Phosphate transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphate-repressible phosphate permease

Species:

Leishmania donovani

UniProt:

A0A3Q8IBK1_LEIDO

TriTrypDb:

LdBPK_200040.1 , LdCL_200005300 , LDHU3_20.0050

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	24
GO:0110165	cellular anatomical entity	1	24

Expansion

Sequence features

A0A3Q8IBK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBK1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	24
GO:0006811	monoatomic ion transport	4	24
GO:0006817	phosphate ion transport	7	24
GO:0006820	monoatomic anion transport	5	24
GO:0015698	inorganic anion transport	6	24
GO:0051179	localization	1	24
GO:0051234	establishment of localization	2	24
GO:0009987	cellular process	1	3
GO:0034220	monoatomic ion transmembrane transport	3	3
GO:0035435	phosphate ion transmembrane transport	6	3
GO:0055085	transmembrane transport	2	3
GO:0098656	monoatomic anion transmembrane transport	4	3
GO:0098660	inorganic ion transmembrane transport	4	3
GO:0098661	inorganic anion transmembrane transport	5	3

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	24
GO:0005315	inorganic phosphate transmembrane transporter activity	4	24
GO:0015291	secondary active transmembrane transporter activity	4	24
GO:0015293	symporter activity	5	24
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	24
GO:0022804	active transmembrane transporter activity	3	24
GO:0022857	transmembrane transporter activity	2	24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.191
CLV_NRD_NRD_1	247	249	PF00675	0.225
CLV_NRD_NRD_1	323	325	PF00675	0.321
CLV_PCSK_KEX2_1	246	248	PF00082	0.270
CLV_PCSK_KEX2_1	323	325	PF00082	0.178
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.332
CLV_PCSK_SKI1_1	187	191	PF00082	0.255
CLV_PCSK_SKI1_1	247	251	PF00082	0.199
CLV_PCSK_SKI1_1	39	43	PF00082	0.313
DEG_SPOP_SBC_1	110	114	PF00917	0.296
DEG_SPOP_SBC_1	312	316	PF00917	0.370
DEG_SPOP_SBC_1	417	421	PF00917	0.267
DEG_SPOP_SBC_1	482	486	PF00917	0.342
DOC_CKS1_1	456	461	PF01111	0.560
DOC_CYCLIN_yCln2_LP_2	190	196	PF00134	0.210
DOC_MAPK_MEF2A_6	187	196	PF00069	0.452
DOC_MAPK_MEF2A_6	507	514	PF00069	0.563
DOC_MAPK_NFAT4_5	187	195	PF00069	0.391
DOC_MAPK_NFAT4_5	507	515	PF00069	0.556
DOC_PP1_RVXF_1	213	219	PF00149	0.294
DOC_PP2B_LxvP_1	107	110	PF13499	0.477
DOC_PP2B_LxvP_1	190	193	PF13499	0.210
DOC_PP2B_LxvP_1	310	313	PF13499	0.370
DOC_PP4_FxxP_1	157	160	PF00568	0.326
DOC_USP7_MATH_1	110	114	PF00917	0.326
DOC_USP7_MATH_1	13	17	PF00917	0.343
DOC_USP7_MATH_1	303	307	PF00917	0.389
DOC_USP7_MATH_1	325	329	PF00917	0.435
DOC_USP7_MATH_1	346	350	PF00917	0.508
DOC_USP7_MATH_1	407	411	PF00917	0.330
DOC_USP7_MATH_1	482	486	PF00917	0.342
DOC_USP7_MATH_1	526	530	PF00917	0.361
DOC_USP7_UBL2_3	246	250	PF12436	0.378
