Protein tyrosine kinase/Protein kinase domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein kinase domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBH5_LEIDO

TriTrypDb:

LdBPK_220990.1 , LdCL_220017300 , LDHU3_22.1500

Length:

932

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	1
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IBH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBH5

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0000278	mitotic cell cycle	3	1
GO:0007049	cell cycle	2	1
GO:0010564	regulation of cell cycle process	5	1
GO:0032465	regulation of cytokinesis	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051302	regulation of cell division	4	1
GO:0051726	regulation of cell cycle	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.657
CLV_C14_Caspase3-7	498	502	PF00656	0.663
CLV_C14_Caspase3-7	791	795	PF00656	0.677
CLV_NRD_NRD_1	156	158	PF00675	0.684
CLV_NRD_NRD_1	461	463	PF00675	0.639
CLV_NRD_NRD_1	523	525	PF00675	0.647
CLV_NRD_NRD_1	612	614	PF00675	0.499
CLV_NRD_NRD_1	631	633	PF00675	0.469
CLV_NRD_NRD_1	697	699	PF00675	0.628
CLV_NRD_NRD_1	721	723	PF00675	0.703
CLV_NRD_NRD_1	830	832	PF00675	0.689
CLV_PCSK_KEX2_1	461	463	PF00082	0.639
CLV_PCSK_KEX2_1	52	54	PF00082	0.460
CLV_PCSK_KEX2_1	523	525	PF00082	0.682
CLV_PCSK_KEX2_1	554	556	PF00082	0.652
CLV_PCSK_KEX2_1	611	613	PF00082	0.501
CLV_PCSK_KEX2_1	631	633	PF00082	0.466
CLV_PCSK_KEX2_1	676	678	PF00082	0.613
CLV_PCSK_KEX2_1	697	699	PF00082	0.628
CLV_PCSK_KEX2_1	720	722	PF00082	0.706
CLV_PCSK_KEX2_1	830	832	PF00082	0.689
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.460
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.652
CLV_PCSK_PC1ET2_1	611	613	PF00082	0.501
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.582
CLV_PCSK_PC1ET2_1	697	699	PF00082	0.616
CLV_PCSK_PC7_1	48	54	PF00082	0.444
CLV_PCSK_PC7_1	608	614	PF00082	0.490
CLV_PCSK_SKI1_1	108	112	PF00082	0.463
CLV_PCSK_SKI1_1	149	153	PF00082	0.612
CLV_PCSK_SKI1_1	175	179	PF00082	0.633
CLV_PCSK_SKI1_1	180	184	PF00082	0.641
CLV_PCSK_SKI1_1	262	266	PF00082	0.421
CLV_PCSK_SKI1_1	367	371	PF00082	0.385
CLV_PCSK_SKI1_1	37	41	PF00082	0.464
CLV_PCSK_SKI1_1	52	56	PF00082	0.378
CLV_PCSK_SKI1_1	608	612	PF00082	0.565
CLV_PCSK_SKI1_1	631	635	PF00082	0.555
CLV_PCSK_SKI1_1	79	83	PF00082	0.490
