Ciliary basal body-associated, B9 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

B9 domain-containing protein 2

Species:

Leishmania donovani

UniProt:

A0A3Q8IBM1_LEIDO

TriTrypDb:

LdBPK_250330.1 , LdCL_250008400 , LDHU3_25.0400

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	9
GO:0032991	protein-containing complex	1	1
GO:0035869	ciliary transition zone	2	1
GO:0036038	MKS complex	2	1

Expansion

Sequence features

A0A3Q8IBM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBM1

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0030030	cell projection organization	4	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0006996	organelle organization	4	1
GO:0022607	cellular component assembly	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.528
CLV_C14_Caspase3-7	49	53	PF00656	0.499
CLV_PCSK_SKI1_1	173	177	PF00082	0.559
DEG_APCC_DBOX_1	152	160	PF00400	0.455
DOC_CDC14_PxL_1	135	143	PF14671	0.515
DOC_MAPK_MEF2A_6	125	134	PF00069	0.455
DOC_PP2B_LxvP_1	98	101	PF13499	0.507
DOC_PP2B_PxIxI_1	72	78	PF00149	0.515
LIG_14-3-3_CanoR_1	125	131	PF00244	0.499
LIG_BIR_II_1	1	5	PF00653	0.530
LIG_BRCT_BRCA1_1	18	22	PF00533	0.515
LIG_EH1_1	4	12	PF00400	0.432
LIG_FHA_1	127	133	PF00498	0.499
LIG_FHA_1	93	99	PF00498	0.507
LIG_FHA_2	32	38	PF00498	0.515
LIG_LIR_Gen_1	167	175	PF02991	0.515
LIG_LIR_Gen_1	31	37	PF02991	0.460
LIG_LIR_Gen_1	65	73	PF02991	0.507
LIG_LIR_Nem_3	19	25	PF02991	0.426
LIG_LIR_Nem_3	31	36	PF02991	0.421
LIG_LIR_Nem_3	65	69	PF02991	0.437
LIG_LYPXL_yS_3	138	141	PF13949	0.515
LIG_MLH1_MIPbox_1	18	22	PF16413	0.515
LIG_PDZ_Class_2	178	183	PF00595	0.611
LIG_SH2_NCK_1	25	29	PF00017	0.515
LIG_SH2_STAT5	21	24	PF00017	0.424
LIG_SH2_STAT5	97	100	PF00017	0.523
MOD_CK1_1	41	47	PF00069	0.431
MOD_CK1_1	65	71	PF00069	0.500
MOD_CK2_1	31	37	PF00069	0.424
MOD_GlcNHglycan	120	123	PF01048	0.315
MOD_GlcNHglycan	160	163	PF01048	0.227
MOD_GlcNHglycan	40	43	PF01048	0.241
MOD_GlcNHglycan	48	51	PF01048	0.254
MOD_GSK3_1	126	133	PF00069	0.557
MOD_GSK3_1	160	167	PF00069	0.524
MOD_GSK3_1	17	24	PF00069	0.499
MOD_GSK3_1	37	44	PF00069	0.352
MOD_NEK2_1	108	113	PF00069	0.536
MOD_NEK2_1	117	122	PF00069	0.468
MOD_NEK2_1	126	131	PF00069	0.440
MOD_NEK2_1	16	21	PF00069	0.515
MOD_NEK2_1	166	171	PF00069	0.515
MOD_PIKK_1	28	34	PF00454	0.515
MOD_PKA_2	130	136	PF00069	0.515
MOD_PKA_2	38	44	PF00069	0.446
MOD_Plk_1	142	148	PF00069	0.480
MOD_Plk_1	17	23	PF00069	0.536
MOD_Plk_4	130	136	PF00069	0.486
MOD_Plk_4	142	148	PF00069	0.446
MOD_Plk_4	17	23	PF00069	0.455
TRG_ENDOCYTIC_2	138	141	PF00928	0.467
TRG_ENDOCYTIC_2	25	28	PF00928	0.448
TRG_ENDOCYTIC_2	97	100	PF00928	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P898	Leptomonas seymouri	85%	100%
A0A1X0P4P8	Trypanosomatidae	49%	99%
A0A3S5IQX5	Trypanosoma rangeli	51%	99%
A4I175	Leishmania infantum	100%	100%
D0A5G1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	99%
E9AXA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
M9MRD5	Drosophila melanogaster	31%	100%
P0C5J2	Rattus norvegicus	26%	90%
P0C5J3	Rattus norvegicus	33%	100%
Q3UK10	Mus musculus	33%	100%
Q4QA63	Leishmania major	98%	100%
Q503B7	Danio rerio	25%	91%
Q56JY9	Bos taurus	33%	100%
Q5BJ61	Xenopus tropicalis	27%	92%
Q6DFD7	Xenopus laevis	27%	92%
Q6DGZ1	Danio rerio	37%	100%
Q6GN70	Xenopus laevis	34%	100%
Q9BPU9	Homo sapiens	33%	100%
Q9R1S0	Mus musculus	25%	90%
Q9UPM9	Homo sapiens	25%	90%
Q9VF59	Drosophila melanogaster	28%	76%
V5DPD0	Trypanosoma cruzi	51%	99%