DOC_WW_Pin1_4	156	161	PF00397	0.326
DOC_WW_Pin1_4	308	313	PF00397	0.514
DOC_WW_Pin1_4	332	337	PF00397	0.463
DOC_WW_Pin1_4	455	460	PF00397	0.485
LIG_14-3-3_CanoR_1	180	186	PF00244	0.435
LIG_14-3-3_CanoR_1	187	193	PF00244	0.472
LIG_14-3-3_CanoR_1	255	259	PF00244	0.375
LIG_Actin_WH2_2	167	182	PF00022	0.229
LIG_BRCT_BRCA1_1	237	241	PF00533	0.355
LIG_BRCT_BRCA1_1	28	32	PF00533	0.486
LIG_BRCT_BRCA1_1	459	463	PF00533	0.331
LIG_BRCT_BRCA1_1	528	532	PF00533	0.381
LIG_CaM_NSCaTE_8	426	433	PF13499	0.356
LIG_FHA_1	106	112	PF00498	0.447
LIG_FHA_1	161	167	PF00498	0.401
LIG_FHA_1	189	195	PF00498	0.518
LIG_FHA_1	197	203	PF00498	0.333
LIG_FHA_1	412	418	PF00498	0.310
LIG_FHA_1	423	429	PF00498	0.349
LIG_FHA_1	484	490	PF00498	0.353
LIG_FHA_1	519	525	PF00498	0.333
LIG_FHA_1	64	70	PF00498	0.270
LIG_FHA_2	370	376	PF00498	0.468
LIG_GBD_Chelix_1	194	202	PF00786	0.349
LIG_HCF-1_HBM_1	81	84	PF13415	0.286
LIG_LIR_Apic_2	155	160	PF02991	0.326
LIG_LIR_Apic_2	477	482	PF02991	0.342
LIG_LIR_Gen_1	105	111	PF02991	0.529
LIG_LIR_Gen_1	203	212	PF02991	0.326
LIG_LIR_Gen_1	81	91	PF02991	0.245
LIG_LIR_LC3C_4	468	473	PF02991	0.353
LIG_LIR_Nem_3	105	109	PF02991	0.529
LIG_LIR_Nem_3	141	146	PF02991	0.263
LIG_LIR_Nem_3	173	179	PF02991	0.199
LIG_LIR_Nem_3	203	209	PF02991	0.326
LIG_LIR_Nem_3	238	244	PF02991	0.332
LIG_LIR_Nem_3	375	381	PF02991	0.474
LIG_NRBOX	445	451	PF00104	0.486
LIG_Pex14_2	201	205	PF04695	0.327
LIG_SH2_CRK	378	382	PF00017	0.486
LIG_SH2_CRK	479	483	PF00017	0.383
LIG_SH2_CRK	88	92	PF00017	0.355
LIG_SH2_NCK_1	317	321	PF00017	0.378
LIG_SH2_STAT5	380	383	PF00017	0.326
LIG_SH3_3	281	287	PF00018	0.524
LIG_SH3_3	306	312	PF00018	0.459
LIG_SH3_3	453	459	PF00018	0.560
LIG_Sin3_3	469	476	PF02671	0.431
LIG_SUMO_SIM_anti_2	44	51	PF11976	0.428
LIG_SUMO_SIM_anti_2	452	458	PF11976	0.560
LIG_SUMO_SIM_par_1	191	197	PF11976	0.352
LIG_SUMO_SIM_par_1	349	356	PF11976	0.382
LIG_SUMO_SIM_par_1	39	44	PF11976	0.496
LIG_SUMO_SIM_par_1	45	51	PF11976	0.316
LIG_SUMO_SIM_par_1	520	525	PF11976	0.353
LIG_WRC_WIRS_1	14	19	PF05994	0.354
LIG_WRC_WIRS_1	439	444	PF05994	0.383
LIG_WRC_WIRS_1	472	477	PF05994	0.355
MOD_CDK_SPxK_1	455	461	PF00069	0.485
MOD_CK1_1	113	119	PF00069	0.289
MOD_CK1_1	16	22	PF00069	0.351
MOD_CK1_1	311	317	PF00069	0.479
MOD_CK1_1	319	325	PF00069	0.462
MOD_CK1_1	335	341	PF00069	0.472
MOD_CK1_1	396	402	PF00069	0.277
MOD_CK1_1	422	428	PF00069	0.369
MOD_CK1_1	474	480	PF00069	0.342
MOD_CK2_1	350	356	PF00069	0.518
MOD_CK2_1	360	366	PF00069	0.434
MOD_CK2_1	369	375	PF00069	0.413
MOD_CK2_1	48	54	PF00069	0.337
MOD_GlcNHglycan	305	308	PF01048	0.186
MOD_GlcNHglycan	318	321	PF01048	0.239
MOD_GlcNHglycan	347	351	PF01048	0.214
MOD_GlcNHglycan	362	365	PF01048	0.370
MOD_GlcNHglycan	463	466	PF01048	0.322
MOD_GlcNHglycan	467	470	PF01048	0.319
