Leucine Rich repeat/Leucine rich repeat/Leucine Rich Repeat/Leucine Rich repeats (2 copies), putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 49, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBM2_LEIDO

TriTrypDb:

LdBPK_200350.1 , LdCL_200008300 , LDHU3_20.0400

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3Q8IBM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.735
CLV_C14_Caspase3-7	245	249	PF00656	0.798
CLV_C14_Caspase3-7	500	504	PF00656	0.699
CLV_C14_Caspase3-7	511	515	PF00656	0.771
CLV_C14_Caspase3-7	516	520	PF00656	0.647
CLV_NRD_NRD_1	159	161	PF00675	0.615
CLV_NRD_NRD_1	256	258	PF00675	0.798
CLV_NRD_NRD_1	301	303	PF00675	0.550
CLV_NRD_NRD_1	320	322	PF00675	0.461
CLV_NRD_NRD_1	382	384	PF00675	0.508
CLV_NRD_NRD_1	49	51	PF00675	0.396
CLV_NRD_NRD_1	535	537	PF00675	0.728
CLV_NRD_NRD_1	539	541	PF00675	0.724
CLV_NRD_NRD_1	573	575	PF00675	0.709
CLV_NRD_NRD_1	597	599	PF00675	0.856
CLV_PCSK_KEX2_1	159	161	PF00082	0.615
CLV_PCSK_KEX2_1	255	257	PF00082	0.796
CLV_PCSK_KEX2_1	301	303	PF00082	0.643
CLV_PCSK_KEX2_1	382	384	PF00082	0.508
CLV_PCSK_KEX2_1	474	476	PF00082	0.595
CLV_PCSK_KEX2_1	539	541	PF00082	0.825
CLV_PCSK_KEX2_1	573	575	PF00082	0.709
CLV_PCSK_KEX2_1	597	599	PF00082	0.856
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.809
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.602
CLV_PCSK_PC1ET2_1	597	599	PF00082	0.856
CLV_PCSK_PC7_1	252	258	PF00082	0.694
CLV_PCSK_PC7_1	470	476	PF00082	0.577
CLV_PCSK_SKI1_1	26	30	PF00082	0.459
CLV_PCSK_SKI1_1	302	306	PF00082	0.515
CLV_PCSK_SKI1_1	336	340	PF00082	0.494
CLV_PCSK_SKI1_1	576	580	PF00082	0.716
DEG_APCC_DBOX_1	335	343	PF00400	0.486
DEG_SPOP_SBC_1	420	424	PF00917	0.599
DOC_CYCLIN_RxL_1	23	33	PF00134	0.450
DOC_CYCLIN_RxL_1	316	329	PF00134	0.475
DOC_CYCLIN_RxL_1	47	58	PF00134	0.455
DOC_CYCLIN_yCln2_LP_2	128	134	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	307	313	PF00134	0.467
DOC_MAPK_gen_1	10	18	PF00069	0.462
DOC_MAPK_gen_1	301	307	PF00069	0.523
DOC_MAPK_gen_1	316	325	PF00069	0.539
DOC_MAPK_gen_1	382	392	PF00069	0.473
DOC_MAPK_gen_1	438	448	PF00069	0.547
DOC_MAPK_gen_1	573	579	PF00069	0.712
DOC_MAPK_MEF2A_6	11	20	PF00069	0.462
DOC_PP4_FxxP_1	491	494	PF00568	0.603
DOC_USP7_MATH_1	102	106	PF00917	0.430
DOC_USP7_MATH_1	293	297	PF00917	0.514
DOC_USP7_MATH_1	37	41	PF00917	0.509
DOC_USP7_MATH_1	421	425	PF00917	0.613
DOC_USP7_MATH_1	584	588	PF00917	0.809
DOC_USP7_UBL2_3	474	478	PF12436	0.607
DOC_WW_Pin1_4	127	132	PF00397	0.454
DOC_WW_Pin1_4	2	7	PF00397	0.595
DOC_WW_Pin1_4	289	294	PF00397	0.690
DOC_WW_Pin1_4	490	495	PF00397	0.644
