Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBH6_LEIDO

TriTrypDb:

LdBPK_230750.1 , LdCL_230014000 , LDHU3_23.1040

Length:

1068

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IBH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBH6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.580
CLV_C14_Caspase3-7	771	775	PF00656	0.706
CLV_C14_Caspase3-7	781	785	PF00656	0.630
CLV_C14_Caspase3-7	822	826	PF00656	0.627
CLV_C14_Caspase3-7	973	977	PF00656	0.511
CLV_NRD_NRD_1	1002	1004	PF00675	0.466
CLV_NRD_NRD_1	1029	1031	PF00675	0.438
CLV_NRD_NRD_1	150	152	PF00675	0.809
CLV_NRD_NRD_1	321	323	PF00675	0.419
CLV_NRD_NRD_1	657	659	PF00675	0.695
CLV_NRD_NRD_1	868	870	PF00675	0.625
CLV_NRD_NRD_1	940	942	PF00675	0.745
CLV_NRD_NRD_1	948	950	PF00675	0.527
CLV_NRD_NRD_1	989	991	PF00675	0.440
CLV_PCSK_KEX2_1	1001	1003	PF00082	0.478
CLV_PCSK_KEX2_1	1029	1031	PF00082	0.438
CLV_PCSK_KEX2_1	150	152	PF00082	0.739
CLV_PCSK_KEX2_1	321	323	PF00082	0.419
CLV_PCSK_KEX2_1	656	658	PF00082	0.699
CLV_PCSK_KEX2_1	867	869	PF00082	0.625
CLV_PCSK_KEX2_1	940	942	PF00082	0.688
CLV_PCSK_KEX2_1	946	948	PF00082	0.595
CLV_PCSK_KEX2_1	989	991	PF00082	0.440
CLV_PCSK_PC1ET2_1	946	948	PF00082	0.660
CLV_PCSK_PC7_1	998	1004	PF00082	0.496
CLV_PCSK_SKI1_1	1003	1007	PF00082	0.443
CLV_PCSK_SKI1_1	1032	1036	PF00082	0.441
CLV_PCSK_SKI1_1	133	137	PF00082	0.445
CLV_PCSK_SKI1_1	171	175	PF00082	0.654
CLV_PCSK_SKI1_1	392	396	PF00082	0.589
CLV_PCSK_SKI1_1	500	504	PF00082	0.363
CLV_PCSK_SKI1_1	747	751	PF00082	0.703
CLV_PCSK_SKI1_1	799	803	PF00082	0.639
CLV_PCSK_SKI1_1	834	838	PF00082	0.558
CLV_PCSK_SKI1_1	862	866	PF00082	0.704
CLV_PCSK_SKI1_1	88	92	PF00082	0.411
CLV_Separin_Metazoa	479	483	PF03568	0.396
DEG_APCC_DBOX_1	1002	1010	PF00400	0.432
DEG_APCC_DBOX_1	1031	1039	PF00400	0.428
DEG_APCC_DBOX_1	567	575	PF00400	0.374
DEG_APCC_DBOX_1	87	95	PF00400	0.392
DEG_SPOP_SBC_1	532	536	PF00917	0.481
DEG_SPOP_SBC_1	649	653	PF00917	0.673
DOC_CDC14_PxL_1	1011	1019	PF14671	0.470
DOC_CYCLIN_RxL_1	497	508	PF00134	0.471
DOC_CYCLIN_RxL_1	672	681	PF00134	0.493
DOC_CYCLIN_RxL_1	984	997	PF00134	0.449
DOC_MAPK_DCC_7	270	279	PF00069	0.498
DOC_MAPK_gen_1	1029	1037	PF00069	0.437
DOC_MAPK_gen_1	482	490	PF00069	0.455
