Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IBH8_LEIDO

TriTrypDb:

LdBPK_291520.1 , LdCL_290020700 , LDHU3_29.2210

Length:

899

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IBH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBH8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	618	622	PF00656	0.724
CLV_C14_Caspase3-7	676	680	PF00656	0.603
CLV_C14_Caspase3-7	704	708	PF00656	0.776
CLV_C14_Caspase3-7	71	75	PF00656	0.690
CLV_C14_Caspase3-7	859	863	PF00656	0.688
CLV_NRD_NRD_1	101	103	PF00675	0.671
CLV_NRD_NRD_1	144	146	PF00675	0.843
CLV_NRD_NRD_1	179	181	PF00675	0.675
CLV_NRD_NRD_1	290	292	PF00675	0.854
CLV_NRD_NRD_1	298	300	PF00675	0.702
CLV_NRD_NRD_1	517	519	PF00675	0.747
CLV_PCSK_FUR_1	570	574	PF00082	0.652
CLV_PCSK_KEX2_1	101	103	PF00082	0.671
CLV_PCSK_KEX2_1	144	146	PF00082	0.843
CLV_PCSK_KEX2_1	179	181	PF00082	0.757
CLV_PCSK_KEX2_1	290	292	PF00082	0.854
CLV_PCSK_KEX2_1	572	574	PF00082	0.740
CLV_PCSK_KEX2_1	885	887	PF00082	0.723
CLV_PCSK_KEX2_1	894	896	PF00082	0.585
CLV_PCSK_PC1ET2_1	572	574	PF00082	0.740
CLV_PCSK_PC1ET2_1	885	887	PF00082	0.723
CLV_PCSK_PC1ET2_1	894	896	PF00082	0.585
CLV_PCSK_PC7_1	140	146	PF00082	0.766
CLV_PCSK_PC7_1	890	896	PF00082	0.700
CLV_PCSK_SKI1_1	111	115	PF00082	0.730
CLV_PCSK_SKI1_1	646	650	PF00082	0.658
CLV_PCSK_SKI1_1	828	832	PF00082	0.692
CLV_PCSK_SKI1_1	845	849	PF00082	0.515
CLV_PCSK_SKI1_1	894	898	PF00082	0.770
DEG_APCC_DBOX_1	110	118	PF00400	0.729
DEG_APCC_DBOX_1	412	420	PF00400	0.716
DEG_APCC_DBOX_1	645	653	PF00400	0.653
DEG_APCC_DBOX_1	819	827	PF00400	0.716
DEG_Kelch_actinfilin_1	752	756	PF01344	0.716
DEG_SCF_FBW7_1	338	345	PF00400	0.779
DEG_SCF_FBW7_1	93	99	PF00400	0.645
DEG_SCF_FBW7_2	397	403	PF00400	0.638
DEG_SCF_FBW7_2	794	801	PF00400	0.727
DEG_SPOP_SBC_1	161	165	PF00917	0.762
DEG_SPOP_SBC_1	388	392	PF00917	0.762
DEG_SPOP_SBC_1	47	51	PF00917	0.606
DEG_SPOP_SBC_1	625	629	PF00917	0.749
DEG_SPOP_SBC_1	756	760	PF00917	0.720
DOC_CDC14_PxL_1	470	478	PF14671	0.791
DOC_CKS1_1	157	162	PF01111	0.833
DOC_CKS1_1	255	260	PF01111	0.852
DOC_CKS1_1	397	402	PF01111	0.770
DOC_CKS1_1	580	585	PF01111	0.780
DOC_CKS1_1	93	98	PF01111	0.646
DOC_CYCLIN_RxL_1	642	650	PF00134	0.657
DOC_MAPK_gen_1	642	649	PF00069	0.621
DOC_MAPK_gen_1	70	79	PF00069	0.694
DOC_PP1_SILK_1	551	556	PF00149	0.672
DOC_PP2B_LxvP_1	191	194	PF13499	0.817
DOC_PP2B_LxvP_1	271	274	PF13499	0.617
DOC_PP2B_LxvP_1	42	45	PF13499	0.709
DOC_PP4_FxxP_1	157	160	PF00568	0.831
DOC_PP4_FxxP_1	811	814	PF00568	0.581
DOC_SPAK_OSR1_1	890	894	PF12202	0.700
DOC_USP7_MATH_1	195	199	PF00917	0.848
DOC_USP7_MATH_1	210	214	PF00917	0.801
DOC_USP7_MATH_1	3	7	PF00917	0.766
DOC_USP7_MATH_1	47	51	PF00917	0.633
DOC_USP7_MATH_1	527	531	PF00917	0.817
DOC_USP7_MATH_1	53	57	PF00917	0.604
DOC_USP7_MATH_1	556	560	PF00917	0.748
DOC_USP7_MATH_1	571	575	PF00917	0.624
DOC_USP7_MATH_1	636	640	PF00917	0.768
DOC_USP7_MATH_1	863	867	PF00917	0.685
DOC_WW_Pin1_4	156	161	PF00397	0.831
DOC_WW_Pin1_4	16	21	PF00397	0.833
DOC_WW_Pin1_4	254	259	PF00397	0.852
DOC_WW_Pin1_4	326	331	PF00397	0.777
DOC_WW_Pin1_4	338	343	PF00397	0.664
DOC_WW_Pin1_4	346	351	PF00397	0.558
DOC_WW_Pin1_4	352	357	PF00397	0.603
DOC_WW_Pin1_4	377	382	PF00397	0.821
DOC_WW_Pin1_4	393	398	PF00397	0.840
DOC_WW_Pin1_4	442	447	PF00397	0.619
DOC_WW_Pin1_4	579	584	PF00397	0.862
DOC_WW_Pin1_4	647	652	PF00397	0.731
DOC_WW_Pin1_4	734	739	PF00397	0.698
DOC_WW_Pin1_4	794	799	PF00397	0.768
DOC_WW_Pin1_4	92	97	PF00397	0.649
LIG_14-3-3_CanoR_1	101	107	PF00244	0.762
LIG_14-3-3_CanoR_1	179	188	PF00244	0.708
LIG_14-3-3_CanoR_1	204	208	PF00244	0.660
LIG_14-3-3_CanoR_1	290	295	PF00244	0.660
LIG_14-3-3_CanoR_1	413	417	PF00244	0.664
LIG_14-3-3_CanoR_1	437	442	PF00244	0.643
LIG_14-3-3_CanoR_1	518	524	PF00244	0.733
LIG_14-3-3_CanoR_1	52	58	PF00244	0.642
LIG_14-3-3_CanoR_1	555	561	PF00244	0.788
LIG_14-3-3_CanoR_1	573	583	PF00244	0.564
LIG_14-3-3_CanoR_1	685	693	PF00244	0.685
LIG_14-3-3_CanoR_1	766	773	PF00244	0.615
LIG_14-3-3_CanoR_1	804	814	PF00244	0.661
LIG_14-3-3_CanoR_1	835	840	PF00244	0.645
LIG_Actin_WH2_2	503	520	PF00022	0.771
LIG_AP2alpha_1	119	123	PF02296	0.760
LIG_APCC_ABBA_1	116	121	PF00400	0.761
LIG_BIR_III_2	707	711	PF00653	0.773
LIG_BRCT_BRCA1_1	807	811	PF00533	0.595
LIG_CtBP_PxDLS_1	223	227	PF00389	0.769
LIG_EH_1	424	428	PF12763	0.689
LIG_EH1_1	890	898	PF00400	0.696
LIG_FHA_1	137	143	PF00498	0.667
LIG_FHA_1	204	210	PF00498	0.829
LIG_FHA_1	266	272	PF00498	0.630
LIG_FHA_1	29	35	PF00498	0.757
LIG_FHA_1	594	600	PF00498	0.704
LIG_FHA_1	602	608	PF00498	0.674
LIG_FHA_1	609	615	PF00498	0.591
LIG_FHA_1	682	688	PF00498	0.764
LIG_FHA_1	727	733	PF00498	0.631
LIG_FHA_1	757	763	PF00498	0.655
LIG_FHA_1	80	86	PF00498	0.721
LIG_FHA_1	834	840	PF00498	0.819
LIG_FHA_2	389	395	PF00498	0.723
LIG_FHA_2	684	690	PF00498	0.817
LIG_FHA_2	746	752	PF00498	0.593
LIG_FHA_2	795	801	PF00498	0.766
LIG_FHA_2	870	876	PF00498	0.803
LIG_LIR_Apic_2	155	160	PF02991	0.821
