LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3Q8IBK4_LEIDO
TriTrypDb:
LdBPK_231260.1 , LdCL_230019700 , LDHU3_23.1660
Length:
692

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IBK4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBK4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 379 383 PF00656 0.617
CLV_NRD_NRD_1 10 12 PF00675 0.747
CLV_NRD_NRD_1 128 130 PF00675 0.773
CLV_NRD_NRD_1 462 464 PF00675 0.726
CLV_NRD_NRD_1 634 636 PF00675 0.603
CLV_PCSK_KEX2_1 10 12 PF00082 0.747
CLV_PCSK_KEX2_1 127 129 PF00082 0.777
CLV_PCSK_KEX2_1 462 464 PF00082 0.655
CLV_PCSK_KEX2_1 483 485 PF00082 0.714
CLV_PCSK_KEX2_1 634 636 PF00082 0.603
CLV_PCSK_PC1ET2_1 483 485 PF00082 0.758
CLV_PCSK_SKI1_1 180 184 PF00082 0.647
CLV_PCSK_SKI1_1 436 440 PF00082 0.754
CLV_PCSK_SKI1_1 466 470 PF00082 0.628
CLV_PCSK_SKI1_1 519 523 PF00082 0.643
CLV_PCSK_SKI1_1 635 639 PF00082 0.679
DEG_APCC_DBOX_1 633 641 PF00400 0.606
DEG_Nend_UBRbox_3 1 3 PF02207 0.702
DEG_SPOP_SBC_1 418 422 PF00917 0.732
DEG_SPOP_SBC_1 48 52 PF00917 0.730
DEG_SPOP_SBC_1 654 658 PF00917 0.733
DOC_CKS1_1 205 210 PF01111 0.742
DOC_CKS1_1 660 665 PF01111 0.711
DOC_CYCLIN_RxL_1 516 524 PF00134 0.637
DOC_CYCLIN_RxL_1 629 642 PF00134 0.664
DOC_MAPK_gen_1 10 16 PF00069 0.738
DOC_MAPK_gen_1 462 471 PF00069 0.658
DOC_MAPK_gen_1 634 640 PF00069 0.613
DOC_MAPK_MEF2A_6 462 471 PF00069 0.658
DOC_PP2B_LxvP_1 199 202 PF13499 0.694
DOC_PP2B_LxvP_1 469 472 PF13499 0.677
DOC_PP4_FxxP_1 211 214 PF00568 0.720
DOC_USP7_MATH_1 114 118 PF00917 0.771
DOC_USP7_MATH_1 140 144 PF00917 0.720
DOC_USP7_MATH_1 315 319 PF00917 0.781
DOC_USP7_MATH_1 322 326 PF00917 0.681
DOC_USP7_MATH_1 362 366 PF00917 0.744
DOC_USP7_MATH_1 418 422 PF00917 0.732
DOC_USP7_MATH_1 443 447 PF00917 0.726
DOC_USP7_MATH_1 567 571 PF00917 0.756
DOC_USP7_MATH_1 572 576 PF00917 0.663
DOC_USP7_MATH_1 611 615 PF00917 0.706
DOC_USP7_MATH_1 653 657 PF00917 0.703
DOC_USP7_MATH_1 68 72 PF00917 0.739
DOC_USP7_MATH_1 77 81 PF00917 0.679
DOC_WW_Pin1_4 133 138 PF00397 0.757
DOC_WW_Pin1_4 204 209 PF00397 0.771
DOC_WW_Pin1_4 289 294 PF00397 0.763
DOC_WW_Pin1_4 385 390 PF00397 0.637
DOC_WW_Pin1_4 399 404 PF00397 0.630
DOC_WW_Pin1_4 425 430 PF00397 0.723
DOC_WW_Pin1_4 448 453 PF00397 0.707
DOC_WW_Pin1_4 544 549 PF00397 0.763
DOC_WW_Pin1_4 607 612 PF00397 0.700
DOC_WW_Pin1_4 645 650 PF00397 0.739
DOC_WW_Pin1_4 655 660 PF00397 0.678
DOC_WW_Pin1_4 66 71 PF00397 0.749
DOC_WW_Pin1_4 79 84 PF00397 0.603
DOC_WW_Pin1_4 93 98 PF00397 0.696
LIG_14-3-3_CanoR_1 115 119 PF00244 0.687
LIG_14-3-3_CanoR_1 163 169 PF00244 0.677
LIG_14-3-3_CanoR_1 210 214 PF00244 0.759
LIG_14-3-3_CanoR_1 218 226 PF00244 0.551
LIG_14-3-3_CanoR_1 46 55 PF00244 0.814
LIG_14-3-3_CanoR_1 634 638 PF00244 0.606
LIG_Actin_WH2_2 176 194 PF00022 0.583
LIG_Actin_WH2_2 618 636 PF00022 0.580
LIG_BIR_III_4 373 377 PF00653 0.705
LIG_CaM_IQ_9 227 243 PF13499 0.528
LIG_FHA_1 225 231 PF00498 0.713
LIG_FHA_1 358 364 PF00498 0.747
LIG_FHA_1 379 385 PF00498 0.779
LIG_FHA_1 388 394 PF00498 0.654
LIG_FHA_1 50 56 PF00498 0.773
LIG_FHA_1 541 547 PF00498 0.696
LIG_FHA_1 575 581 PF00498 0.682
LIG_FHA_1 616 622 PF00498 0.650
LIG_FHA_1 655 661 PF00498 0.746
LIG_FHA_1 669 675 PF00498 0.586
LIG_FHA_2 377 383 PF00498 0.647
LIG_FHA_2 392 398 PF00498 0.571
LIG_FHA_2 410 416 PF00498 0.650
LIG_FHA_2 51 57 PF00498 0.779
LIG_FHA_2 634 640 PF00498 0.677
LIG_GBD_Chelix_1 183 191 PF00786 0.573
LIG_Integrin_RGD_1 277 279 PF01839 0.704
LIG_IRF3_LxIS_1 413 420 PF10401 0.734
LIG_LIR_Gen_1 412 419 PF02991 0.735
LIG_LIR_Gen_1 501 511 PF02991 0.730
LIG_LIR_Nem_3 412 417 PF02991 0.735
LIG_LIR_Nem_3 501 507 PF02991 0.740
LIG_LIR_Nem_3 516 521 PF02991 0.496
LIG_LIR_Nem_3 556 561 PF02991 0.721
LIG_Pex14_1 619 623 PF04695 0.634
LIG_PTAP_UEV_1 82 87 PF05743 0.608
LIG_SH2_NCK_1 584 588 PF00017 0.660
LIG_SH2_PTP2 13 16 PF00017 0.733
LIG_SH2_SRC 416 419 PF00017 0.735
LIG_SH2_STAP1 224 228 PF00017 0.712
LIG_SH2_STAP1 281 285 PF00017 0.627
LIG_SH2_STAT3 392 395 PF00017 0.728
LIG_SH2_STAT5 13 16 PF00017 0.733
LIG_SH2_STAT5 270 273 PF00017 0.630
LIG_SH2_STAT5 392 395 PF00017 0.789
LIG_SH2_STAT5 416 419 PF00017 0.735
LIG_SH2_STAT5 584 587 PF00017 0.661
LIG_SH2_STAT5 81 84 PF00017 0.611
LIG_SH3_2 83 88 PF14604 0.785
LIG_SH3_3 268 274 PF00018 0.629
LIG_SH3_3 287 293 PF00018 0.625
LIG_SH3_3 296 302 PF00018 0.654
LIG_SH3_3 31 37 PF00018 0.695
LIG_SH3_3 348 354 PF00018 0.776
LIG_SH3_3 435 441 PF00018 0.776
LIG_SH3_3 542 548 PF00018 0.632
LIG_SH3_3 67 73 PF00018 0.776
LIG_SH3_3 80 86 PF00018 0.672
