Ser/thr protein phosphatase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ser/thr protein phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBC4_LEIDO

TriTrypDb:

LdBPK_221450.1 , LdCL_220021800 , LDHU3_22.2080

Length:

811

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IBC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBC4

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006797	polyphosphate metabolic process	4	1
GO:0006798	polyphosphate catabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016787	hydrolase activity	2	8
GO:0000298	endopolyphosphatase activity	6	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.547
CLV_NRD_NRD_1	254	256	PF00675	0.803
CLV_NRD_NRD_1	414	416	PF00675	0.336
CLV_NRD_NRD_1	480	482	PF00675	0.417
CLV_NRD_NRD_1	75	77	PF00675	0.811
CLV_NRD_NRD_1	777	779	PF00675	0.466
CLV_PCSK_FUR_1	411	415	PF00082	0.391
CLV_PCSK_KEX2_1	413	415	PF00082	0.391
CLV_PCSK_KEX2_1	427	429	PF00082	0.391
CLV_PCSK_KEX2_1	480	482	PF00082	0.417
CLV_PCSK_KEX2_1	75	77	PF00082	0.811
CLV_PCSK_KEX2_1	799	801	PF00082	0.501
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.391
CLV_PCSK_PC1ET2_1	799	801	PF00082	0.501
CLV_PCSK_PC7_1	423	429	PF00082	0.391
CLV_PCSK_SKI1_1	361	365	PF00082	0.468
CLV_PCSK_SKI1_1	415	419	PF00082	0.391
CLV_PCSK_SKI1_1	6	10	PF00082	0.784
CLV_PCSK_SKI1_1	611	615	PF00082	0.665
CLV_PCSK_SKI1_1	663	667	PF00082	0.664
CLV_PCSK_SKI1_1	739	743	PF00082	0.443
CLV_PCSK_SKI1_1	785	789	PF00082	0.466
CLV_PCSK_SKI1_1	800	804	PF00082	0.347
CLV_Separin_Metazoa	333	337	PF03568	0.592
DEG_APCC_DBOX_1	5	13	PF00400	0.783
DEG_APCC_DBOX_1	687	695	PF00400	0.480
DEG_Nend_UBRbox_2	1	3	PF02207	0.723
DEG_SCF_FBW7_1	652	659	PF00400	0.758
DEG_SPOP_SBC_1	153	157	PF00917	0.641
DEG_SPOP_SBC_1	172	176	PF00917	0.706
DEG_SPOP_SBC_1	267	271	PF00917	0.776
DEG_SPOP_SBC_1	293	297	PF00917	0.661
DEG_SPOP_SBC_1	45	49	PF00917	0.698
DEG_SPOP_SBC_1	656	660	PF00917	0.723
DOC_CDC14_PxL_1	557	565	PF14671	0.440
DOC_CKS1_1	416	421	PF01111	0.391
DOC_CKS1_1	653	658	PF01111	0.684
DOC_CKS1_1	664	669	PF01111	0.682
DOC_CYCLIN_RxL_1	3	13	PF00134	0.783
DOC_CYCLIN_yClb5_NLxxxL_5	4	12	PF00134	0.706
DOC_CYCLIN_yCln2_LP_2	615	621	PF00134	0.681
DOC_MAPK_gen_1	361	371	PF00069	0.399
DOC_MAPK_gen_1	449	458	PF00069	0.332
DOC_MAPK_gen_1	506	516	PF00069	0.522
DOC_MAPK_gen_1	799	810	PF00069	0.478
DOC_MAPK_MEF2A_6	698	707	PF00069	0.460
DOC_PP2B_LxvP_1	573	576	PF13499	0.624
DOC_PP2B_LxvP_1	615	618	PF13499	0.619
DOC_PP2B_LxvP_1	707	710	PF13499	0.576
DOC_PP4_FxxP_1	558	561	PF00568	0.426
DOC_PP4_FxxP_1	733	736	PF00568	0.376
DOC_USP7_MATH_1	116	120	PF00917	0.721