DOC_MAPK_gen_1	568	576	PF00069	0.382
DOC_MAPK_gen_1	586	596	PF00069	0.504
DOC_MAPK_gen_1	865	875	PF00069	0.581
DOC_MAPK_gen_1	926	934	PF00069	0.722
DOC_MAPK_HePTP_8	654	668	PF00069	0.589
DOC_MAPK_MEF2A_6	189	197	PF00069	0.585
DOC_MAPK_MEF2A_6	270	279	PF00069	0.498
DOC_MAPK_MEF2A_6	888	896	PF00069	0.736
DOC_MAPK_MEF2A_6	926	934	PF00069	0.693
DOC_MAPK_MEF2A_6	957	964	PF00069	0.426
DOC_PP2B_LxvP_1	195	198	PF13499	0.675
DOC_PP2B_LxvP_1	271	274	PF13499	0.589
DOC_PP2B_LxvP_1	409	412	PF13499	0.382
DOC_PP4_FxxP_1	333	336	PF00568	0.474
DOC_SPAK_OSR1_1	814	818	PF12202	0.563
DOC_USP7_MATH_1	1028	1032	PF00917	0.431
DOC_USP7_MATH_1	155	159	PF00917	0.808
DOC_USP7_MATH_1	218	222	PF00917	0.681
DOC_USP7_MATH_1	432	436	PF00917	0.454
DOC_USP7_MATH_1	533	537	PF00917	0.591
DOC_USP7_MATH_1	561	565	PF00917	0.407
DOC_USP7_MATH_1	644	648	PF00917	0.669
DOC_USP7_MATH_1	649	653	PF00917	0.692
DOC_USP7_MATH_1	691	695	PF00917	0.546
DOC_USP7_MATH_1	704	708	PF00917	0.666
DOC_USP7_MATH_1	73	77	PF00917	0.461
DOC_USP7_MATH_1	761	765	PF00917	0.649
DOC_USP7_MATH_1	898	902	PF00917	0.719
DOC_USP7_MATH_1	905	909	PF00917	0.562
DOC_WW_Pin1_4	18	23	PF00397	0.694
DOC_WW_Pin1_4	451	456	PF00397	0.647
DOC_WW_Pin1_4	712	717	PF00397	0.695
DOC_WW_Pin1_4	741	746	PF00397	0.671
DOC_WW_Pin1_4	854	859	PF00397	0.726
DOC_WW_Pin1_4	875	880	PF00397	0.751
DOC_WW_Pin1_4	888	893	PF00397	0.673
DOC_WW_Pin1_4	903	908	PF00397	0.510
LIG_14-3-3_CanoR_1	1001	1006	PF00244	0.421
LIG_14-3-3_CanoR_1	1029	1035	PF00244	0.441
LIG_14-3-3_CanoR_1	150	160	PF00244	0.765
LIG_14-3-3_CanoR_1	189	193	PF00244	0.641
LIG_14-3-3_CanoR_1	392	402	PF00244	0.507
LIG_14-3-3_CanoR_1	577	585	PF00244	0.575
LIG_14-3-3_CanoR_1	586	596	PF00244	0.265
LIG_14-3-3_CanoR_1	705	709	PF00244	0.593
LIG_14-3-3_CanoR_1	747	755	PF00244	0.704
LIG_14-3-3_CanoR_1	807	817	PF00244	0.683
LIG_14-3-3_CanoR_1	851	858	PF00244	0.746
LIG_14-3-3_CanoR_1	88	98	PF00244	0.413
LIG_14-3-3_CanoR_1	886	892	PF00244	0.723
LIG_14-3-3_CanoR_1	966	974	PF00244	0.366
LIG_Actin_WH2_2	1006	1024	PF00022	0.406
LIG_Actin_WH2_2	225	243	PF00022	0.492
LIG_Actin_WH2_2	517	532	PF00022	0.392
LIG_Actin_WH2_2	74	90	PF00022	0.368
LIG_Actin_WH2_2	742	758	PF00022	0.701
LIG_BIR_II_1	1	5	PF00653	0.390
LIG_BIR_III_4	1056	1060	PF00653	0.407
