Kinetoplast_ribosomal_PPR-repeat_containing_prote in_3_putative/GeneDB:LmjF.20.0480

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast ribosomal PPR-repeat containing protein 3, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBN5_LEIDO

TriTrypDb:

LdBPK_200550.1 , LdCL_200010200 , LDHU3_20.0650

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0032991	protein-containing complex	1	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8IBN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBN5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	210	212	PF00675	0.472
CLV_NRD_NRD_1	25	27	PF00675	0.601
CLV_NRD_NRD_1	267	269	PF00675	0.520
CLV_NRD_NRD_1	312	314	PF00675	0.508
CLV_NRD_NRD_1	488	490	PF00675	0.449
CLV_NRD_NRD_1	500	502	PF00675	0.381
CLV_NRD_NRD_1	7	9	PF00675	0.606
CLV_NRD_NRD_1	73	75	PF00675	0.581
CLV_PCSK_KEX2_1	24	26	PF00082	0.644
CLV_PCSK_KEX2_1	267	269	PF00082	0.540
CLV_PCSK_KEX2_1	312	314	PF00082	0.407
CLV_PCSK_KEX2_1	319	321	PF00082	0.417
CLV_PCSK_KEX2_1	488	490	PF00082	0.446
CLV_PCSK_KEX2_1	499	501	PF00082	0.409
CLV_PCSK_KEX2_1	7	9	PF00082	0.608
CLV_PCSK_KEX2_1	73	75	PF00082	0.581
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.443
CLV_PCSK_PC7_1	3	9	PF00082	0.590
CLV_PCSK_SKI1_1	106	110	PF00082	0.611
CLV_PCSK_SKI1_1	11	15	PF00082	0.612
CLV_PCSK_SKI1_1	274	278	PF00082	0.587
CLV_PCSK_SKI1_1	353	357	PF00082	0.362
CLV_PCSK_SKI1_1	360	364	PF00082	0.406
CLV_PCSK_SKI1_1	488	492	PF00082	0.431
CLV_PCSK_SKI1_1	514	518	PF00082	0.389
CLV_PCSK_SKI1_1	548	552	PF00082	0.577
DEG_Nend_UBRbox_3	1	3	PF02207	0.667
DEG_SPOP_SBC_1	342	346	PF00917	0.501
DOC_CKS1_1	299	304	PF01111	0.587
DOC_CKS1_1	434	439	PF01111	0.505
DOC_CKS1_1	63	68	PF01111	0.612
DOC_CYCLIN_RxL_1	349	359	PF00134	0.383
DOC_CYCLIN_RxL_1	511	519	PF00134	0.363
DOC_CYCLIN_yCln2_LP_2	397	403	PF00134	0.513
DOC_MAPK_DCC_7	320	330	PF00069	0.505
DOC_MAPK_HePTP_8	533	545	PF00069	0.463
DOC_MAPK_MEF2A_6	536	545	PF00069	0.461
DOC_PP2B_LxvP_1	286	289	PF13499	0.734
DOC_PP2B_LxvP_1	397	400	PF13499	0.530
DOC_PP4_FxxP_1	322	325	PF00568	0.473
DOC_SPAK_OSR1_1	98	102	PF12202	0.473
DOC_USP7_MATH_1	130	134	PF00917	0.422
DOC_USP7_MATH_1	287	291	PF00917	0.699
DOC_USP7_MATH_1	33	37	PF00917	0.610
DOC_USP7_MATH_1	38	42	PF00917	0.544
DOC_WW_Pin1_4	111	116	PF00397	0.467
DOC_WW_Pin1_4	219	224	PF00397	0.439
DOC_WW_Pin1_4	298	303	PF00397	0.624
DOC_WW_Pin1_4	321	326	PF00397	0.380
DOC_WW_Pin1_4	433	438	PF00397	0.505
DOC_WW_Pin1_4	62	67	PF00397	0.684
LIG_14-3-3_CanoR_1	11	16	PF00244	0.628
LIG_14-3-3_CanoR_1	129	135	PF00244	0.438
LIG_14-3-3_CanoR_1	312	322	PF00244	0.406
LIG_14-3-3_CanoR_1	367	376	PF00244	0.337
LIG_14-3-3_CanoR_1	389	397	PF00244	0.480
LIG_14-3-3_CanoR_1	463	468	PF00244	0.461
LIG_14-3-3_CanoR_1	488	497	PF00244	0.419
LIG_14-3-3_CanoR_1	520	525	PF00244	0.444