DOC_USP7_MATH_1	153	157	PF00917	0.641
DOC_USP7_MATH_1	171	175	PF00917	0.741
DOC_USP7_MATH_1	205	209	PF00917	0.765
DOC_USP7_MATH_1	221	225	PF00917	0.528
DOC_USP7_MATH_1	236	240	PF00917	0.707
DOC_USP7_MATH_1	266	270	PF00917	0.706
DOC_USP7_MATH_1	281	285	PF00917	0.698
DOC_USP7_MATH_1	293	297	PF00917	0.685
DOC_USP7_MATH_1	38	42	PF00917	0.707
DOC_USP7_MATH_1	464	468	PF00917	0.276
DOC_USP7_MATH_1	57	61	PF00917	0.594
DOC_USP7_MATH_1	624	628	PF00917	0.707
DOC_USP7_MATH_1	92	96	PF00917	0.706
DOC_USP7_UBL2_3	493	497	PF12436	0.518
DOC_USP7_UBL2_3	799	803	PF12436	0.436
DOC_WW_Pin1_4	141	146	PF00397	0.699
DOC_WW_Pin1_4	158	163	PF00397	0.643
DOC_WW_Pin1_4	193	198	PF00397	0.759
DOC_WW_Pin1_4	271	276	PF00397	0.749
DOC_WW_Pin1_4	29	34	PF00397	0.696
DOC_WW_Pin1_4	41	46	PF00397	0.745
DOC_WW_Pin1_4	415	420	PF00397	0.391
DOC_WW_Pin1_4	549	554	PF00397	0.502
DOC_WW_Pin1_4	597	602	PF00397	0.674
DOC_WW_Pin1_4	652	657	PF00397	0.667
DOC_WW_Pin1_4	663	668	PF00397	0.685
DOC_WW_Pin1_4	791	796	PF00397	0.577
DOC_WW_Pin1_4	88	93	PF00397	0.723
LIG_14-3-3_CanoR_1	16	23	PF00244	0.634
LIG_14-3-3_CanoR_1	166	171	PF00244	0.730
LIG_14-3-3_CanoR_1	6	15	PF00244	0.756
LIG_14-3-3_CanoR_1	688	692	PF00244	0.493
LIG_14-3-3_CanoR_1	698	707	PF00244	0.468
LIG_BIR_III_4	127	131	PF00653	0.579
LIG_BIR_III_4	313	317	PF00653	0.496
LIG_deltaCOP1_diTrp_1	502	508	PF00928	0.440
LIG_deltaCOP1_diTrp_1	731	737	PF00928	0.558
LIG_FHA_1	175	181	PF00498	0.712
LIG_FHA_1	232	238	PF00498	0.712
LIG_FHA_1	322	328	PF00498	0.487
LIG_FHA_1	533	539	PF00498	0.389
LIG_FHA_1	542	548	PF00498	0.378
LIG_FHA_1	598	604	PF00498	0.563
LIG_FHA_1	61	67	PF00498	0.716
LIG_FHA_1	642	648	PF00498	0.711
LIG_FHA_1	657	663	PF00498	0.636
LIG_FHA_1	666	672	PF00498	0.767
LIG_FHA_1	676	682	PF00498	0.511
LIG_FHA_1	695	701	PF00498	0.332
LIG_FHA_1	736	742	PF00498	0.441
LIG_FHA_1	760	766	PF00498	0.450
LIG_FHA_1	805	811	PF00498	0.498
LIG_FHA_1	91	97	PF00498	0.715
LIG_FHA_2	416	422	PF00498	0.332
LIG_LIR_Apic_2	556	561	PF02991	0.484
LIG_LIR_Apic_2	731	736	PF02991	0.466
LIG_LIR_Gen_1	337	346	PF02991	0.332
LIG_LIR_Gen_1	402	410	PF02991	0.391
LIG_LIR_Gen_1	502	511	PF02991	0.480
LIG_LIR_Gen_1	735	745	PF02991	0.514
LIG_LIR_Nem_3	313	318	PF02991	0.489
LIG_LIR_Nem_3	337	343	PF02991	0.332
LIG_LIR_Nem_3	402	406	PF02991	0.391
LIG_LIR_Nem_3	502	507	PF02991	0.443
LIG_LIR_Nem_3	519	524	PF02991	0.476
LIG_LIR_Nem_3	556	560	PF02991	0.473
LIG_LIR_Nem_3	731	737	PF02991	0.459
LIG_MYND_1	145	149	PF01753	0.772
LIG_MYND_3	563	567	PF01753	0.568
LIG_PCNA_PIPBox_1	781	790	PF02747	0.474
LIG_PCNA_yPIPBox_3	210	219	PF02747	0.689
LIG_PCNA_yPIPBox_3	470	481	PF02747	0.562
LIG_PCNA_yPIPBox_3	778	788	PF02747	0.482
