DUF1508 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IBI0_LEIDO

TriTrypDb:

LdBPK_200210.1 , LdCL_200006900 , LDHU3_20.0220

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IBI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBI0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.615
CLV_NRD_NRD_1	138	140	PF00675	0.586
CLV_NRD_NRD_1	168	170	PF00675	0.528
CLV_NRD_NRD_1	176	178	PF00675	0.453
CLV_NRD_NRD_1	2	4	PF00675	0.649
CLV_NRD_NRD_1	62	64	PF00675	0.659
CLV_PCSK_FUR_1	2	6	PF00082	0.540
CLV_PCSK_KEX2_1	138	140	PF00082	0.685
CLV_PCSK_KEX2_1	168	170	PF00082	0.518
CLV_PCSK_KEX2_1	175	177	PF00082	0.452
CLV_PCSK_KEX2_1	2	4	PF00082	0.669
CLV_PCSK_KEX2_1	61	63	PF00082	0.787
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.475
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.561
DEG_Nend_UBRbox_1	1	4	PF02207	0.596
DEG_SPOP_SBC_1	44	48	PF00917	0.684
DOC_PP2B_LxvP_1	38	41	PF13499	0.479
DOC_SPAK_OSR1_1	80	84	PF12202	0.385
DOC_USP7_MATH_1	17	21	PF00917	0.561
DOC_USP7_MATH_1	45	49	PF00917	0.667
DOC_USP7_MATH_1	57	61	PF00917	0.651
DOC_USP7_MATH_1	66	70	PF00917	0.685
DOC_WW_Pin1_4	52	57	PF00397	0.739
LIG_14-3-3_CanoR_1	130	137	PF00244	0.646
LIG_14-3-3_CanoR_1	3	9	PF00244	0.534
LIG_14-3-3_CanoR_1	39	45	PF00244	0.630
LIG_14-3-3_CanoR_1	61	66	PF00244	0.680
LIG_14-3-3_CterR_2	196	200	PF00244	0.653
LIG_BIR_III_4	76	80	PF00653	0.434
LIG_BRCT_BRCA1_1	151	155	PF00533	0.504
LIG_BRCT_BRCA1_1	45	49	PF00533	0.536
LIG_deltaCOP1_diTrp_1	166	170	PF00928	0.455
LIG_eIF4E_1	31	37	PF01652	0.386
LIG_FHA_1	33	39	PF00498	0.526
LIG_FHA_1	8	14	PF00498	0.535
LIG_FHA_1	86	92	PF00498	0.557
LIG_FHA_2	124	130	PF00498	0.724
LIG_LIR_Gen_1	149	157	PF02991	0.534
LIG_LIR_Nem_3	149	154	PF02991	0.505
LIG_LIR_Nem_3	166	170	PF02991	0.366
LIG_PCNA_PIPBox_1	24	33	PF02747	0.481
LIG_Pex14_2	147	151	PF04695	0.396
LIG_RPA_C_Fungi	164	176	PF08784	0.480
LIG_SH2_STAP1	144	148	PF00017	0.496
LIG_SH2_STAP1	25	29	PF00017	0.387
LIG_SH2_STAT5	8	11	PF00017	0.561
LIG_WRC_WIRS_1	67	72	PF05994	0.561
MOD_CK1_1	149	155	PF00069	0.508
MOD_CK1_1	171	177	PF00069	0.582
MOD_CK1_1	48	54	PF00069	0.696
MOD_CK1_1	7	13	PF00069	0.568
MOD_CK2_1	123	129	PF00069	0.724
MOD_CK2_1	52	58	PF00069	0.708
MOD_GlcNHglycan	131	134	PF01048	0.726
MOD_GlcNHglycan	170	173	PF01048	0.590
MOD_GlcNHglycan	189	192	PF01048	0.345
MOD_GlcNHglycan	51	54	PF01048	0.630
MOD_GlcNHglycan	85	88	PF01048	0.550
MOD_GSK3_1	13	20	PF00069	0.521
MOD_GSK3_1	142	149	PF00069	0.563
MOD_GSK3_1	183	190	PF00069	0.492
MOD_GSK3_1	3	10	PF00069	0.643
MOD_GSK3_1	39	46	PF00069	0.636
MOD_GSK3_1	48	55	PF00069	0.645
MOD_GSK3_1	57	64	PF00069	0.532
MOD_N-GLC_1	13	18	PF02516	0.483
MOD_NEK2_1	146	151	PF00069	0.396
MOD_NEK2_1	183	188	PF00069	0.344
MOD_NEK2_1	49	54	PF00069	0.683
MOD_PKA_1	168	174	PF00069	0.532
MOD_PKA_1	3	9	PF00069	0.613
MOD_PKA_1	61	67	PF00069	0.661
MOD_PKA_2	129	135	PF00069	0.683
MOD_PKA_2	168	174	PF00069	0.581
MOD_PKA_2	4	10	PF00069	0.516
MOD_PKA_2	61	67	PF00069	0.697
MOD_Plk_4	142	148	PF00069	0.434
MOD_Plk_4	183	189	PF00069	0.346
MOD_Plk_4	32	38	PF00069	0.508
MOD_Plk_4	4	10	PF00069	0.599
MOD_Plk_4	45	51	PF00069	0.636
MOD_ProDKin_1	52	58	PF00069	0.739
MOD_SUMO_rev_2	20	30	PF00179	0.554
TRG_DiLeu_BaEn_1	179	184	PF01217	0.510
TRG_ENDOCYTIC_2	144	147	PF00928	0.426
TRG_ER_diArg_1	1	3	PF00400	0.746
TRG_ER_diArg_1	137	139	PF00400	0.666
TRG_ER_diArg_1	167	169	PF00400	0.526
TRG_ER_diArg_1	61	63	PF00400	0.679
TRG_ER_diArg_1	78	81	PF00400	0.469
TRG_NLS_MonoExtN_4	2	7	PF00514	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWU9	Leptomonas seymouri	33%	100%
A0A1X0NWM2	Trypanosomatidae	26%	100%
A0A422NEH1	Trypanosoma rangeli	28%	100%
A4HYL0	Leishmania infantum	96%	99%
E9AI73	Leishmania braziliensis	65%	66%
E9AUF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4QD25	Leishmania major	92%	100%