CLV_Separin_Metazoa	328	332	PF03568	0.385
DEG_APCC_DBOX_1	377	385	PF00400	0.385
DEG_SCF_FBW7_1	186	192	PF00400	0.588
DEG_SCF_FBW7_1	811	818	PF00400	0.572
DOC_CKS1_1	186	191	PF01111	0.641
DOC_CYCLIN_yCln2_LP_2	407	413	PF00134	0.265
DOC_CYCLIN_yCln2_LP_2	650	656	PF00134	0.590
DOC_CYCLIN_yCln2_LP_2	819	825	PF00134	0.703
DOC_MAPK_DCC_7	378	386	PF00069	0.385
DOC_MAPK_gen_1	881	890	PF00069	0.626
DOC_MAPK_MEF2A_6	378	386	PF00069	0.385
DOC_MAPK_MEF2A_6	820	827	PF00069	0.689
DOC_MAPK_RevD_3	661	677	PF00069	0.571
DOC_PP2B_LxvP_1	819	822	PF13499	0.705
DOC_PP2B_PxIxI_1	101	107	PF00149	0.324
DOC_PP4_FxxP_1	412	415	PF00568	0.462
DOC_PP4_FxxP_1	847	850	PF00568	0.641
DOC_USP7_MATH_1	131	135	PF00917	0.590
DOC_USP7_MATH_1	136	140	PF00917	0.607
DOC_USP7_MATH_1	189	193	PF00917	0.611
DOC_USP7_MATH_1	240	244	PF00917	0.691
DOC_USP7_MATH_1	251	255	PF00917	0.537
DOC_USP7_MATH_1	549	553	PF00917	0.679
DOC_USP7_MATH_1	559	563	PF00917	0.609
DOC_USP7_MATH_1	568	572	PF00917	0.537
DOC_USP7_MATH_1	710	714	PF00917	0.698
DOC_USP7_MATH_1	807	811	PF00917	0.609
DOC_USP7_MATH_1	815	819	PF00917	0.641
DOC_USP7_MATH_1	832	836	PF00917	0.531
DOC_USP7_MATH_1	842	846	PF00917	0.598
DOC_WW_Pin1_4	185	190	PF00397	0.648
DOC_WW_Pin1_4	220	225	PF00397	0.655
DOC_WW_Pin1_4	234	239	PF00397	0.543
DOC_WW_Pin1_4	393	398	PF00397	0.385
DOC_WW_Pin1_4	476	481	PF00397	0.650
DOC_WW_Pin1_4	545	550	PF00397	0.682
DOC_WW_Pin1_4	564	569	PF00397	0.532
DOC_WW_Pin1_4	671	676	PF00397	0.659
DOC_WW_Pin1_4	712	717	PF00397	0.650
DOC_WW_Pin1_4	747	752	PF00397	0.621
DOC_WW_Pin1_4	771	776	PF00397	0.637
DOC_WW_Pin1_4	811	816	PF00397	0.593
DOC_WW_Pin1_4	838	843	PF00397	0.605
LIG_14-3-3_CanoR_1	180	189	PF00244	0.615
LIG_14-3-3_CanoR_1	322	326	PF00244	0.385
LIG_14-3-3_CanoR_1	37	46	PF00244	0.459
LIG_14-3-3_CanoR_1	436	445	PF00244	0.486
LIG_14-3-3_CanoR_1	523	530	PF00244	0.632
LIG_14-3-3_CanoR_1	626	631	PF00244	0.478
LIG_14-3-3_CanoR_1	70	76	PF00244	0.475
LIG_14-3-3_CanoR_1	720	729	PF00244	0.599
LIG_14-3-3_CanoR_1	831	837	PF00244	0.637
LIG_BRCT_BRCA1_1	304	308	PF00533	0.385
LIG_deltaCOP1_diTrp_1	57	62	PF00928	0.609
LIG_eIF4E_1	95	101	PF01652	0.435
LIG_FHA_1	38	44	PF00498	0.468
LIG_FHA_1	578	584	PF00498	0.548
LIG_FHA_1	618	624	PF00498	0.598
LIG_FHA_1	803	809	PF00498	0.694
LIG_FHA_1	904	910	PF00498	0.622
LIG_FHA_1	915	921	PF00498	0.559
LIG_FHA_2	143	149	PF00498	0.699
LIG_FHA_2	416	422	PF00498	0.536
LIG_FHA_2	493	499	PF00498	0.694
LIG_FHA_2	812	818	PF00498	0.635
LIG_GBD_Chelix_1	384	392	PF00786	0.385
LIG_Integrin_isoDGR_2	459	461	PF01839	0.634
LIG_LIR_Apic_2	845	850	PF02991	0.639
LIG_LIR_Gen_1	479	488	PF02991	0.689
LIG_LIR_Gen_1	92	102	PF02991	0.441
LIG_LIR_Gen_1	923	932	PF02991	0.574
LIG_LIR_Nem_3	333	338	PF02991	0.385
LIG_LIR_Nem_3	479	485	PF02991	0.690
LIG_LIR_Nem_3	923	929	PF02991	0.522
LIG_MYND_1	379	383	PF01753	0.287
LIG_MYND_1	586	590	PF01753	0.639
LIG_MYND_1	851	855	PF01753	0.565
LIG_PCNA_yPIPBox_3	12	24	PF02747	0.481
LIG_PDZ_Class_1	927	932	PF00595	0.502
LIG_RPA_C_Fungi	457	469	PF08784	0.579
LIG_SH2_SRC	919	922	PF00017	0.614
LIG_SH2_STAP1	50	54	PF00017	0.448
LIG_SH2_STAT5	338	341	PF00017	0.385
LIG_SH2_STAT5	350	353	PF00017	0.255
LIG_SH2_STAT5	45	48	PF00017	0.425
LIG_SH2_STAT5	695	698	PF00017	0.640
LIG_SH2_STAT5	80	83	PF00017	0.412
LIG_SH2_STAT5	919	922	PF00017	0.614
LIG_SH3_1	373	379	PF00018	0.342
LIG_SH3_3	373	379	PF00018	0.385
LIG_SH3_3	527	533	PF00018	0.667
LIG_SH3_3	580	586	PF00018	0.614
LIG_SH3_3	820	826	PF00018	0.653
LIG_SH3_3	849	855	PF00018	0.656
LIG_SUMO_SIM_anti_2	662	669	PF11976	0.625
LIG_SUMO_SIM_par_1	382	387	PF11976	0.287
LIG_SUMO_SIM_par_1	653	658	PF11976	0.641
LIG_TRAF2_1	396	399	PF00917	0.385
LIG_TRAF2_1	814	817	PF00917	0.592
LIG_TRFH_1	411	415	PF08558	0.368
LIG_TYR_ITIM	348	353	PF00017	0.342
LIG_UBA3_1	100	108	PF00899	0.452
LIG_WRC_WIRS_1	485	490	PF05994	0.687
LIG_WW_3	531	535	PF00397	0.637
MOD_CDK_SPK_2	671	676	PF00069	0.692
MOD_CDK_SPxK_1	671	677	PF00069	0.573
MOD_CDK_SPxxK_3	393	400	PF00069	0.385
MOD_CK1_1	139	145	PF00069	0.659
MOD_CK1_1	176	182	PF00069	0.625
MOD_CK1_1	185	191	PF00069	0.628
MOD_CK1_1	196	202	PF00069	0.554
MOD_CK1_1	222	228	PF00069	0.695
MOD_CK1_1	450	456	PF00069	0.661
MOD_CK1_1	484	490	PF00069	0.633
MOD_CK1_1	522	528	PF00069	0.633
MOD_CK1_1	543	549	PF00069	0.630
MOD_CK1_1	577	583	PF00069	0.558
MOD_CK1_1	669	675	PF00069	0.627
MOD_CK1_1	715	721	PF00069	0.703
MOD_CK1_1	728	734	PF00069	0.582
MOD_CK1_1	750	756	PF00069	0.617
MOD_CK1_1	774	780	PF00069	0.698
MOD_CK1_1	788	794	PF00069	0.553
MOD_CK1_1	810	816	PF00069	0.690
MOD_CK1_1	856	862	PF00069	0.682
MOD_CK1_1	90	96	PF00069	0.401
MOD_CK2_1	142	148	PF00069	0.665
MOD_CK2_1	189	195	PF00069	0.651
MOD_CK2_1	393	399	PF00069	0.385
MOD_CK2_1	415	421	PF00069	0.541
MOD_CK2_1	513	519	PF00069	0.724
MOD_CK2_1	811	817	PF00069	0.636
MOD_Cter_Amidation	459	462	PF01082	0.636
MOD_DYRK1A_RPxSP_1	771	775	PF00069	0.636
MOD_GlcNHglycan	112	115	PF01048	0.363
MOD_GlcNHglycan	133	136	PF01048	0.612
MOD_GlcNHglycan	171	174	PF01048	0.673
MOD_GlcNHglycan	189	192	PF01048	0.766
MOD_GlcNHglycan	489	492	PF01048	0.682
MOD_GlcNHglycan	501	505	PF01048	0.610
MOD_GlcNHglycan	512	518	PF01048	0.609
MOD_GlcNHglycan	542	545	PF01048	0.673
MOD_GlcNHglycan	549	552	PF01048	0.637
MOD_GlcNHglycan	576	579	PF01048	0.623
MOD_GlcNHglycan	668	671	PF01048	0.690
MOD_GlcNHglycan	717	720	PF01048	0.661
MOD_GSK3_1	100	107	PF00069	0.447
MOD_GSK3_1	131	138	PF00069	0.580
MOD_GSK3_1	165	172	PF00069	0.689
MOD_GSK3_1	181	188	PF00069	0.634
MOD_GSK3_1	189	196	PF00069	0.650
MOD_GSK3_1	2	9	PF00069	0.610
MOD_GSK3_1	219	226	PF00069	0.721
MOD_GSK3_1	247	254	PF00069	0.585
MOD_GSK3_1	298	305	PF00069	0.385
MOD_GSK3_1	522	529	PF00069	0.699
MOD_GSK3_1	536	543	PF00069	0.572
MOD_GSK3_1	545	552	PF00069	0.650
MOD_GSK3_1	559	566	PF00069	0.549
MOD_GSK3_1	568	575	PF00069	0.590
MOD_GSK3_1	655	662	PF00069	0.659
MOD_GSK3_1	665	672	PF00069	0.604
MOD_GSK3_1	710	717	PF00069	0.665
MOD_GSK3_1	721	728	PF00069	0.633
MOD_GSK3_1	747	754	PF00069	0.645
MOD_GSK3_1	758	765	PF00069	0.562
MOD_GSK3_1	767	774	PF00069	0.565
MOD_GSK3_1	784	791	PF00069	0.573
MOD_GSK3_1	807	814	PF00069	0.601
MOD_GSK3_1	838	845	PF00069	0.639
MOD_GSK3_1	853	860	PF00069	0.571
MOD_GSK3_1	924	931	PF00069	0.552
MOD_N-GLC_1	104	109	PF02516	0.337
MOD_N-GLC_1	139	144	PF02516	0.569
MOD_N-GLC_1	725	730	PF02516	0.669
MOD_N-GLC_1	857	862	PF02516	0.663
MOD_N-GLC_1	90	95	PF02516	0.419
MOD_NEK2_1	1	6	PF00069	0.657
MOD_NEK2_1	110	115	PF00069	0.433
MOD_NEK2_1	182	187	PF00069	0.626
MOD_NEK2_1	247	252	PF00069	0.581
MOD_NEK2_1	298	303	PF00069	0.462
MOD_NEK2_1	318	323	PF00069	0.210
MOD_NEK2_1	558	563	PF00069	0.639
MOD_NEK2_1	871	876	PF00069	0.665
MOD_NEK2_2	362	367	PF00069	0.385
MOD_NEK2_2	549	554	PF00069	0.656
MOD_NEK2_2	815	820	PF00069	0.694
MOD_NEK2_2	832	837	PF00069	0.533
MOD_NEK2_2	842	847	PF00069	0.584
MOD_PIKK_1	193	199	PF00454	0.657
MOD_PIKK_1	624	630	PF00454	0.585
MOD_PIKK_1	710	716	PF00454	0.693
MOD_PKA_1	157	163	PF00069	0.671
MOD_PKA_1	721	727	PF00069	0.600
MOD_PKA_2	298	304	PF00069	0.385
MOD_PKA_2	318	324	PF00069	0.199
MOD_PKA_2	374	380	PF00069	0.426
MOD_PKA_2	437	443	PF00069	0.540
MOD_PKA_2	522	528	PF00069	0.690
MOD_PKA_2	721	727	PF00069	0.600
MOD_PKA_2	853	859	PF00069	0.638
MOD_PKA_2	924	930	PF00069	0.495
MOD_PKB_1	436	444	PF00069	0.540
MOD_PKB_1	720	728	PF00069	0.654
MOD_Plk_1	725	731	PF00069	0.669
MOD_Plk_1	785	791	PF00069	0.686
MOD_Plk_1	857	863	PF00069	0.659
MOD_Plk_1	90	96	PF00069	0.401
MOD_Plk_2-3	200	206	PF00069	0.603
MOD_Plk_4	173	179	PF00069	0.701
MOD_Plk_4	256	262	PF00069	0.363
MOD_Plk_4	447	453	PF00069	0.658
MOD_Plk_4	481	487	PF00069	0.689
MOD_Plk_4	646	652	PF00069	0.598
MOD_Plk_4	754	760	PF00069	0.621
MOD_Plk_4	762	768	PF00069	0.569
MOD_Plk_4	785	791	PF00069	0.686
MOD_Plk_4	842	848	PF00069	0.643
MOD_Plk_4	857	863	PF00069	0.574
MOD_Plk_4	90	96	PF00069	0.445
MOD_Plk_4	915	921	PF00069	0.559
MOD_ProDKin_1	185	191	PF00069	0.649
MOD_ProDKin_1	220	226	PF00069	0.658
MOD_ProDKin_1	234	240	PF00069	0.539
MOD_ProDKin_1	393	399	PF00069	0.385
MOD_ProDKin_1	476	482	PF00069	0.651
MOD_ProDKin_1	545	551	PF00069	0.680
MOD_ProDKin_1	564	570	PF00069	0.534
MOD_ProDKin_1	671	677	PF00069	0.660
MOD_ProDKin_1	712	718	PF00069	0.652
MOD_ProDKin_1	747	753	PF00069	0.620
MOD_ProDKin_1	771	777	PF00069	0.637
MOD_ProDKin_1	811	817	PF00069	0.595
MOD_ProDKin_1	838	844	PF00069	0.606
MOD_SUMO_for_1	151	154	PF00179	0.613
MOD_SUMO_for_1	633	636	PF00179	0.575
TRG_DiLeu_BaEn_1	619	624	PF01217	0.596
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.385
TRG_DiLeu_BaLyEn_6	643	648	PF01217	0.537
TRG_ENDOCYTIC_2	350	353	PF00928	0.385
TRG_ENDOCYTIC_2	607	610	PF00928	0.605
TRG_ENDOCYTIC_2	95	98	PF00928	0.498
TRG_ER_diArg_1	32	35	PF00400	0.450
TRG_ER_diArg_1	355	358	PF00400	0.366
TRG_ER_diArg_1	373	376	PF00400	0.238
TRG_ER_diArg_1	435	438	PF00400	0.514
TRG_ER_diArg_1	461	464	PF00400	0.662
TRG_ER_diArg_1	630	632	PF00400	0.489
TRG_ER_diArg_1	720	722	PF00400	0.704
TRG_ER_diArg_1	830	832	PF00400	0.667
TRG_ER_diArg_1	881	884	PF00400	0.631
TRG_NLS_MonoExtN_4	608	615	PF00514	0.488
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HCF9	Leishmania braziliensis	62%	99%
A4HZY8	Leishmania infantum	100%	100%
E9AVU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	95%
Q4QBN0	Leishmania major	87%	99%