Leucine Rich repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBH7_LEIDO

TriTrypDb:

LdBPK_120650.1 , LdCL_120012200 , LDHU3_12.0990

Length:

850

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	14
GO:0042995	cell projection	2	14
GO:0043226	organelle	2	14
GO:0043227	membrane-bounded organelle	3	14
GO:0110165	cellular anatomical entity	1	14
GO:0120025	plasma membrane bounded cell projection	3	14

Expansion

Sequence features

A0A3Q8IBH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBH7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	147	149	PF00675	0.558
CLV_NRD_NRD_1	52	54	PF00675	0.372
CLV_NRD_NRD_1	809	811	PF00675	0.493
CLV_NRD_NRD_1	843	845	PF00675	0.726
CLV_PCSK_KEX2_1	147	149	PF00082	0.558
CLV_PCSK_KEX2_1	183	185	PF00082	0.408
CLV_PCSK_KEX2_1	221	223	PF00082	0.369
CLV_PCSK_KEX2_1	33	35	PF00082	0.581
CLV_PCSK_KEX2_1	52	54	PF00082	0.516
CLV_PCSK_KEX2_1	690	692	PF00082	0.586
CLV_PCSK_KEX2_1	709	711	PF00082	0.314
CLV_PCSK_KEX2_1	792	794	PF00082	0.509
CLV_PCSK_KEX2_1	842	844	PF00082	0.694
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.388
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.369
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.581
CLV_PCSK_PC1ET2_1	690	692	PF00082	0.621
CLV_PCSK_PC1ET2_1	709	711	PF00082	0.294
CLV_PCSK_PC1ET2_1	792	794	PF00082	0.482
CLV_PCSK_PC1ET2_1	842	844	PF00082	0.677
CLV_PCSK_PC7_1	788	794	PF00082	0.493
CLV_PCSK_PC7_1	838	844	PF00082	0.558
CLV_PCSK_SKI1_1	218	222	PF00082	0.479
CLV_PCSK_SKI1_1	400	404	PF00082	0.747
CLV_PCSK_SKI1_1	48	52	PF00082	0.444
CLV_PCSK_SKI1_1	538	542	PF00082	0.370
CLV_PCSK_SKI1_1	776	780	PF00082	0.500
CLV_Separin_Metazoa	661	665	PF03568	0.511
DEG_APCC_DBOX_1	792	800	PF00400	0.484
DEG_Nend_Nbox_1	1	3	PF02207	0.465
DEG_ODPH_VHL_1	64	76	PF01847	0.361
DEG_SCF_FBW7_1	419	426	PF00400	0.545
DEG_SPOP_SBC_1	413	417	PF00917	0.718
DOC_CDC14_PxL_1	95	103	PF14671	0.365
DOC_CKS1_1	283	288	PF01111	0.530
DOC_CYCLIN_RxL_1	218	226	PF00134	0.370
DOC_CYCLIN_RxL_1	532	542	PF00134	0.284
DOC_MAPK_gen_1	183	190	PF00069	0.338
DOC_MAPK_HePTP_8	575	587	PF00069	0.425
DOC_MAPK_MEF2A_6	462	470	PF00069	0.413
DOC_MAPK_MEF2A_6	578	587	PF00069	0.325
DOC_MAPK_MEF2A_6	756	763	PF00069	0.626
DOC_USP7_MATH_1	151	155	PF00917	0.589
DOC_USP7_MATH_1	157	161	PF00917	0.531
DOC_USP7_MATH_1	162	166	PF00917	0.402
DOC_USP7_MATH_1	322	326	PF00917	0.405
DOC_USP7_MATH_1	448	452	PF00917	0.692
DOC_USP7_MATH_1	805	809	PF00917	0.588
