Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBG1_LEIDO

TriTrypDb:

LdBPK_191550.1 , LdCL_190021300 , LDHU3_19.1880

Length:

785

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IBG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBG1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.633
CLV_NRD_NRD_1	136	138	PF00675	0.613
CLV_NRD_NRD_1	190	192	PF00675	0.684
CLV_NRD_NRD_1	323	325	PF00675	0.540
CLV_NRD_NRD_1	358	360	PF00675	0.476
CLV_NRD_NRD_1	413	415	PF00675	0.655
CLV_NRD_NRD_1	431	433	PF00675	0.318
CLV_NRD_NRD_1	454	456	PF00675	0.428
CLV_NRD_NRD_1	617	619	PF00675	0.575
CLV_NRD_NRD_1	758	760	PF00675	0.594
CLV_PCSK_FUR_1	134	138	PF00082	0.707
CLV_PCSK_FUR_1	756	760	PF00082	0.693
CLV_PCSK_KEX2_1	136	138	PF00082	0.636
CLV_PCSK_KEX2_1	190	192	PF00082	0.687
CLV_PCSK_KEX2_1	322	324	PF00082	0.545
CLV_PCSK_KEX2_1	413	415	PF00082	0.655
CLV_PCSK_KEX2_1	431	433	PF00082	0.318
CLV_PCSK_KEX2_1	454	456	PF00082	0.428
CLV_PCSK_KEX2_1	546	548	PF00082	0.480
CLV_PCSK_KEX2_1	707	709	PF00082	0.480
CLV_PCSK_KEX2_1	758	760	PF00082	0.576
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.480
CLV_PCSK_PC1ET2_1	707	709	PF00082	0.480
CLV_PCSK_SKI1_1	338	342	PF00082	0.533
CLV_PCSK_SKI1_1	513	517	PF00082	0.369
CLV_PCSK_SKI1_1	647	651	PF00082	0.434
CLV_PCSK_SKI1_1	747	751	PF00082	0.510
DEG_SCF_FBW7_1	401	408	PF00400	0.591
DEG_SPOP_SBC_1	57	61	PF00917	0.627
DOC_CKS1_1	402	407	PF01111	0.589
DOC_CKS1_1	528	533	PF01111	0.397
DOC_CYCLIN_yCln2_LP_2	385	388	PF00134	0.354
DOC_MAPK_gen_1	196	205	PF00069	0.596
DOC_MAPK_gen_1	357	366	PF00069	0.409
DOC_MAPK_gen_1	431	439	PF00069	0.374
DOC_MAPK_gen_1	451	459	PF00069	0.343
DOC_MAPK_gen_1	474	482	PF00069	0.462
DOC_MAPK_gen_1	546	552	PF00069	0.407
DOC_MAPK_gen_1	618	628	PF00069	0.538
DOC_MAPK_gen_1	645	653	PF00069	0.440
DOC_MAPK_gen_1	707	713	PF00069	0.481
DOC_MAPK_MEF2A_6	432	441	PF00069	0.381
DOC_MAPK_MEF2A_6	454	461	PF00069	0.454
DOC_MAPK_MEF2A_6	488	495	PF00069	0.434
DOC_MAPK_MEF2A_6	518	525	PF00069	0.429
DOC_MAPK_MEF2A_6	645	653	PF00069	0.440
DOC_MAPK_NFAT4_5	454	462	PF00069	0.436
DOC_PP1_RVXF_1	603	610	PF00149	0.368
DOC_PP2B_LxvP_1	385	388	PF13499	0.361
DOC_PP4_FxxP_1	528	531	PF00568	0.401
DOC_PP4_FxxP_1	7	10	PF00568	0.576
DOC_USP7_MATH_1	10	14	PF00917	0.605
DOC_USP7_MATH_1	142	146	PF00917	0.685
DOC_USP7_MATH_1	241	245	PF00917	0.739
