Calpain-like cysteine peptidase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IBJ7_LEIDO

TriTrypDb:

LdBPK_221360.1 , LdCL_220020800 , LDHU3_22.1960

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IBJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBJ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	366	370	PF00656	0.392
CLV_NRD_NRD_1	222	224	PF00675	0.629
CLV_NRD_NRD_1	4	6	PF00675	0.609
CLV_PCSK_KEX2_1	383	385	PF00082	0.533
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.493
CLV_PCSK_SKI1_1	176	180	PF00082	0.785
CLV_PCSK_SKI1_1	224	228	PF00082	0.622
CLV_PCSK_SKI1_1	240	244	PF00082	0.480
CLV_PCSK_SKI1_1	348	352	PF00082	0.433
CLV_PCSK_SKI1_1	392	396	PF00082	0.467
CLV_PCSK_SKI1_1	6	10	PF00082	0.507
DEG_MDM2_SWIB_1	404	411	PF02201	0.483
DEG_Nend_Nbox_1	1	3	PF02207	0.441
DEG_SCF_FBW7_1	281	288	PF00400	0.486
DOC_CKS1_1	282	287	PF01111	0.488
DOC_CKS1_1	326	331	PF01111	0.528
DOC_CYCLIN_RxL_1	2	11	PF00134	0.485
DOC_MAPK_FxFP_2	343	346	PF00069	0.410
DOC_PP4_FxxP_1	343	346	PF00568	0.410
DOC_PP4_FxxP_1	376	379	PF00568	0.459
DOC_USP7_MATH_1	114	118	PF00917	0.837
DOC_USP7_MATH_1	159	163	PF00917	0.663
DOC_USP7_MATH_1	189	193	PF00917	0.707
DOC_USP7_MATH_1	206	210	PF00917	0.659
DOC_USP7_MATH_1	268	272	PF00917	0.696
DOC_USP7_MATH_1	319	323	PF00917	0.476
DOC_USP7_MATH_1	59	63	PF00917	0.635
DOC_USP7_MATH_1	77	81	PF00917	0.539
DOC_USP7_MATH_1	93	97	PF00917	0.685
DOC_USP7_UBL2_3	176	180	PF12436	0.694
DOC_USP7_UBL2_3	392	396	PF12436	0.479
DOC_WW_Pin1_4	110	115	PF00397	0.661
DOC_WW_Pin1_4	127	132	PF00397	0.623
DOC_WW_Pin1_4	195	200	PF00397	0.671
DOC_WW_Pin1_4	228	233	PF00397	0.597
DOC_WW_Pin1_4	270	275	PF00397	0.494
DOC_WW_Pin1_4	281	286	PF00397	0.522
DOC_WW_Pin1_4	325	330	PF00397	0.535
DOC_WW_Pin1_4	409	414	PF00397	0.547
LIG_14-3-3_CanoR_1	401	411	PF00244	0.444
LIG_CtBP_PxDLS_1	488	492	PF00389	0.525
LIG_DCNL_PONY_1	1	4	PF03556	0.443
LIG_FHA_1	306	312	PF00498	0.445
LIG_FHA_1	357	363	PF00498	0.416
LIG_FHA_1	405	411	PF00498	0.425
LIG_FHA_1	453	459	PF00498	0.544
LIG_FHA_1	491	497	PF00498	0.604
LIG_FHA_1	61	67	PF00498	0.612
LIG_FHA_2	203	209	PF00498	0.574
LIG_FHA_2	286	292	PF00498	0.555
LIG_FHA_2	46	52	PF00498	0.550
LIG_IRF3_LxIS_1	483	490	PF10401	0.516
LIG_LIR_Apic_2	340	346	PF02991	0.413
LIG_LIR_Apic_2	375	379	PF02991	0.458
LIG_LIR_Gen_1	301	309	PF02991	0.392
LIG_LIR_Gen_1	405	415	PF02991	0.491
LIG_LIR_Nem_3	301	305	PF02991	0.372
LIG_LIR_Nem_3	405	411	PF02991	0.448
LIG_Pex14_1	68	72	PF04695	0.639
LIG_Pex14_2	345	349	PF04695	0.594
LIG_Pex14_2	404	408	PF04695	0.394
LIG_SH2_CRK	279	283	PF00017	0.462
LIG_SH2_SRC	140	143	PF00017	0.671
LIG_SH2_STAP1	279	283	PF00017	0.462
LIG_SH2_STAT5	344	347	PF00017	0.514
LIG_SH2_STAT5	356	359	PF00017	0.384
LIG_SH2_STAT5	403	406	PF00017	0.462
LIG_SH2_STAT5	414	417	PF00017	0.469
LIG_SH3_3	104	110	PF00018	0.680
LIG_SH3_3	146	152	PF00018	0.672
LIG_SH3_3	193	199	PF00018	0.634
LIG_SH3_3	407	413	PF00018	0.520
