Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBC8_LEIDO

TriTrypDb:

LdBPK_190530.1 , LdCL_190010300 , LDHU3_19.0590

Length:

742

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	9
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1

Expansion

Sequence features

A0A3Q8IBC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBC8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.734
CLV_C14_Caspase3-7	441	445	PF00656	0.518
CLV_C14_Caspase3-7	562	566	PF00656	0.745
CLV_C14_Caspase3-7	593	597	PF00656	0.706
CLV_NRD_NRD_1	132	134	PF00675	0.673
CLV_NRD_NRD_1	216	218	PF00675	0.715
CLV_NRD_NRD_1	399	401	PF00675	0.657
CLV_NRD_NRD_1	470	472	PF00675	0.705
CLV_NRD_NRD_1	585	587	PF00675	0.645
CLV_PCSK_FUR_1	56	60	PF00082	0.763
CLV_PCSK_KEX2_1	132	134	PF00082	0.739
CLV_PCSK_KEX2_1	216	218	PF00082	0.681
CLV_PCSK_KEX2_1	399	401	PF00082	0.657
CLV_PCSK_KEX2_1	470	472	PF00082	0.674
CLV_PCSK_KEX2_1	58	60	PF00082	0.711
CLV_PCSK_KEX2_1	584	586	PF00082	0.644
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.759
CLV_PCSK_SKI1_1	229	233	PF00082	0.582
CLV_PCSK_SKI1_1	330	334	PF00082	0.511
CLV_PCSK_SKI1_1	391	395	PF00082	0.595
CLV_PCSK_SKI1_1	543	547	PF00082	0.743
CLV_PCSK_SKI1_1	735	739	PF00082	0.632
DEG_APCC_DBOX_1	725	733	PF00400	0.644
DEG_SCF_TRCP1_1	629	635	PF00400	0.551
DEG_SPOP_SBC_1	687	691	PF00917	0.710
DOC_CKS1_1	165	170	PF01111	0.744
DOC_CKS1_1	196	201	PF01111	0.612
DOC_CYCLIN_RxL_1	294	303	PF00134	0.486
DOC_MAPK_gen_1	470	476	PF00069	0.669
DOC_MAPK_gen_1	548	556	PF00069	0.695
DOC_PIKK_1	484	491	PF02985	0.635
DOC_PP1_RVXF_1	97	104	PF00149	0.778
DOC_PP2B_LxvP_1	322	325	PF13499	0.473
DOC_PP2B_LxvP_1	434	437	PF13499	0.562
DOC_PP2B_LxvP_1	472	475	PF13499	0.764
DOC_PP2B_LxvP_1	77	80	PF13499	0.732
DOC_USP7_MATH_1	110	114	PF00917	0.699
DOC_USP7_MATH_1	25	29	PF00917	0.710
DOC_USP7_MATH_1	41	45	PF00917	0.515
DOC_USP7_MATH_1	522	526	PF00917	0.627
DOC_USP7_MATH_1	544	548	PF00917	0.678
DOC_USP7_MATH_1	579	583	PF00917	0.705
DOC_USP7_MATH_1	588	592	PF00917	0.732
DOC_USP7_MATH_1	655	659	PF00917	0.683
DOC_USP7_MATH_1	694	698	PF00917	0.716
DOC_USP7_MATH_1	711	715	PF00917	0.661
DOC_USP7_MATH_1	737	741	PF00917	0.663
DOC_WW_Pin1_4	164	169	PF00397	0.740
DOC_WW_Pin1_4	195	200	PF00397	0.634
DOC_WW_Pin1_4	330	335	PF00397	0.436
DOC_WW_Pin1_4	410	415	PF00397	0.690
LIG_14-3-3_CanoR_1	148	156	PF00244	0.721