LIG_BRCT_BRCA1_1	907	911	PF00533	0.596
LIG_Clathr_ClatBox_1	126	130	PF01394	0.512
LIG_EH_1	928	932	PF12763	0.598
LIG_EH1_1	490	498	PF00400	0.372
LIG_eIF4E_1	1014	1020	PF01652	0.400
LIG_EVH1_1	271	275	PF00568	0.592
LIG_FHA_1	234	240	PF00498	0.502
LIG_FHA_1	408	414	PF00498	0.387
LIG_FHA_1	649	655	PF00498	0.702
LIG_FHA_1	684	690	PF00498	0.563
LIG_FHA_1	694	700	PF00498	0.560
LIG_FHA_1	77	83	PF00498	0.406
LIG_FHA_1	995	1001	PF00498	0.608
LIG_FHA_2	142	148	PF00498	0.809
LIG_FHA_2	218	224	PF00498	0.696
LIG_FHA_2	363	369	PF00498	0.547
LIG_FHA_2	521	527	PF00498	0.388
LIG_FHA_2	795	801	PF00498	0.647
LIG_GBD_Chelix_1	308	316	PF00786	0.422
LIG_GBD_Chelix_1	521	529	PF00786	0.378
LIG_HCF-1_HBM_1	983	986	PF13415	0.428
LIG_LIR_Apic_2	332	336	PF02991	0.387
LIG_LIR_Gen_1	191	200	PF02991	0.582
LIG_LIR_LC3C_4	572	576	PF02991	0.385
LIG_LIR_Nem_3	1053	1058	PF02991	0.404
LIG_LIR_Nem_3	191	195	PF02991	0.584
LIG_LIR_Nem_3	295	301	PF02991	0.526
LIG_LRP6_Inhibitor_1	856	862	PF00058	0.588
LIG_LYPXL_S_1	1013	1017	PF13949	0.391
LIG_LYPXL_yS_3	1014	1017	PF13949	0.395
LIG_NRBOX	311	317	PF00104	0.375
LIG_PCNA_yPIPBox_3	675	683	PF02747	0.490
LIG_PROFILIN_1	272	278	PF00235	0.548
LIG_RPA_C_Fungi	944	956	PF08784	0.482
LIG_SH2_CRK	1055	1059	PF00017	0.397
LIG_SH2_GRB2like	603	606	PF00017	0.540
LIG_SH2_NCK_1	1055	1059	PF00017	0.397
LIG_SH2_STAP1	298	302	PF00017	0.403
LIG_SH2_STAP1	967	971	PF00017	0.428
LIG_SH2_STAT3	1023	1026	PF00017	0.489
LIG_SH2_STAT5	1023	1026	PF00017	0.489
LIG_SH2_STAT5	301	304	PF00017	0.385
LIG_SH2_STAT5	65	68	PF00017	0.400
LIG_SH2_STAT5	843	846	PF00017	0.620
LIG_SH2_STAT5	967	970	PF00017	0.438
LIG_SH2_STAT5	987	990	PF00017	0.283
LIG_SH3_1	270	276	PF00018	0.525
LIG_SH3_2	455	460	PF14604	0.613
LIG_SH3_3	269	275	PF00018	0.582
LIG_SH3_3	452	458	PF00018	0.691
LIG_SH3_3	69	75	PF00018	0.542
LIG_SH3_3	889	895	PF00018	0.791
LIG_SH3_3	927	933	PF00018	0.596
LIG_Sin3_3	251	258	PF02671	0.502
LIG_SUMO_SIM_anti_2	306	314	PF11976	0.460
LIG_SUMO_SIM_anti_2	523	529	PF11976	0.373
LIG_SUMO_SIM_par_1	1050	1056	PF11976	0.504
LIG_SUMO_SIM_par_1	125	130	PF11976	0.503
LIG_TRAF2_1	365	368	PF00917	0.462
LIG_TYR_ITIM	965	970	PF00017	0.422
LIG_ULM_U2AF65_1	946	951	PF00076	0.502