DOC_USP7_MATH_1	830	834	PF00917	0.590
DOC_USP7_UBL2_3	842	846	PF12436	0.598
DOC_WW_Pin1_4	136	141	PF00397	0.549
DOC_WW_Pin1_4	233	238	PF00397	0.561
DOC_WW_Pin1_4	26	31	PF00397	0.456
DOC_WW_Pin1_4	260	265	PF00397	0.617
DOC_WW_Pin1_4	282	287	PF00397	0.522
DOC_WW_Pin1_4	419	424	PF00397	0.549
DOC_WW_Pin1_4	462	467	PF00397	0.650
DOC_WW_Pin1_4	516	521	PF00397	0.403
LIG_14-3-3_CanoR_1	163	169	PF00244	0.578
LIG_14-3-3_CanoR_1	295	301	PF00244	0.429
LIG_14-3-3_CanoR_1	34	44	PF00244	0.531
LIG_14-3-3_CanoR_1	400	409	PF00244	0.762
LIG_14-3-3_CanoR_1	412	421	PF00244	0.630
LIG_14-3-3_CanoR_1	597	603	PF00244	0.251
LIG_14-3-3_CanoR_1	727	735	PF00244	0.593
LIG_14-3-3_CanoR_1	756	760	PF00244	0.553
LIG_14-3-3_CanoR_1	844	850	PF00244	0.537
LIG_Actin_WH2_2	69	86	PF00022	0.351
LIG_Actin_WH2_2	9	24	PF00022	0.363
LIG_Clathr_ClatBox_1	565	569	PF01394	0.432
LIG_Clathr_ClatBox_1	636	640	PF01394	0.363
LIG_Clathr_ClatBox_1	73	77	PF01394	0.453
LIG_EH_1	227	231	PF12763	0.520
LIG_FHA_1	16	22	PF00498	0.379
LIG_FHA_1	27	33	PF00498	0.448
LIG_FHA_1	35	41	PF00498	0.490
LIG_FHA_1	432	438	PF00498	0.642
LIG_FHA_1	479	485	PF00498	0.438
LIG_FHA_1	815	821	PF00498	0.643
LIG_FHA_2	100	106	PF00498	0.433
LIG_FHA_2	36	42	PF00498	0.525
LIG_FHA_2	439	445	PF00498	0.551
LIG_FHA_2	698	704	PF00498	0.420
LIG_FHA_2	738	744	PF00498	0.472
LIG_LIR_Gen_1	102	111	PF02991	0.322
LIG_LIR_Gen_1	610	615	PF02991	0.363
LIG_LIR_Nem_3	102	106	PF02991	0.323
LIG_LIR_Nem_3	610	614	PF02991	0.294
LIG_NRBOX	535	541	PF00104	0.284
LIG_PDZ_Class_1	845	850	PF00595	0.512
LIG_SH2_CRK	2	6	PF00017	0.596
LIG_SH2_GRB2like	168	171	PF00017	0.376
LIG_SH2_GRB2like	198	201	PF00017	0.350
LIG_SH2_SRC	168	171	PF00017	0.376
LIG_SH2_STAP1	17	21	PF00017	0.446
LIG_SH2_STAP1	198	202	PF00017	0.290
LIG_SH2_STAP1	36	40	PF00017	0.514
LIG_SH2_STAT3	198	201	PF00017	0.497
LIG_SH2_STAT3	453	456	PF00017	0.537
LIG_SH2_STAT3	620	623	PF00017	0.314
LIG_SH2_STAT3	728	731	PF00017	0.560
LIG_SH2_STAT5	103	106	PF00017	0.275
LIG_SH2_STAT5	168	171	PF00017	0.416
LIG_SH2_STAT5	17	20	PF00017	0.381
LIG_SH2_STAT5	36	39	PF00017	0.524
LIG_SH2_STAT5	496	499	PF00017	0.286
LIG_SH2_STAT5	620	623	PF00017	0.430
LIG_SH2_STAT5	728	731	PF00017	0.560
LIG_SH3_1	280	286	PF00018	0.597
LIG_SH3_3	280	286	PF00018	0.570
LIG_SH3_3	558	564	PF00018	0.347
LIG_SUMO_SIM_anti_2	567	573	PF11976	0.298
LIG_SUMO_SIM_par_1	186	193	PF11976	0.344
LIG_SUMO_SIM_par_1	207	212	PF11976	0.458
