOD_GSK3_1 169 176 PF00069 0.579
MOD_GSK3_1 20 27 PF00069 0.415
MOD_GSK3_1 384 391 PF00069 0.346
MOD_N-GLC_1 20 25 PF02516 0.437
MOD_N-GLC_1 87 92 PF02516 0.505
MOD_NEK2_1 2 7 PF00069 0.556
MOD_NEK2_1 204 209 PF00069 0.463
MOD_NEK2_1 298 303 PF00069 0.742
MOD_NEK2_1 30 35 PF00069 0.410
MOD_NEK2_2 241 246 PF00069 0.500
MOD_NEK2_2 75 80 PF00069 0.638
MOD_PIKK_1 327 333 PF00454 0.417
MOD_PIKK_1 87 93 PF00454 0.533
MOD_PKA_2 2 8 PF00069 0.542
MOD_PKA_2 222 228 PF00069 0.478
MOD_PKA_2 388 394 PF00069 0.294
MOD_Plk_1 311 317 PF00069 0.342
MOD_Plk_1 321 327 PF00069 0.244
MOD_Plk_1 87 93 PF00069 0.550
MOD_Plk_4 152 158 PF00069 0.526
MOD_Plk_4 343 349 PF00069 0.456
MOD_Plk_4 388 394 PF00069 0.285
MOD_Plk_4 418 424 PF00069 0.555
MOD_Plk_4 47 53 PF00069 0.447
MOD_Plk_4 8 14 PF00069 0.425
MOD_ProDKin_1 373 379 PF00069 0.296
MOD_ProDKin_1 90 96 PF00069 0.402
MOD_ProDKin_1 99 105 PF00069 0.408
MOD_SUMO_rev_2 188 197 PF00179 0.492
MOD_SUMO_rev_2 303 313 PF00179 0.691
MOD_SUMO_rev_2 338 346 PF00179 0.296
TRG_AP2beta_CARGO_1 240 249 PF09066 0.483
TRG_DiLeu_BaEn_1 354 359 PF01217 0.381
TRG_DiLeu_BaEn_4 149 155 PF01217 0.525
TRG_DiLeu_BaLyEn_6 403 408 PF01217 0.441
TRG_ENDOCYTIC_2 110 113 PF00928 0.409
TRG_ENDOCYTIC_2 153 156 PF00928 0.448
TRG_ENDOCYTIC_2 201 204 PF00928 0.369
TRG_ENDOCYTIC_2 258 261 PF00928 0.395
TRG_ENDOCYTIC_2 347 350 PF00928 0.331
TRG_ENDOCYTIC_2 39 42 PF00928 0.315
TRG_ER_diArg_1 138 140 PF00400 0.473
TRG_ER_diArg_1 288 290 PF00400 0.581

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3U5 Leptomonas seymouri 82% 99%
A0A0S4JVQ8 Bodo saltans 46% 100%
A0A1X0NLX7 Trypanosomatidae 58% 100%
A0A422NXL7 Trypanosoma rangeli 62% 100%
A4HE36 Leishmania braziliensis 93% 100%
A4I1E2 Leishmania infantum 100% 100%
C9ZJV9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 100%
E9AXH9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
Q4Q9Z3 Leishmania major 97% 100%
V5BGC6 Trypanosoma cruzi 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS