Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBH3_LEIDO

TriTrypDb:

LdBPK_200420.1 , LdCL_200008900 , LDHU3_20.0490

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 16, no: 2
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

A0A3Q8IBH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBH3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.423
CLV_C14_Caspase3-7	277	281	PF00656	0.666
CLV_C14_Caspase3-7	309	313	PF00656	0.621
CLV_PCSK_KEX2_1	2	4	PF00082	0.710
CLV_PCSK_KEX2_1	263	265	PF00082	0.413
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.702
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.355
DEG_Nend_UBRbox_1	1	4	PF02207	0.613
DOC_CYCLIN_yClb1_LxF_4	110	116	PF00134	0.440
DOC_MAPK_gen_1	7	15	PF00069	0.281
DOC_MAPK_MEF2A_6	9	17	PF00069	0.323
DOC_WW_Pin1_4	1	6	PF00397	0.639
DOC_WW_Pin1_4	293	298	PF00397	0.727
LIG_14-3-3_CanoR_1	27	32	PF00244	0.155
LIG_14-3-3_CanoR_1	36	43	PF00244	0.191
LIG_14-3-3_CanoR_1	7	15	PF00244	0.357
LIG_Actin_WH2_2	112	128	PF00022	0.410
LIG_eIF4E_1	209	215	PF01652	0.404
LIG_FHA_1	172	178	PF00498	0.308
LIG_FHA_1	21	27	PF00498	0.375
LIG_FHA_1	8	14	PF00498	0.307
LIG_FHA_2	191	197	PF00498	0.376
LIG_FHA_2	275	281	PF00498	0.652
LIG_LIR_Gen_1	131	142	PF02991	0.431
LIG_LIR_Nem_3	114	120	PF02991	0.311
LIG_LIR_Nem_3	131	137	PF02991	0.429
LIG_LIR_Nem_3	179	183	PF02991	0.302
LIG_LIR_Nem_3	189	194	PF02991	0.364
LIG_NRBOX	13	19	PF00104	0.428
LIG_PCNA_yPIPBox_3	165	173	PF02747	0.403
LIG_Pex14_1	176	180	PF04695	0.245
LIG_SH2_CRK	117	121	PF00017	0.290
LIG_SH2_NCK_1	310	314	PF00017	0.612
LIG_SH2_SRC	183	186	PF00017	0.470
LIG_SH2_STAP1	173	177	PF00017	0.252
LIG_SH2_STAP1	29	33	PF00017	0.278
LIG_SH2_STAT3	172	175	PF00017	0.380
LIG_SH2_STAT3	181	184	PF00017	0.418
LIG_SH2_STAT3	50	53	PF00017	0.245
LIG_SH2_STAT5	173	176	PF00017	0.274
LIG_SH2_STAT5	261	264	PF00017	0.581
LIG_SH2_STAT5	50	53	PF00017	0.276
LIG_SH3_3	136	142	PF00018	0.238
LIG_SH3_3	189	195	PF00018	0.425
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.357
LIG_SUMO_SIM_par_1	238	244	PF11976	0.281
MOD_CDC14_SPxK_1	4	7	PF00782	0.441
MOD_CDK_SPxK_1	1	7	PF00069	0.475
MOD_CK1_1	186	192	PF00069	0.575
MOD_CK1_1	56	62	PF00069	0.364
MOD_CK1_1	89	95	PF00069	0.407
MOD_CK2_1	157	163	PF00069	0.316
MOD_CK2_1	308	314	PF00069	0.700
MOD_GlcNHglycan	37	40	PF01048	0.364
MOD_GlcNHglycan	54	58	PF01048	0.425
MOD_GlcNHglycan	69	72	PF01048	0.450
MOD_GlcNHglycan	91	94	PF01048	0.602
MOD_GSK3_1	186	193	PF00069	0.445
MOD_GSK3_1	3	10	PF00069	0.461
MOD_GSK3_1	63	70	PF00069	0.389
MOD_GSK3_1	89	96	PF00069	0.386
MOD_N-GLC_1	146	151	PF02516	0.585
MOD_N-GLC_1	97	102	PF02516	0.472
MOD_NEK2_1	20	25	PF00069	0.340
MOD_NEK2_2	121	126	PF00069	0.374
MOD_NEK2_2	302	307	PF00069	0.502
MOD_PIKK_1	171	177	PF00454	0.413
MOD_PIKK_1	216	222	PF00454	0.594
MOD_PIKK_1	284	290	PF00454	0.531
MOD_PK_1	27	33	PF00069	0.244
MOD_PKA_2	216	222	PF00069	0.557
MOD_PKA_2	35	41	PF00069	0.226
MOD_PKA_2	89	95	PF00069	0.553
MOD_Plk_1	111	117	PF00069	0.356
MOD_Plk_1	146	152	PF00069	0.574
MOD_Plk_1	186	192	PF00069	0.545
MOD_Plk_1	302	308	PF00069	0.608
MOD_Plk_1	97	103	PF00069	0.544
MOD_Plk_2-3	308	314	PF00069	0.646
MOD_Plk_4	111	117	PF00069	0.386
MOD_Plk_4	146	152	PF00069	0.519
MOD_Plk_4	168	174	PF00069	0.370
MOD_Plk_4	186	192	PF00069	0.399
MOD_Plk_4	56	62	PF00069	0.272
MOD_ProDKin_1	1	7	PF00069	0.635
MOD_ProDKin_1	293	299	PF00069	0.677
TRG_ENDOCYTIC_2	117	120	PF00928	0.344
TRG_ENDOCYTIC_2	134	137	PF00928	0.397
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P471	Leptomonas seymouri	66%	100%
A0A0N1I022	Leptomonas seymouri	35%	94%
A0A1X0NWG4	Trypanosomatidae	31%	88%
A0A1X0NWG7	Trypanosomatidae	34%	87%
A0A1X0NWG9	Trypanosomatidae	34%	88%
A0A1X0NXT1	Trypanosomatidae	34%	88%
A0A1X0NY10	Trypanosomatidae	32%	100%
A0A3S5H4S6	Leishmania donovani	36%	96%
A4H335	Leishmania braziliensis	35%	100%
A4HRC3	Leishmania infantum	36%	100%
A4HYN5	Leishmania infantum	98%	100%
E9ABZ0	Leishmania major	37%	100%
E9AI94	Leishmania braziliensis	74%	100%
E9AJ87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AUH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QD05	Leishmania major	96%	100%
V5DS51	Trypanosoma cruzi	32%	90%