LIG_SUMO_SIM_par_1	470	475	PF11976	0.308
LIG_SUMO_SIM_par_1	481	487	PF11976	0.448
LIG_SUMO_SIM_par_1	564	569	PF11976	0.437
LIG_TRAF2_1	801	804	PF00917	0.577
LIG_TYR_ITIM	101	106	PF00017	0.295
MOD_CDC14_SPxK_1	426	429	PF00782	0.495
MOD_CDK_SPxK_1	423	429	PF00069	0.494
MOD_CDK_SPxxK_3	26	33	PF00069	0.440
MOD_CK1_1	119	125	PF00069	0.666
MOD_CK1_1	260	266	PF00069	0.713
MOD_CK1_1	425	431	PF00069	0.761
MOD_CK1_1	501	507	PF00069	0.497
MOD_CK2_1	189	195	PF00069	0.578
MOD_CK2_1	35	41	PF00069	0.529
MOD_CK2_1	438	444	PF00069	0.550
MOD_CK2_1	737	743	PF00069	0.477
MOD_CK2_1	822	828	PF00069	0.623
MOD_GlcNHglycan	118	121	PF01048	0.677
MOD_GlcNHglycan	134	137	PF01048	0.723
MOD_GlcNHglycan	153	156	PF01048	0.718
MOD_GlcNHglycan	159	162	PF01048	0.637
MOD_GlcNHglycan	224	228	PF01048	0.493
MOD_GlcNHglycan	237	240	PF01048	0.633
MOD_GlcNHglycan	259	262	PF01048	0.612
MOD_GlcNHglycan	280	283	PF01048	0.600
MOD_GlcNHglycan	333	336	PF01048	0.439
MOD_GlcNHglycan	450	453	PF01048	0.751
MOD_GlcNHglycan	541	544	PF01048	0.288
MOD_GlcNHglycan	832	835	PF01048	0.629
MOD_GSK3_1	1	8	PF00069	0.462
MOD_GSK3_1	112	119	PF00069	0.591
MOD_GSK3_1	132	139	PF00069	0.585
MOD_GSK3_1	253	260	PF00069	0.641
MOD_GSK3_1	278	285	PF00069	0.580
MOD_GSK3_1	294	301	PF00069	0.328
MOD_GSK3_1	304	311	PF00069	0.326
MOD_GSK3_1	413	420	PF00069	0.699
MOD_GSK3_1	421	428	PF00069	0.693
MOD_GSK3_1	438	445	PF00069	0.804
MOD_GSK3_1	448	455	PF00069	0.791
MOD_GSK3_1	490	497	PF00069	0.510
MOD_GSK3_1	830	837	PF00069	0.760
MOD_LATS_1	410	416	PF00433	0.489
MOD_N-GLC_1	331	336	PF02516	0.522
MOD_N-GLC_1	516	521	PF02516	0.395
MOD_N-GLC_1	589	594	PF02516	0.287
MOD_N-GLC_1	645	650	PF02516	0.459
MOD_N-GLC_1	684	689	PF02516	0.381
MOD_NEK2_1	1	6	PF00069	0.460
MOD_NEK2_1	216	221	PF00069	0.403
MOD_NEK2_1	223	228	PF00069	0.321
MOD_NEK2_1	293	298	PF00069	0.386
MOD_NEK2_1	331	336	PF00069	0.470
MOD_NEK2_1	35	40	PF00069	0.523
MOD_NEK2_1	362	367	PF00069	0.516
MOD_NEK2_1	479	484	PF00069	0.437
MOD_NEK2_1	490	495	PF00069	0.497
MOD_NEK2_1	498	503	PF00069	0.409
MOD_NEK2_1	526	531	PF00069	0.410
MOD_NEK2_1	539	544	PF00069	0.335
MOD_NEK2_1	570	575	PF00069	0.343
MOD_NEK2_1	60	65	PF00069	0.439
MOD_NEK2_1	614	619	PF00069	0.333
MOD_NEK2_1	626	631	PF00069	0.402
MOD_NEK2_2	125	130	PF00069	0.448
MOD_PIKK_1	446	452	PF00454	0.584
MOD_PIKK_1	805	811	PF00454	0.598
MOD_PKA_1	844	850	PF00069	0.702
MOD_PKA_2	162	168	PF00069	0.628
MOD_PKA_2	21	27	PF00069	0.539
MOD_PKA_2	294	300	PF00069	0.434
