Actin-interacting protein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-interacting protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IBC2_LEIDO

TriTrypDb:

LdBPK_241160.1 , LdCL_240016700 , LDHU3_24.1370

Length:

988

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IBC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBC2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.742
CLV_C14_Caspase3-7	566	570	PF00656	0.586
CLV_C14_Caspase3-7	589	593	PF00656	0.757
CLV_C14_Caspase3-7	720	724	PF00656	0.674
CLV_NRD_NRD_1	172	174	PF00675	0.705
CLV_NRD_NRD_1	20	22	PF00675	0.587
CLV_NRD_NRD_1	204	206	PF00675	0.582
CLV_NRD_NRD_1	231	233	PF00675	0.553
CLV_NRD_NRD_1	27	29	PF00675	0.387
CLV_NRD_NRD_1	397	399	PF00675	0.556
CLV_NRD_NRD_1	416	418	PF00675	0.383
CLV_NRD_NRD_1	476	478	PF00675	0.529
CLV_NRD_NRD_1	619	621	PF00675	0.559
CLV_NRD_NRD_1	7	9	PF00675	0.578
CLV_NRD_NRD_1	732	734	PF00675	0.655
CLV_NRD_NRD_1	780	782	PF00675	0.745
CLV_NRD_NRD_1	967	969	PF00675	0.744
CLV_PCSK_FUR_1	856	860	PF00082	0.611
CLV_PCSK_KEX2_1	171	173	PF00082	0.686
CLV_PCSK_KEX2_1	204	206	PF00082	0.582
CLV_PCSK_KEX2_1	231	233	PF00082	0.553
CLV_PCSK_KEX2_1	397	399	PF00082	0.556
CLV_PCSK_KEX2_1	416	418	PF00082	0.556
CLV_PCSK_KEX2_1	476	478	PF00082	0.529
CLV_PCSK_KEX2_1	619	621	PF00082	0.600
CLV_PCSK_KEX2_1	780	782	PF00082	0.740
CLV_PCSK_KEX2_1	858	860	PF00082	0.614
CLV_PCSK_KEX2_1	966	968	PF00082	0.753
CLV_PCSK_PC1ET2_1	858	860	PF00082	0.614
CLV_PCSK_SKI1_1	244	248	PF00082	0.667
CLV_PCSK_SKI1_1	367	371	PF00082	0.581
CLV_PCSK_SKI1_1	8	12	PF00082	0.686
CLV_PCSK_SKI1_1	859	863	PF00082	0.611
CLV_Separin_Metazoa	486	490	PF03568	0.649
DEG_APCC_DBOX_1	27	35	PF00400	0.550
DEG_Nend_Nbox_1	1	3	PF02207	0.615
DEG_SIAH_1	759	767	PF03145	0.758
DOC_ANK_TNKS_1	811	818	PF00023	0.617
DOC_CKS1_1	68	73	PF01111	0.763
DOC_CKS1_1	960	965	PF01111	0.753
DOC_CYCLIN_RxL_1	510	520	PF00134	0.443
DOC_MAPK_DCC_7	895	904	PF00069	0.574
DOC_MAPK_gen_1	510	518	PF00069	0.556
DOC_MAPK_gen_1	803	811	PF00069	0.602
DOC_MAPK_MEF2A_6	223	230	PF00069	0.367
DOC_USP7_MATH_1	176	180	PF00917	0.817
DOC_USP7_MATH_1	263	267	PF00917	0.490
DOC_USP7_MATH_1	281	285	PF00917	0.440
DOC_USP7_MATH_1	371	375	PF00917	0.780
DOC_USP7_MATH_1	577	581	PF00917	0.684
DOC_USP7_MATH_1	654	658	PF00917	0.651
DOC_USP7_MATH_1	693	697	PF00917	0.601
DOC_USP7_MATH_1	775	779	PF00917	0.634
DOC_USP7_MATH_1	827	831	PF00917	0.775
DOC_USP7_MATH_1	833	837	PF00917	0.600
DOC_USP7_MATH_1	839	843	PF00917	0.588
DOC_USP7_MATH_1	851	855	PF00917	0.569
DOC_USP7_MATH_1	878	882	PF00917	0.690
DOC_USP7_MATH_1	910	914	PF00917	0.595
DOC_USP7_UBL2_3	730	734	PF12436	0.547
DOC_WW_Pin1_4	150	155	PF00397	0.789
DOC_WW_Pin1_4	301	306	PF00397	0.742
DOC_WW_Pin1_4	665	670	PF00397	0.727
DOC_WW_Pin1_4	67	72	PF00397	0.752
DOC_WW_Pin1_4	885	890	PF00397	0.701
DOC_WW_Pin1_4	906	911	PF00397	0.731
DOC_WW_Pin1_4	917	922	PF00397	0.737
DOC_WW_Pin1_4	926	931	PF00397	0.755
DOC_WW_Pin1_4	959	964	PF00397	0.716
LIG_14-3-3_CanoR_1	159	165	PF00244	0.782
LIG_14-3-3_CanoR_1	223	227	PF00244	0.583
LIG_14-3-3_CanoR_1	250	257	PF00244	0.490
LIG_14-3-3_CanoR_1	28	32	PF00244	0.321
LIG_14-3-3_CanoR_1	285	293	PF00244	0.646
LIG_14-3-3_CanoR_1	347	355	PF00244	0.576
LIG_14-3-3_CanoR_1	441	450	PF00244	0.677
LIG_14-3-3_CanoR_1	476	485	PF00244	0.562
