SAM domain (Sterile alpha motif), putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 24

Species:

Leishmania donovani

UniProt:

A0A3Q8IBP4_LEIDO

TriTrypDb:

LdBPK_292740.1 , LdCL_290033500 , LDHU3_29.4040

Length:

1237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A0A3Q8IBP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBP4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1106	1110	PF00656	0.683
CLV_C14_Caspase3-7	1186	1190	PF00656	0.728
CLV_C14_Caspase3-7	248	252	PF00656	0.485
CLV_C14_Caspase3-7	423	427	PF00656	0.752
CLV_C14_Caspase3-7	509	513	PF00656	0.717
CLV_C14_Caspase3-7	551	555	PF00656	0.580
CLV_C14_Caspase3-7	797	801	PF00656	0.701
CLV_NRD_NRD_1	1056	1058	PF00675	0.387
CLV_NRD_NRD_1	1095	1097	PF00675	0.452
CLV_NRD_NRD_1	127	129	PF00675	0.504
CLV_NRD_NRD_1	300	302	PF00675	0.359
CLV_NRD_NRD_1	35	37	PF00675	0.425
CLV_NRD_NRD_1	579	581	PF00675	0.413
CLV_NRD_NRD_1	643	645	PF00675	0.421
CLV_NRD_NRD_1	882	884	PF00675	0.435
CLV_NRD_NRD_1	919	921	PF00675	0.375
CLV_PCSK_KEX2_1	1056	1058	PF00082	0.401
CLV_PCSK_KEX2_1	1094	1096	PF00082	0.446
CLV_PCSK_KEX2_1	127	129	PF00082	0.506
CLV_PCSK_KEX2_1	282	284	PF00082	0.372
CLV_PCSK_KEX2_1	300	302	PF00082	0.291
CLV_PCSK_KEX2_1	35	37	PF00082	0.424
CLV_PCSK_KEX2_1	364	366	PF00082	0.438
CLV_PCSK_KEX2_1	543	545	PF00082	0.481
CLV_PCSK_KEX2_1	643	645	PF00082	0.396
CLV_PCSK_KEX2_1	882	884	PF00082	0.475
CLV_PCSK_KEX2_1	919	921	PF00082	0.375
CLV_PCSK_PC1ET2_1	1094	1096	PF00082	0.446
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.419
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.335
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.481
CLV_PCSK_PC7_1	123	129	PF00082	0.497
CLV_PCSK_SKI1_1	101	105	PF00082	0.409
CLV_PCSK_SKI1_1	282	286	PF00082	0.372
CLV_PCSK_SKI1_1	315	319	PF00082	0.403
CLV_PCSK_SKI1_1	336	340	PF00082	0.345
CLV_PCSK_SKI1_1	489	493	PF00082	0.457
CLV_PCSK_SKI1_1	496	500	PF00082	0.409
CLV_PCSK_SKI1_1	630	634	PF00082	0.499
CLV_PCSK_SKI1_1	643	647	PF00082	0.288
CLV_PCSK_SKI1_1	840	844	PF00082	0.514
CLV_Separin_Metazoa	690	694	PF03568	0.651
DEG_APCC_DBOX_1	100	108	PF00400	0.532
DEG_APCC_DBOX_1	335	343	PF00400	0.680
DEG_APCC_DBOX_1	495	503	PF00400	0.497
DEG_APCC_DBOX_1	775	783	PF00400	0.608
DEG_APCC_DBOX_1	918	926	PF00400	0.587
DEG_MDM2_SWIB_1	148	155	PF02201	0.620
DOC_ANK_TNKS_1	73	80	PF00023	0.567
DOC_ANK_TNKS_1	881	888	PF00023	0.598
DOC_CYCLIN_RxL_1	1021	1032	PF00134	0.646
DOC_CYCLIN_RxL_1	1036	1046	PF00134	0.637
DOC_MAPK_gen_1	580	587	PF00069	0.641
DOC_MAPK_MEF2A_6	496	503	PF00069	0.571
DOC_MAPK_MEF2A_6	580	587	PF00069	0.560
DOC_MAPK_MEF2A_6	693	702	PF00069	0.553
