Phosphorylated CTD interacting factor 1 WW domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphorylated CTD interacting factor 1 WW domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBG9_LEIDO

TriTrypDb:

LdBPK_242080.1 , LdCL_240026500 , LDHU3_24.2530

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IBG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBG9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000993	RNA polymerase II complex binding	5	11
GO:0001098	basal transcription machinery binding	3	11
GO:0001099	basal RNA polymerase II transcription machinery binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008168	methyltransferase activity	4	11
GO:0008173	RNA methyltransferase activity	4	11
GO:0008174	mRNA methyltransferase activity	5	11
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	11
GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	6	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0019899	enzyme binding	3	11
GO:0043175	RNA polymerase core enzyme binding	5	11
GO:0070063	RNA polymerase binding	4	11
GO:0099122	RNA polymerase II C-terminal domain binding	6	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.454
CLV_C14_Caspase3-7	5	9	PF00656	0.716
CLV_NRD_NRD_1	206	208	PF00675	0.500
CLV_NRD_NRD_1	238	240	PF00675	0.576
CLV_NRD_NRD_1	33	35	PF00675	0.384
CLV_NRD_NRD_1	490	492	PF00675	0.523
CLV_NRD_NRD_1	54	56	PF00675	0.517
CLV_PCSK_FUR_1	204	208	PF00082	0.551
CLV_PCSK_KEX2_1	179	181	PF00082	0.430
CLV_PCSK_KEX2_1	2	4	PF00082	0.598
CLV_PCSK_KEX2_1	206	208	PF00082	0.500
CLV_PCSK_KEX2_1	238	240	PF00082	0.575
CLV_PCSK_KEX2_1	33	35	PF00082	0.384
CLV_PCSK_KEX2_1	460	462	PF00082	0.429
CLV_PCSK_KEX2_1	490	492	PF00082	0.608
CLV_PCSK_KEX2_1	572	574	PF00082	0.516
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.430
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.598
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.483
CLV_PCSK_PC1ET2_1	572	574	PF00082	0.510
CLV_PCSK_SKI1_1	21	25	PF00082	0.332
CLV_PCSK_SKI1_1	276	280	PF00082	0.533
CLV_PCSK_SKI1_1	291	295	PF00082	0.233
CLV_PCSK_SKI1_1	34	38	PF00082	0.368
CLV_PCSK_SKI1_1	402	406	PF00082	0.347
CLV_PCSK_SKI1_1	460	464	PF00082	0.411
CLV_PCSK_SKI1_1	517	521	PF00082	0.654
CLV_PCSK_SKI1_1	572	576	PF00082	0.544
CLV_PCSK_SKI1_1	67	71	PF00082	0.351
DEG_APCC_DBOX_1	33	41	PF00400	0.450
DEG_Nend_UBRbox_1	1	4	PF02207	0.600
DEG_SPOP_SBC_1	128	132	PF00917	0.464
DEG_SPOP_SBC_1	470	474	PF00917	0.593
DOC_CKS1_1	214	219	PF01111	0.587
DOC_CKS1_1	339	344	PF01111	0.310
DOC_MAPK_gen_1	97	105	PF00069	0.361
DOC_MAPK_JIP1_4	402	408	PF00069	0.345