MOD_PKA_2	387	393	PF00069	0.563
MOD_PKA_2	596	602	PF00069	0.383
MOD_PKA_2	640	646	PF00069	0.438
MOD_PKA_2	726	732	PF00069	0.593
MOD_PKA_2	755	761	PF00069	0.560
MOD_PKB_1	774	782	PF00069	0.398
MOD_Plk_1	490	496	PF00069	0.502
MOD_Plk_1	589	595	PF00069	0.302
MOD_Plk_1	748	754	PF00069	0.429
MOD_Plk_1	776	782	PF00069	0.685
MOD_Plk_2-3	755	761	PF00069	0.425
MOD_Plk_4	112	118	PF00069	0.538
MOD_Plk_4	125	131	PF00069	0.501
MOD_Plk_4	164	170	PF00069	0.489
MOD_Plk_4	365	371	PF00069	0.364
MOD_Plk_4	479	485	PF00069	0.470
MOD_Plk_4	498	504	PF00069	0.411
MOD_Plk_4	570	576	PF00069	0.413
MOD_Plk_4	616	622	PF00069	0.306
MOD_Plk_4	69	75	PF00069	0.479
MOD_Plk_4	748	754	PF00069	0.429
MOD_Plk_4	776	782	PF00069	0.457
MOD_Plk_4	99	105	PF00069	0.340
MOD_ProDKin_1	136	142	PF00069	0.551
MOD_ProDKin_1	233	239	PF00069	0.564
MOD_ProDKin_1	26	32	PF00069	0.452
MOD_ProDKin_1	260	266	PF00069	0.619
MOD_ProDKin_1	282	288	PF00069	0.519
MOD_ProDKin_1	419	425	PF00069	0.546
MOD_ProDKin_1	462	468	PF00069	0.635
MOD_ProDKin_1	516	522	PF00069	0.403
MOD_SUMO_for_1	658	661	PF00179	0.453
MOD_SUMO_for_1	733	736	PF00179	0.557
MOD_SUMO_rev_2	26	35	PF00179	0.511
MOD_SUMO_rev_2	41	50	PF00179	0.472
MOD_SUMO_rev_2	684	692	PF00179	0.508
MOD_SUMO_rev_2	725	733	PF00179	0.491
TRG_DiLeu_BaEn_1	345	350	PF01217	0.391
TRG_DiLeu_BaLyEn_6	535	540	PF01217	0.251
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.370
TRG_DiLeu_LyEn_5	345	350	PF01217	0.358
TRG_ENDOCYTIC_2	103	106	PF00928	0.277
TRG_ENDOCYTIC_2	13	16	PF00928	0.402
TRG_ENDOCYTIC_2	2	5	PF00928	0.588
TRG_ER_diArg_1	51	53	PF00400	0.502
TRG_NES_CRM1_1	201	212	PF08389	0.358
TRG_NES_CRM1_1	749	760	PF08389	0.579
TRG_NLS_MonoCore_2	841	846	PF00514	0.755
TRG_NLS_MonoExtC_3	841	846	PF00514	0.629
TRG_NLS_MonoExtN_4	841	848	PF00514	0.617
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	435	439	PF00026	0.722
TRG_Pf-PMV_PEXEL_1	712	716	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P337	Leptomonas seymouri	56%	95%
A0A0S4JDM4	Bodo saltans	26%	100%
A0A1X0NMB3	Trypanosomatidae	31%	100%
A0A3R7RCX5	Trypanosoma rangeli	32%	100%
A0A422NEU0	Trypanosoma rangeli	23%	100%
A4H6Y3	Leishmania braziliensis	78%	99%
C9ZHZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AGF7	Leishmania infantum	100%	100%
E9ALE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9ANZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QGM3	Leishmania major	94%	100%
V5AZQ5	Trypanosoma cruzi	32%	100%