LIG_14-3-3_CanoR_1	216	225	PF00244	0.636
LIG_14-3-3_CanoR_1	229	236	PF00244	0.429
LIG_14-3-3_CanoR_1	521	531	PF00244	0.629
LIG_14-3-3_CanoR_1	586	594	PF00244	0.565
LIG_14-3-3_CanoR_1	672	682	PF00244	0.704
LIG_14-3-3_CanoR_1	81	91	PF00244	0.816
LIG_BIR_III_2	331	335	PF00653	0.442
LIG_BIR_III_4	126	130	PF00653	0.695
LIG_BRCT_BRCA1_1	590	594	PF00533	0.672
LIG_deltaCOP1_diTrp_1	238	242	PF00928	0.470
LIG_deltaCOP1_diTrp_1	659	666	PF00928	0.716
LIG_FHA_1	106	112	PF00498	0.660
LIG_FHA_1	191	197	PF00498	0.730
LIG_FHA_1	230	236	PF00498	0.464
LIG_FHA_1	248	254	PF00498	0.470
LIG_FHA_1	339	345	PF00498	0.435
LIG_FHA_1	34	40	PF00498	0.693
LIG_FHA_1	43	49	PF00498	0.669
LIG_FHA_1	569	575	PF00498	0.625
LIG_FHA_1	578	584	PF00498	0.704
LIG_FHA_1	637	643	PF00498	0.674
LIG_FHA_2	21	27	PF00498	0.709
LIG_FHA_2	216	222	PF00498	0.712
LIG_FHA_2	238	244	PF00498	0.428
LIG_FHA_2	439	445	PF00498	0.509
LIG_FHA_2	476	482	PF00498	0.658
LIG_FHA_2	702	708	PF00498	0.735
LIG_LIR_Gen_1	240	249	PF02991	0.463
LIG_LIR_Gen_1	291	301	PF02991	0.365
LIG_LIR_Gen_1	502	511	PF02991	0.597
LIG_LIR_Gen_1	660	671	PF02991	0.711
LIG_LIR_Gen_1	697	703	PF02991	0.711
LIG_LIR_Nem_3	240	245	PF02991	0.524
LIG_LIR_Nem_3	291	296	PF02991	0.374
LIG_LIR_Nem_3	321	326	PF02991	0.390
LIG_LIR_Nem_3	388	393	PF02991	0.491
LIG_LIR_Nem_3	502	507	PF02991	0.580
LIG_LIR_Nem_3	660	666	PF02991	0.573
LIG_LIR_Nem_3	697	701	PF02991	0.721
LIG_MYND_1	531	535	PF01753	0.720
LIG_MYND_3	436	440	PF01753	0.505
LIG_Pex14_2	545	549	PF04695	0.761
LIG_SH2_CRK	15	19	PF00017	0.711
LIG_SH2_CRK	519	523	PF00017	0.614
LIG_SH2_CRK	698	702	PF00017	0.713
LIG_SH2_NCK_1	15	19	PF00017	0.608
LIG_SH2_NCK_1	519	523	PF00017	0.596
LIG_SH2_STAP1	226	230	PF00017	0.586
LIG_SH2_STAT5	118	121	PF00017	0.754
LIG_SH2_STAT5	298	301	PF00017	0.471
LIG_SH2_STAT5	323	326	PF00017	0.492
LIG_SH2_STAT5	519	522	PF00017	0.618
LIG_SH2_STAT5	632	635	PF00017	0.690
LIG_SH2_STAT5	703	706	PF00017	0.672
LIG_SH3_3	193	199	PF00018	0.635
LIG_SH3_3	408	414	PF00018	0.739
LIG_SUMO_SIM_anti_2	243	250	PF11976	0.529
LIG_SUMO_SIM_anti_2	341	346	PF11976	0.405
LIG_SUMO_SIM_par_1	339	346	PF11976	0.433
LIG_TRAF2_1	464	467	PF00917	0.736
LIG_TRAF2_1	658	661	PF00917	0.716
LIG_TYR_ITIM	296	301	PF00017	0.481
LIG_UBA3_1	50	58	PF00899	0.791
LIG_WW_3	78	82	PF00397	0.689
MOD_CDK_SPK_2	164	169	PF00069	0.600
MOD_CK1_1	138	144	PF00069	0.644