DOC_MAPK_MEF2A_6	243	250	PF00069	0.402
DOC_MAPK_MEF2A_6	402	410	PF00069	0.352
DOC_PP1_RVXF_1	282	289	PF00149	0.295
DOC_PP1_RVXF_1	45	52	PF00149	0.544
DOC_PP2B_LxvP_1	408	411	PF13499	0.372
DOC_PP2B_LxvP_1	446	449	PF13499	0.352
DOC_USP7_MATH_1	122	126	PF00917	0.698
DOC_USP7_MATH_1	128	132	PF00917	0.740
DOC_USP7_MATH_1	227	231	PF00917	0.476
DOC_USP7_MATH_1	304	308	PF00917	0.305
DOC_USP7_MATH_1	351	355	PF00917	0.473
DOC_USP7_MATH_1	431	435	PF00917	0.527
DOC_USP7_MATH_1	470	474	PF00917	0.584
DOC_USP7_MATH_1	522	526	PF00917	0.554
DOC_USP7_MATH_1	574	578	PF00917	0.558
DOC_WW_Pin1_4	193	198	PF00397	0.468
DOC_WW_Pin1_4	213	218	PF00397	0.314
DOC_WW_Pin1_4	330	335	PF00397	0.294
DOC_WW_Pin1_4	338	343	PF00397	0.294
DOC_WW_Pin1_4	473	478	PF00397	0.694
DOC_WW_Pin1_4	565	570	PF00397	0.520
DOC_WW_Pin1_4	582	587	PF00397	0.701
DOC_WW_Pin1_4	89	94	PF00397	0.630
LIG_14-3-3_CanoR_1	291	296	PF00244	0.337
LIG_14-3-3_CanoR_1	390	399	PF00244	0.406
LIG_14-3-3_CanoR_1	500	506	PF00244	0.556
LIG_Clathr_ClatBox_1	405	409	PF01394	0.340
LIG_deltaCOP1_diTrp_1	526	535	PF00928	0.388
LIG_FHA_1	196	202	PF00498	0.415
LIG_FHA_1	292	298	PF00498	0.273
LIG_FHA_1	303	309	PF00498	0.314
LIG_FHA_1	405	411	PF00498	0.373
LIG_FHA_1	464	470	PF00498	0.671
LIG_FHA_1	555	561	PF00498	0.367
LIG_FHA_2	141	147	PF00498	0.443
LIG_FHA_2	553	559	PF00498	0.389
LIG_LIR_Apic_2	497	502	PF02991	0.480
LIG_LIR_Apic_2	576	582	PF02991	0.567
LIG_LIR_Gen_1	249	260	PF02991	0.479
LIG_LIR_Gen_1	418	428	PF02991	0.348
LIG_LIR_Gen_1	443	450	PF02991	0.327
LIG_LIR_Gen_1	525	536	PF02991	0.401
LIG_LIR_Nem_3	374	380	PF02991	0.314
LIG_LIR_Nem_3	418	424	PF02991	0.345
LIG_LIR_Nem_3	443	447	PF02991	0.329
LIG_LIR_Nem_3	525	531	PF02991	0.395
LIG_LIR_Nem_3	537	543	PF02991	0.383
LIG_LIR_Nem_3	576	581	PF02991	0.565
LIG_NRBOX	415	421	PF00104	0.461
LIG_PCNA_yPIPBox_3	55	69	PF02747	0.391
LIG_Pex14_2	366	370	PF04695	0.294
LIG_Pex14_2	531	535	PF04695	0.377
LIG_SH2_CRK	499	503	PF00017	0.485
LIG_SH2_NCK_1	160	164	PF00017	0.383
LIG_SH2_PTP2	444	447	PF00017	0.314
LIG_SH2_PTP2	579	582	PF00017	0.437
LIG_SH2_STAP1	144	148	PF00017	0.410
LIG_SH2_STAP1	392	396	PF00017	0.483
LIG_SH2_STAP1	412	416	PF00017	0.235
LIG_SH2_STAT3	144	147	PF00017	0.419
LIG_SH2_STAT5	376	379	PF00017	0.316
LIG_SH2_STAT5	444	447	PF00017	0.318
LIG_SH2_STAT5	542	545	PF00017	0.354
LIG_SH2_STAT5	579	582	PF00017	0.496
LIG_SH3_3	228	234	PF00018	0.408
LIG_SH3_3	245	251	PF00018	0.285
LIG_SH3_3	393	399	PF00018	0.524
LIG_SH3_3	73	79	PF00018	0.543
LIG_SUMO_SIM_anti_2	22	27	PF11976	0.431
LIG_SUMO_SIM_anti_2	443	449	PF11976	0.322
LIG_SUMO_SIM_par_1	402	407	PF11976	0.347
LIG_TYR_ITIM	442	447	PF00017	0.392