DOC_MAPK_MEF2A_6	919	926	PF00069	0.538
DOC_PP1_RVXF_1	956	962	PF00149	0.555
DOC_PP2B_LxvP_1	1085	1088	PF13499	0.630
DOC_PP2B_LxvP_1	611	614	PF13499	0.559
DOC_PP4_MxPP_1	1	4	PF00568	0.460
DOC_USP7_MATH_1	1029	1033	PF00917	0.574
DOC_USP7_MATH_1	1165	1169	PF00917	0.829
DOC_USP7_MATH_1	334	338	PF00917	0.600
DOC_USP7_MATH_1	358	362	PF00917	0.613
DOC_USP7_MATH_1	373	377	PF00917	0.507
DOC_USP7_MATH_1	4	8	PF00917	0.504
DOC_USP7_MATH_1	709	713	PF00917	0.623
DOC_USP7_MATH_1	801	805	PF00917	0.690
DOC_USP7_MATH_1	864	868	PF00917	0.670
DOC_USP7_UBL2_3	992	996	PF12436	0.616
DOC_WW_Pin1_4	1176	1181	PF00397	0.766
DOC_WW_Pin1_4	118	123	PF00397	0.710
DOC_WW_Pin1_4	130	135	PF00397	0.685
DOC_WW_Pin1_4	164	169	PF00397	0.639
DOC_WW_Pin1_4	256	261	PF00397	0.625
DOC_WW_Pin1_4	42	47	PF00397	0.713
DOC_WW_Pin1_4	479	484	PF00397	0.558
DOC_WW_Pin1_4	733	738	PF00397	0.586
DOC_WW_Pin1_4	840	845	PF00397	0.675
LIG_14-3-3_CanoR_1	127	133	PF00244	0.782
LIG_14-3-3_CanoR_1	336	345	PF00244	0.579
LIG_14-3-3_CanoR_1	643	651	PF00244	0.680
LIG_14-3-3_CanoR_1	774	783	PF00244	0.606
LIG_14-3-3_CanoR_1	84	92	PF00244	0.576
LIG_14-3-3_CanoR_1	919	923	PF00244	0.543
LIG_14-3-3_CanoR_1	972	981	PF00244	0.566
LIG_Actin_WH2_2	270	288	PF00022	0.565
LIG_Actin_WH2_2	380	397	PF00022	0.601
LIG_Actin_WH2_2	967	984	PF00022	0.595
LIG_BRCT_BRCA1_1	447	451	PF00533	0.629
LIG_BRCT_BRCA1_1	628	632	PF00533	0.646
LIG_BRCT_BRCA1_1	647	651	PF00533	0.461
LIG_CORNRBOX	393	401	PF00104	0.516
LIG_FHA_1	134	140	PF00498	0.731
LIG_FHA_1	156	162	PF00498	0.674
LIG_FHA_1	177	183	PF00498	0.630
LIG_FHA_1	25	31	PF00498	0.356
LIG_FHA_1	462	468	PF00498	0.569
LIG_FHA_1	47	53	PF00498	0.621
LIG_FHA_1	493	499	PF00498	0.600
LIG_FHA_1	607	613	PF00498	0.567
LIG_FHA_1	634	640	PF00498	0.624
LIG_FHA_1	819	825	PF00498	0.624
LIG_FHA_1	910	916	PF00498	0.646
LIG_FHA_1	945	951	PF00498	0.597
LIG_FHA_1	966	972	PF00498	0.525
LIG_FHA_2	1012	1018	PF00498	0.630
LIG_FHA_2	1035	1041	PF00498	0.592
LIG_FHA_2	1067	1073	PF00498	0.823
LIG_FHA_2	1123	1129	PF00498	0.607
LIG_FHA_2	179	185	PF00498	0.688
LIG_FHA_2	188	194	PF00498	0.534
LIG_FHA_2	339	345	PF00498	0.556
LIG_FHA_2	436	442	PF00498	0.675
LIG_FHA_2	537	543	PF00498	0.712
LIG_FHA_2	549	555	PF00498	0.702
LIG_FHA_2	574	580	PF00498	0.725
LIG_FHA_2	684	690	PF00498	0.609
LIG_FHA_2	745	751	PF00498	0.614
LIG_FHA_2	84	90	PF00498	0.621
LIG_FHA_2	866	872	PF00498	0.571
LIG_FHA_2	934	940	PF00498	0.670
LIG_LIR_Gen_1	1020	1029	PF02991	0.626
LIG_LIR_Gen_1	184	191	PF02991	0.638
LIG_LIR_Gen_1	251	260	PF02991	0.518
LIG_LIR_Gen_1	269	278	PF02991	0.524
LIG_LIR_Gen_1	304	311	PF02991	0.488
LIG_LIR_Gen_1	561	572	PF02991	0.548
