AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBE1_LEIDO

TriTrypDb:

LdBPK_241520.1 , LdCL_240020400 , LDHU3_24.1850

Length:

812

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IBE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBE1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.732
CLV_C14_Caspase3-7	223	227	PF00656	0.656
CLV_NRD_NRD_1	119	121	PF00675	0.675
CLV_NRD_NRD_1	169	171	PF00675	0.643
CLV_NRD_NRD_1	184	186	PF00675	0.763
CLV_NRD_NRD_1	32	34	PF00675	0.754
CLV_NRD_NRD_1	375	377	PF00675	0.756
CLV_NRD_NRD_1	423	425	PF00675	0.591
CLV_NRD_NRD_1	43	45	PF00675	0.592
CLV_NRD_NRD_1	448	450	PF00675	0.609
CLV_NRD_NRD_1	462	464	PF00675	0.333
CLV_NRD_NRD_1	505	507	PF00675	0.790
CLV_NRD_NRD_1	555	557	PF00675	0.450
CLV_NRD_NRD_1	668	670	PF00675	0.677
CLV_NRD_NRD_1	796	798	PF00675	0.683
CLV_PCSK_KEX2_1	118	120	PF00082	0.660
CLV_PCSK_KEX2_1	169	171	PF00082	0.637
CLV_PCSK_KEX2_1	184	186	PF00082	0.715
CLV_PCSK_KEX2_1	270	272	PF00082	0.437
CLV_PCSK_KEX2_1	32	34	PF00082	0.755
CLV_PCSK_KEX2_1	410	412	PF00082	0.530
CLV_PCSK_KEX2_1	422	424	PF00082	0.626
CLV_PCSK_KEX2_1	43	45	PF00082	0.590
CLV_PCSK_KEX2_1	448	450	PF00082	0.609
CLV_PCSK_KEX2_1	462	464	PF00082	0.333
CLV_PCSK_KEX2_1	505	507	PF00082	0.737
CLV_PCSK_KEX2_1	541	543	PF00082	0.537
CLV_PCSK_KEX2_1	554	556	PF00082	0.405
CLV_PCSK_KEX2_1	668	670	PF00082	0.677
CLV_PCSK_KEX2_1	796	798	PF00082	0.683
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.437
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.530
CLV_PCSK_PC1ET2_1	541	543	PF00082	0.554
CLV_PCSK_PC7_1	550	556	PF00082	0.461
CLV_PCSK_PC7_1	792	798	PF00082	0.653
CLV_PCSK_SKI1_1	277	281	PF00082	0.645
CLV_PCSK_SKI1_1	313	317	PF00082	0.550
CLV_PCSK_SKI1_1	355	359	PF00082	0.588
CLV_PCSK_SKI1_1	463	467	PF00082	0.414
CLV_PCSK_SKI1_1	506	510	PF00082	0.711
CLV_PCSK_SKI1_1	586	590	PF00082	0.634
CLV_PCSK_SKI1_1	701	705	PF00082	0.453
CLV_PCSK_SKI1_1	75	79	PF00082	0.626
CLV_PCSK_SKI1_1	785	789	PF00082	0.578
DEG_APCC_DBOX_1	101	109	PF00400	0.729
DEG_APCC_DBOX_1	261	269	PF00400	0.586
DEG_APCC_DBOX_1	423	431	PF00400	0.485
DEG_APCC_DBOX_1	741	749	PF00400	0.510
DEG_COP1_1	208	216	PF00400	0.613
DEG_Nend_UBRbox_3	1	3	PF02207	0.630
DEG_SPOP_SBC_1	13	17	PF00917	0.557
DEG_SPOP_SBC_1	481	485	PF00917	0.553
DEG_SPOP_SBC_1	640	644	PF00917	0.524
DOC_AGCK_PIF_1	301	306	PF00069	0.574
DOC_CKS1_1	194	199	PF01111	0.796
DOC_CKS1_1	688	693	PF01111	0.606
DOC_CYCLIN_yCln2_LP_2	280	286	PF00134	0.600
DOC_CYCLIN_yCln2_LP_2	320	326	PF00134	0.430
DOC_CYCLIN_yCln2_LP_2	692	698	PF00134	0.445
DOC_MAPK_DCC_7	554	562	PF00069	0.534
