Cation transporter, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cation transporter, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBF0_LEIDO

TriTrypDb:

LdBPK_191420.1 , LdCL_190019900 , LDHU3_19.1720

Length:

613

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3Q8IBF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBF0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0022857	transmembrane transporter activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	591	595	PF00656	0.732
CLV_NRD_NRD_1	104	106	PF00675	0.345
CLV_NRD_NRD_1	173	175	PF00675	0.568
CLV_NRD_NRD_1	255	257	PF00675	0.302
CLV_NRD_NRD_1	391	393	PF00675	0.493
CLV_NRD_NRD_1	438	440	PF00675	0.411
CLV_PCSK_KEX2_1	173	175	PF00082	0.568
CLV_PCSK_KEX2_1	255	257	PF00082	0.244
CLV_PCSK_KEX2_1	438	440	PF00082	0.411
CLV_PCSK_KEX2_1	597	599	PF00082	0.429
CLV_PCSK_PC1ET2_1	597	599	PF00082	0.429
CLV_PCSK_SKI1_1	247	251	PF00082	0.264
CLV_PCSK_SKI1_1	553	557	PF00082	0.430
DEG_APCC_DBOX_1	341	349	PF00400	0.563
DEG_SPOP_SBC_1	7	11	PF00917	0.759
DOC_CYCLIN_RxL_1	244	254	PF00134	0.362
DOC_MAPK_gen_1	105	117	PF00069	0.482
DOC_MAPK_gen_1	392	400	PF00069	0.615
DOC_MAPK_HePTP_8	390	402	PF00069	0.621
DOC_MAPK_MEF2A_6	393	402	PF00069	0.621
DOC_PP1_RVXF_1	245	252	PF00149	0.362
DOC_PP4_FxxP_1	542	545	PF00568	0.667
DOC_USP7_MATH_1	195	199	PF00917	0.583
DOC_USP7_MATH_1	240	244	PF00917	0.362
DOC_USP7_MATH_1	365	369	PF00917	0.750
DOC_USP7_MATH_1	379	383	PF00917	0.646
DOC_USP7_MATH_1	437	441	PF00917	0.559
DOC_USP7_MATH_1	480	484	PF00917	0.773
DOC_USP7_MATH_1	496	500	PF00917	0.596
DOC_USP7_MATH_1	505	509	PF00917	0.635
DOC_USP7_MATH_1	592	596	PF00917	0.721
DOC_USP7_MATH_1	609	613	PF00917	0.748
DOC_USP7_MATH_1	74	78	PF00917	0.300
DOC_WW_Pin1_4	185	190	PF00397	0.545
DOC_WW_Pin1_4	374	379	PF00397	0.804
DOC_WW_Pin1_4	512	517	PF00397	0.660
LIG_14-3-3_CanoR_1	180	189	PF00244	0.422
LIG_14-3-3_CanoR_1	438	442	PF00244	0.658
LIG_14-3-3_CanoR_1	531	537	PF00244	0.648
LIG_14-3-3_CanoR_1	547	551	PF00244	0.658
LIG_14-3-3_CanoR_1	553	558	PF00244	0.580
LIG_BRCT_BRCA1_1	498	502	PF00533	0.661
LIG_FHA_1	159	165	PF00498	0.303
LIG_FHA_1	239	245	PF00498	0.318
LIG_FHA_1	252	258	PF00498	0.410
LIG_FHA_1	412	418	PF00498	0.566
LIG_FHA_1	446	452	PF00498	0.643
LIG_FHA_1	513	519	PF00498	0.752
LIG_FHA_1	541	547	PF00498	0.708
LIG_FHA_1	87	93	PF00498	0.367