DOC_USP7_MATH_1	3	7	PF00917	0.649
DOC_USP7_MATH_1	392	396	PF00917	0.554
DOC_USP7_MATH_1	405	409	PF00917	0.518
DOC_USP7_MATH_1	48	52	PF00917	0.751
DOC_USP7_MATH_1	53	57	PF00917	0.741
DOC_USP7_MATH_1	58	62	PF00917	0.704
DOC_USP7_MATH_1	63	67	PF00917	0.640
DOC_USP7_MATH_1	690	694	PF00917	0.616
DOC_USP7_MATH_1	76	80	PF00917	0.485
DOC_USP7_UBL2_3	615	619	PF12436	0.509
DOC_WW_Pin1_4	279	284	PF00397	0.663
DOC_WW_Pin1_4	401	406	PF00397	0.771
DOC_WW_Pin1_4	527	532	PF00397	0.408
DOC_WW_Pin1_4	576	581	PF00397	0.476
DOC_WW_Pin1_4	585	590	PF00397	0.435
DOC_WW_Pin1_4	59	64	PF00397	0.619
DOC_WW_Pin1_4	6	11	PF00397	0.740
DOC_WW_Pin1_4	68	73	PF00397	0.613
LIG_14-3-3_CanoR_1	148	156	PF00244	0.583
LIG_14-3-3_CanoR_1	240	247	PF00244	0.663
LIG_14-3-3_CanoR_1	33	41	PF00244	0.592
LIG_14-3-3_CanoR_1	578	587	PF00244	0.492
LIG_14-3-3_CanoR_1	677	681	PF00244	0.566
LIG_14-3-3_CanoR_1	731	741	PF00244	0.648
LIG_APCC_ABBAyCdc20_2	122	128	PF00400	0.558
LIG_BIR_II_1	1	5	PF00653	0.547
LIG_BRCT_BRCA1_1	142	146	PF00533	0.678
LIG_BRCT_BRCA1_1	392	396	PF00533	0.484
LIG_BRCT_BRCA1_1	93	97	PF00533	0.663
LIG_EH1_1	368	376	PF00400	0.380
LIG_FHA_1	234	240	PF00498	0.703
LIG_FHA_1	346	352	PF00498	0.507
LIG_FHA_1	353	359	PF00498	0.472
LIG_FHA_1	40	46	PF00498	0.669
LIG_FHA_1	766	772	PF00498	0.725
LIG_FHA_1	91	97	PF00498	0.668
LIG_FHA_2	182	188	PF00498	0.536
LIG_FHA_2	304	310	PF00498	0.482
LIG_FHA_2	402	408	PF00498	0.718
LIG_FHA_2	528	534	PF00498	0.374
LIG_FHA_2	725	731	PF00498	0.577
LIG_FHA_2	76	82	PF00498	0.566
LIG_GSK3_LRP6_1	401	406	PF00069	0.511
LIG_Integrin_RGD_1	667	669	PF01839	0.540
LIG_LIR_Apic_2	5	10	PF02991	0.574
LIG_LIR_Apic_2	526	531	PF02991	0.411
LIG_LIR_Gen_1	143	154	PF02991	0.642
LIG_LIR_Gen_1	377	387	PF02991	0.403
LIG_LIR_Gen_1	563	573	PF02991	0.389
LIG_LIR_Gen_1	606	616	PF02991	0.547
LIG_LIR_Nem_3	123	129	PF02991	0.560
LIG_LIR_Nem_3	143	149	PF02991	0.419
LIG_LIR_Nem_3	314	319	PF02991	0.509
LIG_LIR_Nem_3	377	382	PF02991	0.405
LIG_LIR_Nem_3	533	538	PF02991	0.381
LIG_LIR_Nem_3	563	568	PF02991	0.393
LIG_LIR_Nem_3	606	612	PF02991	0.411
LIG_PTB_Apo_2	222	229	PF02174	0.585
LIG_SH2_GRB2like	319	322	PF00017	0.455
LIG_SH2_NCK_1	178	182	PF00017	0.641
LIG_SH2_NCK_1	565	569	PF00017	0.360
LIG_SH2_SRC	178	181	PF00017	0.643
LIG_SH2_SRC	565	568	PF00017	0.442
LIG_SH2_SRC	571	574	PF00017	0.356
