Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBG2_LEIDO

TriTrypDb:

LdBPK_291290.1 , LdCL_290018000 , LDHU3_29.1780

Length:

603

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 1
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3Q8IBG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBG2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.501
CLV_C14_Caspase3-7	115	119	PF00656	0.457
CLV_C14_Caspase3-7	235	239	PF00656	0.551
CLV_NRD_NRD_1	123	125	PF00675	0.719
CLV_NRD_NRD_1	191	193	PF00675	0.672
CLV_NRD_NRD_1	210	212	PF00675	0.694
CLV_NRD_NRD_1	287	289	PF00675	0.719
CLV_NRD_NRD_1	309	311	PF00675	0.693
CLV_NRD_NRD_1	449	451	PF00675	0.487
CLV_NRD_NRD_1	480	482	PF00675	0.521
CLV_NRD_NRD_1	487	489	PF00675	0.439
CLV_NRD_NRD_1	49	51	PF00675	0.641
CLV_PCSK_FUR_1	47	51	PF00082	0.601
CLV_PCSK_FUR_1	478	482	PF00082	0.402
CLV_PCSK_KEX2_1	123	125	PF00082	0.730
CLV_PCSK_KEX2_1	193	195	PF00082	0.681
CLV_PCSK_KEX2_1	210	212	PF00082	0.694
CLV_PCSK_KEX2_1	287	289	PF00082	0.719
CLV_PCSK_KEX2_1	449	451	PF00082	0.487
CLV_PCSK_KEX2_1	480	482	PF00082	0.516
CLV_PCSK_KEX2_1	486	488	PF00082	0.457
CLV_PCSK_KEX2_1	49	51	PF00082	0.641
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.730
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.677
CLV_PCSK_SKI1_1	14	18	PF00082	0.622
CLV_PCSK_SKI1_1	481	485	PF00082	0.529
CLV_PCSK_SKI1_1	506	510	PF00082	0.385
CLV_PCSK_SKI1_1	55	59	PF00082	0.635
CLV_PCSK_SKI1_1	569	573	PF00082	0.420
CLV_PCSK_SKI1_1	590	594	PF00082	0.535
DEG_APCC_DBOX_1	13	21	PF00400	0.474
DEG_APCC_DBOX_1	191	199	PF00400	0.479
DEG_APCC_DBOX_1	505	513	PF00400	0.385
DEG_SPOP_SBC_1	434	438	PF00917	0.659
DOC_CYCLIN_yClb5_NLxxxL_5	194	202	PF00134	0.490
DOC_CYCLIN_yCln2_LP_2	179	185	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	555	561	PF00134	0.385
DOC_MAPK_gen_1	192	201	PF00069	0.506
DOC_MAPK_gen_1	504	513	PF00069	0.455
DOC_MAPK_MEF2A_6	14	22	PF00069	0.473
DOC_MAPK_MEF2A_6	504	513	PF00069	0.385
DOC_MAPK_NFAT4_5	504	512	PF00069	0.385
DOC_PP2B_LxvP_1	179	182	PF13499	0.553
DOC_PP2B_LxvP_1	555	558	PF13499	0.385
DOC_PP4_FxxP_1	541	544	PF00568	0.373
DOC_SPAK_OSR1_1	488	492	PF12202	0.594
DOC_USP7_MATH_1	167	171	PF00917	0.482
DOC_USP7_MATH_1	250	254	PF00917	0.566
DOC_USP7_MATH_1	346	350	PF00917	0.478
DOC_USP7_MATH_1	394	398	PF00917	0.754
DOC_USP7_MATH_1	433	437	PF00917	0.737
DOC_USP7_MATH_1	439	443	PF00917	0.720
DOC_WW_Pin1_4	398	403	PF00397	0.732
DOC_WW_Pin1_4	415	420	PF00397	0.755
DOC_WW_Pin1_4	435	440	PF00397	0.703
DOC_WW_Pin1_4	449	454	PF00397	0.668
DOC_WW_Pin1_4	494	499	PF00397	0.618
