RNA-binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBN4_LEIDO

TriTrypDb:

LdBPK_250530.1 , LdCL_250010400 , LDHU3_25.0630

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0032991	protein-containing complex	1	3
GO:1990904	ribonucleoprotein complex	2	3

Expansion

Sequence features

A0A3Q8IBN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBN4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003729	mRNA binding	5	2
GO:0003730	mRNA 3'-UTR binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	113	117	PF00082	0.325
CLV_PCSK_SKI1_1	229	233	PF00082	0.525
DOC_MAPK_MEF2A_6	133	141	PF00069	0.515
DOC_SPAK_OSR1_1	107	111	PF12202	0.515
DOC_USP7_MATH_1	14	18	PF00917	0.632
DOC_USP7_MATH_1	146	150	PF00917	0.525
DOC_USP7_MATH_1	165	169	PF00917	0.473
DOC_USP7_MATH_1	214	218	PF00917	0.603
DOC_USP7_MATH_1	221	225	PF00917	0.614
DOC_WW_Pin1_4	229	234	PF00397	0.623
DOC_WW_Pin1_4	9	14	PF00397	0.636
LIG_14-3-3_CanoR_1	133	141	PF00244	0.507
LIG_BIR_II_1	1	5	PF00653	0.694
LIG_FHA_1	230	236	PF00498	0.561
LIG_FHA_1	97	103	PF00498	0.515
LIG_LIR_Gen_1	127	137	PF02991	0.519
LIG_LIR_Gen_1	149	158	PF02991	0.546
LIG_LIR_Nem_3	127	132	PF02991	0.592
LIG_LIR_Nem_3	181	185	PF02991	0.533
LIG_LIR_Nem_3	62	67	PF02991	0.526
LIG_LIR_Nem_3	84	90	PF02991	0.525
LIG_LYPXL_S_1	208	212	PF13949	0.534
LIG_LYPXL_yS_3	209	212	PF13949	0.532
LIG_PDZ_Class_2	235	240	PF00595	0.579
LIG_SH2_CRK	129	133	PF00017	0.559
LIG_SH2_CRK	77	81	PF00017	0.515
LIG_SH2_CRK	87	91	PF00017	0.525
LIG_SH2_GRB2like	119	122	PF00017	0.534
LIG_SH2_GRB2like	185	188	PF00017	0.547
LIG_SH2_NCK_1	119	123	PF00017	0.500
LIG_SH2_NCK_1	77	81	PF00017	0.515
LIG_SH2_SRC	119	122	PF00017	0.534
LIG_SH2_SRC	50	53	PF00017	0.473
LIG_SH2_STAT3	151	154	PF00017	0.580
LIG_SH2_STAT5	219	222	PF00017	0.689
LIG_SH2_STAT5	50	53	PF00017	0.525
LIG_TYR_ITIM	75	80	PF00017	0.515
MOD_CK1_1	8	14	PF00069	0.568
MOD_CK2_1	14	20	PF00069	0.772
MOD_Cter_Amidation	111	114	PF01082	0.273
MOD_DYRK1A_RPxSP_1	229	233	PF00069	0.468
MOD_GlcNHglycan	1	4	PF01048	0.525
MOD_GlcNHglycan	134	137	PF01048	0.673
MOD_GlcNHglycan	172	175	PF01048	0.480
MOD_GlcNHglycan	199	202	PF01048	0.567
MOD_GlcNHglycan	223	226	PF01048	0.610
MOD_GlcNHglycan	32	35	PF01048	0.614
MOD_GlcNHglycan	7	10	PF01048	0.543
MOD_GlcNHglycan	96	99	PF01048	0.320
MOD_GSK3_1	166	173	PF00069	0.447
MOD_GSK3_1	221	228	PF00069	0.616
MOD_GSK3_1	5	12	PF00069	0.578
MOD_GSK3_1	96	103	PF00069	0.515
MOD_N-GLC_1	5	10	PF02516	0.573
MOD_NEK2_1	132	137	PF00069	0.538
MOD_NEK2_1	94	99	PF00069	0.476
MOD_NEK2_2	146	151	PF00069	0.545
MOD_NEK2_2	214	219	PF00069	0.487
MOD_PK_1	69	75	PF00069	0.515
MOD_PKA_2	132	138	PF00069	0.507
MOD_PKA_2	197	203	PF00069	0.627
MOD_Plk_4	146	152	PF00069	0.501
MOD_Plk_4	214	220	PF00069	0.680
MOD_ProDKin_1	229	235	PF00069	0.623
MOD_ProDKin_1	9	15	PF00069	0.636
TRG_ENDOCYTIC_2	129	132	PF00928	0.526
TRG_ENDOCYTIC_2	152	155	PF00928	0.555
TRG_ENDOCYTIC_2	209	212	PF00928	0.532
TRG_ENDOCYTIC_2	61	64	PF00928	0.510
TRG_ENDOCYTIC_2	77	80	PF00928	0.472
TRG_ENDOCYTIC_2	87	90	PF00928	0.525
TRG_ENDOCYTIC_2	92	95	PF00928	0.525
TRG_ER_diArg_1	195	198	PF00400	0.610
TRG_NES_CRM1_1	130	143	PF08389	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P674	Leptomonas seymouri	58%	100%
A0A3S7WYY4	Leishmania donovani	47%	100%
A4HDZ4	Leishmania braziliensis	70%	100%
A4I193	Leishmania infantum	100%	100%
E9AXC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AXC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QA43	Leishmania major	93%	100%
Q4QA45	Leishmania major	45%	100%
V5BSY3	Trypanosoma cruzi	56%	100%