LIG_14-3-3_CanoR_1	62	66	PF00244	0.671
LIG_BRCT_BRCA1_1	16	20	PF00533	0.743
LIG_FAT_LD_1	330	338	PF03623	0.350
LIG_FHA_1	159	165	PF00498	0.615
LIG_FHA_1	17	23	PF00498	0.572
LIG_FHA_1	271	277	PF00498	0.683
LIG_FHA_1	334	340	PF00498	0.398
LIG_FHA_1	389	395	PF00498	0.460
LIG_FHA_1	405	411	PF00498	0.202
LIG_FHA_1	434	440	PF00498	0.447
LIG_FHA_1	443	449	PF00498	0.368
LIG_FHA_1	471	477	PF00498	0.344
LIG_FHA_1	489	495	PF00498	0.378
LIG_FHA_1	506	512	PF00498	0.408
LIG_FHA_2	299	305	PF00498	0.612
LIG_FHA_2	78	84	PF00498	0.586
LIG_LIR_Gen_1	17	28	PF02991	0.581
LIG_LIR_Gen_1	359	365	PF02991	0.380
LIG_LIR_Gen_1	457	467	PF02991	0.440
LIG_LIR_Gen_1	472	480	PF02991	0.263
LIG_LIR_Nem_3	17	23	PF02991	0.594
LIG_LIR_Nem_3	359	364	PF02991	0.389
LIG_LIR_Nem_3	368	373	PF02991	0.325
LIG_LIR_Nem_3	472	477	PF02991	0.388
LIG_LIR_Nem_3	484	490	PF02991	0.360
LIG_NRBOX	215	221	PF00104	0.485
LIG_NRBOX	405	411	PF00104	0.426
LIG_NRBOX	442	448	PF00104	0.398
LIG_NRBOX	508	514	PF00104	0.345
LIG_PCNA_yPIPBox_3	503	517	PF02747	0.367
LIG_Pex3_1	513	524	PF04882	0.483
LIG_PTB_Apo_2	236	243	PF02174	0.450
LIG_PTB_Phospho_1	236	242	PF10480	0.443
LIG_SH2_CRK	474	478	PF00017	0.378
LIG_SH2_NCK_1	260	264	PF00017	0.454
LIG_SH2_SRC	172	175	PF00017	0.428
LIG_SH2_SRC	75	78	PF00017	0.701
LIG_SH2_STAP1	242	246	PF00017	0.483
LIG_SH2_STAP1	370	374	PF00017	0.319
LIG_SH2_STAP1	390	394	PF00017	0.200
LIG_SH2_STAP1	474	478	PF00017	0.348
LIG_SH2_STAT3	315	318	PF00017	0.444
LIG_SH2_STAT5	134	137	PF00017	0.527
LIG_SH2_STAT5	172	175	PF00017	0.443
LIG_SH2_STAT5	315	318	PF00017	0.339
LIG_SH2_STAT5	370	373	PF00017	0.372
LIG_SH2_STAT5	390	393	PF00017	0.195
LIG_SH2_STAT5	418	421	PF00017	0.426
LIG_SH2_STAT5	474	477	PF00017	0.411
LIG_SH2_STAT5	75	78	PF00017	0.701
LIG_SH3_1	535	541	PF00018	0.529
LIG_SH3_3	193	199	PF00018	0.527
LIG_SH3_3	293	299	PF00018	0.650
LIG_SH3_3	359	365	PF00018	0.380
LIG_SH3_3	398	404	PF00018	0.513
LIG_SH3_3	431	437	PF00018	0.541
LIG_SH3_3	535	541	PF00018	0.529
LIG_SH3_3	63	69	PF00018	0.665
LIG_SUMO_SIM_anti_2	254	261	PF11976	0.458
LIG_SUMO_SIM_anti_2	335	341	PF11976	0.492
LIG_SUMO_SIM_anti_2	420	427	PF11976	0.306
LIG_SUMO_SIM_anti_2	475	480	PF11976	0.355
LIG_SUMO_SIM_par_1	326	331	PF11976	0.365
LIG_SUMO_SIM_par_1	335	341	PF11976	0.383
LIG_SUMO_SIM_par_1	444	450	PF11976	0.357
LIG_TRAF2_1	124	127	PF00917	0.529
LIG_TRFH_1	361	365	PF08558	0.489
LIG_TYR_ITSM	369	376	PF00017	0.405
LIG_UBA3_1	405	411	PF00899	0.426
LIG_UBA3_1	476	483	PF00899	0.474
LIG_WRC_WIRS_1	521	526	PF05994	0.438
LIG_WW_3	43	47	PF00397	0.489
MOD_CDK_SPK_2	65	70	PF00069	0.699
MOD_CK1_1	261	267	PF00069	0.482
MOD_CK1_1	338	344	PF00069	0.445
MOD_CK1_1	36	42	PF00069	0.687
MOD_CK1_1	424	430	PF00069	0.472
MOD_CK1_1	442	448	PF00069	0.305
MOD_CK2_1	172	178	PF00069	0.432
