Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBL2_LEIDO

TriTrypDb:

LdBPK_200200.1 , LdCL_200006800 , LDHU3_20.0210

Length:

862

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IBL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBL2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.742
CLV_C14_Caspase3-7	628	632	PF00656	0.517
CLV_MEL_PAP_1	33	39	PF00089	0.462
CLV_NRD_NRD_1	209	211	PF00675	0.767
CLV_NRD_NRD_1	35	37	PF00675	0.640
CLV_NRD_NRD_1	408	410	PF00675	0.753
CLV_NRD_NRD_1	434	436	PF00675	0.709
CLV_NRD_NRD_1	453	455	PF00675	0.588
CLV_NRD_NRD_1	478	480	PF00675	0.567
CLV_NRD_NRD_1	49	51	PF00675	0.469
CLV_NRD_NRD_1	569	571	PF00675	0.606
CLV_NRD_NRD_1	580	582	PF00675	0.510
CLV_NRD_NRD_1	808	810	PF00675	0.525
CLV_PCSK_KEX2_1	209	211	PF00082	0.767
CLV_PCSK_KEX2_1	284	286	PF00082	0.598
CLV_PCSK_KEX2_1	35	37	PF00082	0.622
CLV_PCSK_KEX2_1	408	410	PF00082	0.753
CLV_PCSK_KEX2_1	478	480	PF00082	0.567
CLV_PCSK_KEX2_1	569	571	PF00082	0.606
CLV_PCSK_KEX2_1	580	582	PF00082	0.510
CLV_PCSK_KEX2_1	622	624	PF00082	0.620
CLV_PCSK_KEX2_1	808	810	PF00082	0.525
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.598
CLV_PCSK_PC1ET2_1	622	624	PF00082	0.517
CLV_PCSK_SKI1_1	319	323	PF00082	0.761
CLV_PCSK_SKI1_1	409	413	PF00082	0.635
CLV_PCSK_SKI1_1	448	452	PF00082	0.711
CLV_PCSK_SKI1_1	479	483	PF00082	0.551
CLV_PCSK_SKI1_1	581	585	PF00082	0.531
CLV_PCSK_SKI1_1	611	615	PF00082	0.470
CLV_Separin_Metazoa	32	36	PF03568	0.594
DEG_APCC_DBOX_1	133	141	PF00400	0.547
DEG_APCC_DBOX_1	478	486	PF00400	0.551
DEG_SCF_FBW7_1	298	305	PF00400	0.665
DEG_SIAH_1	421	429	PF03145	0.699
DEG_SPOP_SBC_1	626	630	PF00917	0.392
DOC_CKS1_1	299	304	PF01111	0.667
DOC_CKS1_1	802	807	PF01111	0.679
DOC_CYCLIN_RxL_1	130	142	PF00134	0.520
DOC_MAPK_DCC_7	644	654	PF00069	0.397
DOC_MAPK_gen_1	558	566	PF00069	0.501
DOC_MAPK_MEF2A_6	644	651	PF00069	0.478
DOC_PP1_RVXF_1	523	529	PF00149	0.590
DOC_PP2B_LxvP_1	390	393	PF13499	0.711
DOC_PP2B_LxvP_1	647	650	PF13499	0.522
DOC_USP7_MATH_1	114	118	PF00917	0.783
DOC_USP7_MATH_1	122	126	PF00917	0.637
DOC_USP7_MATH_1	25	29	PF00917	0.494
DOC_USP7_MATH_1	265	269	PF00917	0.693
DOC_USP7_MATH_1	302	306	PF00917	0.773
DOC_USP7_MATH_1	346	350	PF00917	0.791
DOC_USP7_MATH_1	541	545	PF00917	0.565
DOC_USP7_MATH_1	61	65	PF00917	0.718
DOC_USP7_MATH_1	626	630	PF00917	0.537
DOC_USP7_MATH_1	704	708	PF00917	0.579
DOC_USP7_MATH_1	739	743	PF00917	0.709
DOC_USP7_UBL2_3	853	857	PF12436	0.652
DOC_WW_Pin1_4	112	117	PF00397	0.742
DOC_WW_Pin1_4	273	278	PF00397	0.743
DOC_WW_Pin1_4	298	303	PF00397	0.724
DOC_WW_Pin1_4	310	315	PF00397	0.687
DOC_WW_Pin1_4	344	349	PF00397	0.702