DOC_MAPK_DCC_7	577	585	PF00069	0.617
DOC_MAPK_gen_1	344	353	PF00069	0.427
DOC_MAPK_gen_1	4	13	PF00069	0.584
DOC_MAPK_gen_1	422	430	PF00069	0.595
DOC_MAPK_gen_1	554	562	PF00069	0.531
DOC_MAPK_HePTP_8	552	564	PF00069	0.513
DOC_MAPK_MEF2A_6	4	13	PF00069	0.547
DOC_MAPK_MEF2A_6	423	432	PF00069	0.466
DOC_MAPK_MEF2A_6	554	562	PF00069	0.531
DOC_MAPK_MEF2A_6	577	585	PF00069	0.617
DOC_PP2B_LxvP_1	28	31	PF13499	0.689
DOC_PP2B_LxvP_1	320	323	PF13499	0.423
DOC_SPAK_OSR1_1	336	340	PF12202	0.511
DOC_USP7_MATH_1	133	137	PF00917	0.755
DOC_USP7_MATH_1	14	18	PF00917	0.675
DOC_USP7_MATH_1	151	155	PF00917	0.697
DOC_USP7_MATH_1	19	23	PF00917	0.615
DOC_USP7_MATH_1	207	211	PF00917	0.617
DOC_USP7_MATH_1	361	365	PF00917	0.683
DOC_USP7_MATH_1	566	570	PF00917	0.365
DOC_USP7_MATH_1	610	614	PF00917	0.730
DOC_USP7_MATH_1	616	620	PF00917	0.686
DOC_USP7_MATH_1	639	643	PF00917	0.536
DOC_WW_Pin1_4	100	105	PF00397	0.601
DOC_WW_Pin1_4	131	136	PF00397	0.616
DOC_WW_Pin1_4	179	184	PF00397	0.677
DOC_WW_Pin1_4	193	198	PF00397	0.709
DOC_WW_Pin1_4	433	438	PF00397	0.441
DOC_WW_Pin1_4	612	617	PF00397	0.747
DOC_WW_Pin1_4	620	625	PF00397	0.623
DOC_WW_Pin1_4	642	647	PF00397	0.738
DOC_WW_Pin1_4	687	692	PF00397	0.671
DOC_WW_Pin1_4	69	74	PF00397	0.706
LIG_14-3-3_CanoR_1	102	110	PF00244	0.606
LIG_14-3-3_CanoR_1	120	126	PF00244	0.718
LIG_14-3-3_CanoR_1	328	332	PF00244	0.460
LIG_14-3-3_CanoR_1	490	498	PF00244	0.716
LIG_14-3-3_CanoR_1	738	746	PF00244	0.653
LIG_Actin_WH2_2	704	720	PF00022	0.434
LIG_BIR_III_2	204	208	PF00653	0.789
LIG_BRCT_BRCA1_1	333	337	PF00533	0.519
LIG_BRCT_BRCA1_1	644	648	PF00533	0.704
LIG_CtBP_PxDLS_1	624	628	PF00389	0.530
LIG_FHA_1	54	60	PF00498	0.691
LIG_FHA_1	590	596	PF00498	0.694
LIG_FHA_1	718	724	PF00498	0.525
LIG_FHA_1	734	740	PF00498	0.565
LIG_FHA_1	78	84	PF00498	0.608
LIG_FHA_2	143	149	PF00498	0.604
LIG_FHA_2	194	200	PF00498	0.783
LIG_FHA_2	213	219	PF00498	0.507
LIG_FHA_2	261	267	PF00498	0.487
LIG_FHA_2	360	366	PF00498	0.670
LIG_FHA_2	386	392	PF00498	0.651
LIG_FHA_2	445	451	PF00498	0.683
LIG_FHA_2	483	489	PF00498	0.719
LIG_FHA_2	647	653	PF00498	0.792
LIG_FHA_2	728	734	PF00498	0.802
LIG_FHA_2	76	82	PF00498	0.609
LIG_Integrin_isoDGR_2	420	422	PF01839	0.609
LIG_IRF3_LxIS_1	557	563	PF10401	0.497
LIG_LIR_Gen_1	546	552	PF02991	0.448
LIG_LIR_Gen_1	704	715	PF02991	0.537
LIG_LIR_LC3C_4	468	472	PF02991	0.367
LIG_LIR_Nem_3	296	301	PF02991	0.410
LIG_LIR_Nem_3	310	315	PF02991	0.433
LIG_LIR_Nem_3	546	551	PF02991	0.455
LIG_LIR_Nem_3	704	710	PF02991	0.540
LIG_MYND_1	69	73	PF01753	0.665
LIG_Pex14_1	333	337	PF04695	0.519
LIG_Pex14_2	297	301	PF04695	0.387