MOD_CK1_1	17	23	PF00069	0.770
MOD_CK1_1	190	196	PF00069	0.725
MOD_CK1_1	271	277	PF00069	0.487
MOD_CK1_1	28	34	PF00069	0.785
MOD_CK1_1	450	456	PF00069	0.641
MOD_CK1_1	547	553	PF00069	0.639
MOD_CK1_1	567	573	PF00069	0.622
MOD_CK1_1	590	596	PF00069	0.643
MOD_CK1_1	65	71	PF00069	0.710
MOD_CK1_1	673	679	PF00069	0.700
MOD_CK2_1	138	144	PF00069	0.781
MOD_CK2_1	215	221	PF00069	0.614
MOD_CK2_1	237	243	PF00069	0.415
MOD_CK2_1	315	321	PF00069	0.507
MOD_CK2_1	37	43	PF00069	0.632
MOD_CK2_1	460	466	PF00069	0.744
MOD_CK2_1	655	661	PF00069	0.670
MOD_CK2_1	701	707	PF00069	0.690
MOD_CMANNOS	239	242	PF00535	0.485
MOD_Cter_Amidation	397	400	PF01082	0.449
MOD_GlcNHglycan	135	138	PF01048	0.710
MOD_GlcNHglycan	176	180	PF01048	0.737
MOD_GlcNHglycan	30	33	PF01048	0.743
MOD_GlcNHglycan	338	341	PF01048	0.578
MOD_GlcNHglycan	39	42	PF01048	0.764
MOD_GlcNHglycan	407	410	PF01048	0.657
MOD_GlcNHglycan	526	529	PF01048	0.621
MOD_GlcNHglycan	600	605	PF01048	0.679
MOD_GlcNHglycan	607	610	PF01048	0.656
MOD_GlcNHglycan	622	625	PF01048	0.633
MOD_GlcNHglycan	629	632	PF01048	0.691
MOD_GlcNHglycan	639	642	PF01048	0.609
MOD_GlcNHglycan	64	67	PF01048	0.670
MOD_GlcNHglycan	676	679	PF01048	0.706
MOD_GlcNHglycan	690	693	PF01048	0.561
MOD_GlcNHglycan	85	88	PF01048	0.796
MOD_GlcNHglycan	94	97	PF01048	0.653
MOD_GSK3_1	133	140	PF00069	0.683
MOD_GSK3_1	143	150	PF00069	0.610
MOD_GSK3_1	216	223	PF00069	0.693
MOD_GSK3_1	225	232	PF00069	0.497
MOD_GSK3_1	268	275	PF00069	0.542
MOD_GSK3_1	300	307	PF00069	0.374
MOD_GSK3_1	33	40	PF00069	0.742
MOD_GSK3_1	447	454	PF00069	0.605
MOD_GSK3_1	462	469	PF00069	0.623
MOD_GSK3_1	50	57	PF00069	0.655
MOD_GSK3_1	517	524	PF00069	0.566
MOD_GSK3_1	543	550	PF00069	0.676
MOD_GSK3_1	555	562	PF00069	0.684
MOD_GSK3_1	564	571	PF00069	0.568
MOD_GSK3_1	61	68	PF00069	0.630
MOD_GSK3_1	616	623	PF00069	0.667
MOD_GSK3_1	632	639	PF00069	0.754
MOD_GSK3_1	666	673	PF00069	0.640
MOD_GSK3_1	83	90	PF00069	0.784
MOD_N-GLC_1	138	143	PF02516	0.735
MOD_N-GLC_1	278	283	PF02516	0.402
MOD_N-GLC_1	577	582	PF02516	0.755
MOD_N-GLC_1	605	610	PF02516	0.713
MOD_N-GLC_2	302	304	PF02516	0.495
MOD_NEK2_1	103	108	PF00069	0.783
MOD_NEK2_1	175	180	PF00069	0.698
MOD_NEK2_1	225	230	PF00069	0.591
MOD_NEK2_1	247	252	PF00069	0.444
MOD_NEK2_1	278	283	PF00069	0.396
MOD_NEK2_1	336	341	PF00069	0.533
MOD_NEK2_1	460	465	PF00069	0.726
MOD_NEK2_1	50	55	PF00069	0.726
