Mannosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Mannosyltransferase

Gene product:

dolichyl-P-Man:GDP-Man5GlcNAc2-PP-dolichyl alpha-1,2-mannosyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBE5_LEIDO

TriTrypDb:

LdBPK_120145.1 , LdCL_120006700 , LDHU3_12.0230

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	9
GO:0016020	membrane	2	9
GO:0031090	organelle membrane	3	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3Q8IBE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBE5

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0043413	macromolecule glycosylation	3	9
GO:0044238	primary metabolic process	2	9
GO:0070085	glycosylation	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:0006487	protein N-linked glycosylation	5	1
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	5	1
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	1
GO:0006629	lipid metabolic process	3	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000026	alpha-1,2-mannosyltransferase activity	6	9
GO:0000030	mannosyltransferase activity	5	9
GO:0003824	catalytic activity	1	9
GO:0016740	transferase activity	2	9
GO:0016757	glycosyltransferase activity	3	9
GO:0016758	hexosyltransferase activity	4	9
GO:0052918	dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity	7	9
GO:0052926	dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity	7	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	496	500	PF00656	0.652
CLV_NRD_NRD_1	337	339	PF00675	0.436
CLV_NRD_NRD_1	511	513	PF00675	0.572
CLV_NRD_NRD_1	585	587	PF00675	0.667
CLV_NRD_NRD_1	768	770	PF00675	0.662
CLV_NRD_NRD_1	802	804	PF00675	0.628
CLV_PCSK_KEX2_1	337	339	PF00082	0.451
CLV_PCSK_KEX2_1	484	486	PF00082	0.559
CLV_PCSK_KEX2_1	511	513	PF00082	0.542
CLV_PCSK_KEX2_1	580	582	PF00082	0.606
CLV_PCSK_KEX2_1	585	587	PF00082	0.638
CLV_PCSK_KEX2_1	802	804	PF00082	0.603
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.559
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.641
CLV_PCSK_PC7_1	581	587	PF00082	0.685
CLV_PCSK_SKI1_1	312	316	PF00082	0.453
CLV_PCSK_SKI1_1	422	426	PF00082	0.282
CLV_PCSK_SKI1_1	560	564	PF00082	0.620
CLV_PCSK_SKI1_1	61	65	PF00082	0.511
CLV_PCSK_SKI1_1	753	757	PF00082	0.570
DEG_APCC_DBOX_1	421	429	PF00400	0.582
DEG_SCF_FBW7_1	196	202	PF00400	0.456
DEG_SPOP_SBC_1	201	205	PF00917	0.456
DEG_SPOP_SBC_1	682	686	PF00917	0.471
DOC_ANK_TNKS_1	353	360	PF00023	0.770
DOC_CDC14_PxL_1	563	571	PF14671	0.389
DOC_CKS1_1	196	201	PF01111	0.456