LIG_PDZ_Class_2	806	811	PF00595	0.494
LIG_Pex14_2	733	737	PF04695	0.381
LIG_PTB_Apo_2	397	404	PF02174	0.391
LIG_PTB_Phospho_1	397	403	PF10480	0.391
LIG_REV1ctd_RIR_1	214	223	PF16727	0.706
LIG_SH2_CRK	395	399	PF00017	0.391
LIG_SH2_CRK	403	407	PF00017	0.391
LIG_SH2_GRB2like	375	378	PF00017	0.468
LIG_SH2_PTP2	340	343	PF00017	0.332
LIG_SH2_SRC	340	343	PF00017	0.332
LIG_SH2_STAP1	712	716	PF00017	0.496
LIG_SH2_STAT5	340	343	PF00017	0.341
LIG_SH2_STAT5	362	365	PF00017	0.394
LIG_SH2_STAT5	375	378	PF00017	0.414
LIG_SH2_STAT5	403	406	PF00017	0.391
LIG_SH2_STAT5	440	443	PF00017	0.332
LIG_SH3_1	329	335	PF00018	0.572
LIG_SH3_1	413	419	PF00018	0.391
LIG_SH3_3	165	171	PF00018	0.755
LIG_SH3_3	175	181	PF00018	0.650
LIG_SH3_3	223	229	PF00018	0.796
LIG_SH3_3	329	335	PF00018	0.574
LIG_SH3_3	413	419	PF00018	0.391
LIG_SH3_3	445	451	PF00018	0.391
LIG_SH3_3	483	489	PF00018	0.533
LIG_SH3_3	558	564	PF00018	0.532
LIG_SH3_3	650	656	PF00018	0.767
LIG_Sin3_3	702	709	PF02671	0.545
LIG_SUMO_SIM_anti_2	701	707	PF11976	0.459
LIG_SUMO_SIM_anti_2	738	744	PF11976	0.439
LIG_SUMO_SIM_par_1	690	695	PF11976	0.412
LIG_UBA3_1	491	497	PF00899	0.592
MOD_CDC14_SPxK_1	660	663	PF00782	0.667
MOD_CDK_SPxK_1	657	663	PF00069	0.668
MOD_CK1_1	10	16	PF00069	0.703
MOD_CK1_1	119	125	PF00069	0.718
MOD_CK1_1	132	138	PF00069	0.609
MOD_CK1_1	156	162	PF00069	0.714
MOD_CK1_1	174	180	PF00069	0.696
MOD_CK1_1	18	24	PF00069	0.697
MOD_CK1_1	193	199	PF00069	0.531
MOD_CK1_1	269	275	PF00069	0.779
MOD_CK1_1	29	35	PF00069	0.702
MOD_CK1_1	294	300	PF00069	0.726
MOD_CK1_1	37	43	PF00069	0.726
MOD_CK1_1	60	66	PF00069	0.629
MOD_CK1_1	607	613	PF00069	0.663
MOD_CK1_1	641	647	PF00069	0.717
MOD_CK1_1	91	97	PF00069	0.702
MOD_CK2_1	721	727	PF00069	0.453
MOD_Cter_Amidation	253	256	PF01082	0.734
MOD_Cter_Amidation	776	779	PF01082	0.454
MOD_DYRK1A_RPxSP_1	415	419	PF00069	0.391
MOD_GlcNHglycan	113	116	PF01048	0.804
MOD_GlcNHglycan	118	121	PF01048	0.760
MOD_GlcNHglycan	12	15	PF01048	0.705
MOD_GlcNHglycan	192	195	PF01048	0.728
MOD_GlcNHglycan	238	241	PF01048	0.715
MOD_GlcNHglycan	271	274	PF01048	0.625
MOD_GlcNHglycan	28	31	PF01048	0.709
MOD_GlcNHglycan	288	291	PF01048	0.667
MOD_GlcNHglycan	36	39	PF01048	0.687
MOD_GlcNHglycan	55	58	PF01048	0.571
MOD_GlcNHglycan	606	609	PF01048	0.593
MOD_GlcNHglycan	625	630	PF01048	0.607
MOD_GlcNHglycan	694	697	PF01048	0.418
MOD_GlcNHglycan	700	703	PF01048	0.374
MOD_GlcNHglycan	723	726	PF01048	0.584
MOD_GSK3_1	107	114	PF00069	0.567
MOD_GSK3_1	129	136	PF00069	0.805
MOD_GSK3_1	141	148	PF00069	0.798
MOD_GSK3_1	152	159	PF00069	0.699
MOD_GSK3_1	160	167	PF00069	0.552
MOD_GSK3_1	188	195	PF00069	0.760
