Cleavage and polyadenylation specificity factor subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cleavage and polyadenylation specificity factor, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBL1_LEIDO

TriTrypDb:

LdBPK_250170.1 , LdCL_250006800 , LDHU3_25.0230

Length:

818

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	11
GO:0005849	mRNA cleavage factor complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0140513	nuclear protein-containing complex	2	11
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IBL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBL1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006378	mRNA polyadenylation	7	11
GO:0006379	mRNA cleavage	7	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0031123	RNA 3'-end processing	7	11
GO:0031124	mRNA 3'-end processing	8	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043631	RNA polyadenylation	6	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	11
GO:0090501	RNA phosphodiester bond hydrolysis	6	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage	8	1
GO:0008334	histone mRNA metabolic process	7	1
GO:0098787	mRNA cleavage involved in mRNA processing	8	1
GO:0098789	pre-mRNA cleavage required for polyadenylation	9	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.563
CLV_NRD_NRD_1	392	394	PF00675	0.475
CLV_NRD_NRD_1	416	418	PF00675	0.499
CLV_NRD_NRD_1	578	580	PF00675	0.430
CLV_NRD_NRD_1	675	677	PF00675	0.355
CLV_NRD_NRD_1	712	714	PF00675	0.392
CLV_NRD_NRD_1	754	756	PF00675	0.457
CLV_NRD_NRD_1	785	787	PF00675	0.313
CLV_NRD_NRD_1	807	809	PF00675	0.335
CLV_PCSK_KEX2_1	307	309	PF00082	0.553
CLV_PCSK_KEX2_1	392	394	PF00082	0.451
CLV_PCSK_KEX2_1	415	417	PF00082	0.497
CLV_PCSK_KEX2_1	518	520	PF00082	0.644
CLV_PCSK_KEX2_1	538	540	PF00082	0.393
CLV_PCSK_KEX2_1	578	580	PF00082	0.494
CLV_PCSK_KEX2_1	675	677	PF00082	0.332
CLV_PCSK_KEX2_1	711	713	PF00082	0.335
CLV_PCSK_KEX2_1	754	756	PF00082	0.474
CLV_PCSK_KEX2_1	807	809	PF00082	0.424
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.553
CLV_PCSK_PC1ET2_1	518	520	PF00082	0.637
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.393
CLV_PCSK_SKI1_1	230	234	PF00082	0.435
CLV_PCSK_SKI1_1	276	280	PF00082	0.460
CLV_PCSK_SKI1_1	307	311	PF00082	0.493
CLV_PCSK_SKI1_1	34	38	PF00082	0.268
CLV_PCSK_SKI1_1	422	426	PF00082	0.580
CLV_PCSK_SKI1_1	459	463	PF00082	0.540
CLV_PCSK_SKI1_1	481	485	PF00082	0.760