LIG_WRC_WIRS_1	575	580	PF05994	0.443
MOD_CDK_SPxxK_3	565	572	PF00069	0.506
MOD_CK1_1	153	159	PF00069	0.469
MOD_CK1_1	266	272	PF00069	0.498
MOD_CK1_1	379	385	PF00069	0.294
MOD_CK1_1	472	478	PF00069	0.677
MOD_CK1_1	89	95	PF00069	0.625
MOD_CK2_1	140	146	PF00069	0.575
MOD_CK2_1	501	507	PF00069	0.516
MOD_CK2_1	552	558	PF00069	0.397
MOD_GlcNHglycan	107	110	PF01048	0.442
MOD_GlcNHglycan	125	128	PF01048	0.540
MOD_GlcNHglycan	161	164	PF01048	0.539
MOD_GlcNHglycan	279	282	PF01048	0.539
MOD_GlcNHglycan	367	370	PF01048	0.296
MOD_GlcNHglycan	381	384	PF01048	0.294
MOD_GlcNHglycan	429	432	PF01048	0.557
MOD_GlcNHglycan	477	480	PF01048	0.659
MOD_GlcNHglycan	93	96	PF01048	0.692
MOD_GSK3_1	123	130	PF00069	0.705
MOD_GSK3_1	427	434	PF00069	0.440
MOD_GSK3_1	469	476	PF00069	0.684
MOD_GSK3_1	581	588	PF00069	0.675
MOD_N-GLC_1	156	161	PF02516	0.517
MOD_N-GLC_1	173	178	PF02516	0.390
MOD_NEK2_1	1	6	PF00069	0.711
MOD_NEK2_1	432	437	PF00069	0.592
MOD_NEK2_1	463	468	PF00069	0.548
MOD_NEK2_1	543	548	PF00069	0.513
MOD_NEK2_2	574	579	PF00069	0.486
MOD_PIKK_1	195	201	PF00454	0.467
MOD_PIKK_1	68	74	PF00454	0.403
MOD_PK_1	150	156	PF00069	0.428
MOD_PKA_1	2	8	PF00069	0.722
MOD_PKA_2	2	8	PF00069	0.722
MOD_Plk_1	150	156	PF00069	0.383
MOD_Plk_1	173	179	PF00069	0.564
MOD_Plk_1	227	233	PF00069	0.433
MOD_Plk_2-3	140	146	PF00069	0.595
MOD_Plk_4	130	136	PF00069	0.546
MOD_Plk_4	291	297	PF00069	0.353
MOD_Plk_4	574	580	PF00069	0.420
MOD_ProDKin_1	193	199	PF00069	0.470
MOD_ProDKin_1	213	219	PF00069	0.304
MOD_ProDKin_1	330	336	PF00069	0.294
MOD_ProDKin_1	338	344	PF00069	0.294
MOD_ProDKin_1	473	479	PF00069	0.686
MOD_ProDKin_1	565	571	PF00069	0.509
MOD_ProDKin_1	582	588	PF00069	0.702
MOD_ProDKin_1	89	95	PF00069	0.621
MOD_SUMO_for_1	456	459	PF00179	0.477
MOD_SUMO_rev_2	394	404	PF00179	0.405
TRG_DiLeu_BaLyEn_6	400	405	PF01217	0.479
TRG_ENDOCYTIC_2	262	265	PF00928	0.387
TRG_ENDOCYTIC_2	325	328	PF00928	0.316
TRG_ENDOCYTIC_2	444	447	PF00928	0.314
TRG_ENDOCYTIC_2	540	543	PF00928	0.348
TRG_ER_diArg_1	203	206	PF00400	0.524
TRG_ER_diArg_1	237	239	PF00400	0.547
TRG_ER_diArg_1	32	34	PF00400	0.369
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	284	289	PF00026	0.295

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II31	Leptomonas seymouri	65%	98%
A0A1X0NXA7	Trypanosomatidae	46%	100%
A0A422NWV1	Trypanosoma rangeli	47%	100%
A4HDR2	Leishmania braziliensis	84%	100%
A4I108	Leishmania infantum	100%	100%
C9ZWA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AX46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QAD0	Leishmania major	94%	100%
V5BAG8	Trypanosoma cruzi	46%	100%