LIG_WRC_WIRS_1	1038	1043	PF05994	0.544
LIG_WRC_WIRS_1	330	335	PF05994	0.485
LIG_WRC_WIRS_1	698	703	PF05994	0.573
LIG_WW_2	275	278	PF00397	0.573
LIG_WW_2	892	895	PF00397	0.708
MOD_CDC14_SPxK_1	457	460	PF00782	0.712
MOD_CDC14_SPxK_1	744	747	PF00782	0.689
MOD_CDK_SPK_2	879	884	PF00069	0.637
MOD_CDK_SPxK_1	454	460	PF00069	0.704
MOD_CDK_SPxK_1	741	747	PF00069	0.692
MOD_CDK_SPxxK_3	879	886	PF00069	0.643
MOD_CK1_1	1039	1045	PF00069	0.541
MOD_CK1_1	172	178	PF00069	0.727
MOD_CK1_1	290	296	PF00069	0.585
MOD_CK1_1	362	368	PF00069	0.478
MOD_CK1_1	447	453	PF00069	0.569
MOD_CK1_1	454	460	PF00069	0.600
MOD_CK1_1	505	511	PF00069	0.398
MOD_CK1_1	534	540	PF00069	0.646
MOD_CK1_1	564	570	PF00069	0.418
MOD_CK1_1	581	587	PF00069	0.489
MOD_CK1_1	647	653	PF00069	0.715
MOD_CK1_1	703	709	PF00069	0.645
MOD_CK1_1	724	730	PF00069	0.752
MOD_CK1_1	751	757	PF00069	0.618
MOD_CK1_1	76	82	PF00069	0.419
MOD_CK1_1	764	770	PF00069	0.514
MOD_CK1_1	778	784	PF00069	0.648
MOD_CK1_1	847	853	PF00069	0.718
MOD_CK1_1	887	893	PF00069	0.770
MOD_CK1_1	92	98	PF00069	0.428
MOD_CK2_1	1062	1068	PF00069	0.525
MOD_CK2_1	217	223	PF00069	0.637
MOD_CK2_1	362	368	PF00069	0.441
MOD_CK2_1	473	479	PF00069	0.492
MOD_CK2_1	520	526	PF00069	0.376
MOD_CK2_1	678	684	PF00069	0.419
MOD_CK2_1	794	800	PF00069	0.645
MOD_CK2_1	875	881	PF00069	0.729
MOD_DYRK1A_RPxSP_1	712	716	PF00069	0.615
MOD_DYRK1A_RPxSP_1	888	892	PF00069	0.744
MOD_GlcNHglycan	103	106	PF01048	0.502
MOD_GlcNHglycan	1041	1044	PF01048	0.477
MOD_GlcNHglycan	1047	1050	PF01048	0.366
MOD_GlcNHglycan	1064	1067	PF01048	0.527
MOD_GlcNHglycan	153	156	PF01048	0.764
MOD_GlcNHglycan	167	170	PF01048	0.605
MOD_GlcNHglycan	22	25	PF01048	0.682
MOD_GlcNHglycan	256	259	PF01048	0.526
MOD_GlcNHglycan	354	357	PF01048	0.573
MOD_GlcNHglycan	361	364	PF01048	0.479
MOD_GlcNHglycan	374	377	PF01048	0.466
MOD_GlcNHglycan	434	437	PF01048	0.541
MOD_GlcNHglycan	439	442	PF01048	0.438
MOD_GlcNHglycan	466	469	PF01048	0.534
MOD_GlcNHglycan	493	496	PF01048	0.369
MOD_GlcNHglycan	539	542	PF01048	0.650
MOD_GlcNHglycan	646	649	PF01048	0.737
MOD_GlcNHglycan	702	705	PF01048	0.760
MOD_GlcNHglycan	726	729	PF01048	0.651
MOD_GlcNHglycan	750	753	PF01048	0.711
MOD_GlcNHglycan	763	766	PF01048	0.531
MOD_GlcNHglycan	776	780	PF01048	0.574