MOD_GlcNHglycan	289	292	PF01048	0.705
MOD_GlcNHglycan	40	43	PF01048	0.648
MOD_GlcNHglycan	415	418	PF01048	0.401
MOD_GSK3_1	168	175	PF00069	0.509
MOD_GSK3_1	270	277	PF00069	0.549
MOD_GSK3_1	32	39	PF00069	0.605
MOD_GSK3_1	338	345	PF00069	0.399
MOD_GSK3_1	368	375	PF00069	0.443
MOD_GSK3_1	442	449	PF00069	0.425
MOD_GSK3_1	61	68	PF00069	0.665
MOD_N-GLC_1	413	418	PF02516	0.426
MOD_N-GLC_1	439	444	PF02516	0.351
MOD_NEK2_1	168	173	PF00069	0.537
MOD_NEK2_1	258	263	PF00069	0.436
MOD_NEK2_1	333	338	PF00069	0.368
MOD_NEK2_1	413	418	PF00069	0.426
MOD_NEK2_1	462	467	PF00069	0.477
MOD_NEK2_1	528	533	PF00069	0.353
MOD_NEK2_2	454	459	PF00069	0.380
MOD_PIKK_1	481	487	PF00454	0.477
MOD_PIKK_1	75	81	PF00454	0.687
MOD_PIKK_1	83	89	PF00454	0.638
MOD_PK_1	463	469	PF00069	0.484
MOD_PKA_1	488	494	PF00069	0.505
MOD_PKA_2	128	134	PF00069	0.432
MOD_PKA_2	366	372	PF00069	0.337
MOD_PKA_2	388	394	PF00069	0.466
MOD_PKA_2	462	468	PF00069	0.547
MOD_PKA_2	488	494	PF00069	0.441
MOD_PKA_2	61	67	PF00069	0.568
MOD_PKA_2	69	75	PF00069	0.623
MOD_PKB_1	24	32	PF00069	0.738
MOD_Plk_1	439	445	PF00069	0.349
MOD_Plk_1	505	511	PF00069	0.564
MOD_Plk_2-3	77	83	PF00069	0.572
MOD_Plk_4	130	136	PF00069	0.457
MOD_Plk_4	168	174	PF00069	0.561
MOD_Plk_4	252	258	PF00069	0.524
MOD_Plk_4	261	267	PF00069	0.462
MOD_Plk_4	335	341	PF00069	0.430
MOD_Plk_4	421	427	PF00069	0.356
MOD_Plk_4	442	448	PF00069	0.430
MOD_Plk_4	472	478	PF00069	0.379
MOD_Plk_4	528	534	PF00069	0.394
MOD_ProDKin_1	111	117	PF00069	0.461
MOD_ProDKin_1	219	225	PF00069	0.443
MOD_ProDKin_1	298	304	PF00069	0.622
MOD_ProDKin_1	321	327	PF00069	0.380
MOD_ProDKin_1	433	439	PF00069	0.497
MOD_ProDKin_1	62	68	PF00069	0.685
TRG_DiLeu_BaEn_1	254	259	PF01217	0.482
TRG_DiLeu_BaEn_1	421	426	PF01217	0.307
TRG_DiLeu_BaEn_1	472	477	PF01217	0.381
TRG_DiLeu_BaEn_2	231	237	PF01217	0.451
TRG_DiLeu_BaLyEn_6	350	355	PF01217	0.352
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.505
TRG_DiLeu_BaLyEn_6	546	551	PF01217	0.561
TRG_ENDOCYTIC_2	373	376	PF00928	0.404
TRG_ENDOCYTIC_2	459	462	PF00928	0.439
TRG_ENDOCYTIC_2	474	477	PF00928	0.238
TRG_ENDOCYTIC_2	529	532	PF00928	0.382
TRG_ER_diArg_1	183	186	PF00400	0.477
TRG_ER_diArg_1	23	26	PF00400	0.736
TRG_ER_diArg_1	266	268	PF00400	0.500
TRG_ER_diArg_1	311	313	PF00400	0.521
TRG_ER_diArg_1	487	489	PF00400	0.454
TRG_ER_diArg_1	499	501	PF00400	0.404
TRG_ER_diArg_1	73	75	PF00400	0.745
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Z9	Leptomonas seymouri	71%	100%
A0A0S4J3K2	Bodo saltans	38%	77%
A0A1X0NWF6	Trypanosomatidae	54%	100%
A0A3R7K7U1	Trypanosoma rangeli	49%	100%
A4HYR3	Leishmania infantum	100%	100%
C9ZI67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AUJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	97%
Q4QCZ2	Leishmania major	96%	100%
V5BQU6	Trypanosoma cruzi	55%	100%