LIG_Pex14_2	783	787	PF04695	0.630
LIG_SH2_CRK	312	316	PF00017	0.415
LIG_SH2_CRK	475	479	PF00017	0.438
LIG_SH2_CRK	712	716	PF00017	0.445
LIG_SH2_STAP1	304	308	PF00017	0.584
LIG_SH2_STAT3	304	307	PF00017	0.457
LIG_SH2_STAT5	162	165	PF00017	0.725
LIG_SH2_STAT5	526	529	PF00017	0.550
LIG_SH2_STAT5	763	766	PF00017	0.457
LIG_SH3_1	475	481	PF00018	0.455
LIG_SH3_2	180	185	PF14604	0.735
LIG_SH3_3	129	135	PF00018	0.770
LIG_SH3_3	177	183	PF00018	0.779
LIG_SH3_3	28	34	PF00018	0.693
LIG_SH3_3	282	288	PF00018	0.632
LIG_SH3_3	434	440	PF00018	0.459
LIG_SH3_3	474	480	PF00018	0.450
LIG_SH3_3	670	676	PF00018	0.767
LIG_SH3_3	685	691	PF00018	0.492
LIG_SUMO_SIM_anti_2	468	474	PF11976	0.492
LIG_SUMO_SIM_par_1	558	563	PF11976	0.425
LIG_SUMO_SIM_par_1	623	628	PF11976	0.581
LIG_TYR_ITIM	710	715	PF00017	0.439
MOD_CDC14_SPxK_1	182	185	PF00782	0.620
MOD_CDK_SPK_2	179	184	PF00069	0.609
MOD_CDK_SPxK_1	179	185	PF00069	0.612
MOD_CDK_SPxK_1	69	75	PF00069	0.616
MOD_CDK_SPxxK_3	687	694	PF00069	0.632
MOD_CK1_1	103	109	PF00069	0.555
MOD_CK1_1	136	142	PF00069	0.723
MOD_CK1_1	154	160	PF00069	0.548
MOD_CK1_1	239	245	PF00069	0.556
MOD_CK1_1	394	400	PF00069	0.700
MOD_CK1_1	483	489	PF00069	0.657
MOD_CK1_1	53	59	PF00069	0.593
MOD_CK1_1	534	540	PF00069	0.453
MOD_CK1_1	642	648	PF00069	0.758
MOD_CK1_1	727	733	PF00069	0.677
MOD_CK2_1	142	148	PF00069	0.616
MOD_CK2_1	205	211	PF00069	0.793
MOD_CK2_1	260	266	PF00069	0.493
MOD_CK2_1	359	365	PF00069	0.656
MOD_CK2_1	444	450	PF00069	0.535
MOD_CK2_1	620	626	PF00069	0.604
MOD_CK2_1	727	733	PF00069	0.793
MOD_Cter_Amidation	41	44	PF01082	0.568
MOD_Cter_Amidation	420	423	PF01082	0.621
MOD_DYRK1A_RPxSP_1	179	183	PF00069	0.603
MOD_GlcNHglycan	157	160	PF01048	0.683
MOD_GlcNHglycan	176	179	PF01048	0.779
MOD_GlcNHglycan	189	192	PF01048	0.580
MOD_GlcNHglycan	21	24	PF01048	0.658
MOD_GlcNHglycan	220	223	PF01048	0.670
MOD_GlcNHglycan	231	234	PF01048	0.656
MOD_GlcNHglycan	333	336	PF01048	0.519
MOD_GlcNHglycan	397	400	PF01048	0.699
MOD_GlcNHglycan	467	470	PF01048	0.535
MOD_GlcNHglycan	612	615	PF01048	0.763
MOD_GlcNHglycan	616	619	PF01048	0.690
MOD_GlcNHglycan	626	630	PF01048	0.440
MOD_GlcNHglycan	655	658	PF01048	0.744
MOD_GlcNHglycan	696	699	PF01048	0.430
MOD_GlcNHglycan	725	729	PF01048	0.654
MOD_GlcNHglycan	803	806	PF01048	0.669
MOD_GlcNHglycan	94	98	PF01048	0.666
MOD_GSK3_1	133	140	PF00069	0.611
MOD_GSK3_1	150	157	PF00069	0.701
MOD_GSK3_1	327	334	PF00069	0.452
MOD_GSK3_1	391	398	PF00069	0.673
MOD_GSK3_1	480	487	PF00069	0.620
MOD_GSK3_1	509	516	PF00069	0.627
MOD_GSK3_1	562	569	PF00069	0.402
MOD_GSK3_1	610	617	PF00069	0.736