LIG_LIR_Gen_1	629	639	PF02991	0.556
LIG_LIR_Gen_1	648	657	PF02991	0.558
LIG_LIR_Gen_1	674	684	PF02991	0.600
LIG_LIR_Nem_3	1017	1022	PF02991	0.638
LIG_LIR_Nem_3	149	155	PF02991	0.591
LIG_LIR_Nem_3	184	189	PF02991	0.635
LIG_LIR_Nem_3	251	256	PF02991	0.515
LIG_LIR_Nem_3	269	273	PF02991	0.535
LIG_LIR_Nem_3	27	31	PF02991	0.306
LIG_LIR_Nem_3	304	310	PF02991	0.603
LIG_LIR_Nem_3	561	567	PF02991	0.537
LIG_LIR_Nem_3	629	635	PF02991	0.568
LIG_LIR_Nem_3	648	654	PF02991	0.557
LIG_LIR_Nem_3	674	680	PF02991	0.593
LIG_LIR_Nem_3	89	95	PF02991	0.476
LIG_NRBOX	1114	1120	PF00104	0.685
LIG_PCNA_yPIPBox_3	485	496	PF02747	0.638
LIG_PCNA_yPIPBox_3	693	703	PF02747	0.556
LIG_PCNA_yPIPBox_3	996	1009	PF02747	0.582
LIG_PDZ_Class_1	1232	1237	PF00595	0.686
LIG_Pex14_2	148	152	PF04695	0.619
LIG_Pex14_2	307	311	PF04695	0.478
LIG_SH2_CRK	92	96	PF00017	0.476
LIG_SH2_STAP1	1220	1224	PF00017	0.677
LIG_SH2_STAT3	556	559	PF00017	0.512
LIG_SH2_STAT5	1022	1025	PF00017	0.595
LIG_SH2_STAT5	178	181	PF00017	0.591
LIG_SH2_STAT5	556	559	PF00017	0.546
LIG_SH3_1	1056	1062	PF00018	0.617
LIG_SH3_2	844	849	PF14604	0.601
LIG_SH3_3	1056	1062	PF00018	0.706
LIG_SH3_3	1179	1185	PF00018	0.689
LIG_SH3_3	136	142	PF00018	0.683
LIG_SH3_3	206	212	PF00018	0.704
LIG_SH3_3	339	345	PF00018	0.587
LIG_SH3_3	477	483	PF00018	0.591
LIG_SH3_3	841	847	PF00018	0.608
LIG_SUMO_SIM_anti_2	1040	1046	PF11976	0.610
LIG_SUMO_SIM_anti_2	113	119	PF11976	0.618
LIG_SUMO_SIM_anti_2	383	388	PF11976	0.525
LIG_SUMO_SIM_anti_2	938	945	PF11976	0.651
LIG_SUMO_SIM_par_1	113	119	PF11976	0.649
LIG_SUMO_SIM_par_1	432	438	PF11976	0.646
LIG_TRAF2_1	1046	1049	PF00917	0.663
LIG_TRAF2_1	1101	1104	PF00917	0.631
LIG_TRAF2_1	238	241	PF00917	0.612
LIG_TRAF2_1	576	579	PF00917	0.724
LIG_TRAF2_1	687	690	PF00917	0.592
LIG_TRAF2_1	712	715	PF00917	0.703
LIG_TRAF2_1	868	871	PF00917	0.640
LIG_TYR_ITIM	90	95	PF00017	0.323
LIG_UBA3_1	1041	1045	PF00899	0.470
LIG_WRC_WIRS_1	183	188	PF05994	0.490
MOD_CDK_SPK_2	118	123	PF00069	0.671
MOD_CDK_SPK_2	130	135	PF00069	0.656
MOD_CDK_SPxxK_3	733	740	PF00069	0.479
MOD_CK1_1	118	124	PF00069	0.718
MOD_CK1_1	1208	1214	PF00069	0.747
MOD_CK1_1	130	136	PF00069	0.659
MOD_CK1_1	164	170	PF00069	0.566
MOD_CK1_1	337	343	PF00069	0.383
MOD_CK1_1	548	554	PF00069	0.614
MOD_CK1_1	65	71	PF00069	0.474
MOD_CK1_1	675	681	PF00069	0.551
MOD_CK1_1	683	689	PF00069	0.509
MOD_CK1_1	777	783	PF00069	0.456
MOD_CK1_1	965	971	PF00069	0.510
MOD_CK2_1	1011	1017	PF00069	0.410
MOD_CK2_1	1034	1040	PF00069	0.568
MOD_CK2_1	1043	1049	PF00069	0.547
MOD_CK2_1	1066	1072	PF00069	0.830
MOD_CK2_1	1097	1103	PF00069	0.697
MOD_CK2_1	1165	1171	PF00069	0.764
MOD_CK2_1	140	146	PF00069	0.602