DOC_WW_Pin1_4	401	406	PF00397	0.793
DOC_WW_Pin1_4	409	414	PF00397	0.664
DOC_WW_Pin1_4	519	524	PF00397	0.719
DOC_WW_Pin1_4	680	685	PF00397	0.466
DOC_WW_Pin1_4	708	713	PF00397	0.682
DOC_WW_Pin1_4	801	806	PF00397	0.684
DOC_WW_Pin1_4	84	89	PF00397	0.696
LIG_14-3-3_CanoR_1	148	156	PF00244	0.594
LIG_14-3-3_CanoR_1	210	219	PF00244	0.697
LIG_14-3-3_CanoR_1	382	392	PF00244	0.659
LIG_14-3-3_CanoR_1	400	405	PF00244	0.687
LIG_14-3-3_CanoR_1	440	446	PF00244	0.685
LIG_14-3-3_CanoR_1	478	486	PF00244	0.510
LIG_14-3-3_CanoR_1	504	508	PF00244	0.614
LIG_14-3-3_CanoR_1	558	567	PF00244	0.646
LIG_14-3-3_CanoR_1	75	79	PF00244	0.596
LIG_14-3-3_CanoR_1	757	763	PF00244	0.554
LIG_14-3-3_CanoR_1	840	850	PF00244	0.419
LIG_Actin_WH2_2	133	150	PF00022	0.579
LIG_AP2alpha_1	487	491	PF02296	0.598
LIG_BIR_II_1	1	5	PF00653	0.683
LIG_BRCT_BRCA1_1	2	6	PF00533	0.552
LIG_BRCT_BRCA1_1	603	607	PF00533	0.550
LIG_Clathr_ClatBox_1	847	851	PF01394	0.587
LIG_eIF4E_1	842	848	PF01652	0.558
LIG_FHA_1	133	139	PF00498	0.552
LIG_FHA_1	193	199	PF00498	0.766
LIG_FHA_1	294	300	PF00498	0.734
LIG_FHA_1	410	416	PF00498	0.628
LIG_FHA_1	459	465	PF00498	0.664
LIG_FHA_1	555	561	PF00498	0.451
LIG_FHA_1	573	579	PF00498	0.599
LIG_FHA_1	681	687	PF00498	0.551
LIG_FHA_1	696	702	PF00498	0.577
LIG_FHA_1	779	785	PF00498	0.599
LIG_FHA_1	833	839	PF00498	0.623
LIG_FHA_1	853	859	PF00498	0.641
LIG_FHA_1	91	97	PF00498	0.656
LIG_FHA_2	121	127	PF00498	0.747
LIG_FHA_2	311	317	PF00498	0.833
LIG_FHA_2	338	344	PF00498	0.738
LIG_FHA_2	348	354	PF00498	0.615
LIG_FHA_2	626	632	PF00498	0.507
LIG_GBD_Chelix_1	509	517	PF00786	0.614
LIG_HCF-1_HBM_1	8	11	PF13415	0.462
LIG_LIR_Apic_2	81	86	PF02991	0.814
LIG_LIR_Gen_1	480	491	PF02991	0.534
LIG_LIR_Nem_3	142	147	PF02991	0.539
LIG_LIR_Nem_3	17	22	PF02991	0.470
LIG_LIR_Nem_3	260	264	PF02991	0.567
LIG_LIR_Nem_3	480	486	PF02991	0.568
LIG_LIR_Nem_3	489	494	PF02991	0.479
LIG_Pex14_2	483	487	PF04695	0.619
LIG_PTAP_UEV_1	303	308	PF05743	0.684
LIG_REV1ctd_RIR_1	488	496	PF16727	0.613
LIG_SH2_CRK	144	148	PF00017	0.615
LIG_SH2_CRK	261	265	PF00017	0.573
LIG_SH2_CRK	83	87	PF00017	0.711
LIG_SH2_SRC	22	25	PF00017	0.483
LIG_SH2_STAP1	141	145	PF00017	0.517
LIG_SH2_STAP1	228	232	PF00017	0.683
LIG_SH2_STAP1	287	291	PF00017	0.640
LIG_SH2_STAT3	762	765	PF00017	0.576
LIG_SH2_STAT3	842	845	PF00017	0.572
LIG_SH2_STAT5	106	109	PF00017	0.587
LIG_SH2_STAT5	131	134	PF00017	0.515
LIG_SH2_STAT5	166	169	PF00017	0.644
LIG_SH2_STAT5	246	249	PF00017	0.687
LIG_SH2_STAT5	287	290	PF00017	0.645
LIG_SH3_3	110	116	PF00018	0.684
LIG_SH3_3	301	307	PF00018	0.745
LIG_SH3_3	325	331	PF00018	0.759
