Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBM3_LEIDO

TriTrypDb:

LdBPK_130040.1 , LdCL_130005400 , LDHU3_13.0060

Length:

294

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IBM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBM3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.669
CLV_C14_Caspase3-7	219	223	PF00656	0.425
CLV_NRD_NRD_1	159	161	PF00675	0.499
CLV_PCSK_KEX2_1	135	137	PF00082	0.716
CLV_PCSK_KEX2_1	159	161	PF00082	0.499
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.716
CLV_PCSK_SKI1_1	105	109	PF00082	0.488
CLV_PCSK_SKI1_1	229	233	PF00082	0.493
CLV_PCSK_SKI1_1	273	277	PF00082	0.490
DEG_APCC_DBOX_1	102	110	PF00400	0.479
DEG_Nend_Nbox_1	1	3	PF02207	0.582
DEG_SCF_FBW7_1	280	286	PF00400	0.489
DOC_CKS1_1	280	285	PF01111	0.489
DOC_PP4_FxxP_1	207	210	PF00568	0.624
DOC_PP4_FxxP_1	29	32	PF00568	0.565
DOC_USP7_MATH_1	137	141	PF00917	0.755
DOC_USP7_MATH_1	22	26	PF00917	0.617
DOC_WW_Pin1_4	142	147	PF00397	0.769
DOC_WW_Pin1_4	279	284	PF00397	0.488
DOC_WW_Pin1_4	34	39	PF00397	0.630
DOC_WW_Pin1_4	43	48	PF00397	0.590
LIG_14-3-3_CanoR_1	136	146	PF00244	0.622
LIG_14-3-3_CanoR_1	202	210	PF00244	0.563
LIG_14-3-3_CanoR_1	217	221	PF00244	0.466
LIG_14-3-3_CanoR_1	273	280	PF00244	0.516
LIG_14-3-3_CanoR_1	50	54	PF00244	0.609
LIG_BRCT_BRCA1_1	25	29	PF00533	0.551
LIG_FHA_1	150	156	PF00498	0.518
LIG_FHA_1	164	170	PF00498	0.470
LIG_FHA_1	280	286	PF00498	0.489
LIG_FHA_1	76	82	PF00498	0.550
LIG_FHA_2	194	200	PF00498	0.577
LIG_FHA_2	217	223	PF00498	0.435
LIG_FHA_2	254	260	PF00498	0.624
LIG_FHA_2	35	41	PF00498	0.761
LIG_LIR_Apic_2	204	210	PF02991	0.643
LIG_LIR_Apic_2	26	32	PF02991	0.557
LIG_LIR_Gen_1	256	266	PF02991	0.573
LIG_LIR_Nem_3	256	261	PF02991	0.585
LIG_SH2_GRB2like	151	154	PF00017	0.521
LIG_SH2_STAP1	151	155	PF00017	0.516
LIG_SH2_STAT5	151	154	PF00017	0.521
LIG_SH3_3	277	283	PF00018	0.556
LIG_TRFH_1	29	33	PF08558	0.565
MOD_CDK_SPxxK_3	43	50	PF00069	0.567
MOD_CK1_1	4	10	PF00069	0.706
MOD_CK1_1	52	58	PF00069	0.590
MOD_CK2_1	220	226	PF00069	0.574
MOD_GlcNHglycan	127	130	PF01048	0.672
MOD_GlcNHglycan	187	190	PF01048	0.567
MOD_GlcNHglycan	25	28	PF01048	0.678
MOD_GlcNHglycan	72	75	PF01048	0.541
MOD_GSK3_1	216	223	PF00069	0.512
MOD_GSK3_1	279	286	PF00069	0.488
MOD_NEK2_1	1	6	PF00069	0.708
MOD_NEK2_1	169	174	PF00069	0.628
MOD_NEK2_1	288	293	PF00069	0.606
MOD_PIKK_1	137	143	PF00454	0.582
MOD_PIKK_1	169	175	PF00454	0.564
MOD_PIKK_1	61	67	PF00454	0.459
MOD_PIKK_1	7	13	PF00454	0.704
MOD_PK_1	232	238	PF00069	0.531
MOD_PKA_2	201	207	PF00069	0.585
MOD_PKA_2	216	222	PF00069	0.590
MOD_PKA_2	49	55	PF00069	0.558
MOD_PKA_2	75	81	PF00069	0.575
MOD_Plk_1	169	175	PF00069	0.599
MOD_Plk_4	216	222	PF00069	0.465
MOD_Plk_4	253	259	PF00069	0.593
MOD_Plk_4	283	289	PF00069	0.565
MOD_Plk_4	49	55	PF00069	0.613
MOD_ProDKin_1	142	148	PF00069	0.770
MOD_ProDKin_1	279	285	PF00069	0.487
MOD_ProDKin_1	34	40	PF00069	0.628
MOD_ProDKin_1	43	49	PF00069	0.581
MOD_SUMO_rev_2	86	92	PF00179	0.582
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.577
TRG_ER_diArg_1	102	105	PF00400	0.448
TRG_ER_diArg_1	98	101	PF00400	0.358
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V4	Leptomonas seymouri	56%	92%
A4H712	Leishmania braziliensis	70%	100%
A4HVE0	Leishmania infantum	100%	100%
E9AP38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QGF0	Leishmania major	91%	100%