MOD_GSK3_1	642	649	PF00069	0.682
MOD_GSK3_1	717	724	PF00069	0.565
MOD_GSK3_1	733	740	PF00069	0.536
MOD_LATS_1	587	593	PF00433	0.685
MOD_N-GLC_1	137	142	PF02516	0.640
MOD_NEK2_1	108	113	PF00069	0.654
MOD_NEK2_1	12	17	PF00069	0.558
MOD_NEK2_1	142	147	PF00069	0.803
MOD_NEK2_1	229	234	PF00069	0.722
MOD_NEK2_1	359	364	PF00069	0.481
MOD_NEK2_1	428	433	PF00069	0.605
MOD_NEK2_1	444	449	PF00069	0.406
MOD_NEK2_1	496	501	PF00069	0.711
MOD_NEK2_1	532	537	PF00069	0.456
MOD_NEK2_1	560	565	PF00069	0.486
MOD_NEK2_1	627	632	PF00069	0.440
MOD_NEK2_1	717	722	PF00069	0.468
MOD_NEK2_1	737	742	PF00069	0.709
MOD_PIKK_1	163	169	PF00454	0.716
MOD_PIKK_1	205	211	PF00454	0.803
MOD_PIKK_1	260	266	PF00454	0.628
MOD_PIKK_1	717	723	PF00454	0.489
MOD_PKA_2	142	148	PF00069	0.681
MOD_PKA_2	160	166	PF00069	0.532
MOD_PKA_2	187	193	PF00069	0.612
MOD_PKA_2	327	333	PF00069	0.450
MOD_PKA_2	385	391	PF00069	0.668
MOD_PKA_2	489	495	PF00069	0.608
MOD_PKA_2	67	73	PF00069	0.753
MOD_PKA_2	717	723	PF00069	0.462
MOD_PKA_2	737	743	PF00069	0.694
MOD_PKB_1	147	155	PF00069	0.720
MOD_Plk_1	137	143	PF00069	0.623
MOD_Plk_1	391	397	PF00069	0.567
MOD_Plk_1	732	738	PF00069	0.653
MOD_Plk_1	779	785	PF00069	0.511
MOD_Plk_2-3	220	226	PF00069	0.761
MOD_Plk_4	428	434	PF00069	0.611
MOD_Plk_4	522	528	PF00069	0.539
MOD_ProDKin_1	100	106	PF00069	0.601
MOD_ProDKin_1	131	137	PF00069	0.621
MOD_ProDKin_1	179	185	PF00069	0.680
MOD_ProDKin_1	193	199	PF00069	0.710
MOD_ProDKin_1	433	439	PF00069	0.445
MOD_ProDKin_1	612	618	PF00069	0.745
MOD_ProDKin_1	620	626	PF00069	0.614
MOD_ProDKin_1	642	648	PF00069	0.749
MOD_ProDKin_1	687	693	PF00069	0.654
MOD_ProDKin_1	69	75	PF00069	0.708
MOD_SUMO_rev_2	241	249	PF00179	0.553
TRG_DiLeu_BaEn_4	759	765	PF01217	0.548
TRG_DiLeu_BaLyEn_6	449	454	PF01217	0.587
TRG_DiLeu_BaLyEn_6	547	552	PF01217	0.520
TRG_ENDOCYTIC_2	312	315	PF00928	0.420
TRG_ENDOCYTIC_2	712	715	PF00928	0.444
TRG_ER_diArg_1	118	120	PF00400	0.691
TRG_ER_diArg_1	169	172	PF00400	0.696
TRG_ER_diArg_1	183	185	PF00400	0.677
TRG_ER_diArg_1	31	33	PF00400	0.753
TRG_ER_diArg_1	422	424	PF00400	0.573
TRG_ER_diArg_1	461	463	PF00400	0.412
TRG_ER_diArg_1	554	556	PF00400	0.436
TRG_ER_diArg_1	667	669	PF00400	0.668
TRG_ER_diArg_1	796	799	PF00400	0.546
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.670
TRG_Pf-PMV_PEXEL_1	796	801	PF00026	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM86	Leptomonas seymouri	43%	100%
A4HDJ4	Leishmania braziliensis	68%	100%
E9AH60	Leishmania infantum	99%	100%
E9AWZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QAI5	Leishmania major	88%	100%