LIG_SH2_STAP1	178	182	PF00017	0.641
LIG_SH2_STAP1	565	569	PF00017	0.424
LIG_SH2_STAT3	182	185	PF00017	0.642
LIG_SH2_STAT3	734	737	PF00017	0.519
LIG_SH2_STAT5	365	368	PF00017	0.446
LIG_SH2_STAT5	571	574	PF00017	0.351
LIG_SH2_STAT5	608	611	PF00017	0.377
LIG_SH2_STAT5	655	658	PF00017	0.439
LIG_SH2_STAT5	734	737	PF00017	0.662
LIG_SH3_3	223	229	PF00018	0.592
LIG_SH3_3	277	283	PF00018	0.640
LIG_SH3_3	395	401	PF00018	0.565
LIG_SH3_3	479	485	PF00018	0.491
LIG_SH3_3	581	587	PF00018	0.448
LIG_SH3_3	66	72	PF00018	0.605
LIG_SH3_3	667	673	PF00018	0.603
LIG_SH3_3	720	726	PF00018	0.610
LIG_SUMO_SIM_par_1	16	23	PF11976	0.526
LIG_TRAF2_1	184	187	PF00917	0.578
LIG_TRAF2_1	426	429	PF00917	0.521
LIG_TRAF2_1	72	75	PF00917	0.695
LIG_UBA3_1	541	546	PF00899	0.463
LIG_UBA3_1	652	658	PF00899	0.450
LIG_WW_3	119	123	PF00397	0.551
MOD_CDK_SPK_2	527	532	PF00069	0.408
MOD_CDK_SPK_2	576	581	PF00069	0.476
MOD_CK1_1	189	195	PF00069	0.605
MOD_CK1_1	278	284	PF00069	0.621
MOD_CK1_1	36	42	PF00069	0.715
MOD_CK1_1	449	455	PF00069	0.534
MOD_CK1_1	56	62	PF00069	0.711
MOD_CK1_1	579	585	PF00069	0.451
MOD_CK1_1	6	12	PF00069	0.613
MOD_CK1_1	65	71	PF00069	0.749
MOD_CK1_1	679	685	PF00069	0.573
MOD_CK1_1	688	694	PF00069	0.552
MOD_CK2_1	181	187	PF00069	0.530
MOD_CK2_1	239	245	PF00069	0.625
MOD_CK2_1	303	309	PF00069	0.584
MOD_CK2_1	346	352	PF00069	0.647
MOD_CK2_1	401	407	PF00069	0.752
MOD_CK2_1	527	533	PF00069	0.388
MOD_CK2_1	68	74	PF00069	0.659
MOD_CK2_1	690	696	PF00069	0.557
MOD_CK2_1	75	81	PF00069	0.563
MOD_CK2_1	770	776	PF00069	0.680
MOD_Cter_Amidation	134	137	PF01082	0.628
MOD_Cter_Amidation	411	414	PF01082	0.475
MOD_Cter_Amidation	705	708	PF01082	0.490
MOD_GlcNHglycan	1	4	PF01048	0.658
MOD_GlcNHglycan	10	13	PF01048	0.731
MOD_GlcNHglycan	255	258	PF01048	0.693
MOD_GlcNHglycan	259	262	PF01048	0.641
MOD_GlcNHglycan	326	331	PF01048	0.556
MOD_GlcNHglycan	50	53	PF01048	0.665
MOD_GlcNHglycan	55	58	PF01048	0.693
MOD_GlcNHglycan	772	775	PF01048	0.690
MOD_GSK3_1	227	234	PF00069	0.674
MOD_GSK3_1	253	260	PF00069	0.632
MOD_GSK3_1	275	282	PF00069	0.645
MOD_GSK3_1	31	38	PF00069	0.646
MOD_GSK3_1	401	408	PF00069	0.737
MOD_GSK3_1	523	530	PF00069	0.389
MOD_GSK3_1	53	60	PF00069	0.668
MOD_GSK3_1	572	579	PF00069	0.418
MOD_GSK3_1	6	13	PF00069	0.648
MOD_GSK3_1	676	683	PF00069	0.560
MOD_GSK3_1	770	777	PF00069	0.729