MOD_GlcNHglycan	784	788	PF01048	0.530
MOD_GlcNHglycan	852	855	PF01048	0.625
MOD_GlcNHglycan	900	903	PF01048	0.690
MOD_GlcNHglycan	919	923	PF01048	0.651
MOD_GlcNHglycan	94	97	PF01048	0.553
MOD_GSK3_1	151	158	PF00069	0.817
MOD_GSK3_1	165	172	PF00069	0.599
MOD_GSK3_1	203	210	PF00069	0.670
MOD_GSK3_1	287	294	PF00069	0.626
MOD_GSK3_1	307	314	PF00069	0.382
MOD_GSK3_1	358	365	PF00069	0.546
MOD_GSK3_1	393	400	PF00069	0.516
MOD_GSK3_1	444	451	PF00069	0.534
MOD_GSK3_1	459	466	PF00069	0.504
MOD_GSK3_1	516	523	PF00069	0.403
MOD_GSK3_1	531	538	PF00069	0.478
MOD_GSK3_1	643	650	PF00069	0.626
MOD_GSK3_1	693	700	PF00069	0.604
MOD_GSK3_1	747	754	PF00069	0.594
MOD_GSK3_1	799	806	PF00069	0.638
MOD_GSK3_1	841	848	PF00069	0.534
MOD_GSK3_1	850	857	PF00069	0.609
MOD_GSK3_1	875	882	PF00069	0.738
MOD_GSK3_1	884	891	PF00069	0.679
MOD_GSK3_1	965	972	PF00069	0.561
MOD_LATS_1	149	155	PF00433	0.734
MOD_LATS_1	207	213	PF00433	0.604
MOD_N-GLC_1	397	402	PF02516	0.463
MOD_NEK2_1	1037	1042	PF00069	0.435
MOD_NEK2_1	156	161	PF00069	0.809
MOD_NEK2_1	165	170	PF00069	0.616
MOD_NEK2_1	188	193	PF00069	0.798
MOD_NEK2_1	254	259	PF00069	0.519
MOD_NEK2_1	311	316	PF00069	0.495
MOD_NEK2_1	351	356	PF00069	0.577
MOD_NEK2_1	372	377	PF00069	0.364
MOD_NEK2_1	427	432	PF00069	0.463
MOD_NEK2_1	448	453	PF00069	0.653
MOD_NEK2_1	464	469	PF00069	0.561
MOD_NEK2_1	473	478	PF00069	0.335
MOD_NEK2_1	491	496	PF00069	0.266
MOD_NEK2_1	520	525	PF00069	0.364
MOD_NEK2_1	556	561	PF00069	0.371
MOD_NEK2_1	596	601	PF00069	0.526
MOD_NEK2_1	699	704	PF00069	0.562
MOD_NEK2_1	755	760	PF00069	0.641
MOD_NEK2_1	783	788	PF00069	0.618
MOD_NEK2_1	874	879	PF00069	0.771
MOD_NEK2_1	917	922	PF00069	0.794
MOD_NEK2_2	264	269	PF00069	0.371
MOD_NEK2_2	628	633	PF00069	0.550
MOD_PIKK_1	427	433	PF00454	0.412
MOD_PIKK_1	76	82	PF00454	0.414
MOD_PIKK_1	841	847	PF00454	0.616
MOD_PK_1	1001	1007	PF00069	0.421
MOD_PK_1	1030	1036	PF00069	0.445
MOD_PKA_1	1001	1007	PF00069	0.421
MOD_PKA_1	150	156	PF00069	0.805
MOD_PKA_2	1001	1007	PF00069	0.421
MOD_PKA_2	1028	1034	PF00069	0.427
MOD_PKA_2	1059	1065	PF00069	0.561
MOD_PKA_2	149	155	PF00069	0.770
MOD_PKA_2	188	194	PF00069	0.587
MOD_PKA_2	240	246	PF00069	0.374
MOD_PKA_2	381	387	PF00069	0.477
MOD_PKA_2	515	521	PF00069	0.404