LIG_SUMO_SIM_par_1 494 501 PF11976 0.758
LIG_SUMO_SIM_par_1 636 642 PF11976 0.684
LIG_SUMO_SIM_par_1 669 675 PF11976 0.638
LIG_TRAF2_1 394 397 PF00917 0.614
LIG_TRAF2_2 274 279 PF00917 0.696
LIG_WW_3 298 302 PF00397 0.693
MOD_CDK_SPxK_1 204 210 PF00069 0.773
MOD_CDK_SPxxK_3 448 455 PF00069 0.730
MOD_CK1_1 109 115 PF00069 0.732
MOD_CK1_1 136 142 PF00069 0.740
MOD_CK1_1 197 203 PF00069 0.752
MOD_CK1_1 212 218 PF00069 0.529
MOD_CK1_1 325 331 PF00069 0.620
MOD_CK1_1 344 350 PF00069 0.568
MOD_CK1_1 388 394 PF00069 0.750
MOD_CK1_1 50 56 PF00069 0.760
MOD_CK1_1 536 542 PF00069 0.674
MOD_CK1_1 547 553 PF00069 0.554
MOD_CK1_1 595 601 PF00069 0.656
MOD_CK1_1 642 648 PF00069 0.692
MOD_CK1_1 684 690 PF00069 0.634
MOD_CK1_1 69 75 PF00069 0.607
MOD_CK1_1 84 90 PF00069 0.606
MOD_CK2_1 150 156 PF00069 0.654
MOD_CK2_1 231 237 PF00069 0.769
MOD_CK2_1 281 287 PF00069 0.801
MOD_CK2_1 391 397 PF00069 0.635
MOD_CK2_1 409 415 PF00069 0.652
MOD_CK2_1 50 56 PF00069 0.802
MOD_CK2_1 567 573 PF00069 0.743
MOD_CK2_1 633 639 PF00069 0.664
MOD_CK2_1 644 650 PF00069 0.610
MOD_GlcNHglycan 108 111 PF01048 0.726
MOD_GlcNHglycan 142 145 PF01048 0.776
MOD_GlcNHglycan 152 155 PF01048 0.589
MOD_GlcNHglycan 192 195 PF01048 0.661
MOD_GlcNHglycan 196 199 PF01048 0.712
MOD_GlcNHglycan 211 214 PF01048 0.546
MOD_GlcNHglycan 254 257 PF01048 0.715
MOD_GlcNHglycan 282 286 PF01048 0.770
MOD_GlcNHglycan 317 320 PF01048 0.694
MOD_GlcNHglycan 346 349 PF01048 0.771
MOD_GlcNHglycan 535 538 PF01048 0.661
MOD_GlcNHglycan 555 558 PF01048 0.571
MOD_GlcNHglycan 573 577 PF01048 0.481
MOD_GlcNHglycan 83 86 PF01048 0.677
MOD_GSK3_1 102 109 PF00069 0.666
MOD_GSK3_1 131 138 PF00069 0.753
MOD_GSK3_1 190 197 PF00069 0.647
MOD_GSK3_1 200 207 PF00069 0.695
MOD_GSK3_1 260 267 PF00069 0.685
MOD_GSK3_1 322 329 PF00069 0.677
MOD_GSK3_1 37 44 PF00069 0.787
MOD_GSK3_1 387 394 PF00069 0.731
MOD_GSK3_1 419 426 PF00069 0.648
MOD_GSK3_1 444 451 PF00069 0.697
MOD_GSK3_1 47 54 PF00069 0.681
MOD_GSK3_1 533 540 PF00069 0.654
MOD_GSK3_1 595 602 PF00069 0.758
MOD_GSK3_1 607 614 PF00069 0.573
MOD_GSK3_1 639 646 PF00069 0.655
MOD_GSK3_1 655 662 PF00069 0.600
MOD_GSK3_1 668 675 PF00069 0.582
MOD_GSK3_1 77 84 PF00069 0.631
MOD_GSK3_1 93 100 PF00069 0.700
MOD_LATS_1 665 671 PF00433 0.667