MOD_NEK2_1	587	592	PF00069	0.662
MOD_NEK2_1	666	671	PF00069	0.652
MOD_NEK2_1	688	693	PF00069	0.747
MOD_NEK2_1	701	706	PF00069	0.733
MOD_NEK2_1	72	77	PF00069	0.771
MOD_NEK2_2	300	305	PF00069	0.480
MOD_NEK2_2	579	584	PF00069	0.702
MOD_PIKK_1	65	71	PF00454	0.751
MOD_PIKK_1	701	707	PF00454	0.711
MOD_PK_1	148	154	PF00069	0.574
MOD_PK_1	369	375	PF00069	0.336
MOD_PK_1	616	622	PF00069	0.563
MOD_PKA_1	216	222	PF00069	0.650
MOD_PKA_2	147	153	PF00069	0.752
MOD_PKA_2	215	221	PF00069	0.684
MOD_PKA_2	520	526	PF00069	0.681
MOD_PKA_2	547	553	PF00069	0.703
MOD_PKA_2	83	89	PF00069	0.828
MOD_PKB_1	59	67	PF00069	0.801
MOD_Plk_1	143	149	PF00069	0.708
MOD_Plk_1	187	193	PF00069	0.685
MOD_Plk_1	220	226	PF00069	0.641
MOD_Plk_1	25	31	PF00069	0.711
MOD_Plk_1	447	453	PF00069	0.639
MOD_Plk_1	564	570	PF00069	0.700
MOD_Plk_1	727	733	PF00069	0.592
MOD_Plk_2-3	221	227	PF00069	0.658
MOD_Plk_4	221	227	PF00069	0.636
MOD_Plk_4	315	321	PF00069	0.526
MOD_Plk_4	369	375	PF00069	0.515
MOD_Plk_4	564	570	PF00069	0.658
MOD_Plk_4	666	672	PF00069	0.600
MOD_ProDKin_1	164	170	PF00069	0.740
MOD_ProDKin_1	195	201	PF00069	0.632
MOD_ProDKin_1	330	336	PF00069	0.438
MOD_ProDKin_1	410	416	PF00069	0.687
MOD_SUMO_for_1	205	208	PF00179	0.650
MOD_SUMO_rev_2	419	424	PF00179	0.495
TRG_DiLeu_BaEn_1	243	248	PF01217	0.479
TRG_DiLeu_BaEn_1	489	494	PF01217	0.627
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.486
TRG_ENDOCYTIC_2	15	18	PF00928	0.712
TRG_ENDOCYTIC_2	298	301	PF00928	0.449
TRG_ENDOCYTIC_2	323	326	PF00928	0.393
TRG_ENDOCYTIC_2	390	393	PF00928	0.496
TRG_ENDOCYTIC_2	698	701	PF00928	0.719
TRG_ER_diArg_1	131	133	PF00400	0.658
TRG_ER_diArg_1	470	472	PF00400	0.769
TRG_ER_diArg_1	583	586	PF00400	0.621
TRG_ER_diArg_1	59	62	PF00400	0.741
TRG_ER_diArg_1	731	734	PF00400	0.528
TRG_NES_CRM1_1	243	258	PF08389	0.483
TRG_NES_CRM1_1	481	496	PF08389	0.636
TRG_NLS_MonoExtN_4	56	62	PF00514	0.800
TRG_Pf-PMV_PEXEL_1	391	396	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	433	438	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I334	Leptomonas seymouri	46%	84%
A0A1X0P7D2	Trypanosomatidae	33%	85%
A0A422P3D4	Trypanosoma rangeli	30%	94%
A4HA11	Leishmania braziliensis	72%	99%
A4HY75	Leishmania infantum	99%	100%
E9AS05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QDG8	Leishmania major	91%	100%
V5BBW9	Trypanosoma cruzi	31%	94%