CLV_PCSK_SKI1_1	581	585	PF00082	0.476
CLV_PCSK_SKI1_1	597	601	PF00082	0.222
CLV_PCSK_SKI1_1	621	625	PF00082	0.411
CLV_PCSK_SKI1_1	631	635	PF00082	0.395
DEG_APCC_DBOX_1	580	588	PF00400	0.485
DEG_Nend_Nbox_1	1	3	PF02207	0.505
DEG_SPOP_SBC_1	639	643	PF00917	0.380
DOC_ANK_TNKS_1	785	792	PF00023	0.424
DOC_CKS1_1	798	803	PF01111	0.424
DOC_CYCLIN_RxL_1	224	235	PF00134	0.550
DOC_CYCLIN_RxL_1	495	507	PF00134	0.631
DOC_CYCLIN_yCln2_LP_2	490	496	PF00134	0.639
DOC_MAPK_gen_1	479	488	PF00069	0.667
DOC_MAPK_gen_1	568	576	PF00069	0.545
DOC_MAPK_gen_1	578	584	PF00069	0.459
DOC_MAPK_gen_1	772	779	PF00069	0.424
DOC_MAPK_HePTP_8	252	264	PF00069	0.448
DOC_MAPK_MEF2A_6	241	250	PF00069	0.381
DOC_MAPK_MEF2A_6	255	264	PF00069	0.325
DOC_MAPK_MEF2A_6	481	490	PF00069	0.723
DOC_MAPK_MEF2A_6	568	576	PF00069	0.521
DOC_MAPK_MEF2A_6	772	779	PF00069	0.332
DOC_MAPK_RevD_3	774	787	PF00069	0.424
DOC_PP1_RVXF_1	32	38	PF00149	0.539
DOC_PP1_RVXF_1	497	504	PF00149	0.603
DOC_PP2B_LxvP_1	488	491	PF13499	0.593
DOC_PP2B_PxIxI_1	327	333	PF00149	0.435
DOC_PP4_FxxP_1	182	185	PF00568	0.473
DOC_PP4_FxxP_1	198	201	PF00568	0.391
DOC_USP7_MATH_1	726	730	PF00917	0.369
DOC_USP7_UBL2_3	146	150	PF12436	0.539
DOC_USP7_UBL2_3	230	234	PF12436	0.541
DOC_USP7_UBL2_3	597	601	PF12436	0.497
DOC_WW_Pin1_4	16	21	PF00397	0.483
DOC_WW_Pin1_4	64	69	PF00397	0.466
DOC_WW_Pin1_4	797	802	PF00397	0.324
DOC_WW_Pin1_4	81	86	PF00397	0.530
LIG_14-3-3_CanoR_1	3	11	PF00244	0.375
LIG_14-3-3_CanoR_1	459	467	PF00244	0.461
LIG_14-3-3_CanoR_1	543	550	PF00244	0.614
LIG_14-3-3_CanoR_1	581	591	PF00244	0.398
LIG_14-3-3_CanoR_1	711	719	PF00244	0.457
LIG_14-3-3_CanoR_1	807	811	PF00244	0.355
LIG_Actin_WH2_2	225	243	PF00022	0.414
LIG_Actin_WH2_2	659	677	PF00022	0.457
LIG_Actin_WH2_2	744	759	PF00022	0.342
LIG_Actin_WH2_2	791	809	PF00022	0.332
LIG_APCC_ABBA_1	776	781	PF00400	0.424
LIG_BIR_III_2	547	551	PF00653	0.713
LIG_BRCT_BRCA1_1	113	117	PF00533	0.512
LIG_BRCT_BRCA1_1	210	214	PF00533	0.484
LIG_BRCT_BRCA1_1	336	340	PF00533	0.484
LIG_BRCT_BRCA1_1	636	640	PF00533	0.557
LIG_BRCT_BRCA1_1	7	11	PF00533	0.409
LIG_BRCT_BRCA1_1	742	746	PF00533	0.424
LIG_Clathr_ClatBox_1	27	31	PF01394	0.473
LIG_Clathr_ClatBox_1	776	780	PF01394	0.387
LIG_CtBP_PxDLS_1	648	652	PF00389	0.525
LIG_deltaCOP1_diTrp_1	38	45	PF00928	0.473
LIG_eIF4E_1	176	182	PF01652	0.473
LIG_FHA_1	114	120	PF00498	0.470
LIG_FHA_1	124	130	PF00498	0.563
LIG_FHA_1	201	207	PF00498	0.365
LIG_FHA_1	293	299	PF00498	0.406