DOC_CKS1_1	655	660	PF01111	0.431
DOC_CYCLIN_RxL_1	750	759	PF00134	0.393
DOC_CYCLIN_RxL_1	802	814	PF00134	0.315
DOC_CYCLIN_yCln2_LP_2	247	253	PF00134	0.520
DOC_CYCLIN_yCln2_LP_2	794	800	PF00134	0.390
DOC_MAPK_gen_1	417	427	PF00069	0.524
DOC_MAPK_MEF2A_6	121	129	PF00069	0.362
DOC_MAPK_MEF2A_6	65	72	PF00069	0.382
DOC_MAPK_NFAT4_5	65	73	PF00069	0.382
DOC_PP1_RVXF_1	208	215	PF00149	0.582
DOC_PP1_RVXF_1	88	94	PF00149	0.424
DOC_PP2B_LxvP_1	333	336	PF13499	0.450
DOC_PP2B_LxvP_1	667	670	PF13499	0.512
DOC_PP2B_LxvP_1	727	730	PF13499	0.451
DOC_PP4_FxxP_1	40	43	PF00568	0.301
DOC_PP4_FxxP_1	447	450	PF00568	0.293
DOC_PP4_FxxP_1	655	658	PF00568	0.445
DOC_USP7_MATH_1	139	143	PF00917	0.345
DOC_USP7_MATH_1	172	176	PF00917	0.517
DOC_USP7_MATH_1	199	203	PF00917	0.590
DOC_USP7_MATH_1	341	345	PF00917	0.716
DOC_USP7_MATH_1	349	353	PF00917	0.736
DOC_USP7_MATH_1	364	368	PF00917	0.800
DOC_USP7_MATH_1	371	375	PF00917	0.746
DOC_USP7_MATH_1	413	417	PF00917	0.514
DOC_USP7_MATH_1	594	598	PF00917	0.566
DOC_USP7_MATH_1	63	67	PF00917	0.284
DOC_USP7_MATH_1	676	680	PF00917	0.570
DOC_USP7_MATH_1	682	686	PF00917	0.605
DOC_USP7_MATH_1	690	694	PF00917	0.500
DOC_USP7_UBL2_3	766	770	PF12436	0.382
DOC_WW_Pin1_4	167	172	PF00397	0.493
DOC_WW_Pin1_4	195	200	PF00397	0.550
DOC_WW_Pin1_4	367	372	PF00397	0.736
DOC_WW_Pin1_4	446	451	PF00397	0.355
DOC_WW_Pin1_4	479	484	PF00397	0.745
DOC_WW_Pin1_4	486	491	PF00397	0.755
DOC_WW_Pin1_4	519	524	PF00397	0.661
DOC_WW_Pin1_4	592	597	PF00397	0.541
DOC_WW_Pin1_4	654	659	PF00397	0.415
DOC_WW_Pin1_4	678	683	PF00397	0.604
DOC_WW_Pin1_4	725	730	PF00397	0.359
DOC_WW_Pin1_4	784	789	PF00397	0.373
LIG_14-3-3_CanoR_1	183	193	PF00244	0.507
LIG_14-3-3_CanoR_1	195	199	PF00244	0.520
LIG_14-3-3_CanoR_1	278	287	PF00244	0.334
LIG_14-3-3_CanoR_1	4	11	PF00244	0.644
LIG_14-3-3_CanoR_1	612	618	PF00244	0.395
LIG_14-3-3_CanoR_1	625	631	PF00244	0.283
LIG_14-3-3_CanoR_1	691	701	PF00244	0.493
LIG_14-3-3_CanoR_1	81	87	PF00244	0.437
LIG_Actin_WH2_2	751	768	PF00022	0.330
LIG_BRCT_BRCA1_1	521	525	PF00533	0.678
LIG_BRCT_BRCA1_1	627	631	PF00533	0.323
LIG_BRCT_BRCA1_1	65	69	PF00533	0.301
LIG_CaM_IQ_9	758	774	PF13499	0.365
LIG_Clathr_ClatBox_1	240	244	PF01394	0.474
LIG_Clathr_ClatBox_1	301	305	PF01394	0.382
LIG_deltaCOP1_diTrp_1	622	630	PF00928	0.320
LIG_deltaCOP1_diTrp_1	633	641	PF00928	0.314
LIG_FHA_1	286	292	PF00498	0.257
LIG_FHA_1	370	376	PF00498	0.769
LIG_FHA_1	4	10	PF00498	0.649
LIG_FHA_1	458	464	PF00498	0.437
LIG_FHA_1	487	493	PF00498	0.764
LIG_FHA_1	606	612	PF00498	0.433
