Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBI6_LEIDO

TriTrypDb:

LdBPK_230970.1 , LdCL_230016300 , LDHU3_23.1320

Length:

460

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8IBI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.709
CLV_NRD_NRD_1	103	105	PF00675	0.499
CLV_NRD_NRD_1	108	110	PF00675	0.504
CLV_NRD_NRD_1	121	123	PF00675	0.425
CLV_NRD_NRD_1	24	26	PF00675	0.578
CLV_NRD_NRD_1	331	333	PF00675	0.395
CLV_NRD_NRD_1	69	71	PF00675	0.579
CLV_PCSK_FUR_1	106	110	PF00082	0.472
CLV_PCSK_KEX2_1	105	107	PF00082	0.511
CLV_PCSK_KEX2_1	108	110	PF00082	0.508
CLV_PCSK_KEX2_1	121	123	PF00082	0.430
CLV_PCSK_KEX2_1	24	26	PF00082	0.578
CLV_PCSK_KEX2_1	309	311	PF00082	0.462
CLV_PCSK_KEX2_1	331	333	PF00082	0.395
CLV_PCSK_KEX2_1	410	412	PF00082	0.576
CLV_PCSK_KEX2_1	69	71	PF00082	0.579
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.474
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.462
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.576
CLV_PCSK_PC7_1	104	110	PF00082	0.471
CLV_PCSK_SKI1_1	132	136	PF00082	0.480
CLV_PCSK_SKI1_1	422	426	PF00082	0.567
DEG_Nend_UBRbox_1	1	4	PF02207	0.379
DEG_SCF_FBW7_1	113	119	PF00400	0.699
DEG_SCF_FBW7_1	148	155	PF00400	0.670
DEG_SPOP_SBC_1	203	207	PF00917	0.711
DOC_CKS1_1	113	118	PF01111	0.700
DOC_MAPK_gen_1	11	20	PF00069	0.354
DOC_MAPK_gen_1	112	120	PF00069	0.665
DOC_MAPK_gen_1	132	141	PF00069	0.629
DOC_MAPK_gen_1	69	76	PF00069	0.366
DOC_MAPK_MEF2A_6	112	120	PF00069	0.698
DOC_MAPK_MEF2A_6	69	76	PF00069	0.366
DOC_MAPK_NFAT4_5	69	77	PF00069	0.365
DOC_PP2B_LxvP_1	341	344	PF13499	0.321
DOC_PP4_FxxP_1	425	428	PF00568	0.394
DOC_USP7_MATH_1	152	156	PF00917	0.706
DOC_USP7_MATH_1	175	179	PF00917	0.699
DOC_USP7_MATH_1	195	199	PF00917	0.704
DOC_USP7_MATH_1	203	207	PF00917	0.677
DOC_USP7_MATH_1	208	212	PF00917	0.662
DOC_USP7_MATH_1	236	240	PF00917	0.663
DOC_USP7_MATH_1	259	263	PF00917	0.709
DOC_USP7_MATH_1	54	58	PF00917	0.410
DOC_USP7_UBL2_3	286	290	PF12436	0.667
DOC_WW_Pin1_4	112	117	PF00397	0.698
DOC_WW_Pin1_4	134	139	PF00397	0.679
DOC_WW_Pin1_4	148	153	PF00397	0.639
DOC_WW_Pin1_4	204	209	PF00397	0.713
DOC_WW_Pin1_4	377	382	PF00397	0.423
LIG_14-3-3_CanoR_1	121	128	PF00244	0.651
LIG_14-3-3_CanoR_1	140	148	PF00244	0.647
LIG_14-3-3_CanoR_1	174	184	PF00244	0.698
LIG_14-3-3_CanoR_1	235	245	PF00244	0.666
LIG_14-3-3_CanoR_1	24	29	PF00244	0.381
LIG_14-3-3_CanoR_1	336	344	PF00244	0.486
LIG_14-3-3_CanoR_1	402	409	PF00244	0.391
LIG_14-3-3_CanoR_1	419	428	PF00244	0.317
LIG_BRCT_BRCA1_1	404	408	PF00533	0.353
LIG_BRCT_BRCA1_1	78	82	PF00533	0.218
LIG_BRCT_BRCA1_2	404	410	PF00533	0.352
LIG_Clathr_ClatBox_1	435	439	PF01394	0.398
LIG_FHA_1	113	119	PF00498	0.699
LIG_FHA_1	336	342	PF00498	0.486
LIG_FHA_1	391	397	PF00498	0.423
LIG_FHA_1	428	434	PF00498	0.382
LIG_FHA_2	189	195	PF00498	0.716
LIG_FHA_2	63	69	PF00498	0.389
LIG_LIR_Apic_2	423	428	PF02991	0.392
LIG_LIR_Gen_1	338	348	PF02991	0.321
LIG_LIR_Gen_1	79	89	PF02991	0.225
LIG_LIR_Nem_3	338	343	PF02991	0.321
LIG_LIR_Nem_3	79	85	PF02991	0.225
LIG_NRBOX	366	372	PF00104	0.372
LIG_Pex14_1	409	413	PF04695	0.378
LIG_SH2_STAP1	337	341	PF00017	0.321
LIG_SH2_STAP1	386	390	PF00017	0.416
