Cell division cycle protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cell division cycle protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IBN9_LEIDO

TriTrypDb:

LdBPK_201580.1 , LdCL_200020600 , LDHU3_20.1960

Length:

814

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8IBN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBN9

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	10
GO:0051301	cell division	2	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	469	473	PF00656	0.536
CLV_C14_Caspase3-7	602	606	PF00656	0.279
CLV_C14_Caspase3-7	631	635	PF00656	0.279
CLV_C14_Caspase3-7	774	778	PF00656	0.556
CLV_MEL_PAP_1	364	370	PF00089	0.540
CLV_NRD_NRD_1	214	216	PF00675	0.597
CLV_NRD_NRD_1	264	266	PF00675	0.348
CLV_NRD_NRD_1	389	391	PF00675	0.527
CLV_NRD_NRD_1	443	445	PF00675	0.550
CLV_NRD_NRD_1	460	462	PF00675	0.507
CLV_NRD_NRD_1	552	554	PF00675	0.297
CLV_NRD_NRD_1	560	562	PF00675	0.297
CLV_NRD_NRD_1	698	700	PF00675	0.642
CLV_PCSK_KEX2_1	264	266	PF00082	0.356
CLV_PCSK_KEX2_1	389	391	PF00082	0.527
CLV_PCSK_KEX2_1	462	464	PF00082	0.619
CLV_PCSK_KEX2_1	552	554	PF00082	0.296
CLV_PCSK_KEX2_1	560	562	PF00082	0.296
CLV_PCSK_KEX2_1	697	699	PF00082	0.629
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.619
CLV_PCSK_PC1ET2_1	697	699	PF00082	0.578
CLV_PCSK_PC7_1	694	700	PF00082	0.551
CLV_PCSK_SKI1_1	151	155	PF00082	0.528
CLV_PCSK_SKI1_1	183	187	PF00082	0.494
CLV_PCSK_SKI1_1	237	241	PF00082	0.564
CLV_PCSK_SKI1_1	423	427	PF00082	0.612
CLV_PCSK_SKI1_1	531	535	PF00082	0.336
CLV_PCSK_SKI1_1	543	547	PF00082	0.261
DEG_APCC_DBOX_1	236	244	PF00400	0.543
DEG_APCC_DBOX_1	264	272	PF00400	0.516
DEG_SPOP_SBC_1	296	300	PF00917	0.548
DEG_SPOP_SBC_1	675	679	PF00917	0.442
DEG_SPOP_SBC_1	793	797	PF00917	0.470
DOC_CYCLIN_RxL_1	549	558	PF00134	0.410
DOC_CYCLIN_RxL_1	55	63	PF00134	0.500
DOC_CYCLIN_yClb5_NLxxxL_5	264	272	PF00134	0.408
DOC_MAPK_gen_1	461	467	PF00069	0.595
DOC_MAPK_gen_1	560	567	PF00069	0.377
DOC_MAPK_gen_1	662	672	PF00069	0.279
DOC_MAPK_JIP1_4	662	668	PF00069	0.279
DOC_MAPK_MEF2A_6	662	670	PF00069	0.279
DOC_PP2B_LxvP_1	10	13	PF13499	0.580
DOC_PP2B_LxvP_1	287	290	PF13499	0.517
DOC_PP2B_LxvP_1	525	528	PF13499	0.558
DOC_PP2B_LxvP_1	554	557	PF13499	0.410
DOC_PP2B_LxvP_1	607	610	PF13499	0.279
DOC_PP2B_LxvP_1	810	813	PF13499	0.468
DOC_USP7_MATH_1	296	300	PF00917	0.594
DOC_USP7_MATH_1	396	400	PF00917	0.615
DOC_USP7_MATH_1	475	479	PF00917	0.673
DOC_USP7_MATH_1	484	488	PF00917	0.677
