Proteasome regulatory non-ATP-ase subunit 9, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATP-ase subunit 9, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBF9_LEIDO

TriTrypDb:

LdBPK_191100.1 , LdCL_190016200 , LDHU3_19.1340

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	11
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0005838	proteasome regulatory particle	2	1
GO:0008541	proteasome regulatory particle, lid subcomplex	2	1
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1

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Expansion

Sequence features

A0A3Q8IBF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBF9

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0005198	structural molecule activity	1	1
GO:0008233	peptidase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.601
CLV_NRD_NRD_1	193	195	PF00675	0.580
CLV_NRD_NRD_1	305	307	PF00675	0.416
CLV_NRD_NRD_1	364	366	PF00675	0.647
CLV_PCSK_KEX2_1	193	195	PF00082	0.580
CLV_PCSK_KEX2_1	364	366	PF00082	0.675
CLV_PCSK_SKI1_1	128	132	PF00082	0.521
CLV_PCSK_SKI1_1	156	160	PF00082	0.545
CLV_PCSK_SKI1_1	201	205	PF00082	0.495
CLV_PCSK_SKI1_1	263	267	PF00082	0.593

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8H3	Leptomonas seymouri	82%	100%
A0A0S4JGV7	Bodo saltans	39%	100%
A0A1X0P6E2	Trypanosomatidae	49%	100%
A0A422N714	Trypanosoma rangeli	50%	100%
A4HA68	Leishmania braziliensis	93%	100%
A4HYC9	Leishmania infantum	100%	100%
B0BN93	Rattus norvegicus	26%	100%
D0A0Q9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AS63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P84169	Gallus gallus	26%	100%

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