LIG_SH2_STAP1	413	417	PF00017	0.506
LIG_SH2_STAT5	334	337	PF00017	0.582
LIG_SH2_STAT5	8	11	PF00017	0.345
LIG_SxIP_EBH_1	140	151	PF03271	0.700
LIG_UBA3_1	435	443	PF00899	0.378
MOD_CDK_SPK_2	377	382	PF00069	0.423
MOD_CDK_SPxK_1	134	140	PF00069	0.681
MOD_CDK_SPxxK_3	377	384	PF00069	0.426
MOD_CK1_1	159	165	PF00069	0.690
MOD_CK1_1	177	183	PF00069	0.620
MOD_CK1_1	207	213	PF00069	0.685
MOD_CK1_1	230	236	PF00069	0.655
MOD_CK1_1	260	266	PF00069	0.708
MOD_CK1_1	380	386	PF00069	0.441
MOD_CK1_1	442	448	PF00069	0.351
MOD_CK2_1	240	246	PF00069	0.673
MOD_CK2_1	298	304	PF00069	0.660
MOD_CK2_1	420	426	PF00069	0.392
MOD_CK2_1	442	448	PF00069	0.393
MOD_GlcNHglycan	124	127	PF01048	0.445
MOD_GlcNHglycan	154	157	PF01048	0.511
MOD_GlcNHglycan	179	182	PF01048	0.437
MOD_GlcNHglycan	210	213	PF01048	0.520
MOD_GlcNHglycan	238	241	PF01048	0.474
MOD_GlcNHglycan	242	245	PF01048	0.472
MOD_GlcNHglycan	254	257	PF01048	0.479
MOD_GlcNHglycan	269	272	PF01048	0.428
MOD_GlcNHglycan	32	35	PF01048	0.610
MOD_GlcNHglycan	422	425	PF01048	0.601
MOD_GlcNHglycan	48	51	PF01048	0.609
MOD_GSK3_1	112	119	PF00069	0.699
MOD_GSK3_1	148	155	PF00069	0.680
MOD_GSK3_1	162	169	PF00069	0.652
MOD_GSK3_1	182	189	PF00069	0.613
MOD_GSK3_1	203	210	PF00069	0.714
MOD_GSK3_1	236	243	PF00069	0.666
MOD_GSK3_1	335	342	PF00069	0.486
MOD_GSK3_1	376	383	PF00069	0.419
MOD_GSK3_1	442	449	PF00069	0.385
MOD_GSK3_1	83	90	PF00069	0.252
MOD_N-GLC_1	152	157	PF02516	0.507
MOD_NEK2_1	141	146	PF00069	0.700
MOD_NEK2_1	184	189	PF00069	0.704
MOD_NEK2_1	227	232	PF00069	0.659
MOD_NEK2_1	298	303	PF00069	0.797
MOD_NEK2_1	348	353	PF00069	0.321
MOD_NEK2_1	38	43	PF00069	0.413
MOD_NEK2_1	418	423	PF00069	0.385
MOD_NEK2_1	83	88	PF00069	0.256
MOD_NEK2_2	116	121	PF00069	0.697
MOD_PIKK_1	146	152	PF00454	0.699
MOD_PIKK_1	175	181	PF00454	0.697
MOD_PKA_1	121	127	PF00069	0.684
MOD_PKA_1	24	30	PF00069	0.384
MOD_PKA_2	121	127	PF00069	0.684
MOD_PKA_2	24	30	PF00069	0.384
MOD_PKA_2	250	256	PF00069	0.710
MOD_PKA_2	257	263	PF00069	0.692
MOD_PKA_2	298	304	PF00069	0.660
MOD_PKA_2	335	341	PF00069	0.486
MOD_PKA_2	418	424	PF00069	0.388
MOD_PKA_2	426	432	PF00069	0.351
MOD_PKB_1	112	120	PF00069	0.665
MOD_Plk_1	245	251	PF00069	0.684
MOD_Plk_2-3	300	306	PF00069	0.656
MOD_Plk_4	159	165	PF00069	0.692
MOD_Plk_4	350	356	PF00069	0.404
MOD_ProDKin_1	112	118	PF00069	0.699
MOD_ProDKin_1	134	140	PF00069	0.681
MOD_ProDKin_1	148	154	PF00069	0.641
MOD_ProDKin_1	204	210	PF00069	0.715
MOD_ProDKin_1	377	383	PF00069	0.421
MOD_SUMO_rev_2	283	287	PF00179	0.665
MOD_SUMO_rev_2	437	445	PF00179	0.373
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.405
TRG_ENDOCYTIC_2	337	340	PF00928	0.321
TRG_ER_diArg_1	104	107	PF00400	0.708
TRG_ER_diArg_1	108	110	PF00400	0.704
TRG_ER_diArg_1	120	122	PF00400	0.632
TRG_ER_diArg_1	23	25	PF00400	0.372
TRG_ER_diArg_1	330	332	PF00400	0.608
TRG_ER_diArg_1	401	404	PF00400	0.417
TRG_ER_diArg_1	69	71	PF00400	0.379
TRG_NES_CRM1_1	366	378	PF08389	0.378
TRG_NLS_MonoExtC_3	104	109	PF00514	0.671
TRG_NLS_MonoExtC_3	287	292	PF00514	0.659
TRG_NLS_MonoExtN_4	102	109	PF00514	0.669
TRG_NLS_MonoExtN_4	286	292	PF00514	0.660
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I0D1	Leishmania infantum	97%	100%