LIG_FHA_1	45	51	PF00498	0.539
LIG_FHA_1	483	489	PF00498	0.621
LIG_FHA_1	507	513	PF00498	0.561
LIG_FHA_1	521	527	PF00498	0.610
LIG_FHA_1	683	689	PF00498	0.406
LIG_FHA_1	790	796	PF00498	0.424
LIG_FHA_1	798	804	PF00498	0.424
LIG_FHA_1	93	99	PF00498	0.495
LIG_FHA_2	116	122	PF00498	0.566
LIG_FHA_2	221	227	PF00498	0.572
LIG_FHA_2	291	297	PF00498	0.412
LIG_FHA_2	732	738	PF00498	0.368
LIG_GBD_Chelix_1	666	674	PF00786	0.424
LIG_KLC1_Yacidic_2	402	407	PF13176	0.576
LIG_LIR_Apic_2	106	112	PF02991	0.563
LIG_LIR_Apic_2	179	185	PF02991	0.473
LIG_LIR_Apic_2	521	527	PF02991	0.511
LIG_LIR_Gen_1	130	139	PF02991	0.460
LIG_LIR_Gen_1	300	309	PF02991	0.560
LIG_LIR_Gen_1	402	412	PF02991	0.483
LIG_LIR_Gen_1	423	432	PF02991	0.693
LIG_LIR_Gen_1	764	775	PF02991	0.424
LIG_LIR_Gen_1	8	15	PF02991	0.417
LIG_LIR_Nem_3	130	136	PF02991	0.460
LIG_LIR_Nem_3	273	278	PF02991	0.401
LIG_LIR_Nem_3	300	304	PF02991	0.542
LIG_LIR_Nem_3	402	408	PF02991	0.479
LIG_LIR_Nem_3	423	428	PF02991	0.685
LIG_LIR_Nem_3	502	506	PF02991	0.665
LIG_LIR_Nem_3	764	770	PF02991	0.424
LIG_LIR_Nem_3	8	14	PF02991	0.403
LIG_LIR_Nem_3	809	814	PF02991	0.333
LIG_Pex14_1	172	176	PF04695	0.460
LIG_Pex14_1	41	45	PF04695	0.473
LIG_Pex14_2	37	41	PF04695	0.539
LIG_Pex14_2	45	49	PF04695	0.539
LIG_Rb_pABgroove_1	31	39	PF01858	0.539
LIG_RPA_C_Fungi	350	362	PF08784	0.538
LIG_SH2_CRK	109	113	PF00017	0.386
LIG_SH2_CRK	24	28	PF00017	0.432
LIG_SH2_CRK	275	279	PF00017	0.372
LIG_SH2_CRK	524	528	PF00017	0.508
LIG_SH2_NCK_1	719	723	PF00017	0.380
LIG_SH2_PTP2	405	408	PF00017	0.538
LIG_SH2_SRC	109	112	PF00017	0.424
LIG_SH2_STAP1	170	174	PF00017	0.457
LIG_SH2_STAP1	225	229	PF00017	0.426
LIG_SH2_STAP1	24	28	PF00017	0.438
LIG_SH2_STAP1	656	660	PF00017	0.483
LIG_SH2_STAP1	814	818	PF00017	0.588
LIG_SH2_STAT3	225	228	PF00017	0.437
LIG_SH2_STAT3	658	661	PF00017	0.478
LIG_SH2_STAT5	183	186	PF00017	0.297
LIG_SH2_STAT5	26	29	PF00017	0.386
LIG_SH2_STAT5	301	304	PF00017	0.553
LIG_SH2_STAT5	349	352	PF00017	0.435
LIG_SH2_STAT5	405	408	PF00017	0.529
LIG_SH3_1	52	58	PF00018	0.380
LIG_SH3_3	17	23	PF00018	0.450
LIG_SH3_3	243	249	PF00018	0.350
LIG_SH3_3	364	370	PF00018	0.438
LIG_SH3_3	486	492	PF00018	0.717
LIG_SH3_3	52	58	PF00018	0.380
LIG_SUMO_SIM_anti_2	359	366	PF11976	0.469
LIG_SUMO_SIM_par_1	26	31	PF11976	0.313
LIG_SUMO_SIM_par_1	359	366	PF11976	0.472
LIG_SUMO_SIM_par_1	647	653	PF11976	0.530
LIG_SUMO_SIM_par_1	774	781	PF11976	0.386
LIG_SUMO_SIM_par_1	790	797	PF11976	0.386