DOC_WW_Pin1_4	530	535	PF00397	0.789
DOC_WW_Pin1_4	60	65	PF00397	0.396
DOC_WW_Pin1_4	600	605	PF00397	0.829
LIG_14-3-3_CanoR_1	159	169	PF00244	0.708
LIG_14-3-3_CanoR_1	193	201	PF00244	0.402
LIG_14-3-3_CanoR_1	321	326	PF00244	0.434
LIG_14-3-3_CanoR_1	81	86	PF00244	0.358
LIG_Actin_WH2_2	332	348	PF00022	0.497
LIG_CaM_IQ_9	462	478	PF13499	0.529
LIG_CtBP_PxDLS_1	155	159	PF00389	0.573
LIG_DLG_GKlike_1	81	88	PF00625	0.358
LIG_FHA_1	186	192	PF00498	0.448
LIG_FHA_1	201	207	PF00498	0.542
LIG_FHA_1	23	29	PF00498	0.541
LIG_FHA_1	426	432	PF00498	0.573
LIG_FHA_2	137	143	PF00498	0.649
LIG_FHA_2	409	415	PF00498	0.633
LIG_Integrin_isoDGR_2	79	81	PF01839	0.280
LIG_IRF3_LxIS_1	365	371	PF10401	0.452
LIG_IRF3_LxIS_1	93	99	PF10401	0.417
LIG_LIR_Apic_2	489	494	PF02991	0.606
LIG_LIR_Gen_1	178	187	PF02991	0.360
LIG_LIR_Gen_1	312	320	PF02991	0.429
LIG_LIR_Gen_1	33	42	PF02991	0.262
LIG_LIR_Gen_1	99	106	PF02991	0.482
LIG_LIR_Nem_3	178	183	PF02991	0.356
LIG_LIR_Nem_3	312	317	PF02991	0.422
LIG_LIR_Nem_3	33	38	PF02991	0.269
LIG_LIR_Nem_3	99	103	PF02991	0.434
LIG_PCNA_PIPBox_1	436	445	PF02747	0.520
LIG_PCNA_yPIPBox_3	436	447	PF02747	0.521
LIG_PCNA_yPIPBox_3	614	627	PF02747	0.724
LIG_PTB_Apo_2	369	376	PF02174	0.525
LIG_PTB_Apo_2	94	101	PF02174	0.483
LIG_SH2_STAT3	386	389	PF00017	0.494
LIG_SH2_STAT5	386	389	PF00017	0.494
LIG_SH3_3	33	39	PF00018	0.438
LIG_SH3_3	554	560	PF00018	0.674
LIG_SH3_3	601	607	PF00018	0.704
LIG_SUMO_SIM_anti_2	91	97	PF11976	0.429
LIG_SUMO_SIM_par_1	187	192	PF11976	0.449
LIG_SUMO_SIM_par_1	309	315	PF11976	0.464
LIG_SUMO_SIM_par_1	366	371	PF11976	0.453
LIG_UBA3_1	439	447	PF00899	0.532
LIG_WRC_WIRS_1	180	185	PF05994	0.479
MOD_CDC14_SPxK_1	533	536	PF00782	0.755
MOD_CDK_SPxK_1	530	536	PF00069	0.761
MOD_CDK_SPxxK_3	530	537	PF00069	0.760
MOD_CK1_1	162	168	PF00069	0.716
MOD_CK1_1	192	198	PF00069	0.460
MOD_CK1_1	377	383	PF00069	0.488
MOD_CK1_1	425	431	PF00069	0.727
MOD_CK1_1	5	11	PF00069	0.491
MOD_CK1_1	508	514	PF00069	0.823
MOD_CK2_1	136	142	PF00069	0.542
MOD_CK2_1	256	262	PF00069	0.620
MOD_CK2_1	309	315	PF00069	0.464
MOD_CK2_1	323	329	PF00069	0.458
MOD_CK2_1	408	414	PF00069	0.620
MOD_CK2_1	490	496	PF00069	0.747
MOD_Cter_Amidation	252	255	PF01082	0.768
MOD_GlcNHglycan	165	168	PF01048	0.661
MOD_GlcNHglycan	220	223	PF01048	0.691
MOD_GlcNHglycan	240	243	PF01048	0.847
MOD_GlcNHglycan	248	251	PF01048	0.821
MOD_GlcNHglycan	258	261	PF01048	0.625
MOD_GlcNHglycan	275	279	PF01048	0.534
MOD_GlcNHglycan	294	298	PF01048	0.349
MOD_GlcNHglycan	325	328	PF01048	0.451
MOD_GlcNHglycan	425	428	PF01048	0.646
MOD_GlcNHglycan	470	473	PF01048	0.628
MOD_GlcNHglycan	516	519	PF01048	0.785