LIG_LIR_Apic_2	808	814	PF02991	0.585
LIG_LIR_Gen_1	469	477	PF02991	0.794
LIG_LIR_Gen_1	484	493	PF02991	0.716
LIG_LIR_Nem_3	469	473	PF02991	0.802
LIG_LIR_Nem_3	484	488	PF02991	0.715
LIG_NRBOX	13	19	PF00104	0.756
LIG_NRBOX	512	518	PF00104	0.684
LIG_PCNA_yPIPBox_3	52	61	PF02747	0.608
LIG_PDZ_Class_2	894	899	PF00595	0.771
LIG_Pex14_2	119	123	PF04695	0.760
LIG_SH2_STAP1	105	109	PF00017	0.786
LIG_SH2_STAT3	829	832	PF00017	0.732
LIG_SH3_1	135	141	PF00018	0.674
LIG_SH3_3	135	141	PF00018	0.696
LIG_SH3_3	17	23	PF00018	0.746
LIG_SH3_3	217	223	PF00018	0.771
LIG_SH3_3	255	261	PF00018	0.838
LIG_SH3_3	353	359	PF00018	0.618
LIG_SH3_3	394	400	PF00018	0.768
LIG_SH3_3	41	47	PF00018	0.823
LIG_SH3_3	468	474	PF00018	0.722
LIG_SH3_3	499	505	PF00018	0.760
LIG_SH3_3	580	586	PF00018	0.856
LIG_SH3_3	703	709	PF00018	0.772
LIG_SH3_3	721	727	PF00018	0.621
LIG_SH3_3	873	879	PF00018	0.773
LIG_SH3_3	881	887	PF00018	0.700
LIG_SH3_4	848	855	PF00018	0.602
LIG_SUMO_SIM_par_1	368	375	PF11976	0.696
LIG_SUMO_SIM_par_1	751	761	PF11976	0.729
LIG_SUMO_SIM_par_1	836	843	PF11976	0.743
LIG_TRAF2_1	229	232	PF00917	0.824
LIG_WRC_WIRS_1	154	159	PF05994	0.739
MOD_CDK_SPxK_1	352	358	PF00069	0.758
MOD_CK1_1	103	109	PF00069	0.633
MOD_CK1_1	156	162	PF00069	0.758
MOD_CK1_1	166	172	PF00069	0.602
MOD_CK1_1	183	189	PF00069	0.826
MOD_CK1_1	198	204	PF00069	0.862
MOD_CK1_1	225	231	PF00069	0.788
MOD_CK1_1	243	249	PF00069	0.559
MOD_CK1_1	361	367	PF00069	0.820
MOD_CK1_1	368	374	PF00069	0.664
MOD_CK1_1	393	399	PF00069	0.824
MOD_CK1_1	415	421	PF00069	0.639
MOD_CK1_1	432	438	PF00069	0.702
MOD_CK1_1	444	450	PF00069	0.607
MOD_CK1_1	484	490	PF00069	0.714
MOD_CK1_1	55	61	PF00069	0.691
MOD_CK1_1	574	580	PF00069	0.786
MOD_CK1_1	6	12	PF00069	0.702
MOD_CK1_1	610	616	PF00069	0.744
MOD_CK1_1	624	630	PF00069	0.586
MOD_CK1_1	731	737	PF00069	0.697
MOD_CK1_1	761	767	PF00069	0.807
MOD_CK1_1	94	100	PF00069	0.740
MOD_CK2_1	166	172	PF00069	0.841
MOD_CK2_1	186	192	PF00069	0.752
MOD_CK2_1	225	231	PF00069	0.788
MOD_CK2_1	388	394	PF00069	0.724
MOD_CK2_1	683	689	PF00069	0.645
MOD_CK2_1	745	751	PF00069	0.602
MOD_CK2_1	85	91	PF00069	0.735
MOD_CK2_1	869	875	PF00069	0.803
MOD_Cter_Amidation	142	145	PF01082	0.847
MOD_GlcNHglycan	102	105	PF01048	0.752
MOD_GlcNHglycan	130	133	PF01048	0.726
MOD_GlcNHglycan	147	150	PF01048	0.535
MOD_GlcNHglycan	166	169	PF01048	0.526
MOD_GlcNHglycan	182	185	PF01048	0.815
MOD_GlcNHglycan	198	201	PF01048	0.700
MOD_GlcNHglycan	227	230	PF01048	0.749
