Metallopeptidase family M24, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Metallopeptidase family M24, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBP5_LEIDO

TriTrypDb:

LdBPK_130570.1 , LdCL_130011100 , LDHU3_13.0760

Length:

574

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 3
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IBP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBP5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004177	aminopeptidase activity	5	5
GO:0008233	peptidase activity	3	5
GO:0008238	exopeptidase activity	4	5
GO:0016787	hydrolase activity	2	5
GO:0140096	catalytic activity, acting on a protein	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	486	492	PF00089	0.319
CLV_NRD_NRD_1	129	131	PF00675	0.637
CLV_NRD_NRD_1	292	294	PF00675	0.258
CLV_NRD_NRD_1	371	373	PF00675	0.416
CLV_NRD_NRD_1	418	420	PF00675	0.366
CLV_NRD_NRD_1	537	539	PF00675	0.476
CLV_NRD_NRD_1	62	64	PF00675	0.724
CLV_NRD_NRD_1	72	74	PF00675	0.721
CLV_PCSK_FUR_1	18	22	PF00082	0.573
CLV_PCSK_FUR_1	356	360	PF00082	0.341
CLV_PCSK_FUR_1	70	74	PF00082	0.723
CLV_PCSK_KEX2_1	129	131	PF00082	0.645
CLV_PCSK_KEX2_1	20	22	PF00082	0.537
CLV_PCSK_KEX2_1	214	216	PF00082	0.361
CLV_PCSK_KEX2_1	291	293	PF00082	0.261
CLV_PCSK_KEX2_1	358	360	PF00082	0.391
CLV_PCSK_KEX2_1	371	373	PF00082	0.401
CLV_PCSK_KEX2_1	418	420	PF00082	0.366
CLV_PCSK_KEX2_1	499	501	PF00082	0.364
CLV_PCSK_KEX2_1	537	539	PF00082	0.538
CLV_PCSK_KEX2_1	563	565	PF00082	0.596
CLV_PCSK_KEX2_1	72	74	PF00082	0.721
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.537
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.343
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.391
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.408
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.596
CLV_PCSK_SKI1_1	113	117	PF00082	0.572
CLV_PCSK_SKI1_1	202	206	PF00082	0.359
CLV_PCSK_SKI1_1	314	318	PF00082	0.332
CLV_PCSK_SKI1_1	371	375	PF00082	0.430
CLV_PCSK_SKI1_1	412	416	PF00082	0.546
CLV_PCSK_SKI1_1	499	503	PF00082	0.412
CLV_PCSK_SKI1_1	64	68	PF00082	0.688
CLV_Separin_Metazoa	60	64	PF03568	0.579
DEG_APCC_DBOX_1	128	136	PF00400	0.510
DEG_APCC_DBOX_1	313	321	PF00400	0.277
DEG_APCC_DBOX_1	62	70	PF00400	0.629
DEG_COP1_1	354	365	PF00400	0.315
DOC_ANK_TNKS_1	358	365	PF00023	0.322
DOC_CKS1_1	513	518	PF01111	0.486
DOC_CYCLIN_RxL_1	199	208	PF00134	0.372
DOC_CYCLIN_yCln2_LP_2	536	542	PF00134	0.381
DOC_MAPK_FxFP_2	445	448	PF00069	0.449
DOC_MAPK_gen_1	18	27	PF00069	0.568
DOC_MAPK_gen_1	459	466	PF00069	0.465
DOC_MAPK_MEF2A_6	11	19	PF00069	0.564
DOC_MAPK_MEF2A_6	247	256	PF00069	0.267
DOC_MAPK_MEF2A_6	459	466	PF00069	0.363
DOC_PP4_FxxP_1	445	448	PF00568	0.449
DOC_USP7_MATH_1	48	52	PF00917	0.679
DOC_USP7_MATH_1	521	525	PF00917	0.462
DOC_USP7_MATH_1	7	11	PF00917	0.706
DOC_USP7_MATH_1	85	89	PF00917	0.710
DOC_USP7_UBL2_3	95	99	PF12436	0.629
DOC_WW_Pin1_4	115	120	PF00397	0.566
DOC_WW_Pin1_4	233	238	PF00397	0.407