LIG_FHA_1	614	620	PF00498	0.301
LIG_FHA_1	750	756	PF00498	0.376
LIG_FHA_1	769	775	PF00498	0.360
LIG_FHA_2	494	500	PF00498	0.748
LIG_GBD_Chelix_1	254	262	PF00786	0.474
LIG_GBD_Chelix_1	534	542	PF00786	0.424
LIG_HP1_1	329	333	PF01393	0.474
LIG_LIR_Apic_2	37	43	PF02991	0.313
LIG_LIR_Apic_2	423	429	PF02991	0.456
LIG_LIR_Apic_2	444	450	PF02991	0.284
LIG_LIR_Apic_2	622	627	PF02991	0.329
LIG_LIR_Apic_2	654	658	PF02991	0.443
LIG_LIR_Gen_1	113	123	PF02991	0.330
LIG_LIR_Gen_1	146	156	PF02991	0.327
LIG_LIR_Gen_1	282	292	PF02991	0.304
LIG_LIR_Gen_1	35	46	PF02991	0.302
LIG_LIR_Gen_1	6	16	PF02991	0.546
LIG_LIR_Gen_1	66	77	PF02991	0.284
LIG_LIR_Gen_1	721	730	PF02991	0.359
LIG_LIR_Gen_1	777	784	PF02991	0.407
LIG_LIR_Gen_1	787	798	PF02991	0.356
LIG_LIR_LC3C_4	260	264	PF02991	0.349
LIG_LIR_Nem_3	113	118	PF02991	0.420
LIG_LIR_Nem_3	146	151	PF02991	0.285
LIG_LIR_Nem_3	163	169	PF02991	0.415
LIG_LIR_Nem_3	26	31	PF02991	0.380
LIG_LIR_Nem_3	282	287	PF02991	0.304
LIG_LIR_Nem_3	288	292	PF02991	0.299
LIG_LIR_Nem_3	35	41	PF02991	0.290
LIG_LIR_Nem_3	564	569	PF02991	0.348
LIG_LIR_Nem_3	622	626	PF02991	0.330
LIG_LIR_Nem_3	633	639	PF02991	0.315
LIG_LIR_Nem_3	66	72	PF02991	0.281
LIG_LIR_Nem_3	710	715	PF02991	0.401
LIG_LIR_Nem_3	721	727	PF02991	0.276
LIG_LIR_Nem_3	777	782	PF02991	0.400
LIG_LIR_Nem_3	787	793	PF02991	0.315
LIG_LYPXL_yS_3	452	455	PF13949	0.337
LIG_LYPXL_yS_3	566	569	PF13949	0.380
LIG_MLH1_MIPbox_1	627	631	PF16413	0.323
LIG_MYND_1	513	517	PF01753	0.654
LIG_NRBOX	126	132	PF00104	0.362
LIG_NRBOX	242	248	PF00104	0.474
LIG_NRBOX	257	263	PF00104	0.474
LIG_Pex14_2	24	28	PF04695	0.420
LIG_Pex14_2	318	322	PF04695	0.437
LIG_Pex14_2	430	434	PF04695	0.323
LIG_Pex14_2	536	540	PF04695	0.437
LIG_Pex14_2	626	630	PF04695	0.312
LIG_PTB_Apo_2	773	780	PF02174	0.392
LIG_PTB_Phospho_1	773	779	PF10480	0.401
LIG_REV1ctd_RIR_1	306	316	PF16727	0.318
LIG_SH2_CRK	624	628	PF00017	0.329
LIG_SH2_NCK_1	169	173	PF00017	0.456
LIG_SH2_PTP2	426	429	PF00017	0.388
LIG_SH2_STAP1	545	549	PF00017	0.402
LIG_SH2_STAP1	615	619	PF00017	0.344
LIG_SH2_STAT5	23	26	PF00017	0.281
LIG_SH2_STAT5	276	279	PF00017	0.289
LIG_SH2_STAT5	426	429	PF00017	0.330
LIG_SH2_STAT5	46	49	PF00017	0.353
LIG_SH2_STAT5	552	555	PF00017	0.363
LIG_SH2_STAT5	615	618	PF00017	0.323
LIG_SH2_STAT5	712	715	PF00017	0.422
LIG_SH2_STAT5	8	11	PF00017	0.629
LIG_SH2_STAT5	92	95	PF00017	0.337
LIG_SH3_2	171	176	PF14604	0.456
LIG_SH3_3	168	174	PF00018	0.456
LIG_SH3_3	447	453	PF00018	0.284
LIG_SH3_3	507	513	PF00018	0.718