DOC_USP7_MATH_1	538	542	PF00917	0.297
DOC_USP7_MATH_1	676	680	PF00917	0.558
DOC_USP7_MATH_1	749	753	PF00917	0.735
DOC_USP7_MATH_1	785	789	PF00917	0.574
DOC_USP7_MATH_1	793	797	PF00917	0.526
DOC_WW_Pin1_4	230	235	PF00397	0.560
DOC_WW_Pin1_4	244	249	PF00397	0.488
DOC_WW_Pin1_4	303	308	PF00397	0.445
DOC_WW_Pin1_4	357	362	PF00397	0.591
DOC_WW_Pin1_4	751	756	PF00397	0.678
DOC_WW_Pin1_4	777	782	PF00397	0.720
LIG_14-3-3_CanoR_1	124	130	PF00244	0.770
LIG_14-3-3_CanoR_1	142	150	PF00244	0.507
LIG_14-3-3_CanoR_1	161	165	PF00244	0.539
LIG_14-3-3_CanoR_1	187	196	PF00244	0.459
LIG_14-3-3_CanoR_1	374	384	PF00244	0.435
LIG_14-3-3_CanoR_1	624	630	PF00244	0.290
LIG_14-3-3_CanoR_1	698	705	PF00244	0.619
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_BRCT_BRCA1_1	225	229	PF00533	0.390
LIG_Clathr_ClatBox_1	274	278	PF01394	0.497
LIG_Clathr_ClatBox_1	310	314	PF01394	0.307
LIG_CSL_BTD_1	15	18	PF09270	0.481
LIG_FHA_1	124	130	PF00498	0.651
LIG_FHA_1	188	194	PF00498	0.436
LIG_FHA_1	245	251	PF00498	0.553
LIG_FHA_1	3	9	PF00498	0.563
LIG_FHA_1	300	306	PF00498	0.574
LIG_FHA_1	329	335	PF00498	0.375
LIG_FHA_1	352	358	PF00498	0.385
LIG_FHA_1	386	392	PF00498	0.536
LIG_FHA_1	405	411	PF00498	0.488
LIG_FHA_1	441	447	PF00498	0.641
LIG_FHA_1	515	521	PF00498	0.428
LIG_FHA_1	542	548	PF00498	0.245
LIG_FHA_1	57	63	PF00498	0.624
LIG_FHA_1	572	578	PF00498	0.464
LIG_FHA_1	713	719	PF00498	0.529
LIG_FHA_1	732	738	PF00498	0.427
LIG_FHA_1	757	763	PF00498	0.567
LIG_FHA_2	128	134	PF00498	0.693
LIG_FHA_2	271	277	PF00498	0.483
LIG_FHA_2	377	383	PF00498	0.508
LIG_FHA_2	612	618	PF00498	0.351
LIG_FHA_2	629	635	PF00498	0.187
LIG_FHA_2	793	799	PF00498	0.728
LIG_Integrin_isoDGR_2	122	124	PF01839	0.589
LIG_Integrin_RGD_1	775	777	PF01839	0.560
LIG_LIR_Gen_1	176	185	PF02991	0.520
LIG_LIR_Gen_1	493	501	PF02991	0.507
LIG_LIR_Gen_1	72	81	PF02991	0.555
LIG_LIR_Nem_3	176	181	PF02991	0.533
LIG_LIR_Nem_3	493	498	PF02991	0.438
LIG_LIR_Nem_3	72	78	PF02991	0.535
LIG_MAD2	643	651	PF02301	0.161
LIG_MYND_1	751	755	PF01753	0.629
LIG_NRBOX	223	229	PF00104	0.438
LIG_NRBOX	238	244	PF00104	0.323
LIG_NRBOX	625	631	PF00104	0.279
LIG_Pex14_1	75	79	PF04695	0.410
LIG_PTAP_UEV_1	436	441	PF05743	0.517
LIG_Rb_pABgroove_1	582	590	PF01858	0.306
LIG_SH2_CRK	101	105	PF00017	0.483
LIG_SH2_CRK	178	182	PF00017	0.622
LIG_SH2_CRK	495	499	PF00017	0.415
LIG_SH2_SRC	811	814	PF00017	0.482
LIG_SH2_STAP1	495	499	PF00017	0.472
LIG_SH2_STAT5	386	389	PF00017	0.470
LIG_SH2_STAT5	729	732	PF00017	0.609
