Protein YIPF

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein YIPF

Gene product:

terbinafine resistance locus protein (yip1)

Species:

Leishmania donovani

UniProt:

A0A3Q8IBE6_LEIDO

TriTrypDb:

LdBPK_230280.1 , LdCL_230008200 , LDHU3_23.0380

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005802	trans-Golgi network	4	1
GO:0031984	organelle subcompartment	2	1
GO:0098791	Golgi apparatus subcompartment	3	1

Expansion

Sequence features

A0A3Q8IBE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBE6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	11
GO:0009987	cellular process	1	11
GO:0016192	vesicle-mediated transport	4	11
GO:0046907	intracellular transport	3	11
GO:0048193	Golgi vesicle transport	5	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	33	35	PF00675	0.381
CLV_PCSK_SKI1_1	106	110	PF00082	0.363
CLV_PCSK_SKI1_1	166	170	PF00082	0.252
CLV_PCSK_SKI1_1	27	31	PF00082	0.447
DEG_MDM2_SWIB_1	86	94	PF02201	0.420
DEG_Nend_Nbox_1	1	3	PF02207	0.734
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.337
DOC_MAPK_gen_1	34	40	PF00069	0.602
DOC_PP1_RVXF_1	104	110	PF00149	0.507
DOC_USP7_MATH_1	173	177	PF00917	0.485
DOC_WW_Pin1_4	178	183	PF00397	0.570
DOC_WW_Pin1_4	189	194	PF00397	0.509
DOC_WW_Pin1_4	205	210	PF00397	0.534
LIG_14-3-3_CanoR_1	159	169	PF00244	0.538
LIG_14-3-3_CanoR_1	203	209	PF00244	0.510
LIG_BRCT_BRCA1_1	82	86	PF00533	0.324
LIG_deltaCOP1_diTrp_1	52	60	PF00928	0.466
LIG_FHA_2	14	20	PF00498	0.604
LIG_LIR_Gen_1	112	121	PF02991	0.333
LIG_LIR_Gen_1	83	94	PF02991	0.324
LIG_LIR_LC3C_4	167	171	PF02991	0.484
LIG_LIR_Nem_3	112	116	PF02991	0.308
LIG_LIR_Nem_3	181	187	PF02991	0.615
LIG_LIR_Nem_3	54	59	PF02991	0.319
LIG_LIR_Nem_3	83	89	PF02991	0.324
LIG_NRBOX	124	130	PF00104	0.384
LIG_NRBOX	136	142	PF00104	0.233
LIG_NRBOX	21	27	PF00104	0.680
LIG_Pex14_1	56	60	PF04695	0.420
LIG_Pex14_2	185	189	PF04695	0.613
LIG_Pex14_2	82	86	PF04695	0.319
LIG_Pex3_1	125	136	PF04882	0.350
LIG_REV1ctd_RIR_1	155	163	PF16727	0.466
LIG_SH2_CRK	113	117	PF00017	0.300
LIG_SH2_STAT5	113	116	PF00017	0.337
LIG_SH2_STAT5	118	121	PF00017	0.300
LIG_SH2_STAT5	195	198	PF00017	0.662
LIG_SH3_1	214	220	PF00018	0.544
LIG_SH3_3	167	173	PF00018	0.592
LIG_SH3_3	214	220	PF00018	0.544
LIG_SH3_3	36	42	PF00018	0.560
LIG_SUMO_SIM_anti_2	167	172	PF11976	0.661
LIG_TRFH_1	118	122	PF08558	0.344
MOD_CDK_SPK_2	189	194	PF00069	0.495
MOD_CK1_1	174	180	PF00069	0.534
MOD_CK1_1	205	211	PF00069	0.516
MOD_CK1_1	67	73	PF00069	0.386
MOD_CK2_1	13	19	PF00069	0.596
MOD_CMANNOS	149	152	PF00535	0.344
MOD_CMANNOS	53	56	PF00535	0.266
MOD_Cter_Amidation	32	35	PF01082	0.373
MOD_GlcNHglycan	162	165	PF01048	0.338
MOD_GlcNHglycan	173	176	PF01048	0.495
MOD_GlcNHglycan	82	85	PF01048	0.364
MOD_GSK3_1	171	178	PF00069	0.539
MOD_GSK3_1	67	74	PF00069	0.392
MOD_N-GLC_1	71	76	PF02516	0.431
MOD_NEK2_1	102	107	PF00069	0.433
MOD_NEK2_1	109	114	PF00069	0.401
MOD_NEK2_1	158	163	PF00069	0.482
MOD_NEK2_1	94	99	PF00069	0.365
MOD_PKA_2	158	164	PF00069	0.466
MOD_PKA_2	202	208	PF00069	0.511
MOD_Plk_4	21	27	PF00069	0.604
MOD_Plk_4	64	70	PF00069	0.420
MOD_ProDKin_1	178	184	PF00069	0.569
MOD_ProDKin_1	189	195	PF00069	0.511
MOD_ProDKin_1	205	211	PF00069	0.538
TRG_ENDOCYTIC_2	113	116	PF00928	0.420
TRG_ER_diArg_1	214	217	PF00400	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2J5	Leptomonas seymouri	76%	100%
A0A0S4IXH1	Bodo saltans	28%	68%
A0A0S4JG02	Bodo saltans	52%	100%
A0A1X0NG82	Trypanosomatidae	60%	100%
A0A3S7WXG4	Leishmania donovani	99%	100%
A0A422MU05	Trypanosoma rangeli	60%	100%
A4HCN9	Leishmania braziliensis	91%	100%
A4I064	Leishmania infantum	99%	100%
A6QLC6	Bos taurus	39%	93%
E9AW27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O64614	Arabidopsis thaliana	37%	78%
Q28CH8	Xenopus tropicalis	38%	94%
Q4QQU5	Rattus norvegicus	38%	93%
Q54RZ2	Dictyostelium discoideum	43%	100%
Q5M7T4	Rattus norvegicus	26%	89%
Q5ZJD7	Gallus gallus	26%	88%
Q6IQ85	Danio rerio	39%	92%
Q6NYF1	Danio rerio	28%	93%
Q86MW5	Leishmania major	95%	100%
Q8BR70	Mus musculus	37%	93%
Q8C407	Mus musculus	26%	89%
Q93VH1	Arabidopsis thaliana	38%	79%
Q96EC8	Homo sapiens	38%	93%
Q9P6P8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	98%