LIG_SH3_3	653	659	PF00018	0.471
LIG_SH3_3	710	716	PF00018	0.424
LIG_SH3_3	803	809	PF00018	0.443
LIG_Sin3_3	328	335	PF02671	0.349
LIG_SUMO_SIM_anti_2	260	265	PF11976	0.349
LIG_SUMO_SIM_par_1	126	132	PF11976	0.299
LIG_SUMO_SIM_par_1	14	19	PF11976	0.396
LIG_SUMO_SIM_par_1	491	496	PF11976	0.746
LIG_SUMO_SIM_par_1	780	785	PF11976	0.442
LIG_SUMO_SIM_par_1	808	814	PF11976	0.362
LIG_TRAF2_1	360	363	PF00917	0.691
LIG_TRAF2_1	660	663	PF00917	0.501
LIG_TYR_ITIM	637	642	PF00017	0.282
LIG_UBA3_1	435	443	PF00899	0.472
LIG_WW_3	207	211	PF00397	0.582
LIG_WW_3	508	512	PF00397	0.757
MOD_CDC14_SPxK_1	173	176	PF00782	0.456
MOD_CDK_SPK_2	479	484	PF00069	0.797
MOD_CDK_SPxK_1	170	176	PF00069	0.520
MOD_CDK_SPxK_1	479	485	PF00069	0.771
MOD_CK1_1	170	176	PF00069	0.532
MOD_CK1_1	202	208	PF00069	0.541
MOD_CK1_1	344	350	PF00069	0.736
MOD_CK1_1	367	373	PF00069	0.729
MOD_CK1_1	416	422	PF00069	0.546
MOD_CK1_1	595	601	PF00069	0.560
MOD_CK1_1	654	660	PF00069	0.447
MOD_CK1_1	681	687	PF00069	0.584
MOD_CK1_1	728	734	PF00069	0.420
MOD_CK1_1	85	91	PF00069	0.436
MOD_CK2_1	553	559	PF00069	0.369
MOD_Cter_Amidation	767	770	PF01082	0.583
MOD_GlcNHglycan	118	121	PF01048	0.400
MOD_GlcNHglycan	186	189	PF01048	0.353
MOD_GlcNHglycan	205	208	PF01048	0.288
MOD_GlcNHglycan	222	225	PF01048	0.413
MOD_GlcNHglycan	237	240	PF01048	0.413
MOD_GlcNHglycan	294	297	PF01048	0.571
MOD_GlcNHglycan	343	346	PF01048	0.546
MOD_GlcNHglycan	351	354	PF01048	0.560
MOD_GlcNHglycan	366	369	PF01048	0.581
MOD_GlcNHglycan	382	385	PF01048	0.382
MOD_GlcNHglycan	477	480	PF01048	0.564
MOD_GlcNHglycan	50	53	PF01048	0.501
MOD_GlcNHglycan	555	558	PF01048	0.590
MOD_GlcNHglycan	663	666	PF01048	0.658
MOD_GlcNHglycan	733	736	PF01048	0.571
MOD_GlcNHglycan	758	761	PF01048	0.624
MOD_GSK3_1	139	146	PF00069	0.337
MOD_GSK3_1	160	167	PF00069	0.370
MOD_GSK3_1	195	202	PF00069	0.550
MOD_GSK3_1	340	347	PF00069	0.702
MOD_GSK3_1	367	374	PF00069	0.770
MOD_GSK3_1	375	382	PF00069	0.752
MOD_GSK3_1	475	482	PF00069	0.720
MOD_GSK3_1	48	55	PF00069	0.301
MOD_GSK3_1	601	608	PF00069	0.478
MOD_GSK3_1	676	683	PF00069	0.588
MOD_GSK3_1	686	693	PF00069	0.581
MOD_N-GLC_1	364	369	PF02516	0.572
MOD_N-GLC_1	756	761	PF02516	0.622
MOD_N-GLC_2	99	101	PF02516	0.382
MOD_NEK2_1	110	115	PF00069	0.394
MOD_NEK2_1	116	121	PF00069	0.394
MOD_NEK2_1	129	134	PF00069	0.491
MOD_NEK2_1	16	21	PF00069	0.402
MOD_NEK2_1	220	225	PF00069	0.437
MOD_NEK2_1	254	259	PF00069	0.425
MOD_NEK2_1	292	297	PF00069	0.382
MOD_NEK2_1	340	345	PF00069	0.708