LIG_SH3_3	21	27	PF00018	0.618
LIG_SH3_3	283	289	PF00018	0.496
LIG_SH3_3	434	440	PF00018	0.661
LIG_SH3_3	657	663	PF00018	0.410
LIG_SH3_3	745	751	PF00018	0.661
LIG_SH3_3	88	94	PF00018	0.480
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.483
LIG_SUMO_SIM_anti_2	278	284	PF11976	0.421
LIG_SUMO_SIM_anti_2	422	429	PF11976	0.398
LIG_SUMO_SIM_anti_2	517	524	PF11976	0.521
LIG_SUMO_SIM_anti_2	568	574	PF11976	0.279
LIG_SUMO_SIM_anti_2	642	649	PF11976	0.395
LIG_SUMO_SIM_anti_2	715	721	PF11976	0.524
LIG_SUMO_SIM_par_1	270	276	PF11976	0.431
LIG_SUMO_SIM_par_1	308	315	PF11976	0.323
LIG_SUMO_SIM_par_1	422	429	PF11976	0.456
LIG_SUMO_SIM_par_1	517	524	PF11976	0.449
LIG_SUMO_SIM_par_1	642	649	PF11976	0.391
LIG_SUMO_SIM_par_1	714	721	PF11976	0.571
LIG_WRC_WIRS_1	350	355	PF05994	0.465
LIG_WW_3	608	612	PF00397	0.279
LIG_WW_3	747	751	PF00397	0.603
MOD_CDK_SPxxK_3	230	237	PF00069	0.504
MOD_CK1_1	112	118	PF00069	0.677
MOD_CK1_1	160	166	PF00069	0.531
MOD_CK1_1	220	226	PF00069	0.520
MOD_CK1_1	295	301	PF00069	0.676
MOD_CK1_1	477	483	PF00069	0.571
MOD_CK1_1	541	547	PF00069	0.279
MOD_CK1_1	571	577	PF00069	0.306
MOD_CK1_1	649	655	PF00069	0.386
MOD_CK2_1	125	131	PF00069	0.646
MOD_CK2_1	146	152	PF00069	0.616
MOD_CK2_1	270	276	PF00069	0.442
MOD_CK2_1	349	355	PF00069	0.464
MOD_CK2_1	375	381	PF00069	0.438
MOD_CK2_1	47	53	PF00069	0.563
MOD_CK2_1	611	617	PF00069	0.410
MOD_CK2_1	751	757	PF00069	0.571
MOD_Cter_Amidation	550	553	PF01082	0.306
MOD_GlcNHglycan	219	222	PF01048	0.536
MOD_GlcNHglycan	294	297	PF01048	0.680
MOD_GlcNHglycan	437	440	PF01048	0.545
MOD_GlcNHglycan	477	480	PF01048	0.745
MOD_GlcNHglycan	538	541	PF01048	0.282
MOD_GlcNHglycan	648	651	PF01048	0.317
MOD_GlcNHglycan	679	682	PF01048	0.613
MOD_GSK3_1	109	116	PF00069	0.629
MOD_GSK3_1	123	130	PF00069	0.753
MOD_GSK3_1	183	190	PF00069	0.580
MOD_GSK3_1	292	299	PF00069	0.607
MOD_GSK3_1	322	329	PF00069	0.544
MOD_GSK3_1	396	403	PF00069	0.544
MOD_GSK3_1	413	420	PF00069	0.473
MOD_GSK3_1	431	438	PF00069	0.576
MOD_GSK3_1	440	447	PF00069	0.673
MOD_GSK3_1	474	481	PF00069	0.684
MOD_GSK3_1	48	55	PF00069	0.685
MOD_GSK3_1	541	548	PF00069	0.308
MOD_GSK3_1	56	63	PF00069	0.511
MOD_GSK3_1	590	597	PF00069	0.407
MOD_GSK3_1	611	618	PF00069	0.294
MOD_GSK3_1	624	631	PF00069	0.248
MOD_GSK3_1	65	72	PF00069	0.406
MOD_GSK3_1	670	677	PF00069	0.537
MOD_N-GLC_1	618	623	PF02516	0.402
MOD_NEK2_1	113	118	PF00069	0.644
MOD_NEK2_1	243	248	PF00069	0.567
MOD_NEK2_1	292	297	PF00069	0.601
MOD_NEK2_1	326	331	PF00069	0.410