LIG_TRAF2_1	318	321	PF00917	0.409
LIG_TRAF2_1	397	400	PF00917	0.562
LIG_TRAF2_1	529	532	PF00917	0.628
LIG_TRAF2_1	760	763	PF00917	0.468
LIG_TRFH_1	193	197	PF08558	0.404
LIG_WRC_WIRS_1	104	109	PF05994	0.438
LIG_WRC_WIRS_1	133	138	PF05994	0.386
LIG_WW_2	367	370	PF00397	0.560
MOD_CK1_1	135	141	PF00069	0.457
MOD_CK1_1	219	225	PF00069	0.483
MOD_CK1_1	394	400	PF00069	0.578
MOD_CK1_1	48	54	PF00069	0.243
MOD_CK1_1	5	11	PF00069	0.346
MOD_CK1_1	510	516	PF00069	0.566
MOD_CK1_1	567	573	PF00069	0.529
MOD_CK1_1	585	591	PF00069	0.476
MOD_CK1_1	641	647	PF00069	0.579
MOD_CK1_1	682	688	PF00069	0.376
MOD_CK1_1	720	726	PF00069	0.333
MOD_CK1_1	797	803	PF00069	0.342
MOD_CK1_1	81	87	PF00069	0.403
MOD_CK2_1	10	16	PF00069	0.493
MOD_CK2_1	135	141	PF00069	0.344
MOD_CK2_1	220	226	PF00069	0.589
MOD_CK2_1	290	296	PF00069	0.418
MOD_CK2_1	315	321	PF00069	0.386
MOD_CK2_1	394	400	PF00069	0.554
MOD_CK2_1	526	532	PF00069	0.582
MOD_CK2_1	681	687	PF00069	0.406
MOD_CK2_1	731	737	PF00069	0.368
MOD_CK2_1	757	763	PF00069	0.468
MOD_GlcNHglycan	317	320	PF01048	0.505
MOD_GlcNHglycan	342	345	PF01048	0.380
MOD_GlcNHglycan	396	399	PF01048	0.585
MOD_GlcNHglycan	4	7	PF01048	0.370
MOD_GlcNHglycan	422	425	PF01048	0.611
MOD_GlcNHglycan	512	515	PF01048	0.514
MOD_GlcNHglycan	586	590	PF01048	0.409
MOD_GlcNHglycan	615	618	PF01048	0.500
MOD_GlcNHglycan	694	698	PF01048	0.456
MOD_GlcNHglycan	742	745	PF01048	0.424
MOD_GlcNHglycan	763	766	PF01048	0.382
MOD_GSK3_1	111	118	PF00069	0.259
MOD_GSK3_1	128	135	PF00069	0.335
MOD_GSK3_1	185	192	PF00069	0.313
MOD_GSK3_1	216	223	PF00069	0.552
MOD_GSK3_1	44	51	PF00069	0.339
MOD_GSK3_1	495	502	PF00069	0.684
MOD_GSK3_1	5	12	PF00069	0.355
MOD_GSK3_1	506	513	PF00069	0.665
MOD_GSK3_1	595	602	PF00069	0.417
MOD_GSK3_1	634	641	PF00069	0.570
MOD_GSK3_1	64	71	PF00069	0.376
MOD_GSK3_1	650	657	PF00069	0.439
MOD_GSK3_1	662	669	PF00069	0.332
MOD_GSK3_1	677	684	PF00069	0.288
MOD_GSK3_1	722	729	PF00069	0.412
MOD_GSK3_1	757	764	PF00069	0.424
MOD_GSK3_1	789	796	PF00069	0.324
MOD_GSK3_1	99	106	PF00069	0.443
MOD_LATS_1	497	503	PF00433	0.729
MOD_N-GLC_1	219	224	PF02516	0.656
MOD_NEK2_1	2	7	PF00069	0.418
MOD_NEK2_1	208	213	PF00069	0.418
MOD_NEK2_1	214	219	PF00069	0.477
MOD_NEK2_1	236	241	PF00069	0.419
MOD_NEK2_1	388	393	PF00069	0.444
MOD_NEK2_1	45	50	PF00069	0.386
MOD_NEK2_1	506	511	PF00069	0.605
MOD_NEK2_1	640	645	PF00069	0.573
MOD_NEK2_1	662	667	PF00069	0.351
MOD_NEK2_1	756	761	PF00069	0.355