LIG_SH3_3	561	567	PF00018	0.467
LIG_SH3_3	686	692	PF00018	0.572
LIG_SH3_3	799	805	PF00018	0.606
LIG_SH3_3	85	91	PF00018	0.733
LIG_SUMO_SIM_anti_2	195	200	PF11976	0.616
LIG_SUMO_SIM_par_1	194	200	PF11976	0.616
LIG_SUMO_SIM_par_1	265	273	PF11976	0.705
LIG_TRAF2_1	186	189	PF00917	0.823
LIG_TRAF2_1	253	256	PF00917	0.536
LIG_TRAF2_1	313	316	PF00917	0.759
LIG_TRAF2_1	350	353	PF00917	0.714
LIG_TRAF2_1	544	547	PF00917	0.496
LIG_UBA3_1	15	21	PF00899	0.619
LIG_WRC_WIRS_1	494	499	PF05994	0.560
LIG_WW_1	667	670	PF00397	0.427
MOD_CDC14_SPxK_1	522	525	PF00782	0.740
MOD_CDK_SPK_2	708	713	PF00069	0.682
MOD_CDK_SPxK_1	519	525	PF00069	0.724
MOD_CDK_SPxxK_3	112	119	PF00069	0.600
MOD_CDK_SPxxK_3	401	408	PF00069	0.797
MOD_CDK_SPxxK_3	801	808	PF00069	0.685
MOD_CK1_1	2	8	PF00069	0.734
MOD_CK1_1	227	233	PF00069	0.733
MOD_CK1_1	441	447	PF00069	0.705
MOD_CK1_1	458	464	PF00069	0.573
MOD_CK1_1	472	478	PF00069	0.343
MOD_CK1_1	534	540	PF00069	0.656
MOD_CK1_1	562	568	PF00069	0.591
MOD_CK1_1	642	648	PF00069	0.587
MOD_CK1_1	719	725	PF00069	0.744
MOD_CK1_1	778	784	PF00069	0.608
MOD_CK1_1	81	87	PF00069	0.752
MOD_CK2_1	120	126	PF00069	0.760
MOD_CK2_1	194	200	PF00069	0.766
MOD_CK2_1	310	316	PF00069	0.753
MOD_CK2_1	337	343	PF00069	0.736
MOD_CK2_1	347	353	PF00069	0.766
MOD_CK2_1	35	41	PF00069	0.466
MOD_CK2_1	541	547	PF00069	0.524
MOD_CK2_1	757	763	PF00069	0.651
MOD_DYRK1A_RPxSP_1	409	413	PF00069	0.635
MOD_GlcNHglycan	213	216	PF01048	0.798
MOD_GlcNHglycan	304	307	PF01048	0.720
MOD_GlcNHglycan	332	335	PF01048	0.677
MOD_GlcNHglycan	37	40	PF01048	0.475
MOD_GlcNHglycan	395	398	PF01048	0.767
MOD_GlcNHglycan	432	435	PF01048	0.753
MOD_GlcNHglycan	441	444	PF01048	0.640
MOD_GlcNHglycan	457	460	PF01048	0.726
MOD_GlcNHglycan	543	546	PF01048	0.634
MOD_GlcNHglycan	57	60	PF01048	0.635
MOD_GlcNHglycan	603	606	PF01048	0.508
MOD_GlcNHglycan	702	705	PF01048	0.478
MOD_GlcNHglycan	83	86	PF01048	0.819
MOD_GSK3_1	184	191	PF00069	0.735
MOD_GSK3_1	265	272	PF00069	0.755
MOD_GSK3_1	285	292	PF00069	0.528
MOD_GSK3_1	298	305	PF00069	0.786
MOD_GSK3_1	330	337	PF00069	0.703
MOD_GSK3_1	344	351	PF00069	0.762
MOD_GSK3_1	409	416	PF00069	0.726
MOD_GSK3_1	469	476	PF00069	0.539
MOD_GSK3_1	691	698	PF00069	0.486
MOD_GSK3_1	700	707	PF00069	0.601
MOD_GSK3_1	719	726	PF00069	0.494
MOD_GSK3_1	74	81	PF00069	0.786
MOD_GSK3_1	90	97	PF00069	0.586
MOD_N-GLC_1	211	216	PF02516	0.706
MOD_N-GLC_1	293	298	PF02516	0.727
MOD_N-GLC_1	383	388	PF02516	0.617
MOD_N-GLC_1	94	99	PF02516	0.734
MOD_NEK2_1	1	6	PF00069	0.612
MOD_NEK2_1	147	152	PF00069	0.592
MOD_NEK2_1	383	388	PF00069	0.617
MOD_NEK2_1	473	478	PF00069	0.623
MOD_NEK2_1	574	579	PF00069	0.543