MOD_GlcNHglycan	282	285	PF01048	0.632
MOD_GlcNHglycan	429	432	PF01048	0.640
MOD_GlcNHglycan	454	457	PF01048	0.764
MOD_GlcNHglycan	490	493	PF01048	0.779
MOD_GlcNHglycan	5	8	PF01048	0.635
MOD_GlcNHglycan	573	576	PF01048	0.852
MOD_GlcNHglycan	655	658	PF01048	0.763
MOD_GlcNHglycan	675	678	PF01048	0.489
MOD_GlcNHglycan	742	745	PF01048	0.741
MOD_GlcNHglycan	779	782	PF01048	0.775
MOD_GlcNHglycan	793	797	PF01048	0.571
MOD_GlcNHglycan	808	811	PF01048	0.616
MOD_GSK3_1	152	159	PF00069	0.673
MOD_GSK3_1	160	167	PF00069	0.703
MOD_GSK3_1	183	190	PF00069	0.758
MOD_GSK3_1	196	203	PF00069	0.652
MOD_GSK3_1	253	260	PF00069	0.835
MOD_GSK3_1	322	329	PF00069	0.785
MOD_GSK3_1	333	340	PF00069	0.593
MOD_GSK3_1	342	349	PF00069	0.551
MOD_GSK3_1	361	368	PF00069	0.631
MOD_GSK3_1	388	395	PF00069	0.752
MOD_GSK3_1	411	418	PF00069	0.679
MOD_GSK3_1	432	439	PF00069	0.662
MOD_GSK3_1	441	448	PF00069	0.680
MOD_GSK3_1	462	469	PF00069	0.737
MOD_GSK3_1	48	55	PF00069	0.682
MOD_GSK3_1	484	491	PF00069	0.792
MOD_GSK3_1	508	515	PF00069	0.657
MOD_GSK3_1	519	526	PF00069	0.629
MOD_GSK3_1	556	563	PF00069	0.789
MOD_GSK3_1	571	578	PF00069	0.597
MOD_GSK3_1	593	600	PF00069	0.770
MOD_GSK3_1	60	67	PF00069	0.655
MOD_GSK3_1	606	613	PF00069	0.674
MOD_GSK3_1	621	628	PF00069	0.595
MOD_GSK3_1	632	639	PF00069	0.648
MOD_GSK3_1	68	75	PF00069	0.506
MOD_GSK3_1	681	688	PF00069	0.763
MOD_GSK3_1	754	761	PF00069	0.768
MOD_GSK3_1	788	795	PF00069	0.635
MOD_GSK3_1	802	809	PF00069	0.584
MOD_GSK3_1	87	94	PF00069	0.640
MOD_GSK3_1	96	103	PF00069	0.677
MOD_N-GLC_1	107	112	PF02516	0.780
MOD_N-GLC_1	352	357	PF02516	0.757
MOD_N-GLC_1	590	595	PF02516	0.826
MOD_N-GLC_1	597	602	PF02516	0.722
MOD_N-GLC_1	607	612	PF02516	0.562
MOD_N-GLC_1	777	782	PF02516	0.648
MOD_N-GLC_1	863	868	PF02516	0.589
MOD_N-GLC_2	360	362	PF02516	0.708
MOD_NEK2_1	119	124	PF00069	0.600
MOD_NEK2_1	153	158	PF00069	0.645
MOD_NEK2_1	302	307	PF00069	0.711
MOD_NEK2_1	344	349	PF00069	0.835
MOD_NEK2_1	365	370	PF00069	0.656
MOD_NEK2_1	372	377	PF00069	0.656
MOD_NEK2_1	427	432	PF00069	0.761
MOD_NEK2_1	436	441	PF00069	0.690
MOD_NEK2_1	488	493	PF00069	0.742
MOD_NEK2_1	560	565	PF00069	0.798
MOD_NEK2_1	601	606	PF00069	0.794
MOD_NEK2_1	607	612	PF00069	0.738
MOD_NEK2_1	632	637	PF00069	0.806
MOD_NEK2_1	740	745	PF00069	0.749
MOD_NEK2_1	768	773	PF00069	0.652
MOD_NEK2_1	776	781	PF00069	0.581
MOD_NEK2_1	840	845	PF00069	0.747
MOD_NEK2_2	96	101	PF00069	0.640
MOD_OFUCOSY	765	772	PF10250	0.702
MOD_PIKK_1	243	249	PF00454	0.786
