UDP-galactose_transporter_putative/GeneDB:LmjF.22.1010

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-galactose transporter, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBG5_LEIDO

TriTrypDb:

LdBPK_220830.1 , LdCL_220015700 , LDHU3_22.1340

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	10
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3Q8IBG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBG5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0009987	cellular process	1	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0055085	transmembrane transport	2	10
GO:0006811	monoatomic ion transport	4	1
GO:0006820	monoatomic anion transport	5	1
GO:0015711	organic anion transport	5	1
GO:0015780	nucleotide-sugar transmembrane transport	3	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072334	UDP-galactose transmembrane transport	5	1
GO:0090481	pyrimidine nucleotide-sugar transmembrane transport	4	1
GO:0098656	monoatomic anion transmembrane transport	4	1
GO:1901264	carbohydrate derivative transport	5	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	1
GO:0005459	UDP-galactose transmembrane transporter activity	6	1
GO:0005460	UDP-glucose transmembrane transporter activity	6	1
GO:0008509	monoatomic anion transmembrane transporter activity	4	1
GO:0008514	organic anion transmembrane transporter activity	5	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.686
CLV_NRD_NRD_1	154	156	PF00675	0.426
CLV_NRD_NRD_1	188	190	PF00675	0.445
CLV_NRD_NRD_1	213	215	PF00675	0.462
CLV_NRD_NRD_1	266	268	PF00675	0.515
CLV_NRD_NRD_1	454	456	PF00675	0.316
CLV_PCSK_KEX2_1	103	105	PF00082	0.686
CLV_PCSK_KEX2_1	154	156	PF00082	0.427
CLV_PCSK_KEX2_1	188	190	PF00082	0.445
CLV_PCSK_KEX2_1	213	215	PF00082	0.462
CLV_PCSK_KEX2_1	266	268	PF00082	0.511
CLV_PCSK_KEX2_1	320	322	PF00082	0.296
CLV_PCSK_KEX2_1	507	509	PF00082	0.503
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.296
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.398
CLV_PCSK_SKI1_1	168	172	PF00082	0.502
CLV_PCSK_SKI1_1	266	270	PF00082	0.507
CLV_PCSK_SKI1_1	48	52	PF00082	0.330
CLV_PCSK_SKI1_1	75	79	PF00082	0.516
DEG_APCC_DBOX_1	331	339	PF00400	0.458
DEG_SPOP_SBC_1	277	281	PF00917	0.296
DEG_SPOP_SBC_1	288	292	PF00917	0.219
DEG_SPOP_SBC_1	520	524	PF00917	0.745
DOC_CKS1_1	16	21	PF01111	0.733
DOC_CYCLIN_yClb5_NLxxxL_5	330	339	PF00134	0.363
DOC_MAPK_gen_1	213	221	PF00069	0.262
DOC_MAPK_gen_1	224	234	PF00069	0.316
DOC_MAPK_gen_1	246	254	PF00069	0.508
DOC_MAPK_gen_1	320	329	PF00069	0.529
DOC_MAPK_gen_1	455	462	PF00069	0.262
DOC_MAPK_HePTP_8	221	233	PF00069	0.316
DOC_MAPK_MEF2A_6	224	233	PF00069	0.316
DOC_MAPK_MEF2A_6	323	331	PF00069	0.529
DOC_MAPK_MEF2A_6	455	464	PF00069	0.262
DOC_PP1_RVXF_1	405	412	PF00149	0.210
DOC_USP7_MATH_1	110	114	PF00917	0.472
DOC_USP7_MATH_1	140	144	PF00917	0.448
DOC_USP7_MATH_1	172	176	PF00917	0.693
DOC_USP7_MATH_1	272	276	PF00917	0.267
DOC_USP7_MATH_1	288	292	PF00917	0.235
DOC_USP7_MATH_1	369	373	PF00917	0.288
DOC_USP7_MATH_1	518	522	PF00917	0.728
DOC_USP7_MATH_1	542	546	PF00917	0.702
