RING-H2_zinc_finger/Ring_finger_domain/Zinc_finge r_C3HC4_type_(RING_finger)_containing_protein_putative/Pfam:PF12678/Pfam:PF13639/Pfam:PF00097/Pfam:PF13923

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RING-H2 zinc finger, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBP7_LEIDO

TriTrypDb:

LdBPK_231780.1 , LdCL_230024900 , LDHU3_23.2350

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IBP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBP7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004842	ubiquitin-protein transferase activity	4	8
GO:0005488	binding	1	8
GO:0008270	zinc ion binding	6	7
GO:0016740	transferase activity	2	8
GO:0019787	ubiquitin-like protein transferase activity	3	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046914	transition metal ion binding	5	7
GO:0061630	ubiquitin protein ligase activity	5	8
GO:0061659	ubiquitin-like protein ligase activity	4	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.727
CLV_C14_Caspase3-7	316	320	PF00656	0.678
CLV_NRD_NRD_1	73	75	PF00675	0.663
CLV_PCSK_KEX2_1	3	5	PF00082	0.730
CLV_PCSK_KEX2_1	73	75	PF00082	0.663
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.730
CLV_PCSK_SKI1_1	247	251	PF00082	0.674
CLV_PCSK_SKI1_1	66	70	PF00082	0.605
CLV_PCSK_SKI1_1	74	78	PF00082	0.592
DEG_APCC_DBOX_1	73	81	PF00400	0.601
DEG_SPOP_SBC_1	394	398	PF00917	0.768
DOC_CYCLIN_yClb5_NLxxxL_5	255	264	PF00134	0.665
DOC_PP4_FxxP_1	367	370	PF00568	0.551
DOC_USP7_MATH_1	185	189	PF00917	0.720
DOC_USP7_MATH_1	222	226	PF00917	0.753
DOC_USP7_MATH_1	312	316	PF00917	0.592
DOC_USP7_MATH_1	339	343	PF00917	0.531
DOC_USP7_MATH_1	393	397	PF00917	0.752
DOC_USP7_UBL2_3	355	359	PF12436	0.608
DOC_WW_Pin1_4	201	206	PF00397	0.809
DOC_WW_Pin1_4	223	228	PF00397	0.766
DOC_WW_Pin1_4	25	30	PF00397	0.697
DOC_WW_Pin1_4	346	351	PF00397	0.607
DOC_WW_Pin1_4	66	71	PF00397	0.557
LIG_14-3-3_CanoR_1	6	14	PF00244	0.788
LIG_Clathr_ClatBox_1	287	291	PF01394	0.528
LIG_FHA_1	29	35	PF00498	0.791
LIG_FHA_1	320	326	PF00498	0.430
LIG_FHA_1	379	385	PF00498	0.525
LIG_FHA_2	130	136	PF00498	0.728
LIG_FHA_2	211	217	PF00498	0.733
LIG_FHA_2	246	252	PF00498	0.749
LIG_FHA_2	281	287	PF00498	0.654
LIG_FHA_2	314	320	PF00498	0.565
LIG_FHA_2	70	76	PF00498	0.521
LIG_FHA_2	85	91	PF00498	0.711
LIG_LIR_Gen_1	135	144	PF02991	0.813
LIG_LIR_Gen_1	281	290	PF02991	0.497
LIG_LIR_Nem_3	281	287	PF02991	0.500
LIG_SH2_STAP1	137	141	PF00017	0.736
LIG_SH2_STAP1	284	288	PF00017	0.528
LIG_SH3_3	171	177	PF00018	0.753
LIG_SUMO_SIM_anti_2	213	219	PF11976	0.721
LIG_SUMO_SIM_par_1	19	25	PF11976	0.690
LIG_SUMO_SIM_par_1	285	292	PF11976	0.531
LIG_TRAF2_1	161	164	PF00917	0.838