MOD_CK2_1	164	170	PF00069	0.554
MOD_CK2_1	178	184	PF00069	0.576
MOD_CK2_1	187	193	PF00069	0.520
MOD_CK2_1	318	324	PF00069	0.581
MOD_CK2_1	337	343	PF00069	0.469
MOD_CK2_1	401	407	PF00069	0.449
MOD_CK2_1	536	542	PF00069	0.656
MOD_CK2_1	573	579	PF00069	0.668
MOD_CK2_1	678	684	PF00069	0.537
MOD_CK2_1	709	715	PF00069	0.573
MOD_CK2_1	733	739	PF00069	0.625
MOD_CK2_1	865	871	PF00069	0.457
MOD_CK2_1	933	939	PF00069	0.537
MOD_CK2_1	942	948	PF00069	0.416
MOD_CK2_1	970	976	PF00069	0.489
MOD_CK2_1	992	998	PF00069	0.520
MOD_DYRK1A_RPxSP_1	840	844	PF00069	0.470
MOD_GlcNHglycan	1031	1034	PF01048	0.529
MOD_GlcNHglycan	1078	1082	PF01048	0.706
MOD_GlcNHglycan	1100	1103	PF01048	0.665
MOD_GlcNHglycan	118	121	PF01048	0.608
MOD_GlcNHglycan	1186	1189	PF01048	0.633
MOD_GlcNHglycan	1201	1204	PF01048	0.708
MOD_GlcNHglycan	1207	1210	PF01048	0.680
MOD_GlcNHglycan	1211	1214	PF01048	0.694
MOD_GlcNHglycan	1234	1237	PF01048	0.716
MOD_GlcNHglycan	142	145	PF01048	0.651
MOD_GlcNHglycan	163	166	PF01048	0.523
MOD_GlcNHglycan	320	323	PF01048	0.597
MOD_GlcNHglycan	377	380	PF01048	0.505
MOD_GlcNHglycan	455	458	PF01048	0.633
MOD_GlcNHglycan	711	714	PF01048	0.577
MOD_GlcNHglycan	739	743	PF01048	0.519
MOD_GlcNHglycan	779	782	PF01048	0.550
MOD_GlcNHglycan	796	800	PF01048	0.760
MOD_GlcNHglycan	802	806	PF01048	0.801
MOD_GlcNHglycan	897	900	PF01048	0.638
MOD_GlcNHglycan	952	955	PF01048	0.501
MOD_GlcNHglycan	983	986	PF01048	0.706
MOD_GSK3_1	1043	1050	PF00069	0.468
MOD_GSK3_1	1066	1073	PF00069	0.735
MOD_GSK3_1	1205	1212	PF00069	0.725
MOD_GSK3_1	1227	1234	PF00069	0.701
MOD_GSK3_1	123	130	PF00069	0.607
MOD_GSK3_1	133	140	PF00069	0.630
MOD_GSK3_1	178	185	PF00069	0.637
MOD_GSK3_1	309	316	PF00069	0.463
MOD_GSK3_1	334	341	PF00069	0.392
MOD_GSK3_1	385	392	PF00069	0.434
MOD_GSK3_1	40	47	PF00069	0.564
MOD_GSK3_1	617	624	PF00069	0.498
MOD_GSK3_1	633	640	PF00069	0.536
MOD_GSK3_1	671	678	PF00069	0.485
MOD_GSK3_1	731	738	PF00069	0.536
MOD_GSK3_1	938	945	PF00069	0.520
MOD_NEK2_1	1001	1006	PF00069	0.447
MOD_NEK2_1	1043	1048	PF00069	0.458
MOD_NEK2_1	116	121	PF00069	0.500
MOD_NEK2_1	155	160	PF00069	0.601
MOD_NEK2_1	182	187	PF00069	0.569
MOD_NEK2_1	318	323	PF00069	0.673
MOD_NEK2_1	389	394	PF00069	0.319
MOD_NEK2_1	462	467	PF00069	0.502
MOD_NEK2_1	492	497	PF00069	0.444
MOD_NEK2_1	633	638	PF00069	0.426
MOD_NEK2_1	673	678	PF00069	0.529
MOD_NEK2_1	83	88	PF00069	0.541
MOD_NEK2_1	918	923	PF00069	0.450
MOD_NEK2_1	981	986	PF00069	0.650
MOD_NEK2_2	967	972	PF00069	0.419
MOD_PIKK_1	1165	1171	PF00454	0.620
MOD_PIKK_1	543	549	PF00454	0.584
MOD_PIKK_1	774	780	PF00454	0.541
MOD_PK_1	128	134	PF00069	0.521
MOD_PKA_1	127	133	PF00069	0.647