MOD_GlcNHglycan	476	479	PF01048	0.289
MOD_GlcNHglycan	528	531	PF01048	0.339
MOD_GlcNHglycan	69	72	PF01048	0.464
MOD_GSK3_1	105	112	PF00069	0.443
MOD_GSK3_1	152	159	PF00069	0.329
MOD_GSK3_1	308	315	PF00069	0.454
MOD_GSK3_1	346	353	PF00069	0.447
MOD_GSK3_1	407	414	PF00069	0.239
MOD_GSK3_1	418	425	PF00069	0.251
MOD_GSK3_1	457	464	PF00069	0.477
MOD_GSK3_1	483	490	PF00069	0.325
MOD_GSK3_1	518	525	PF00069	0.357
MOD_GSK3_1	63	70	PF00069	0.289
MOD_NEK2_1	32	37	PF00069	0.486
MOD_NEK2_1	369	374	PF00069	0.486
MOD_NEK2_1	41	46	PF00069	0.335
MOD_NEK2_1	471	476	PF00069	0.342
MOD_NEK2_1	48	53	PF00069	0.306
MOD_NEK2_1	522	527	PF00069	0.376
MOD_NEK2_2	407	412	PF00069	0.197
MOD_PIKK_1	41	47	PF00454	0.431
MOD_PKA_2	254	260	PF00069	0.567
MOD_Plk_1	346	352	PF00069	0.475
MOD_Plk_2-3	132	138	PF00069	0.183
MOD_Plk_4	102	108	PF00069	0.329
MOD_Plk_4	13	19	PF00069	0.354
MOD_Plk_4	152	158	PF00069	0.299
MOD_Plk_4	254	260	PF00069	0.551
MOD_Plk_4	335	341	PF00069	0.467
MOD_Plk_4	407	413	PF00069	0.192
MOD_Plk_4	422	428	PF00069	0.202
MOD_Plk_4	518	524	PF00069	0.241
MOD_ProDKin_1	156	162	PF00069	0.326
MOD_ProDKin_1	308	314	PF00069	0.514
MOD_ProDKin_1	332	338	PF00069	0.463
MOD_ProDKin_1	455	461	PF00069	0.485
TRG_DiLeu_BaLyEn_6	157	162	PF01217	0.316
TRG_DiLeu_BaLyEn_6	240	245	PF01217	0.311
TRG_DiLeu_BaLyEn_6	445	450	PF01217	0.456
TRG_ENDOCYTIC_2	378	381	PF00928	0.453
TRG_ENDOCYTIC_2	84	87	PF00928	0.327
TRG_ENDOCYTIC_2	88	91	PF00928	0.317
TRG_ER_diArg_1	247	249	PF00400	0.429
TRG_NLS_MonoExtC_3	245	250	PF00514	0.467
TRG_NLS_MonoExtN_4	243	250	PF00514	0.425
TRG_Pf-PMV_PEXEL_1	448	452	PF00026	0.242

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S5	Leptomonas seymouri	70%	100%
A0A1X0NXY5	Trypanosomatidae	58%	100%
A0A3Q8I8Y3	Leishmania donovani	62%	91%
A0A3R7K4N2	Trypanosoma rangeli	54%	100%
A0A3R7L5P3	Trypanosoma rangeli	27%	90%
A0A3S5H545	Leishmania donovani	48%	95%
A4H5Y5	Leishmania braziliensis	62%	91%
A4H6C2	Leishmania braziliensis	62%	91%
A4HBH2	Leishmania braziliensis	80%	100%
A4HH06	Leishmania braziliensis	47%	100%
A4HUP5	Leishmania infantum	62%	91%
A4HYJ6	Leishmania infantum	100%	100%
C9ZHT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
C9ZHU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9ACJ5	Leishmania major	46%	100%
E9AG39	Leishmania infantum	46%	100%
E9AJT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AN09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	91%
E9ANE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	91%
E9AUE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
P15710	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	30%	92%
P38361	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	94%
Q4QH82	Leishmania major	62%	91%
Q4QHL7	Leishmania major	62%	91%
V5DS90	Trypanosoma cruzi	57%	100%