LIG_SH3_3	446	452	PF00018	0.545
LIG_SH3_3	49	55	PF00018	0.590
LIG_SUMO_SIM_anti_2	445	451	PF11976	0.477
LIG_SUMO_SIM_par_1	307	313	PF11976	0.392
LIG_SUMO_SIM_par_1	487	493	PF11976	0.522
LIG_TRAF2_1	205	208	PF00917	0.575
LIG_TRAF2_1	73	76	PF00917	0.764
LIG_TRAF2_1	83	86	PF00917	0.717
LIG_UBA3_1	1	6	PF00899	0.462
MOD_CDK_SPK_2	270	275	PF00069	0.447
MOD_CDK_SPxK_1	325	331	PF00069	0.532
MOD_CK1_1	113	119	PF00069	0.827
MOD_CK1_1	162	168	PF00069	0.751
MOD_CK1_1	198	204	PF00069	0.799
MOD_CK1_1	217	223	PF00069	0.545
MOD_CK1_1	228	234	PF00069	0.451
MOD_CK1_1	292	298	PF00069	0.597
MOD_CK1_1	339	345	PF00069	0.631
MOD_CK1_1	368	374	PF00069	0.444
MOD_CK1_1	423	429	PF00069	0.534
MOD_CK1_1	454	460	PF00069	0.722
MOD_CK1_1	490	496	PF00069	0.539
MOD_CK2_1	202	208	PF00069	0.606
MOD_CK2_1	261	267	PF00069	0.540
MOD_CK2_1	285	291	PF00069	0.546
MOD_CK2_1	84	90	PF00069	0.844
MOD_CK2_1	93	99	PF00069	0.706
MOD_GlcNHglycan	116	119	PF01048	0.749
MOD_GlcNHglycan	144	147	PF01048	0.690
MOD_GlcNHglycan	191	194	PF01048	0.759
MOD_GlcNHglycan	207	211	PF01048	0.625
MOD_GlcNHglycan	216	219	PF01048	0.625
MOD_GlcNHglycan	227	230	PF01048	0.478
MOD_GlcNHglycan	291	294	PF01048	0.595
MOD_GlcNHglycan	319	322	PF01048	0.500
MOD_GlcNHglycan	426	429	PF01048	0.562
MOD_GSK3_1	110	117	PF00069	0.659
MOD_GSK3_1	165	172	PF00069	0.706
MOD_GSK3_1	198	205	PF00069	0.702
MOD_GSK3_1	246	253	PF00069	0.430
MOD_GSK3_1	281	288	PF00069	0.509
MOD_GSK3_1	313	320	PF00069	0.458
MOD_GSK3_1	332	339	PF00069	0.533
MOD_GSK3_1	344	351	PF00069	0.520
MOD_GSK3_1	420	427	PF00069	0.606
MOD_GSK3_1	60	67	PF00069	0.735
MOD_N-GLC_1	125	130	PF02516	0.620
MOD_N-GLC_1	189	194	PF02516	0.587
MOD_N-GLC_1	471	476	PF02516	0.505
MOD_N-GLC_2	473	475	PF02516	0.557
MOD_NEK2_1	300	305	PF00069	0.375
MOD_NEK2_1	317	322	PF00069	0.440
MOD_NEK2_1	45	50	PF00069	0.462
MOD_NEK2_1	84	89	PF00069	0.597
MOD_PIKK_1	420	426	PF00454	0.694
MOD_Plk_1	300	306	PF00069	0.376
MOD_Plk_1	368	374	PF00069	0.444
MOD_Plk_1	84	90	PF00069	0.588
MOD_Plk_4	14	20	PF00069	0.544
MOD_Plk_4	183	189	PF00069	0.677
MOD_Plk_4	261	267	PF00069	0.557
MOD_Plk_4	310	316	PF00069	0.482
MOD_Plk_4	339	345	PF00069	0.596
MOD_Plk_4	64	70	PF00069	0.577
MOD_ProDKin_1	110	116	PF00069	0.663
MOD_ProDKin_1	127	133	PF00069	0.622
MOD_ProDKin_1	195	201	PF00069	0.672
MOD_ProDKin_1	228	234	PF00069	0.594
MOD_ProDKin_1	270	276	PF00069	0.486
MOD_ProDKin_1	281	287	PF00069	0.529
MOD_ProDKin_1	325	331	PF00069	0.532
MOD_ProDKin_1	409	415	PF00069	0.552
MOD_SUMO_for_1	150	153	PF00179	0.580
MOD_SUMO_rev_2	103	113	PF00179	0.591
MOD_SUMO_rev_2	375	385	PF00179	0.482
TRG_ENDOCYTIC_2	279	282	PF00928	0.474
TRG_ENDOCYTIC_2	29	32	PF00928	0.663
TRG_ENDOCYTIC_2	323	326	PF00928	0.528
TRG_ENDOCYTIC_2	461	464	PF00928	0.551
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC61	Leptomonas seymouri	41%	91%
A4I010	Leishmania infantum	100%	100%
E9AVY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QBJ6	Leishmania major	92%	100%