LIG_TRAF2_1	249	252	PF00917	0.731
LIG_TRAF2_1	283	286	PF00917	0.530
LIG_WRC_WIRS_1	108	113	PF05994	0.817
MOD_CDK_SPxxK_3	223	230	PF00069	0.776
MOD_CDK_SPxxK_3	66	73	PF00069	0.548
MOD_CK1_1	28	34	PF00069	0.721
MOD_CK1_1	331	337	PF00069	0.533
MOD_CK1_1	342	348	PF00069	0.483
MOD_CK2_1	129	135	PF00069	0.780
MOD_CK2_1	169	175	PF00069	0.571
MOD_CK2_1	245	251	PF00069	0.686
MOD_CK2_1	280	286	PF00069	0.528
MOD_CK2_1	84	90	PF00069	0.695
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.605
MOD_GlcNHglycan	103	106	PF01048	0.693
MOD_GlcNHglycan	243	246	PF01048	0.737
MOD_GlcNHglycan	316	319	PF01048	0.644
MOD_GlcNHglycan	328	333	PF01048	0.380
MOD_GlcNHglycan	341	344	PF01048	0.317
MOD_GlcNHglycan	350	353	PF01048	0.301
MOD_GSK3_1	125	132	PF00069	0.735
MOD_GSK3_1	185	192	PF00069	0.754
MOD_GSK3_1	21	28	PF00069	0.737
MOD_GSK3_1	241	248	PF00069	0.713
MOD_GSK3_1	331	338	PF00069	0.559
MOD_GSK3_1	339	346	PF00069	0.569
MOD_GSK3_1	374	381	PF00069	0.607
MOD_GSK3_1	6	13	PF00069	0.795
MOD_N-GLC_1	295	300	PF02516	0.603
MOD_N-GLC_1	378	383	PF02516	0.342
MOD_N-GLC_1	7	12	PF02516	0.770
MOD_NEK2_1	119	124	PF00069	0.783
MOD_NEK2_1	125	130	PF00069	0.824
MOD_NEK2_1	305	310	PF00069	0.623
MOD_NEK2_1	313	318	PF00069	0.557
MOD_NEK2_1	330	335	PF00069	0.418
MOD_NEK2_1	39	44	PF00069	0.773
MOD_NEK2_1	61	66	PF00069	0.503
MOD_PIKK_1	125	131	PF00454	0.738
MOD_PIKK_1	28	34	PF00454	0.793
MOD_PIKK_1	374	380	PF00454	0.577
MOD_PIKK_1	39	45	PF00454	0.582
MOD_PKA_2	153	159	PF00069	0.782
MOD_PKA_2	241	247	PF00069	0.733
MOD_PKA_2	313	319	PF00069	0.674
MOD_PKA_2	61	67	PF00069	0.593
MOD_PKB_1	4	12	PF00069	0.729
MOD_Plk_1	10	16	PF00069	0.729
MOD_Plk_1	280	286	PF00069	0.528
MOD_Plk_1	89	95	PF00069	0.644
MOD_Plk_2-3	280	286	PF00069	0.538
MOD_Plk_4	210	216	PF00069	0.739
MOD_Plk_4	89	95	PF00069	0.630
MOD_ProDKin_1	201	207	PF00069	0.808
MOD_ProDKin_1	223	229	PF00069	0.772
MOD_ProDKin_1	25	31	PF00069	0.697
MOD_ProDKin_1	346	352	PF00069	0.607
MOD_ProDKin_1	66	72	PF00069	0.554
TRG_DiLeu_BaEn_2	174	180	PF01217	0.795
TRG_DiLeu_BaEn_4	148	154	PF01217	0.744
TRG_DiLeu_BaEn_4	285	291	PF01217	0.527
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.716
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.626
TRG_ENDOCYTIC_2	137	140	PF00928	0.817
TRG_ENDOCYTIC_2	284	287	PF00928	0.494
TRG_NLS_MonoExtN_4	2	7	PF00514	0.732

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKS7	Leptomonas seymouri	45%	100%
A4HD23	Leishmania braziliensis	79%	100%
A4I0L0	Leishmania infantum	99%	100%
C9ZVI2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AWH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QB00	Leishmania major	92%	100%