Leucine-rich repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat-containing protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IBL9_LEIDO

TriTrypDb:

LdBPK_292320.1 , LdCL_290029300 , LDHU3_29.3430

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A0A3Q8IBL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBL9

Function

Biological processes
Term	Name	Level	Count
GO:0000281	mitotic cytokinesis	4	1
GO:0000910	cytokinesis	3	1
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0030030	cell projection organization	4	1
GO:0044782	cilium organization	5	1
GO:0061640	cytoskeleton-dependent cytokinesis	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1
GO:1903047	mitotic cell cycle process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.534
CLV_NRD_NRD_1	11	13	PF00675	0.250
CLV_NRD_NRD_1	224	226	PF00675	0.500
CLV_NRD_NRD_1	358	360	PF00675	0.504
CLV_NRD_NRD_1	442	444	PF00675	0.466
CLV_PCSK_FUR_1	225	229	PF00082	0.599
CLV_PCSK_KEX2_1	10	12	PF00082	0.250
CLV_PCSK_KEX2_1	227	229	PF00082	0.525
CLV_PCSK_KEX2_1	247	249	PF00082	0.654
CLV_PCSK_KEX2_1	254	256	PF00082	0.649
CLV_PCSK_KEX2_1	358	360	PF00082	0.507
CLV_PCSK_KEX2_1	442	444	PF00082	0.466
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.556
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.675
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.671
CLV_PCSK_PC7_1	438	444	PF00082	0.460
CLV_PCSK_SKI1_1	254	258	PF00082	0.582
CLV_PCSK_SKI1_1	267	271	PF00082	0.431
CLV_PCSK_SKI1_1	370	374	PF00082	0.639
CLV_PCSK_SKI1_1	63	67	PF00082	0.271
CLV_Separin_Metazoa	7	11	PF03568	0.502
DEG_APCC_DBOX_1	362	370	PF00400	0.611
DEG_APCC_DBOX_1	403	411	PF00400	0.744
DEG_SPOP_SBC_1	384	388	PF00917	0.697
DOC_CDC14_PxL_1	136	144	PF14671	0.502
DOC_CKS1_1	231	236	PF01111	0.683
DOC_CKS1_1	437	442	PF01111	0.464
DOC_CYCLIN_RxL_1	262	273	PF00134	0.501
DOC_MAPK_gen_1	262	270	PF00069	0.591
DOC_MAPK_gen_1	317	325	PF00069	0.390
DOC_MAPK_gen_1	63	73	PF00069	0.471
DOC_MAPK_HePTP_8	156	168	PF00069	0.609
DOC_MAPK_MEF2A_6	159	168	PF00069	0.585
DOC_MAPK_MEF2A_6	271	278	PF00069	0.479
DOC_MAPK_MEF2A_6	317	325	PF00069	0.390
DOC_MAPK_MEF2A_6	66	75	PF00069	0.450
DOC_MAPK_MEF2A_6	92	99	PF00069	0.450
DOC_MAPK_NFAT4_5	92	100	PF00069	0.450
DOC_MAPK_RevD_3	345	359	PF00069	0.520
DOC_PP1_RVXF_1	61	68	PF00149	0.529
DOC_PP2B_LxvP_1	321	324	PF13499	0.451
DOC_USP7_MATH_1	402	406	PF00917	0.672
DOC_USP7_UBL2_3	197	201	PF12436	0.602
DOC_WW_Pin1_4	206	211	PF00397	0.473
DOC_WW_Pin1_4	230	235	PF00397	0.676
DOC_WW_Pin1_4	385	390	PF00397	0.769
DOC_WW_Pin1_4	416	421	PF00397	0.758
DOC_WW_Pin1_4	436	441	PF00397	0.441
LIG_14-3-3_CanoR_1	3	7	PF00244	0.463
LIG_14-3-3_CanoR_1	338	347	PF00244	0.518
LIG_14-3-3_CanoR_1	404	408	PF00244	0.775
LIG_14-3-3_CterR_2	443	447	PF00244	0.456
LIG_AP2alpha_2	192	194	PF02296	0.513
LIG_Clathr_ClatBox_1	407	411	PF01394	0.748
LIG_EH_1	111	115	PF12763	0.529
LIG_EVH1_2	390	394	PF00568	0.553
LIG_FHA_1	298	304	PF00498	0.440
LIG_FHA_1	3	9	PF00498	0.450
LIG_FHA_1	340	346	PF00498	0.476
LIG_FHA_1	432	438	PF00498	0.713
LIG_FHA_2	124	130	PF00498	0.502
LIG_FHA_2	207	213	PF00498	0.461
LIG_FHA_2	255	261	PF00498	0.525
LIG_FHA_2	404	410	PF00498	0.777
LIG_FHA_2	77	83	PF00498	0.458
LIG_LIR_Nem_3	128	134	PF02991	0.464
LIG_LIR_Nem_3	263	268	PF02991	0.599
LIG_RPA_C_Fungi	354	366	PF08784	0.600
LIG_SH2_GRB2like	70	73	PF00017	0.303
LIG_SH2_SRC	134	137	PF00017	0.375