MOD_GSK3_1	92	99	PF00069	0.544
MOD_LATS_1	157	163	PF00433	0.566
MOD_LATS_1	238	244	PF00433	0.627
MOD_N-GLC_1	523	528	PF02516	0.364
MOD_N-GLC_1	629	634	PF02516	0.470
MOD_N-GLC_2	204	206	PF02516	0.558
MOD_NEK2_1	129	134	PF00069	0.713
MOD_NEK2_1	239	244	PF00069	0.550
MOD_NEK2_1	676	681	PF00069	0.544
MOD_NEK2_1	732	737	PF00069	0.663
MOD_NEK2_2	92	97	PF00069	0.667
MOD_PIKK_1	129	135	PF00454	0.628
MOD_PIKK_1	181	187	PF00454	0.623
MOD_PIKK_1	189	195	PF00454	0.666
MOD_PIKK_1	446	452	PF00454	0.578
MOD_PIKK_1	724	730	PF00454	0.646
MOD_PKA_1	359	365	PF00069	0.403
MOD_PKA_2	189	195	PF00069	0.605
MOD_PKA_2	239	245	PF00069	0.625
MOD_PKA_2	275	281	PF00069	0.668
MOD_PKA_2	300	306	PF00069	0.655
MOD_PKA_2	32	38	PF00069	0.638
MOD_PKA_2	676	682	PF00069	0.564
MOD_Plk_1	303	309	PF00069	0.601
MOD_Plk_1	326	332	PF00069	0.483
MOD_Plk_1	774	780	PF00069	0.583
MOD_Plk_4	275	281	PF00069	0.636
MOD_Plk_4	303	309	PF00069	0.583
MOD_Plk_4	359	365	PF00069	0.403
MOD_Plk_4	537	543	PF00069	0.450
MOD_Plk_4	92	98	PF00069	0.538
MOD_ProDKin_1	279	285	PF00069	0.663
MOD_ProDKin_1	401	407	PF00069	0.774
MOD_ProDKin_1	527	533	PF00069	0.407
MOD_ProDKin_1	576	582	PF00069	0.477
MOD_ProDKin_1	585	591	PF00069	0.435
MOD_ProDKin_1	59	65	PF00069	0.621
MOD_ProDKin_1	6	12	PF00069	0.740
MOD_ProDKin_1	68	74	PF00069	0.615
MOD_SUMO_for_1	626	629	PF00179	0.534
MOD_SUMO_rev_2	742	749	PF00179	0.494
TRG_ENDOCYTIC_2	126	129	PF00928	0.563
TRG_ENDOCYTIC_2	565	568	PF00928	0.385
TRG_ER_diArg_1	134	137	PF00400	0.637
TRG_ER_diArg_1	322	324	PF00400	0.454
TRG_ER_diArg_1	380	383	PF00400	0.393
TRG_ER_diArg_1	413	415	PF00400	0.655
TRG_ER_diArg_1	431	433	PF00400	0.318
TRG_ER_diArg_1	454	456	PF00400	0.428
TRG_ER_diArg_1	756	759	PF00400	0.694
TRG_NES_CRM1_1	467	478	PF08389	0.430
TRG_NES_CRM1_1	742	754	PF08389	0.566
TRG_NLS_MonoExtN_4	615	622	PF00514	0.470
TRG_Pf-PMV_PEXEL_1	14	19	PF00026	0.686
TRG_Pf-PMV_PEXEL_1	599	604	PF00026	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A9	Leptomonas seymouri	70%	85%
A0A1X0P5Z6	Trypanosomatidae	55%	100%
A0A3S5IRX2	Trypanosoma rangeli	52%	100%
A4HAA1	Leishmania braziliensis	85%	100%
A4HYI2	Leishmania infantum	100%	100%
D0A0V4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	98%
E9ASA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QD57	Leishmania major	96%	100%
V5B4C3	Trypanosoma cruzi	50%	87%