DOC_WW_Pin1_4	15	20	PF00397	0.700
DOC_WW_Pin1_4	30	35	PF00397	0.673
DOC_WW_Pin1_4	516	521	PF00397	0.722
DOC_WW_Pin1_4	529	534	PF00397	0.755
DOC_WW_Pin1_4	572	577	PF00397	0.758
LIG_14-3-3_CanoR_1	11	17	PF00244	0.708
LIG_14-3-3_CanoR_1	154	158	PF00244	0.586
LIG_14-3-3_CanoR_1	213	218	PF00244	0.333
LIG_Actin_WH2_2	138	156	PF00022	0.336
LIG_Actin_WH2_2	439	457	PF00022	0.316
LIG_Actin_WH2_2	485	502	PF00022	0.470
LIG_BIR_II_1	1	5	PF00653	0.755
LIG_BRCT_BRCA1_1	199	203	PF00533	0.458
LIG_BRCT_BRCA1_1	292	296	PF00533	0.318
LIG_BRCT_BRCA1_1	342	346	PF00533	0.438
LIG_Clathr_ClatBox_1	345	349	PF01394	0.341
LIG_deltaCOP1_diTrp_1	352	361	PF00928	0.305
LIG_EH1_1	295	303	PF00400	0.244
LIG_EVH1_1	16	20	PF00568	0.693
LIG_FHA_1	11	17	PF00498	0.750
LIG_FHA_1	132	138	PF00498	0.361
LIG_FHA_1	253	259	PF00498	0.330
LIG_FHA_1	26	32	PF00498	0.563
LIG_FHA_1	312	318	PF00498	0.462
LIG_FHA_1	331	337	PF00498	0.316
LIG_FHA_1	395	401	PF00498	0.323
LIG_FHA_1	437	443	PF00498	0.458
LIG_GBD_Chelix_1	52	60	PF00786	0.341
LIG_LIR_Gen_1	206	217	PF02991	0.340
LIG_LIR_Gen_1	32	43	PF02991	0.689
LIG_LIR_Gen_1	352	361	PF02991	0.300
LIG_LIR_Gen_1	406	416	PF02991	0.298
LIG_LIR_Gen_1	473	484	PF02991	0.419
LIG_LIR_Gen_1	489	499	PF02991	0.376
LIG_LIR_Nem_3	32	38	PF02991	0.667
LIG_LIR_Nem_3	352	358	PF02991	0.300
LIG_LIR_Nem_3	406	411	PF02991	0.275
LIG_LIR_Nem_3	441	446	PF02991	0.316
LIG_LIR_Nem_3	473	479	PF02991	0.358
LIG_LIR_Nem_3	489	494	PF02991	0.361
LIG_NRBOX	301	307	PF00104	0.380
LIG_NRBOX	423	429	PF00104	0.458
LIG_PAM2_1	18	30	PF00658	0.615
LIG_Pex14_1	357	361	PF04695	0.333
LIG_Pex14_2	199	203	PF04695	0.341
LIG_PTAP_UEV_1	19	24	PF05743	0.647
LIG_SH2_GRB2like	310	313	PF00017	0.523
LIG_SH2_GRB2like	491	494	PF00017	0.490
LIG_SH2_PTP2	491	494	PF00017	0.490
LIG_SH2_SRC	491	494	PF00017	0.490
LIG_SH2_STAT5	124	127	PF00017	0.418
LIG_SH2_STAT5	310	313	PF00017	0.523
LIG_SH2_STAT5	491	494	PF00017	0.490
LIG_SH2_STAT5	81	84	PF00017	0.411
LIG_SH3_1	14	20	PF00018	0.694
LIG_SH3_2	20	25	PF14604	0.647
LIG_SH3_3	114	120	PF00018	0.475
LIG_SH3_3	14	20	PF00018	0.760
LIG_SH3_3	28	34	PF00018	0.646
LIG_SUMO_SIM_anti_2	46	53	PF11976	0.502
LIG_SUMO_SIM_par_1	216	222	PF11976	0.265
LIG_SUMO_SIM_par_1	346	352	PF11976	0.294
LIG_SUMO_SIM_par_1	444	449	PF11976	0.363
LIG_ULM_U2AF65_1	320	325	PF00076	0.529
LIG_Vh1_VBS_1	446	464	PF01044	0.346
LIG_WRC_WIRS_1	358	363	PF05994	0.333
LIG_WRC_WIRS_1	537	542	PF05994	0.626
MOD_CDC14_SPxK_1	575	578	PF00782	0.737
MOD_CDK_SPxK_1	572	578	PF00069	0.732
MOD_CK1_1	15	21	PF00069	0.727
MOD_CK1_1	156	162	PF00069	0.532
MOD_CK1_1	276	282	PF00069	0.323
MOD_CK1_1	290	296	PF00069	0.319
MOD_CK1_1	30	36	PF00069	0.627
MOD_CK1_1	362	368	PF00069	0.274
MOD_CK1_1	392	398	PF00069	0.325
MOD_CK1_1	426	432	PF00069	0.416
MOD_CK1_1	519	525	PF00069	0.719
MOD_CK1_1	545	551	PF00069	0.686
MOD_GlcNHglycan	142	145	PF01048	0.416
MOD_GlcNHglycan	163	166	PF01048	0.416
MOD_GlcNHglycan	20	23	PF01048	0.530
MOD_GlcNHglycan	270	273	PF01048	0.490
MOD_GlcNHglycan	275	278	PF01048	0.478
MOD_GlcNHglycan	35	38	PF01048	0.444
MOD_GlcNHglycan	367	370	PF01048	0.524