LIG_14-3-3_CanoR_1	145	150	PF00244	0.497
LIG_14-3-3_CanoR_1	244	251	PF00244	0.495
LIG_14-3-3_CanoR_1	488	498	PF00244	0.641
LIG_14-3-3_CanoR_1	8	15	PF00244	0.567
LIG_Actin_WH2_2	554	571	PF00022	0.385
LIG_BIR_II_1	1	5	PF00653	0.558
LIG_BIR_III_1	1	5	PF00653	0.492
LIG_BIR_III_3	1	5	PF00653	0.492
LIG_BIR_III_4	382	386	PF00653	0.691
LIG_deltaCOP1_diTrp_1	363	372	PF00928	0.664
LIG_EH1_1	350	358	PF00400	0.342
LIG_EVH1_1	69	73	PF00568	0.411
LIG_FAT_LD_1	195	203	PF03623	0.458
LIG_FHA_1	240	246	PF00498	0.507
LIG_FHA_1	293	299	PF00498	0.505
LIG_FHA_1	320	326	PF00498	0.468
LIG_FHA_1	340	346	PF00498	0.309
LIG_FHA_1	435	441	PF00498	0.644
LIG_FHA_2	403	409	PF00498	0.770
LIG_GBD_Chelix_1	513	521	PF00786	0.363
LIG_LIR_Gen_1	322	331	PF02991	0.471
LIG_LIR_Gen_1	342	352	PF02991	0.448
LIG_LIR_Gen_1	499	509	PF02991	0.493
LIG_LIR_Gen_1	552	562	PF02991	0.423
LIG_LIR_Gen_1	91	101	PF02991	0.412
LIG_LIR_LC3C_4	552	557	PF02991	0.385
LIG_LIR_Nem_3	322	327	PF02991	0.563
LIG_LIR_Nem_3	342	347	PF02991	0.442
LIG_LIR_Nem_3	499	505	PF02991	0.493
LIG_LIR_Nem_3	520	525	PF02991	0.554
LIG_LIR_Nem_3	552	557	PF02991	0.380
LIG_LIR_Nem_3	91	96	PF02991	0.414
LIG_NBox_RRM_1	343	353	PF00076	0.342
LIG_NRBOX	194	200	PF00104	0.483
LIG_NRBOX	504	510	PF00104	0.385
LIG_Pex14_1	269	273	PF04695	0.468
LIG_Pex14_1	339	343	PF04695	0.342
LIG_Pex14_2	542	546	PF04695	0.363
LIG_REV1ctd_RIR_1	4	12	PF16727	0.538
LIG_REV1ctd_RIR_1	499	508	PF16727	0.493
LIG_RPA_C_Fungi	482	494	PF08784	0.497
LIG_SH2_CRK	223	227	PF00017	0.622
LIG_SH2_CRK	457	461	PF00017	0.641
LIG_SH2_PTP2	344	347	PF00017	0.265
LIG_SH2_STAP1	529	533	PF00017	0.501
LIG_SH2_STAT5	324	327	PF00017	0.534
LIG_SH2_STAT5	344	347	PF00017	0.320
LIG_SH2_STAT5	554	557	PF00017	0.414
LIG_SH2_STAT5	93	96	PF00017	0.489
LIG_SH3_3	147	153	PF00018	0.625
LIG_SH3_3	29	35	PF00018	0.525
LIG_SH3_3	303	309	PF00018	0.579
LIG_SH3_3	67	73	PF00018	0.535
LIG_Sin3_3	23	30	PF02671	0.413
LIG_TRAF2_1	574	577	PF00917	0.518
LIG_TYR_ITSM	340	347	PF00017	0.320
LIG_UBA3_1	500	504	PF00899	0.385
LIG_UBA3_1	561	569	PF00899	0.471
LIG_WRC_WIRS_1	578	583	PF05994	0.507
MOD_CK1_1	253	259	PF00069	0.711
MOD_CK1_1	377	383	PF00069	0.642
MOD_CK1_1	38	44	PF00069	0.528
MOD_CK1_1	397	403	PF00069	0.646
MOD_CK1_1	413	419	PF00069	0.730
MOD_CK1_1	420	426	PF00069	0.673
MOD_CK1_1	438	444	PF00069	0.563
MOD_CK2_1	145	151	PF00069	0.654
MOD_CK2_1	402	408	PF00069	0.699
MOD_CK2_1	570	576	PF00069	0.458
MOD_CK2_1	89	95	PF00069	0.377
MOD_CMANNOS	519	522	PF00535	0.385
MOD_Cter_Amidation	447	450	PF01082	0.609
MOD_GlcNHglycan	157	160	PF01048	0.551
MOD_GlcNHglycan	226	229	PF01048	0.585