LIG_SH2_STAT5	134	137	PF00017	0.322
LIG_SH2_STAT5	50	53	PF00017	0.303
LIG_SH2_STAT5	55	58	PF00017	0.303
LIG_SH2_STAT5	70	73	PF00017	0.117
LIG_SH3_1	271	277	PF00018	0.481
LIG_SH3_3	190	196	PF00018	0.479
LIG_SH3_3	271	277	PF00018	0.481
LIG_SH3_3	344	350	PF00018	0.429
LIG_SH3_3	434	440	PF00018	0.508
LIG_SUMO_SIM_anti_2	308	313	PF11976	0.523
LIG_SUMO_SIM_anti_2	34	41	PF11976	0.303
LIG_SUMO_SIM_anti_2	5	10	PF11976	0.322
LIG_SUMO_SIM_par_1	162	172	PF11976	0.527
LIG_SUMO_SIM_par_1	287	293	PF11976	0.479
LIG_SUMO_SIM_par_1	405	412	PF11976	0.743
LIG_TRAF2_1	169	172	PF00917	0.533
LIG_TRAF2_1	209	212	PF00917	0.462
LIG_TRAF2_1	257	260	PF00917	0.516
LIG_TYR_ITIM	68	73	PF00017	0.303
LIG_WW_1	195	198	PF00397	0.528
LIG_WW_3	439	443	PF00397	0.457
MOD_CDK_SPxK_1	436	442	PF00069	0.467
MOD_CDK_SPxxK_3	206	213	PF00069	0.463
MOD_CDK_SPxxK_3	436	443	PF00069	0.468
MOD_CK1_1	105	111	PF00069	0.384
MOD_CK1_1	339	345	PF00069	0.483
MOD_CK1_1	377	383	PF00069	0.749
MOD_CK1_1	418	424	PF00069	0.768
MOD_CK2_1	123	129	PF00069	0.364
MOD_CK2_1	206	212	PF00069	0.486
MOD_CK2_1	254	260	PF00069	0.532
MOD_CK2_1	403	409	PF00069	0.774
MOD_CK2_1	54	60	PF00069	0.315
MOD_GlcNHglycan	382	385	PF01048	0.724
MOD_GSK3_1	101	108	PF00069	0.391
MOD_GSK3_1	114	121	PF00069	0.338
MOD_GSK3_1	250	257	PF00069	0.626
MOD_GSK3_1	297	304	PF00069	0.539
MOD_GSK3_1	370	377	PF00069	0.654
MOD_GSK3_1	379	386	PF00069	0.707
MOD_GSK3_1	414	421	PF00069	0.759
MOD_GSK3_1	426	433	PF00069	0.580
MOD_N-GLC_1	377	382	PF02516	0.518
MOD_N-GLC_1	424	429	PF02516	0.593
MOD_N-GLC_1	76	81	PF02516	0.322
MOD_NEK2_1	114	119	PF00069	0.314
MOD_NEK2_1	297	302	PF00069	0.443
MOD_NEK2_1	345	350	PF00069	0.428
MOD_NEK2_1	414	419	PF00069	0.754
MOD_NEK2_1	93	98	PF00069	0.303
MOD_PKA_1	254	260	PF00069	0.531
MOD_PKA_2	2	8	PF00069	0.322
MOD_PKA_2	254	260	PF00069	0.555
MOD_PKA_2	337	343	PF00069	0.572
MOD_PKA_2	403	409	PF00069	0.774
MOD_Plk_1	76	82	PF00069	0.319
MOD_Plk_1	93	99	PF00069	0.238
MOD_Plk_4	105	111	PF00069	0.384
MOD_Plk_4	298	304	PF00069	0.440
MOD_Plk_4	403	409	PF00069	0.774
MOD_ProDKin_1	206	212	PF00069	0.466
MOD_ProDKin_1	230	236	PF00069	0.682
MOD_ProDKin_1	385	391	PF00069	0.770
MOD_ProDKin_1	416	422	PF00069	0.761
MOD_ProDKin_1	436	442	PF00069	0.442
MOD_SUMO_for_1	182	185	PF00179	0.445
TRG_DiLeu_BaEn_1	34	39	PF01217	0.375
TRG_DiLeu_BaEn_2	292	298	PF01217	0.507
TRG_DiLeu_BaEn_3	211	217	PF01217	0.445
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.488
TRG_ENDOCYTIC_2	70	73	PF00928	0.284
TRG_ER_diArg_1	363	366	PF00400	0.556
TRG_ER_diArg_1	441	443	PF00400	0.458
TRG_ER_diArg_1	9	12	PF00400	0.303
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.657

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R7	Leptomonas seymouri	75%	91%
A0A0S4IYI1	Bodo saltans	61%	100%
A0A1L8G016	Xenopus laevis	37%	95%
A0A1X0P946	Trypanosomatidae	64%	100%
A0A3R7LV56	Trypanosoma rangeli	63%	100%
A4HHM1	Leishmania braziliensis	83%	100%
A4I4T0	Leishmania infantum	99%	100%
B3DH20	Danio rerio	36%	100%
C9ZLH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9AE83	Leishmania major	95%	100%
E9ALK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O88978	Mus musculus	35%	95%
Q1RMR5	Bos taurus	35%	95%
Q28FY0	Xenopus tropicalis	38%	95%
Q4R3F0	Macaca fascicularis	34%	96%
Q86X45	Homo sapiens	32%	96%
Q9NJE9	Trypanosoma brucei brucei	61%	100%
Q9VR52	Drosophila melanogaster	36%	100%