LIG_FHA_2	220	226	PF00498	0.384
LIG_FHA_2	589	595	PF00498	0.639
LIG_LIR_Apic_2	541	545	PF02991	0.618
LIG_LIR_Gen_1	145	155	PF02991	0.290
LIG_LIR_Gen_1	216	223	PF02991	0.518
LIG_LIR_Gen_1	445	452	PF02991	0.571
LIG_LIR_Gen_1	538	546	PF02991	0.668
LIG_LIR_Gen_1	83	93	PF02991	0.237
LIG_LIR_Gen_1	97	103	PF02991	0.231
LIG_LIR_Nem_3	145	151	PF02991	0.318
LIG_LIR_Nem_3	323	327	PF02991	0.508
LIG_LIR_Nem_3	445	450	PF02991	0.567
LIG_LIR_Nem_3	538	542	PF02991	0.578
LIG_LIR_Nem_3	60	66	PF02991	0.307
LIG_LIR_Nem_3	83	88	PF02991	0.261
LIG_LIR_Nem_3	97	101	PF02991	0.339
LIG_PCNA_yPIPBox_3	229	237	PF02747	0.315
LIG_Pex14_2	397	401	PF04695	0.624
LIG_SH2_GRB2like	327	330	PF00017	0.638
LIG_SH2_NCK_1	418	422	PF00017	0.645
LIG_SH2_PTP2	98	101	PF00017	0.340
LIG_SH2_SRC	327	330	PF00017	0.638
LIG_SH2_STAP1	223	227	PF00017	0.335
LIG_SH2_STAP1	409	413	PF00017	0.536
LIG_SH2_STAT3	46	49	PF00017	0.485
LIG_SH2_STAT5	456	459	PF00017	0.731
LIG_SH2_STAT5	46	49	PF00017	0.485
LIG_SH2_STAT5	98	101	PF00017	0.319
LIG_SUMO_SIM_anti_2	77	83	PF11976	0.244
LIG_SUMO_SIM_par_1	413	420	PF11976	0.578
LIG_SUMO_SIM_par_1	448	454	PF11976	0.664
LIG_TRAF2_1	202	205	PF00917	0.491
LIG_TRAF2_1	535	538	PF00917	0.656
LIG_TRAF2_1	549	552	PF00917	0.487
LIG_TYR_ITIM	416	421	PF00017	0.635
LIG_TYR_ITIM	96	101	PF00017	0.269
LIG_WRC_WIRS_1	539	544	PF05994	0.614
MOD_CK1_1	185	191	PF00069	0.551
MOD_CK1_1	34	40	PF00069	0.697
MOD_CK1_1	374	380	PF00069	0.756
MOD_CK1_1	454	460	PF00069	0.646
MOD_CK1_1	483	489	PF00069	0.690
MOD_CK1_1	508	514	PF00069	0.662
MOD_CK1_1	559	565	PF00069	0.642
MOD_CK1_1	599	605	PF00069	0.776
MOD_CK2_1	150	156	PF00069	0.231
MOD_CK2_1	199	205	PF00069	0.584
MOD_CK2_1	219	225	PF00069	0.306
MOD_CK2_1	317	323	PF00069	0.428
MOD_CK2_1	365	371	PF00069	0.682
MOD_CK2_1	532	538	PF00069	0.651
MOD_CK2_1	546	552	PF00069	0.478
MOD_CK2_1	568	574	PF00069	0.676
MOD_GlcNHglycan	121	125	PF01048	0.359
MOD_GlcNHglycan	184	187	PF01048	0.746
MOD_GlcNHglycan	278	281	PF01048	0.299
MOD_GlcNHglycan	3	6	PF01048	0.555
MOD_GlcNHglycan	331	336	PF01048	0.350
MOD_GlcNHglycan	367	370	PF01048	0.543
MOD_GlcNHglycan	42	45	PF01048	0.387
MOD_GlcNHglycan	421	424	PF01048	0.444
MOD_GlcNHglycan	482	485	PF01048	0.485
MOD_GlcNHglycan	498	501	PF01048	0.374
MOD_GlcNHglycan	509	513	PF01048	0.449
MOD_GlcNHglycan	581	584	PF01048	0.438
MOD_GlcNHglycan	586	589	PF01048	0.485