MOD_PIKK_1	519	525	PF00454	0.812
MOD_PIKK_1	726	732	PF00454	0.727
MOD_PIKK_1	788	794	PF00454	0.761
MOD_PIKK_1	79	85	PF00454	0.728
MOD_PK_1	429	435	PF00069	0.740
MOD_PKA_1	290	296	PF00069	0.764
MOD_PKA_2	100	106	PF00069	0.651
MOD_PKA_2	136	142	PF00069	0.787
MOD_PKA_2	143	149	PF00069	0.784
MOD_PKA_2	186	192	PF00069	0.771
MOD_PKA_2	196	202	PF00069	0.772
MOD_PKA_2	203	209	PF00069	0.646
MOD_PKA_2	243	249	PF00069	0.800
MOD_PKA_2	290	296	PF00069	0.764
MOD_PKA_2	302	308	PF00069	0.640
MOD_PKA_2	412	418	PF00069	0.637
MOD_PKA_2	436	442	PF00069	0.705
MOD_PKA_2	517	523	PF00069	0.650
MOD_PKA_2	556	562	PF00069	0.683
MOD_PKA_2	834	840	PF00069	0.630
MOD_PKA_2	889	895	PF00069	0.701
MOD_PKB_1	185	193	PF00069	0.650
MOD_Plk_1	210	216	PF00069	0.712
MOD_Plk_1	372	378	PF00069	0.814
MOD_Plk_1	527	533	PF00069	0.763
MOD_Plk_1	597	603	PF00069	0.700
MOD_Plk_1	678	684	PF00069	0.751
MOD_Plk_1	863	869	PF00069	0.588
MOD_Plk_4	119	125	PF00069	0.598
MOD_Plk_4	166	172	PF00069	0.765
MOD_Plk_4	365	371	PF00069	0.631
MOD_Plk_4	372	378	PF00069	0.634
MOD_Plk_4	429	435	PF00069	0.638
MOD_Plk_4	466	472	PF00069	0.679
MOD_Plk_4	512	518	PF00069	0.800
MOD_Plk_4	549	555	PF00069	0.640
MOD_Plk_4	601	607	PF00069	0.643
MOD_Plk_4	835	841	PF00069	0.818
MOD_ProDKin_1	156	162	PF00069	0.832
MOD_ProDKin_1	16	22	PF00069	0.826
MOD_ProDKin_1	254	260	PF00069	0.852
MOD_ProDKin_1	326	332	PF00069	0.777
MOD_ProDKin_1	338	344	PF00069	0.665
MOD_ProDKin_1	346	352	PF00069	0.558
MOD_ProDKin_1	377	383	PF00069	0.823
MOD_ProDKin_1	393	399	PF00069	0.843
MOD_ProDKin_1	442	448	PF00069	0.622
MOD_ProDKin_1	579	585	PF00069	0.860
MOD_ProDKin_1	647	653	PF00069	0.730
MOD_ProDKin_1	734	740	PF00069	0.700
MOD_ProDKin_1	794	800	PF00069	0.767
MOD_ProDKin_1	92	98	PF00069	0.647
MOD_SUMO_rev_2	62	71	PF00179	0.767
TRG_DiLeu_BaEn_1	10	15	PF01217	0.809
TRG_DiLeu_BaLyEn_6	536	541	PF01217	0.718
TRG_DiLeu_BaLyEn_6	892	897	PF01217	0.696
TRG_ER_diArg_1	134	137	PF00400	0.745
TRG_ER_diArg_1	144	147	PF00400	0.675
TRG_ER_diArg_1	178	180	PF00400	0.748
TRG_ER_diArg_1	185	188	PF00400	0.696
TRG_ER_diArg_1	311	314	PF00400	0.609
TRG_ER_diArg_1	554	557	PF00400	0.752
TRG_Pf-PMV_PEXEL_1	27	32	PF00026	0.761
TRG_Pf-PMV_PEXEL_1	417	422	PF00026	0.683
TRG_Pf-PMV_PEXEL_1	858	862	PF00026	0.715

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HHF2	Leishmania braziliensis	51%	100%
A4I4K1	Leishmania infantum	100%	100%
E9AE00	Leishmania major	88%	100%
E9ALT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%