MOD_GSK3_1	267	274	PF00069	0.718
MOD_GSK3_1	282	289	PF00069	0.622
MOD_GSK3_1	300	307	PF00069	0.440
MOD_GSK3_1	34	41	PF00069	0.811
MOD_GSK3_1	44	51	PF00069	0.652
MOD_GSK3_1	53	60	PF00069	0.586
MOD_GSK3_1	593	600	PF00069	0.615
MOD_GSK3_1	630	637	PF00069	0.637
MOD_GSK3_1	641	648	PF00069	0.657
MOD_GSK3_1	652	659	PF00069	0.652
MOD_GSK3_1	694	701	PF00069	0.456
MOD_GSK3_1	791	798	PF00069	0.569
MOD_GSK3_1	88	95	PF00069	0.734
MOD_N-GLC_1	604	609	PF02516	0.760
MOD_N-GLC_1	641	646	PF02516	0.727
MOD_N-GLC_1	66	71	PF02516	0.738
MOD_NEK2_1	111	116	PF00069	0.782
MOD_NEK2_1	192	197	PF00069	0.647
MOD_NEK2_1	321	326	PF00069	0.480
MOD_NEK2_1	643	648	PF00069	0.670
MOD_NEK2_1	66	71	PF00069	0.738
MOD_NEK2_1	675	680	PF00069	0.634
MOD_NEK2_1	692	697	PF00069	0.326
MOD_PIKK_1	66	72	PF00454	0.618
MOD_PIKK_1	7	13	PF00454	0.706
MOD_PIKK_1	726	732	PF00454	0.583
MOD_PK_1	182	188	PF00069	0.785
MOD_PKA_2	15	21	PF00069	0.632
MOD_PKA_2	593	599	PF00069	0.612
MOD_PKA_2	687	693	PF00069	0.491
MOD_Plk_1	401	407	PF00069	0.332
MOD_Plk_1	625	631	PF00069	0.680
MOD_Plk_1	759	765	PF00069	0.474
MOD_Plk_4	129	135	PF00069	0.630
MOD_Plk_4	18	24	PF00069	0.697
MOD_Plk_4	401	407	PF00069	0.332
MOD_Plk_4	48	54	PF00069	0.506
MOD_Plk_4	687	693	PF00069	0.432
MOD_Plk_4	804	810	PF00069	0.456
MOD_ProDKin_1	141	147	PF00069	0.704
MOD_ProDKin_1	158	164	PF00069	0.642
MOD_ProDKin_1	193	199	PF00069	0.759
MOD_ProDKin_1	271	277	PF00069	0.745
MOD_ProDKin_1	29	35	PF00069	0.698
MOD_ProDKin_1	41	47	PF00069	0.745
MOD_ProDKin_1	415	421	PF00069	0.391
MOD_ProDKin_1	549	555	PF00069	0.496
MOD_ProDKin_1	597	603	PF00069	0.675
MOD_ProDKin_1	652	658	PF00069	0.666
MOD_ProDKin_1	663	669	PF00069	0.685
MOD_ProDKin_1	791	797	PF00069	0.570
MOD_ProDKin_1	88	94	PF00069	0.723
MOD_SUMO_for_1	564	567	PF00179	0.588
MOD_SUMO_rev_2	567	573	PF00179	0.623
TRG_DiLeu_BaEn_2	782	788	PF01217	0.472
TRG_DiLeu_BaEn_4	474	480	PF01217	0.481
TRG_DiLeu_BaLyEn_6	736	741	PF01217	0.513
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.680
TRG_ENDOCYTIC_2	340	343	PF00928	0.341
TRG_ENDOCYTIC_2	395	398	PF00928	0.391
TRG_ENDOCYTIC_2	403	406	PF00928	0.391
TRG_ENDOCYTIC_2	521	524	PF00928	0.562
TRG_ER_diArg_1	411	414	PF00400	0.390
TRG_ER_diArg_1	479	481	PF00400	0.419
TRG_NES_CRM1_1	699	713	PF08389	0.479
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.785
TRG_Pf-PMV_PEXEL_1	778	783	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Q2	Leptomonas seymouri	64%	100%
A0A3R7K273	Trypanosoma rangeli	42%	100%
A4HCK0	Leishmania braziliensis	83%	100%
A4I019	Leishmania infantum	100%	100%
E9AVZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QBI7	Leishmania major	95%	100%