MOD_NEK2_1	375	380	PF00069	0.754
MOD_NEK2_1	392	397	PF00069	0.657
MOD_NEK2_1	436	441	PF00069	0.430
MOD_NEK2_1	457	462	PF00069	0.374
MOD_NEK2_1	48	53	PF00069	0.301
MOD_NEK2_1	541	546	PF00069	0.351
MOD_NEK2_1	641	646	PF00069	0.331
MOD_NEK2_1	751	756	PF00069	0.356
MOD_NEK2_1	798	803	PF00069	0.472
MOD_NEK2_2	23	28	PF00069	0.299
MOD_PIKK_1	160	166	PF00454	0.492
MOD_PIKK_1	605	611	PF00454	0.503
MOD_PIKK_1	768	774	PF00454	0.509
MOD_PKA_1	511	517	PF00069	0.784
MOD_PKA_2	194	200	PF00069	0.563
MOD_PKA_2	277	283	PF00069	0.355
MOD_PKA_2	3	9	PF00069	0.655
MOD_PKA_2	380	386	PF00069	0.745
MOD_PKA_2	416	422	PF00069	0.582
MOD_PKA_2	511	517	PF00069	0.784
MOD_PKA_2	690	696	PF00069	0.511
MOD_PKA_2	768	774	PF00069	0.528
MOD_PKB_1	377	385	PF00069	0.750
MOD_Plk_1	34	40	PF00069	0.324
MOD_Plk_1	364	370	PF00069	0.795
MOD_Plk_1	756	762	PF00069	0.423
MOD_Plk_4	110	116	PF00069	0.377
MOD_Plk_4	139	145	PF00069	0.396
MOD_Plk_4	257	263	PF00069	0.488
MOD_Plk_4	265	271	PF00069	0.353
MOD_Plk_4	371	377	PF00069	0.782
MOD_Plk_4	392	398	PF00069	0.667
MOD_Plk_4	626	632	PF00069	0.344
MOD_Plk_4	651	657	PF00069	0.453
MOD_Plk_4	746	752	PF00069	0.422
MOD_ProDKin_1	167	173	PF00069	0.493
MOD_ProDKin_1	195	201	PF00069	0.550
MOD_ProDKin_1	367	373	PF00069	0.736
MOD_ProDKin_1	446	452	PF00069	0.355
MOD_ProDKin_1	479	485	PF00069	0.745
MOD_ProDKin_1	486	492	PF00069	0.754
MOD_ProDKin_1	519	525	PF00069	0.655
MOD_ProDKin_1	592	598	PF00069	0.542
MOD_ProDKin_1	654	660	PF00069	0.414
MOD_ProDKin_1	678	684	PF00069	0.603
MOD_ProDKin_1	725	731	PF00069	0.365
MOD_ProDKin_1	784	790	PF00069	0.376
MOD_SUMO_for_1	483	486	PF00179	0.760
TRG_DiLeu_BaEn_2	35	41	PF01217	0.301
TRG_ENDOCYTIC_2	289	292	PF00928	0.324
TRG_ENDOCYTIC_2	452	455	PF00928	0.337
TRG_ENDOCYTIC_2	566	569	PF00928	0.335
TRG_ENDOCYTIC_2	614	617	PF00928	0.382
TRG_ENDOCYTIC_2	639	642	PF00928	0.335
TRG_ENDOCYTIC_2	779	782	PF00928	0.400
TRG_ENDOCYTIC_2	795	798	PF00928	0.324
TRG_ENDOCYTIC_2	8	11	PF00928	0.622
TRG_ENDOCYTIC_2	92	95	PF00928	0.359
TRG_ER_diArg_1	336	338	PF00400	0.670
TRG_ER_diArg_1	376	379	PF00400	0.753
TRG_ER_diArg_1	510	512	PF00400	0.798
TRG_ER_diArg_1	584	586	PF00400	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3C3	Leptomonas seymouri	53%	100%
A0A0S4ITY5	Bodo saltans	27%	100%
A0A422NUF2	Trypanosoma rangeli	40%	100%
C9ZQC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AGA5	Leishmania infantum	99%	100%
E9ANU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	98%
Q4QGS7	Leishmania major	80%	99%