MOD_GlcNHglycan	252	255	PF01048	0.637
MOD_GlcNHglycan	256	259	PF01048	0.586
MOD_GlcNHglycan	348	351	PF01048	0.359
MOD_GlcNHglycan	37	40	PF01048	0.600
MOD_GlcNHglycan	376	379	PF01048	0.569
MOD_GlcNHglycan	393	397	PF01048	0.580
MOD_GlcNHglycan	402	405	PF01048	0.629
MOD_GlcNHglycan	412	415	PF01048	0.541
MOD_GlcNHglycan	425	428	PF01048	0.741
MOD_GlcNHglycan	491	494	PF01048	0.540
MOD_GlcNHglycan	533	536	PF01048	0.541
MOD_GlcNHglycan	572	575	PF01048	0.450
MOD_GSK3_1	124	131	PF00069	0.600
MOD_GSK3_1	141	148	PF00069	0.596
MOD_GSK3_1	250	257	PF00069	0.693
MOD_GSK3_1	288	295	PF00069	0.704
MOD_GSK3_1	33	40	PF00069	0.596
MOD_GSK3_1	394	401	PF00069	0.737
MOD_GSK3_1	413	420	PF00069	0.737
MOD_GSK3_1	434	441	PF00069	0.716
MOD_GSK3_1	525	532	PF00069	0.685
MOD_N-GLC_1	374	379	PF02516	0.613
MOD_NEK2_1	100	105	PF00069	0.475
MOD_NEK2_1	183	188	PF00069	0.619
MOD_NEK2_1	292	297	PF00069	0.614
MOD_NEK2_1	37	42	PF00069	0.580
MOD_NEK2_1	422	427	PF00069	0.660
MOD_NEK2_1	489	494	PF00069	0.560
MOD_NEK2_1	517	522	PF00069	0.379
MOD_NEK2_1	7	12	PF00069	0.562
MOD_NEK2_2	339	344	PF00069	0.320
MOD_NEK2_2	549	554	PF00069	0.265
MOD_PK_1	145	151	PF00069	0.610
MOD_PKA_1	124	130	PF00069	0.579
MOD_PKA_2	204	210	PF00069	0.575
MOD_PKA_2	397	403	PF00069	0.740
MOD_PKA_2	7	13	PF00069	0.531
MOD_Plk_1	288	294	PF00069	0.613
MOD_Plk_1	374	380	PF00069	0.615
MOD_Plk_4	145	151	PF00069	0.628
MOD_Plk_4	293	299	PF00069	0.652
MOD_Plk_4	301	307	PF00069	0.581
MOD_Plk_4	319	325	PF00069	0.409
MOD_Plk_4	496	502	PF00069	0.581
MOD_Plk_4	542	548	PF00069	0.482
MOD_Plk_4	549	555	PF00069	0.367
MOD_Plk_4	89	95	PF00069	0.454
MOD_ProDKin_1	398	404	PF00069	0.665
MOD_ProDKin_1	415	421	PF00069	0.697
MOD_ProDKin_1	435	441	PF00069	0.625
MOD_ProDKin_1	449	455	PF00069	0.579
MOD_ProDKin_1	494	500	PF00069	0.500
MOD_SUMO_for_1	104	107	PF00179	0.470
TRG_DiLeu_BaEn_1	229	234	PF01217	0.638
TRG_DiLeu_BaEn_1	588	593	PF01217	0.524
TRG_DiLeu_BaLyEn_6	503	508	PF01217	0.385
TRG_ENDOCYTIC_2	3	6	PF00928	0.564
TRG_ENDOCYTIC_2	324	327	PF00928	0.720
TRG_ENDOCYTIC_2	344	347	PF00928	0.320
TRG_ENDOCYTIC_2	457	460	PF00928	0.645
TRG_ENDOCYTIC_2	554	557	PF00928	0.456
TRG_ENDOCYTIC_2	93	96	PF00928	0.489
TRG_ER_diArg_1	192	195	PF00400	0.586
TRG_ER_diArg_1	209	211	PF00400	0.604
TRG_ER_diArg_1	478	481	PF00400	0.617
TRG_ER_diArg_1	485	488	PF00400	0.562
TRG_ER_diArg_1	49	51	PF00400	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HHD2	Leishmania braziliensis	69%	99%
A4I4H7	Leishmania infantum	100%	100%
E9ADX8	Leishmania major	92%	100%
E9ALV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%