DOC_WW_Pin1_4	417	422	PF00397	0.493
DOC_WW_Pin1_4	512	517	PF00397	0.485
DOC_WW_Pin1_4	556	561	PF00397	0.633
DOC_WW_Pin1_4	80	85	PF00397	0.513
DOC_WW_Pin1_4	87	92	PF00397	0.538
LIG_14-3-3_CanoR_1	111	119	PF00244	0.600
LIG_14-3-3_CanoR_1	21	26	PF00244	0.633
LIG_14-3-3_CanoR_1	218	223	PF00244	0.291
LIG_14-3-3_CanoR_1	291	300	PF00244	0.397
LIG_14-3-3_CanoR_1	371	378	PF00244	0.425
LIG_14-3-3_CanoR_1	406	416	PF00244	0.441
LIG_14-3-3_CanoR_1	429	437	PF00244	0.355
LIG_14-3-3_CanoR_1	489	495	PF00244	0.310
LIG_14-3-3_CanoR_1	500	504	PF00244	0.347
LIG_14-3-3_CanoR_1	520	528	PF00244	0.438
LIG_14-3-3_CanoR_1	63	67	PF00244	0.566
LIG_14-3-3_CanoR_1	73	79	PF00244	0.761
LIG_Actin_WH2_2	311	327	PF00022	0.407
LIG_BRCT_BRCA1_1	124	128	PF00533	0.624
LIG_DLG_GKlike_1	23	30	PF00625	0.556
LIG_FHA_1	184	190	PF00498	0.300
LIG_FHA_1	268	274	PF00498	0.322
LIG_FHA_1	332	338	PF00498	0.324
LIG_FHA_1	491	497	PF00498	0.353
LIG_FHA_1	508	514	PF00498	0.489
LIG_FHA_1	56	62	PF00498	0.721
LIG_FHA_1	63	69	PF00498	0.786
LIG_FHA_2	190	196	PF00498	0.368
LIG_FHA_2	280	286	PF00498	0.340
LIG_FHA_2	372	378	PF00498	0.459
LIG_FHA_2	406	412	PF00498	0.444
LIG_FHA_2	418	424	PF00498	0.360
LIG_FHA_2	434	440	PF00498	0.366
LIG_FHA_2	520	526	PF00498	0.555
LIG_LIR_Apic_2	442	448	PF02991	0.447
LIG_LIR_Gen_1	541	549	PF02991	0.460
LIG_LIR_Nem_3	541	545	PF02991	0.533
LIG_MAD2	67	75	PF02301	0.587
LIG_PCNA_yPIPBox_3	218	232	PF02747	0.334
LIG_PCNA_yPIPBox_3	325	337	PF02747	0.347
LIG_Pex14_2	445	449	PF04695	0.445
LIG_PTAP_UEV_1	508	513	PF05743	0.376
LIG_RPA_C_Fungi	18	30	PF08784	0.677
LIG_SH2_STAT3	344	347	PF00017	0.407
LIG_SH2_STAT5	485	488	PF00017	0.414
LIG_SH3_3	506	512	PF00018	0.403
LIG_SUMO_SIM_anti_2	531	537	PF11976	0.506
LIG_SUMO_SIM_par_1	269	275	PF11976	0.304
LIG_SUMO_SIM_par_1	491	497	PF11976	0.346
LIG_TRAF2_1	436	439	PF00917	0.398
MOD_CDC14_SPxK_1	236	239	PF00782	0.407
MOD_CDK_SPxK_1	233	239	PF00069	0.407
MOD_CDK_SPxxK_3	115	122	PF00069	0.483
MOD_CDK_SPxxK_3	556	563	PF00069	0.630
MOD_CK1_1	221	227	PF00069	0.318
MOD_CK1_1	279	285	PF00069	0.311
MOD_CK1_1	301	307	PF00069	0.412
MOD_CK1_1	354	360	PF00069	0.324
MOD_CK1_1	51	57	PF00069	0.762
MOD_CK1_1	524	530	PF00069	0.534
MOD_CK1_1	558	564	PF00069	0.633
MOD_CK1_1	77	83	PF00069	0.728
MOD_CK2_1	143	149	PF00069	0.571
MOD_CK2_1	189	195	PF00069	0.265
MOD_CK2_1	224	230	PF00069	0.395
MOD_CK2_1	405	411	PF00069	0.440
MOD_CK2_1	433	439	PF00069	0.433
MOD_CK2_1	519	525	PF00069	0.568
MOD_Cter_Amidation	212	215	PF01082	0.356
MOD_GlcNHglycan	106	109	PF01048	0.660
MOD_GlcNHglycan	11	14	PF01048	0.534
MOD_GlcNHglycan	124	127	PF01048	0.495
MOD_GlcNHglycan	265	268	PF01048	0.325
MOD_GlcNHglycan	278	281	PF01048	0.170
MOD_GlcNHglycan	303	306	PF01048	0.372
MOD_GlcNHglycan	46	49	PF01048	0.589
MOD_GlcNHglycan	490	493	PF01048	0.306
MOD_GlcNHglycan	5	8	PF01048	0.648
MOD_GlcNHglycan	54	57	PF01048	0.573
MOD_GlcNHglycan	560	563	PF01048	0.541
MOD_GSK3_1	100	107	PF00069	0.664
MOD_GSK3_1	111	118	PF00069	0.565