MOD_N-GLC_1 231 236 PF02516 0.765
MOD_N-GLC_1 385 390 PF02516 0.724
MOD_NEK2_1 164 169 PF00069 0.693
MOD_NEK2_1 252 257 PF00069 0.635
MOD_NEK2_1 341 346 PF00069 0.583
MOD_NEK2_1 423 428 PF00069 0.664
MOD_NEK2_1 444 449 PF00069 0.742
MOD_NEK2_1 49 54 PF00069 0.794
MOD_NEK2_1 633 638 PF00069 0.660
MOD_NEK2_1 668 673 PF00069 0.744
MOD_PIKK_1 339 345 PF00454 0.743
MOD_PIKK_1 391 397 PF00454 0.729
MOD_PIKK_1 526 532 PF00454 0.614
MOD_PIKK_1 547 553 PF00454 0.597
MOD_PKA_1 326 332 PF00069 0.717
MOD_PKA_2 114 120 PF00069 0.764
MOD_PKA_2 131 137 PF00069 0.536
MOD_PKA_2 209 215 PF00069 0.756
MOD_PKA_2 633 639 PF00069 0.636
MOD_PKA_2 642 648 PF00069 0.651
MOD_Plk_1 265 271 PF00069 0.631
MOD_Plk_1 668 674 PF00069 0.678
MOD_Plk_4 212 218 PF00069 0.705
MOD_Plk_4 388 394 PF00069 0.693
MOD_Plk_4 409 415 PF00069 0.738
MOD_Plk_4 615 621 PF00069 0.595
MOD_ProDKin_1 133 139 PF00069 0.761
MOD_ProDKin_1 204 210 PF00069 0.773
MOD_ProDKin_1 289 295 PF00069 0.764
MOD_ProDKin_1 385 391 PF00069 0.637
MOD_ProDKin_1 399 405 PF00069 0.628
MOD_ProDKin_1 425 431 PF00069 0.723
MOD_ProDKin_1 448 454 PF00069 0.703
MOD_ProDKin_1 544 550 PF00069 0.762
MOD_ProDKin_1 607 613 PF00069 0.694
MOD_ProDKin_1 645 651 PF00069 0.741
MOD_ProDKin_1 655 661 PF00069 0.677
MOD_ProDKin_1 66 72 PF00069 0.749
MOD_ProDKin_1 79 85 PF00069 0.602
MOD_ProDKin_1 93 99 PF00069 0.694
MOD_SUMO_rev_2 284 293 PF00179 0.698
MOD_SUMO_rev_2 428 438 PF00179 0.776
TRG_DiLeu_BaEn_4 30 36 PF01217 0.744
TRG_ENDOCYTIC_2 13 16 PF00928 0.710
TRG_ENDOCYTIC_2 416 419 PF00928 0.735
TRG_ENDOCYTIC_2 558 561 PF00928 0.720
TRG_ER_diArg_1 126 129 PF00400 0.772
TRG_ER_diArg_1 168 171 PF00400 0.702
TRG_ER_diArg_1 274 277 PF00400 0.758
TRG_ER_diArg_1 462 465 PF00400 0.658
TRG_ER_diArg_1 633 635 PF00400 0.590
TRG_ER_diArg_1 9 11 PF00400 0.745
TRG_Pf-PMV_PEXEL_1 10 15 PF00026 0.741
TRG_Pf-PMV_PEXEL_1 166 170 PF00026 0.640
TRG_Pf-PMV_PEXEL_1 519 523 PF00026 0.643
TRG_Pf-PMV_PEXEL_1 635 639 PF00026 0.679

Homologs

Protein Taxonomy Sequence identity Coverage
A4HCX5 Leishmania braziliensis 62% 99%
A4I0F8 Leishmania infantum 99% 100%
E9AWC1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4QB51 Leishmania major 90% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS