Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBH2_LEIDO

TriTrypDb:

LdBPK_200050.1 , LdCL_200005400 , LDHU3_20.0060

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IBH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBH2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.513
CLV_NRD_NRD_1	124	126	PF00675	0.547
CLV_NRD_NRD_1	144	146	PF00675	0.424
CLV_NRD_NRD_1	197	199	PF00675	0.368
CLV_NRD_NRD_1	208	210	PF00675	0.392
CLV_NRD_NRD_1	245	247	PF00675	0.478
CLV_NRD_NRD_1	279	281	PF00675	0.556
CLV_NRD_NRD_1	46	48	PF00675	0.499
CLV_PCSK_FUR_1	277	281	PF00082	0.430
CLV_PCSK_KEX2_1	113	115	PF00082	0.552
CLV_PCSK_KEX2_1	123	125	PF00082	0.600
CLV_PCSK_KEX2_1	143	145	PF00082	0.434
CLV_PCSK_KEX2_1	18	20	PF00082	0.511
CLV_PCSK_KEX2_1	197	199	PF00082	0.391
CLV_PCSK_KEX2_1	208	210	PF00082	0.414
CLV_PCSK_KEX2_1	244	246	PF00082	0.488
CLV_PCSK_KEX2_1	279	281	PF00082	0.558
CLV_PCSK_KEX2_1	320	322	PF00082	0.680
CLV_PCSK_KEX2_1	46	48	PF00082	0.499
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.543
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.626
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.636
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.565
CLV_PCSK_PC7_1	140	146	PF00082	0.491
CLV_PCSK_PC7_1	316	322	PF00082	0.564
CLV_PCSK_SKI1_1	110	114	PF00082	0.480
CLV_PCSK_SKI1_1	197	201	PF00082	0.378
CLV_PCSK_SKI1_1	280	284	PF00082	0.507
DEG_Nend_Nbox_1	1	3	PF02207	0.470
DOC_MIT_MIM_1	254	264	PF04212	0.393
DOC_USP7_MATH_1	130	134	PF00917	0.535
DOC_USP7_MATH_1	74	78	PF00917	0.621
DOC_USP7_UBL2_3	268	272	PF12436	0.530
DOC_WW_Pin1_4	223	228	PF00397	0.348
LIG_14-3-3_CanoR_1	235	243	PF00244	0.582
LIG_14-3-3_CanoR_1	46	56	PF00244	0.486
LIG_14-3-3_CanoR_1	63	71	PF00244	0.454
LIG_AP2alpha_1	67	71	PF02296	0.542
LIG_APCC_ABBAyCdc20_2	197	203	PF00400	0.374
LIG_BRCT_BRCA1_1	178	182	PF00533	0.395
LIG_BRCT_BRCA1_1	54	58	PF00533	0.468
LIG_Clathr_ClatBox_1	155	159	PF01394	0.547
LIG_deltaCOP1_diTrp_1	39	45	PF00928	0.647
LIG_FHA_2	224	230	PF00498	0.515
LIG_LIR_Apic_2	97	103	PF02991	0.515
LIG_LIR_Gen_1	172	182	PF02991	0.375
LIG_LIR_Gen_1	216	227	PF02991	0.518
LIG_LIR_Gen_1	256	264	PF02991	0.509
LIG_LIR_Nem_3	216	222	PF02991	0.506
LIG_LIR_Nem_3	229	233	PF02991	0.328
LIG_LIR_Nem_3	256	261	PF02991	0.515
LIG_LIR_Nem_3	39	45	PF02991	0.633
LIG_MLH1_MIPbox_1	178	182	PF16413	0.395
LIG_Pex14_2	54	58	PF04695	0.601
LIG_Pex14_2	67	71	PF04695	0.649
LIG_RPA_C_Fungi	241	253	PF08784	0.505
LIG_SH2_SRC	100	103	PF00017	0.493
LIG_SH2_STAP1	258	262	PF00017	0.417
LIG_SH2_STAT5	134	137	PF00017	0.490
LIG_Sin3_3	286	293	PF02671	0.472
LIG_SUMO_SIM_par_1	154	159	PF11976	0.548
LIG_TRAF2_1	151	154	PF00917	0.540
LIG_UBA3_1	108	115	PF00899	0.556
MOD_CK1_1	133	139	PF00069	0.563
MOD_CK1_1	146	152	PF00069	0.272
MOD_CK1_1	220	226	PF00069	0.516
MOD_CK1_1	309	315	PF00069	0.619
MOD_CK1_1	37	43	PF00069	0.684
MOD_CK1_1	65	71	PF00069	0.586
MOD_CK1_1	76	82	PF00069	0.715
MOD_CK2_1	223	229	PF00069	0.482
MOD_CK2_1	33	39	PF00069	0.540
MOD_Cter_Amidation	195	198	PF01082	0.481
MOD_Cter_Amidation	318	321	PF01082	0.558
MOD_GlcNHglycan	178	181	PF01048	0.443
MOD_GlcNHglycan	193	197	PF01048	0.298
MOD_GlcNHglycan	2	5	PF01048	0.508
MOD_GlcNHglycan	64	67	PF01048	0.537
MOD_GlcNHglycan	80	83	PF01048	0.631
MOD_GlcNHglycan	90	93	PF01048	0.638
MOD_GSK3_1	169	176	PF00069	0.495
MOD_GSK3_1	217	224	PF00069	0.443
MOD_GSK3_1	306	313	PF00069	0.586
MOD_GSK3_1	33	40	PF00069	0.683
MOD_GSK3_1	52	59	PF00069	0.543
MOD_GSK3_1	70	77	PF00069	0.543
MOD_N-GLC_1	88	93	PF02516	0.565
MOD_NEK2_1	169	174	PF00069	0.489
MOD_NEK2_1	56	61	PF00069	0.526
MOD_NEK2_1	62	67	PF00069	0.547
MOD_PKA_1	143	149	PF00069	0.508
MOD_PKA_1	46	52	PF00069	0.608
MOD_PKA_2	130	136	PF00069	0.698
MOD_PKA_2	143	149	PF00069	0.379
MOD_PKA_2	46	52	PF00069	0.584
MOD_PKA_2	62	68	PF00069	0.405
MOD_PKB_1	171	179	PF00069	0.484
MOD_PKB_1	85	93	PF00069	0.570
MOD_Plk_4	130	136	PF00069	0.569
MOD_Plk_4	173	179	PF00069	0.424
MOD_ProDKin_1	223	229	PF00069	0.347
MOD_SUMO_rev_2	224	233	PF00179	0.524
TRG_DiLeu_BaEn_1	39	44	PF01217	0.564
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.490
TRG_ENDOCYTIC_2	258	261	PF00928	0.423
TRG_ER_diArg_1	124	126	PF00400	0.593
TRG_ER_diArg_1	143	145	PF00400	0.566
TRG_ER_diArg_1	171	174	PF00400	0.437
TRG_ER_diArg_1	243	246	PF00400	0.520
TRG_ER_diArg_1	277	280	PF00400	0.572
TRG_ER_diArg_1	45	47	PF00400	0.508
TRG_ER_diArg_1	84	87	PF00400	0.594
TRG_NLS_Bipartite_1	113	127	PF00514	0.572
TRG_NLS_MonoExtC_3	122	127	PF00514	0.512
TRG_NLS_MonoExtN_4	110	117	PF00514	0.362
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	198	203	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.659

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL4	Leptomonas seymouri	40%	100%
A0A1X0NX15	Trypanosomatidae	23%	100%
A0A3R7NEK1	Trypanosoma rangeli	26%	100%
A4HYJ7	Leishmania infantum	99%	100%
C9ZHU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AUE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q9BJ45	Leishmania major	87%	100%
V5BAF9	Trypanosoma cruzi	25%	92%