MOD_NEK2_1	585	590	PF00069	0.467
MOD_NEK2_1	677	682	PF00069	0.522
MOD_NEK2_1	78	83	PF00069	0.752
MOD_NEK2_2	639	644	PF00069	0.667
MOD_PIKK_1	147	153	PF00454	0.604
MOD_PIKK_1	348	354	PF00454	0.688
MOD_PIKK_1	375	381	PF00454	0.788
MOD_PIKK_1	559	565	PF00454	0.578
MOD_PIKK_1	696	702	PF00454	0.463
MOD_PIKK_1	731	737	PF00454	0.796
MOD_PIKK_1	841	847	PF00454	0.542
MOD_PK_1	508	514	PF00069	0.559
MOD_PKA_1	35	41	PF00069	0.481
MOD_PKA_2	147	153	PF00069	0.604
MOD_PKA_2	208	214	PF00069	0.766
MOD_PKA_2	35	41	PF00069	0.466
MOD_PKA_2	361	367	PF00069	0.689
MOD_PKA_2	439	445	PF00069	0.699
MOD_PKA_2	477	483	PF00069	0.549
MOD_PKA_2	503	509	PF00069	0.613
MOD_PKA_2	74	80	PF00069	0.628
MOD_PKA_2	756	762	PF00069	0.660
MOD_Plk_1	187	193	PF00069	0.811
MOD_Plk_1	383	389	PF00069	0.614
MOD_Plk_1	469	475	PF00069	0.636
MOD_Plk_1	531	537	PF00069	0.659
MOD_Plk_1	770	776	PF00069	0.548
MOD_Plk_1	832	838	PF00069	0.564
MOD_Plk_1	94	100	PF00069	0.730
MOD_Plk_2-3	184	190	PF00069	0.767
MOD_Plk_4	194	200	PF00069	0.616
MOD_Plk_4	265	271	PF00069	0.703
MOD_Plk_4	508	514	PF00069	0.618
MOD_Plk_4	574	580	PF00069	0.582
MOD_Plk_4	770	776	PF00069	0.503
MOD_ProDKin_1	112	118	PF00069	0.743
MOD_ProDKin_1	273	279	PF00069	0.746
MOD_ProDKin_1	298	304	PF00069	0.717
MOD_ProDKin_1	310	316	PF00069	0.687
MOD_ProDKin_1	344	350	PF00069	0.702
MOD_ProDKin_1	401	407	PF00069	0.794
MOD_ProDKin_1	409	415	PF00069	0.664
MOD_ProDKin_1	519	525	PF00069	0.724
MOD_ProDKin_1	680	686	PF00069	0.460
MOD_ProDKin_1	708	714	PF00069	0.698
MOD_ProDKin_1	801	807	PF00069	0.678
MOD_ProDKin_1	84	90	PF00069	0.697
MOD_SUMO_for_1	283	286	PF00179	0.706
MOD_SUMO_for_1	643	646	PF00179	0.538
MOD_SUMO_rev_2	349	357	PF00179	0.700
MOD_SUMO_rev_2	711	720	PF00179	0.670
TRG_DiLeu_BaEn_1	547	552	PF01217	0.568
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.545
TRG_DiLeu_BaLyEn_6	682	687	PF01217	0.647
TRG_DiLeu_BaLyEn_6	833	838	PF01217	0.516
TRG_ENDOCYTIC_2	144	147	PF00928	0.619
TRG_ENDOCYTIC_2	261	264	PF00928	0.572
TRG_ENDOCYTIC_2	488	491	PF00928	0.603
TRG_ER_diArg_1	133	136	PF00400	0.556
TRG_ER_diArg_1	34	36	PF00400	0.603
TRG_ER_diArg_1	477	479	PF00400	0.556
TRG_ER_diArg_1	569	571	PF00400	0.609
TRG_ER_diArg_1	579	581	PF00400	0.474
TRG_ER_diArg_1	834	837	PF00400	0.566
TRG_Pf-PMV_PEXEL_1	549	554	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	558	563	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NX86	Trypanosomatidae	23%	100%
A4HYK9	Leishmania infantum	100%	100%
E9AI72	Leishmania braziliensis	59%	100%
E9AUF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	92%
Q4QD26	Leishmania major	84%	100%