MOD_NEK2_1	341	346	PF00069	0.517
MOD_NEK2_1	375	380	PF00069	0.568
MOD_NEK2_1	400	405	PF00069	0.635
MOD_NEK2_1	412	417	PF00069	0.354
MOD_NEK2_1	56	61	PF00069	0.539
MOD_NEK2_1	587	592	PF00069	0.357
MOD_NEK2_1	65	70	PF00069	0.481
MOD_PIKK_1	232	238	PF00454	0.476
MOD_PIKK_1	628	634	PF00454	0.410
MOD_PKA_1	444	450	PF00069	0.532
MOD_PKA_1	698	704	PF00069	0.617
MOD_PKA_2	123	129	PF00069	0.606
MOD_PKA_2	143	149	PF00069	0.509
MOD_PKA_2	160	166	PF00069	0.542
MOD_PKA_2	612	618	PF00069	0.322
MOD_PKA_2	698	704	PF00069	0.617
MOD_PKA_2	749	755	PF00069	0.676
MOD_Plk_1	176	182	PF00069	0.396
MOD_Plk_1	622	628	PF00069	0.279
MOD_Plk_1	73	79	PF00069	0.518
MOD_Plk_2-3	270	276	PF00069	0.482
MOD_Plk_4	160	166	PF00069	0.406
MOD_Plk_4	176	182	PF00069	0.606
MOD_Plk_4	223	229	PF00069	0.362
MOD_Plk_4	246	252	PF00069	0.499
MOD_Plk_4	270	276	PF00069	0.374
MOD_Plk_4	322	328	PF00069	0.409
MOD_Plk_4	431	437	PF00069	0.560
MOD_Plk_4	52	58	PF00069	0.639
MOD_Plk_4	568	574	PF00069	0.297
MOD_Plk_4	625	631	PF00069	0.279
MOD_ProDKin_1	230	236	PF00069	0.556
MOD_ProDKin_1	244	250	PF00069	0.490
MOD_ProDKin_1	303	309	PF00069	0.434
MOD_ProDKin_1	357	363	PF00069	0.596
MOD_ProDKin_1	751	757	PF00069	0.673
MOD_ProDKin_1	777	783	PF00069	0.724
TRG_DiLeu_BaEn_1	176	181	PF01217	0.509
TRG_DiLeu_BaEn_1	270	275	PF01217	0.379
TRG_DiLeu_BaEn_1	314	319	PF01217	0.365
TRG_DiLeu_BaEn_1	721	726	PF01217	0.543
TRG_DiLeu_BaEn_4	176	182	PF01217	0.505
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.530
TRG_ENDOCYTIC_2	101	104	PF00928	0.545
TRG_ENDOCYTIC_2	178	181	PF00928	0.560
TRG_ENDOCYTIC_2	495	498	PF00928	0.397
TRG_ER_diArg_1	142	145	PF00400	0.564
TRG_ER_diArg_1	264	266	PF00400	0.479
TRG_ER_diArg_1	389	391	PF00400	0.461
TRG_ER_diArg_1	552	554	PF00400	0.297
TRG_ER_diArg_1	560	562	PF00400	0.296
TRG_ER_diArg_1	610	613	PF00400	0.326
TRG_NES_CRM1_1	510	524	PF08389	0.532
TRG_NLS_Bipartite_1	444	465	PF00514	0.504
TRG_NLS_MonoExtC_3	460	466	PF00514	0.510
TRG_NLS_MonoExtC_3	696	702	PF00514	0.580
TRG_NLS_MonoExtN_4	694	701	PF00514	0.552
TRG_Pf-PMV_PEXEL_1	135	140	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E7	Leptomonas seymouri	51%	100%
A0A1X0NXH5	Trypanosomatidae	33%	100%
A0A3R7NWG6	Trypanosoma rangeli	34%	100%
A4HZ08	Leishmania infantum	99%	100%
C9ZIP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AIL0	Leishmania braziliensis	76%	100%
E9AUU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QCP1	Leishmania major	93%	100%
V5BCV9	Trypanosoma cruzi	34%	100%