MOD_GlcNHglycan	594	597	PF01048	0.500
MOD_GlcNHglycan	598	601	PF01048	0.501
MOD_GlcNHglycan	72	75	PF01048	0.482
MOD_GSK3_1	150	157	PF00069	0.288
MOD_GSK3_1	181	188	PF00069	0.545
MOD_GSK3_1	195	202	PF00069	0.579
MOD_GSK3_1	276	283	PF00069	0.294
MOD_GSK3_1	367	374	PF00069	0.759
MOD_GSK3_1	377	384	PF00069	0.731
MOD_GSK3_1	456	463	PF00069	0.752
MOD_GSK3_1	479	486	PF00069	0.660
MOD_GSK3_1	496	503	PF00069	0.607
MOD_GSK3_1	508	515	PF00069	0.615
MOD_GSK3_1	553	560	PF00069	0.614
MOD_GSK3_1	584	591	PF00069	0.635
MOD_GSK3_1	592	599	PF00069	0.625
MOD_GSK3_1	70	77	PF00069	0.323
MOD_GSK3_1	8	15	PF00069	0.689
MOD_N-GLC_1	181	186	PF02516	0.680
MOD_N-GLC_1	454	459	PF02516	0.468
MOD_N-GLC_2	344	346	PF02516	0.324
MOD_NEK2_1	120	125	PF00069	0.505
MOD_NEK2_1	154	159	PF00069	0.308
MOD_NEK2_1	251	256	PF00069	0.433
MOD_NEK2_1	303	308	PF00069	0.285
MOD_NEK2_1	317	322	PF00069	0.433
MOD_NEK2_1	451	456	PF00069	0.675
MOD_NEK2_1	64	69	PF00069	0.360
MOD_PKA_2	251	257	PF00069	0.428
MOD_PKA_2	437	443	PF00069	0.582
MOD_PKA_2	546	552	PF00069	0.666
MOD_Plk_1	331	337	PF00069	0.605
MOD_Plk_1	386	392	PF00069	0.684
MOD_Plk_1	460	466	PF00069	0.672
MOD_Plk_1	551	557	PF00069	0.656
MOD_Plk_2-3	150	156	PF00069	0.209
MOD_Plk_2-3	568	574	PF00069	0.648
MOD_Plk_4	150	156	PF00069	0.348
MOD_Plk_4	240	246	PF00069	0.317
MOD_Plk_4	280	286	PF00069	0.260
MOD_Plk_4	317	323	PF00069	0.426
MOD_Plk_4	411	417	PF00069	0.535
MOD_Plk_4	446	452	PF00069	0.607
MOD_ProDKin_1	185	191	PF00069	0.549
MOD_ProDKin_1	374	380	PF00069	0.807
MOD_ProDKin_1	512	518	PF00069	0.659
TRG_DiLeu_BaEn_1	428	433	PF01217	0.653
TRG_DiLeu_BaLyEn_6	576	581	PF01217	0.574
TRG_ENDOCYTIC_2	314	317	PF00928	0.284
TRG_ENDOCYTIC_2	418	421	PF00928	0.644
TRG_ENDOCYTIC_2	98	101	PF00928	0.308
TRG_ER_diArg_1	109	112	PF00400	0.457
TRG_ER_diArg_1	255	257	PF00400	0.536
TRG_NLS_MonoExtC_3	104	109	PF00514	0.482
TRG_Pf-PMV_PEXEL_1	439	444	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHD4	Leptomonas seymouri	61%	97%
A0A0S4IWL9	Bodo saltans	36%	100%
A0A1X0P615	Trypanosomatidae	49%	100%
A0A3R7MPI1	Trypanosoma rangeli	44%	100%
A4HA88	Leishmania braziliensis	77%	100%
A4HYG8	Leishmania infantum	100%	100%
D0A0T8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AS92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QD72	Leishmania major	94%	100%
V5B132	Trypanosoma cruzi	46%	100%