MOD_GSK3_1	149	156	PF00069	0.485
MOD_GSK3_1	19	26	PF00069	0.649
MOD_GSK3_1	263	270	PF00069	0.315
MOD_GSK3_1	272	279	PF00069	0.321
MOD_GSK3_1	3	10	PF00069	0.573
MOD_GSK3_1	44	51	PF00069	0.725
MOD_GSK3_1	484	491	PF00069	0.363
MOD_GSK3_1	52	59	PF00069	0.702
MOD_GSK3_1	73	80	PF00069	0.686
MOD_GSK3_1	83	90	PF00069	0.608
MOD_N-GLC_1	154	159	PF02516	0.518
MOD_N-GLC_1	224	229	PF02516	0.270
MOD_N-GLC_1	233	238	PF02516	0.269
MOD_N-GLC_1	354	359	PF02516	0.293
MOD_N-GLC_1	433	438	PF02516	0.528
MOD_NEK2_1	154	159	PF00069	0.513
MOD_NEK2_1	19	24	PF00069	0.676
MOD_NEK2_1	205	210	PF00069	0.481
MOD_NEK2_1	490	495	PF00069	0.351
MOD_NEK2_1	78	83	PF00069	0.767
MOD_NEK2_2	62	67	PF00069	0.521
MOD_PIKK_1	120	126	PF00454	0.682
MOD_PIKK_1	428	434	PF00454	0.331
MOD_PKA_1	291	297	PF00069	0.264
MOD_PKA_1	371	377	PF00069	0.421
MOD_PKA_1	499	505	PF00069	0.352
MOD_PKA_2	13	19	PF00069	0.566
MOD_PKA_2	291	297	PF00069	0.444
MOD_PKA_2	371	377	PF00069	0.421
MOD_PKA_2	405	411	PF00069	0.409
MOD_PKA_2	428	434	PF00069	0.425
MOD_PKA_2	488	494	PF00069	0.307
MOD_PKA_2	499	505	PF00069	0.327
MOD_PKA_2	519	525	PF00069	0.445
MOD_PKA_2	62	68	PF00069	0.560
MOD_PKB_1	111	119	PF00069	0.571
MOD_PKB_1	21	29	PF00069	0.525
MOD_PKB_1	291	299	PF00069	0.226
MOD_Plk_1	149	155	PF00069	0.551
MOD_Plk_1	224	230	PF00069	0.271
MOD_Plk_1	433	439	PF00069	0.543
MOD_Plk_1	48	54	PF00069	0.734
MOD_Plk_1	524	530	PF00069	0.425
MOD_Plk_4	149	155	PF00069	0.420
MOD_Plk_4	412	418	PF00069	0.340
MOD_Plk_4	499	505	PF00069	0.342
MOD_Plk_4	74	80	PF00069	0.771
MOD_ProDKin_1	115	121	PF00069	0.563
MOD_ProDKin_1	233	239	PF00069	0.407
MOD_ProDKin_1	417	423	PF00069	0.505
MOD_ProDKin_1	512	518	PF00069	0.487
MOD_ProDKin_1	556	562	PF00069	0.632
MOD_ProDKin_1	80	86	PF00069	0.514
MOD_ProDKin_1	87	93	PF00069	0.539
TRG_DiLeu_BaEn_1	531	536	PF01217	0.312
TRG_ER_diArg_1	128	130	PF00400	0.569
TRG_ER_diArg_1	291	293	PF00400	0.196
TRG_ER_diArg_1	371	373	PF00400	0.416
TRG_ER_diArg_1	417	419	PF00400	0.349
TRG_ER_diArg_1	536	538	PF00400	0.532
TRG_ER_diArg_1	564	567	PF00400	0.621
TRG_ER_diArg_1	69	72	PF00400	0.726
TRG_NLS_MonoExtC_3	562	568	PF00514	0.550
TRG_NLS_MonoExtN_4	18	24	PF00514	0.568
TRG_NLS_MonoExtN_4	560	567	PF00514	0.554
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM06	Leptomonas seymouri	69%	99%
A0A0S4J160	Bodo saltans	31%	100%
A0A1X0NPS8	Trypanosomatidae	46%	100%
A0A3Q8IBA7	Leishmania donovani	31%	94%
A0A3R7KN75	Trypanosoma rangeli	45%	100%
A4H757	Leishmania braziliensis	80%	99%
A4H9X3	Leishmania braziliensis	31%	99%
A4HVJ6	Leishmania infantum	99%	100%
D0A6Q9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AGR8	Leishmania infantum	31%	94%
E9AP92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	97%
E9ARW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	94%
O60180	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q4QDK5	Leishmania major	31%	94%
Q4QG86	Leishmania major	93%	100%
V5BFG1	Trypanosoma cruzi	45%	100%