MOD_PKA_2	704	710	PF00069	0.632
MOD_PKA_2	755	761	PF00069	0.664
MOD_PKA_2	806	812	PF00069	0.694
MOD_PKA_2	850	856	PF00069	0.692
MOD_PKA_2	887	893	PF00069	0.767
MOD_PKA_2	965	971	PF00069	0.384
MOD_PKB_1	884	892	PF00069	0.748
MOD_Plk_1	218	224	PF00069	0.604
MOD_Plk_1	324	330	PF00069	0.510
MOD_Plk_1	367	373	PF00069	0.500
MOD_Plk_1	397	403	PF00069	0.496
MOD_Plk_1	444	450	PF00069	0.622
MOD_Plk_1	516	522	PF00069	0.401
MOD_Plk_1	799	805	PF00069	0.631
MOD_Plk_4	107	113	PF00069	0.395
MOD_Plk_4	188	194	PF00069	0.589
MOD_Plk_4	307	313	PF00069	0.375
MOD_Plk_4	324	330	PF00069	0.350
MOD_Plk_4	367	373	PF00069	0.407
MOD_Plk_4	444	450	PF00069	0.622
MOD_Plk_4	473	479	PF00069	0.408
MOD_Plk_4	516	522	PF00069	0.426
MOD_Plk_4	650	656	PF00069	0.707
MOD_Plk_4	678	684	PF00069	0.550
MOD_Plk_4	778	784	PF00069	0.673
MOD_Plk_4	799	805	PF00069	0.631
MOD_Plk_4	905	911	PF00069	0.605
MOD_ProDKin_1	18	24	PF00069	0.700
MOD_ProDKin_1	451	457	PF00069	0.650
MOD_ProDKin_1	712	718	PF00069	0.694
MOD_ProDKin_1	741	747	PF00069	0.673
MOD_ProDKin_1	854	860	PF00069	0.725
MOD_ProDKin_1	875	881	PF00069	0.754
MOD_ProDKin_1	888	894	PF00069	0.673
MOD_ProDKin_1	903	909	PF00069	0.510
TRG_DiLeu_BaEn_1	368	373	PF01217	0.359
TRG_DiLeu_BaEn_2	926	932	PF01217	0.694
TRG_DiLeu_BaEn_3	366	372	PF01217	0.516
TRG_DiLeu_BaEn_4	616	622	PF01217	0.617
TRG_ENDOCYTIC_2	1014	1017	PF00928	0.399
TRG_ENDOCYTIC_2	1055	1058	PF00928	0.399
TRG_ENDOCYTIC_2	967	970	PF00928	0.428
TRG_ER_diArg_1	1000	1003	PF00400	0.487
TRG_ER_diArg_1	1029	1032	PF00400	0.447
TRG_ER_diArg_1	228	231	PF00400	0.448
TRG_ER_diArg_1	320	322	PF00400	0.456
TRG_ER_diArg_1	568	571	PF00400	0.413
TRG_ER_diArg_1	655	658	PF00400	0.703
TRG_ER_diArg_1	867	869	PF00400	0.625
TRG_ER_diArg_1	883	886	PF00400	0.761
TRG_ER_diArg_1	947	949	PF00400	0.538
TRG_ER_diArg_1	988	990	PF00400	0.430
TRG_NLS_MonoCore_2	945	950	PF00514	0.512
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	675	680	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	796	800	PF00026	0.732

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PED4	Leptomonas seymouri	45%	91%
A4I0A9	Leishmania infantum	100%	100%
E9AW73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QBA5	Leishmania major	90%	100%