MOD_PKA_1	543	549	PF00069	0.596
MOD_PKA_2	127	133	PF00069	0.628
MOD_PKA_2	401	407	PF00069	0.559
MOD_PKA_2	543	549	PF00069	0.681
MOD_PKA_2	83	89	PF00069	0.465
MOD_PKA_2	918	924	PF00069	0.444
MOD_PKA_2	981	987	PF00069	0.626
MOD_PKB_1	1068	1076	PF00069	0.626
MOD_Plk_1	230	236	PF00069	0.598
MOD_Plk_1	730	736	PF00069	0.542
MOD_Plk_1	738	744	PF00069	0.441
MOD_Plk_1	938	944	PF00069	0.532
MOD_Plk_2-3	1122	1128	PF00069	0.519
MOD_Plk_2-3	573	579	PF00069	0.679
MOD_Plk_4	1047	1053	PF00069	0.444
MOD_Plk_4	110	116	PF00069	0.506
MOD_Plk_4	178	184	PF00069	0.485
MOD_Plk_4	196	202	PF00069	0.414
MOD_Plk_4	385	391	PF00069	0.445
MOD_Plk_4	462	468	PF00069	0.456
MOD_Plk_4	603	609	PF00069	0.517
MOD_Plk_4	78	84	PF00069	0.398
MOD_Plk_4	876	882	PF00069	0.472
MOD_Plk_4	938	944	PF00069	0.566
MOD_ProDKin_1	1176	1182	PF00069	0.727
MOD_ProDKin_1	118	124	PF00069	0.655
MOD_ProDKin_1	130	136	PF00069	0.618
MOD_ProDKin_1	164	170	PF00069	0.552
MOD_ProDKin_1	256	262	PF00069	0.531
MOD_ProDKin_1	42	48	PF00069	0.652
MOD_ProDKin_1	479	485	PF00069	0.436
MOD_ProDKin_1	733	739	PF00069	0.481
MOD_ProDKin_1	840	846	PF00069	0.603
MOD_SUMO_for_1	458	461	PF00179	0.481
MOD_SUMO_rev_2	108	113	PF00179	0.619
MOD_SUMO_rev_2	1221	1230	PF00179	0.611
MOD_SUMO_rev_2	515	524	PF00179	0.737
MOD_SUMO_rev_2	573	583	PF00179	0.533
TRG_DiLeu_BaEn_1	764	769	PF01217	0.445
TRG_DiLeu_BaLyEn_6	1021	1026	PF01217	0.434
TRG_DiLeu_BaLyEn_6	1114	1119	PF01217	0.502
TRG_DiLeu_BaLyEn_6	641	646	PF01217	0.404
TRG_ENDOCYTIC_2	1022	1025	PF00928	0.493
TRG_ENDOCYTIC_2	92	95	PF00928	0.324
TRG_ER_diArg_1	1055	1057	PF00400	0.480
TRG_ER_diArg_1	299	301	PF00400	0.487
TRG_ER_diArg_1	585	588	PF00400	0.531
TRG_ER_diArg_1	642	644	PF00400	0.533
TRG_ER_diArg_1	703	706	PF00400	0.422
TRG_ER_diArg_1	881	883	PF00400	0.598
TRG_ER_diArg_1	918	920	PF00400	0.450
TRG_NES_CRM1_1	385	399	PF08389	0.376
TRG_Pf-PMV_PEXEL_1	1045	1049	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	1056	1060	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	1117	1122	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	644	649	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	693	697	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	972	976	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J6	Leptomonas seymouri	43%	99%
A0A1X0P9W2	Trypanosomatidae	25%	76%
A0A3R7MCK0	Trypanosoma rangeli	24%	77%
A4HHR1	Leishmania braziliensis	65%	100%
A4I4T9	Leishmania infantum	99%	100%
C9ZKY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	75%
E9AEC5	Leishmania major	89%	100%
E9ALG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5C230	Trypanosoma cruzi	24%	78%