MOD_GlcNHglycan	53	57	PF01048	0.367
MOD_GlcNHglycan	542	545	PF01048	0.801
MOD_GlcNHglycan	586	589	PF01048	0.739
MOD_GlcNHglycan	627	630	PF01048	0.646
MOD_GlcNHglycan	88	91	PF01048	0.406
MOD_GSK3_1	1	8	PF00069	0.561
MOD_GSK3_1	154	161	PF00069	0.676
MOD_GSK3_1	185	192	PF00069	0.442
MOD_GSK3_1	234	241	PF00069	0.802
MOD_GSK3_1	274	281	PF00069	0.812
MOD_GSK3_1	289	296	PF00069	0.461
MOD_GSK3_1	419	426	PF00069	0.696
MOD_GSK3_1	508	515	PF00069	0.797
MOD_GSK3_1	559	566	PF00069	0.671
MOD_GSK3_1	60	67	PF00069	0.387
MOD_GSK3_1	621	628	PF00069	0.631
MOD_N-GLC_1	96	101	PF02516	0.422
MOD_NEK2_1	1	6	PF00069	0.680
MOD_NEK2_1	109	114	PF00069	0.467
MOD_NEK2_1	12	17	PF00069	0.545
MOD_NEK2_1	158	163	PF00069	0.615
MOD_NEK2_1	323	328	PF00069	0.450
MOD_NEK2_1	368	373	PF00069	0.403
MOD_NEK2_1	374	379	PF00069	0.402
MOD_NEK2_1	52	57	PF00069	0.396
MOD_NEK2_1	621	626	PF00069	0.629
MOD_NEK2_1	88	93	PF00069	0.417
MOD_NEK2_1	96	101	PF00069	0.342
MOD_PKA_1	159	165	PF00069	0.634
MOD_PKA_1	256	262	PF00069	0.733
MOD_PKA_1	321	327	PF00069	0.466
MOD_PKA_2	158	164	PF00069	0.705
MOD_PKA_2	192	198	PF00069	0.475
MOD_PKA_2	218	224	PF00069	0.726
MOD_PKA_2	256	262	PF00069	0.753
MOD_PKA_2	315	321	PF00069	0.517
MOD_PKA_2	512	518	PF00069	0.764
MOD_PKB_1	319	327	PF00069	0.433
MOD_Plk_1	109	115	PF00069	0.378
MOD_Plk_1	293	299	PF00069	0.463
MOD_Plk_1	96	102	PF00069	0.495
MOD_Plk_2-3	14	20	PF00069	0.508
MOD_Plk_2-3	226	232	PF00069	0.826
MOD_Plk_4	185	191	PF00069	0.443
MOD_Plk_4	309	315	PF00069	0.464
MOD_Plk_4	559	565	PF00069	0.669
MOD_Plk_4	91	97	PF00069	0.429
MOD_ProDKin_1	127	133	PF00069	0.459
MOD_ProDKin_1	2	8	PF00069	0.582
MOD_ProDKin_1	289	295	PF00069	0.679
MOD_ProDKin_1	490	496	PF00069	0.645
MOD_ProDKin_1	530	536	PF00069	0.788
MOD_ProDKin_1	60	66	PF00069	0.396
MOD_ProDKin_1	600	606	PF00069	0.824
MOD_SUMO_rev_2	549	555	PF00179	0.641
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.520
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.608
TRG_DiLeu_BaLyEn_6	435	440	PF01217	0.528
TRG_ENDOCYTIC_2	177	180	PF00928	0.459
TRG_ER_diArg_1	158	160	PF00400	0.586
TRG_ER_diArg_1	381	383	PF00400	0.506
TRG_ER_diArg_1	572	574	PF00400	0.708
TRG_NES_CRM1_1	315	329	PF08389	0.477
TRG_NLS_MonoCore_2	253	258	PF00514	0.667
TRG_NLS_MonoExtC_3	535	540	PF00514	0.829
TRG_NLS_MonoExtN_4	252	259	PF00514	0.765
TRG_NLS_MonoExtN_4	534	540	PF00514	0.826
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N9	Leptomonas seymouri	55%	98%
A4HYR8	Leishmania infantum	100%	100%
E9AI88	Leishmania braziliensis	73%	97%
E9AUH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QD11	Leishmania major	92%	100%