MOD_NEK2_1	78	83	PF00069	0.443
MOD_NEK2_1	806	811	PF00069	0.374
MOD_NEK2_2	145	150	PF00069	0.334
MOD_NEK2_2	185	190	PF00069	0.269
MOD_PIKK_1	726	732	PF00454	0.420
MOD_PIKK_1	812	818	PF00454	0.481
MOD_PKA_1	711	717	PF00069	0.424
MOD_PKA_2	2	8	PF00069	0.404
MOD_PKA_2	220	226	PF00069	0.589
MOD_PKA_2	391	397	PF00069	0.477
MOD_PKA_2	613	619	PF00069	0.430
MOD_PKA_2	677	683	PF00069	0.386
MOD_PKA_2	711	717	PF00069	0.424
MOD_PKA_2	756	762	PF00069	0.366
MOD_PKA_2	806	812	PF00069	0.355
MOD_PKB_1	755	763	PF00069	0.424
MOD_Plk_1	185	191	PF00069	0.300
MOD_Plk_1	45	51	PF00069	0.361
MOD_Plk_1	520	526	PF00069	0.512
MOD_Plk_1	662	668	PF00069	0.424
MOD_Plk_2-3	334	340	PF00069	0.387
MOD_Plk_4	10	16	PF00069	0.390
MOD_Plk_4	128	134	PF00069	0.424
MOD_Plk_4	168	174	PF00069	0.445
MOD_Plk_4	45	51	PF00069	0.355
MOD_Plk_4	595	601	PF00069	0.463
MOD_Plk_4	742	748	PF00069	0.386
MOD_Plk_4	84	90	PF00069	0.416
MOD_Plk_4	99	105	PF00069	0.424
MOD_ProDKin_1	16	22	PF00069	0.475
MOD_ProDKin_1	64	70	PF00069	0.322
MOD_ProDKin_1	797	803	PF00069	0.324
MOD_ProDKin_1	81	87	PF00069	0.411
MOD_SUMO_for_1	437	440	PF00179	0.714
MOD_SUMO_rev_2	300	309	PF00179	0.573
TRG_DiLeu_BaEn_1	531	536	PF01217	0.487
TRG_DiLeu_BaEn_4	531	537	PF01217	0.649
TRG_DiLeu_BaLyEn_6	772	777	PF01217	0.424
TRG_ENDOCYTIC_2	133	136	PF00928	0.322
TRG_ENDOCYTIC_2	170	173	PF00928	0.321
TRG_ENDOCYTIC_2	24	27	PF00928	0.439
TRG_ENDOCYTIC_2	275	278	PF00928	0.376
TRG_ENDOCYTIC_2	301	304	PF00928	0.553
TRG_ENDOCYTIC_2	405	408	PF00928	0.484
TRG_ENDOCYTIC_2	767	770	PF00928	0.424
TRG_ER_diArg_1	392	395	PF00400	0.485
TRG_ER_diArg_1	415	417	PF00400	0.550
TRG_ER_diArg_1	578	581	PF00400	0.495
TRG_ER_diArg_1	674	676	PF00400	0.355
TRG_ER_diArg_1	711	713	PF00400	0.358
TRG_ER_diArg_1	753	755	PF00400	0.451
TRG_ER_diArg_1	806	808	PF00400	0.424
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.313
TRG_Pf-PMV_PEXEL_1	754	758	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEP3	Leptomonas seymouri	75%	99%
A0A0S4JJR9	Bodo saltans	30%	86%
A0A1X0P5N3	Trypanosomatidae	51%	100%
A0A422NF58	Trypanosoma rangeli	51%	100%
A4HDW4	Leishmania braziliensis	89%	100%
A4I159	Leishmania infantum	100%	100%
A8XUS3	Caenorhabditis briggsae	23%	97%
D0A5E4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AX93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QA79	Leishmania major	95%	100%
Q652P4	Oryza sativa subsp. japonica	23%	100%
Q9V3D6	Drosophila melanogaster	25%	100%