MOD_GlcNHglycan	393	397	PF01048	0.512
MOD_GlcNHglycan	428	431	PF01048	0.404
MOD_GlcNHglycan	472	475	PF01048	0.512
MOD_GlcNHglycan	524	527	PF01048	0.500
MOD_GlcNHglycan	540	543	PF01048	0.513
MOD_GlcNHglycan	549	553	PF01048	0.513
MOD_GlcNHglycan	85	88	PF01048	0.580
MOD_GSK3_1	129	136	PF00069	0.335
MOD_GSK3_1	25	32	PF00069	0.712
MOD_GSK3_1	268	275	PF00069	0.264
MOD_GSK3_1	276	283	PF00069	0.240
MOD_GSK3_1	287	294	PF00069	0.266
MOD_GSK3_1	330	337	PF00069	0.313
MOD_GSK3_1	353	360	PF00069	0.277
MOD_GSK3_1	365	372	PF00069	0.195
MOD_GSK3_1	438	445	PF00069	0.461
MOD_GSK3_1	456	463	PF00069	0.264
MOD_GSK3_1	514	521	PF00069	0.735
MOD_GSK3_1	538	545	PF00069	0.696
MOD_GSK3_1	88	95	PF00069	0.411
MOD_N-GLC_1	172	177	PF02516	0.506
MOD_N-GLC_1	272	277	PF02516	0.491
MOD_N-GLC_1	311	316	PF02516	0.262
MOD_N-GLC_1	529	534	PF02516	0.514
MOD_N-GLC_1	545	550	PF02516	0.438
MOD_N-GLC_2	181	183	PF02516	0.455
MOD_N-GLC_2	63	65	PF02516	0.416
MOD_NEK2_1	133	138	PF00069	0.440
MOD_NEK2_1	153	158	PF00069	0.605
MOD_NEK2_1	197	202	PF00069	0.397
MOD_NEK2_1	203	208	PF00069	0.409
MOD_NEK2_1	252	257	PF00069	0.421
MOD_NEK2_1	29	34	PF00069	0.657
MOD_NEK2_1	330	335	PF00069	0.354
MOD_NEK2_1	423	428	PF00069	0.409
MOD_NEK2_1	446	451	PF00069	0.334
MOD_NEK2_1	88	93	PF00069	0.434
MOD_NEK2_2	124	129	PF00069	0.395
MOD_NEK2_2	67	72	PF00069	0.363
MOD_PIKK_1	131	137	PF00454	0.463
MOD_PIKK_1	311	317	PF00454	0.462
MOD_PK_1	456	462	PF00069	0.280
MOD_PKA_1	213	219	PF00069	0.333
MOD_PKA_1	266	272	PF00069	0.210
MOD_PKA_2	10	16	PF00069	0.775
MOD_PKA_2	153	159	PF00069	0.575
MOD_PKA_2	213	219	PF00069	0.333
MOD_PKA_2	266	272	PF00069	0.294
MOD_PKA_2	389	395	PF00069	0.371
MOD_Plk_1	403	409	PF00069	0.363
MOD_Plk_1	495	501	PF00069	0.601
MOD_Plk_4	124	130	PF00069	0.303
MOD_Plk_4	148	154	PF00069	0.546
MOD_Plk_4	181	187	PF00069	0.641
MOD_Plk_4	291	297	PF00069	0.373
MOD_Plk_4	325	331	PF00069	0.507
MOD_Plk_4	334	340	PF00069	0.311
MOD_Plk_4	423	429	PF00069	0.324
MOD_Plk_4	449	455	PF00069	0.316
MOD_Plk_4	456	462	PF00069	0.262
MOD_ProDKin_1	15	21	PF00069	0.699
MOD_ProDKin_1	30	36	PF00069	0.669
MOD_ProDKin_1	516	522	PF00069	0.725
MOD_ProDKin_1	529	535	PF00069	0.754
MOD_ProDKin_1	572	578	PF00069	0.761
MOD_SUMO_for_1	71	74	PF00179	0.291
TRG_ENDOCYTIC_2	209	212	PF00928	0.326
TRG_ENDOCYTIC_2	491	494	PF00928	0.490
TRG_ENDOCYTIC_2	537	540	PF00928	0.724
TRG_ER_diArg_1	153	155	PF00400	0.618
TRG_ER_diArg_1	212	214	PF00400	0.262
TRG_ER_diArg_1	239	242	PF00400	0.535
TRG_ER_diArg_1	266	268	PF00400	0.311
TRG_ER_diArg_1	321	324	PF00400	0.563
TRG_ER_diLys_1	578	583	PF00400	0.798

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7F6	Leptomonas seymouri	50%	100%
A0A1X0NV21	Trypanosomatidae	37%	100%
A0A422N3L8	Trypanosoma rangeli	36%	100%
A4HCB7	Leishmania braziliensis	69%	98%
A4HZX4	Leishmania infantum	100%	100%
C9ZSL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AVT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
P0CP32	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	28%	100%
P0CP33	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	28%	100%
Q4QBP6	Leishmania major	88%	98%