LIG_14-3-3_CanoR_1	579	588	PF00244	0.640
LIG_14-3-3_CanoR_1	8	14	PF00244	0.664
LIG_14-3-3_CanoR_1	812	819	PF00244	0.754
LIG_14-3-3_CanoR_1	856	866	PF00244	0.794
LIG_APCC_ABBA_1	404	409	PF00400	0.552
LIG_BIR_III_2	671	675	PF00653	0.711
LIG_BIR_III_4	592	596	PF00653	0.744
LIG_eIF4E_1	550	556	PF01652	0.672
LIG_EVH1_1	959	963	PF00568	0.656
LIG_FHA_1	116	122	PF00498	0.732
LIG_FHA_1	223	229	PF00498	0.511
LIG_FHA_1	257	263	PF00498	0.562
LIG_FHA_1	28	34	PF00498	0.651
LIG_FHA_1	286	292	PF00498	0.621
LIG_FHA_1	482	488	PF00498	0.503
LIG_FHA_1	689	695	PF00498	0.550
LIG_FHA_2	109	115	PF00498	0.704
LIG_FHA_2	123	129	PF00498	0.829
LIG_FHA_2	250	256	PF00498	0.524
LIG_FHA_2	481	487	PF00498	0.569
LIG_FHA_2	518	524	PF00498	0.446
LIG_FHA_2	589	595	PF00498	0.671
LIG_FHA_2	641	647	PF00498	0.621
LIG_FHA_2	718	724	PF00498	0.612
LIG_FHA_2	749	755	PF00498	0.730
LIG_FHA_2	766	772	PF00498	0.815
LIG_LYPXL_yS_3	979	982	PF13949	0.690
LIG_MYND_1	835	839	PF01753	0.719
LIG_MYND_1	921	925	PF01753	0.770
LIG_PTAP_UEV_1	756	761	PF05743	0.756
LIG_PTAP_UEV_1	914	919	PF05743	0.714
LIG_SH2_PTP2	607	610	PF00017	0.580
LIG_SH2_STAT5	389	392	PF00017	0.660
LIG_SH2_STAT5	550	553	PF00017	0.567
LIG_SH2_STAT5	607	610	PF00017	0.558
LIG_SH3_1	957	963	PF00018	0.759
LIG_SH3_3	302	308	PF00018	0.609
LIG_SH3_3	365	371	PF00018	0.779
LIG_SH3_3	754	760	PF00018	0.753
LIG_SH3_3	819	825	PF00018	0.755
LIG_SH3_3	909	915	PF00018	0.791
LIG_SH3_3	922	928	PF00018	0.737
LIG_SH3_3	957	963	PF00018	0.788
LIG_SH3_3	974	980	PF00018	0.559
LIG_SUMO_SIM_anti_2	30	37	PF11976	0.649
LIG_SUMO_SIM_anti_2	483	490	PF11976	0.650
LIG_SUMO_SIM_anti_2	723	729	PF11976	0.611
LIG_SUMO_SIM_par_1	224	229	PF11976	0.362
LIG_TRAF2_1	252	255	PF00917	0.565
LIG_TRAF2_1	318	321	PF00917	0.704
LIG_TRAF2_1	536	539	PF00917	0.560
LIG_TYR_ITIM	977	982	PF00017	0.691
LIG_UBA3_1	700	709	PF00899	0.514
LIG_WW_1	975	978	PF00397	0.787
MOD_CDK_SPK_2	926	931	PF00069	0.811
MOD_CDK_SPxxK_3	69	76	PF00069	0.733
MOD_CDK_SPxxK_3	959	966	PF00069	0.755
MOD_CK1_1	153	159	PF00069	0.765
MOD_CK1_1	179	185	PF00069	0.813
MOD_CK1_1	27	33	PF00069	0.549
MOD_CK1_1	284	290	PF00069	0.589
MOD_CK1_1	304	310	PF00069	0.494
MOD_CK1_1	517	523	PF00069	0.442
MOD_CK1_1	580	586	PF00069	0.790
MOD_CK1_1	641	647	PF00069	0.753
MOD_CK1_1	758	764	PF00069	0.739
MOD_CK1_1	854	860	PF00069	0.630
MOD_CK1_1	865	871	PF00069	0.560
MOD_CK1_1	913	919	PF00069	0.727
MOD_CK1_1	926	932	PF00069	0.748
MOD_CK2_1	122	128	PF00069	0.800
MOD_CK2_1	249	255	PF00069	0.545
MOD_CK2_1	263	269	PF00069	0.577
MOD_CK2_1	480	486	PF00069	0.570
MOD_CK2_1	517	523	PF00069	0.442
MOD_CK2_1	588	594	PF00069	0.655
MOD_CK2_1	640	646	PF00069	0.709
MOD_CK2_1	654	660	PF00069	0.561
MOD_CK2_1	673	679	PF00069	0.679
MOD_CK2_1	700	706	PF00069	0.618
MOD_CK2_1	748	754	PF00069	0.716
MOD_CK2_1	87	93	PF00069	0.729
MOD_CK2_1	9	15	PF00069	0.567
MOD_CK2_1	926	932	PF00069	0.849
MOD_GlcNHglycan	146	149	PF01048	0.719
MOD_GlcNHglycan	167	170	PF01048	0.727
MOD_GlcNHglycan	178	181	PF01048	0.663
MOD_GlcNHglycan	265	268	PF01048	0.580
MOD_GlcNHglycan	582	585	PF01048	0.690
MOD_GlcNHglycan	588	591	PF01048	0.606
MOD_GlcNHglycan	656	659	PF01048	0.629
MOD_GlcNHglycan	660	664	PF01048	0.605
MOD_GlcNHglycan	675	678	PF01048	0.671
MOD_GlcNHglycan	691	694	PF01048	0.599
MOD_GlcNHglycan	757	760	PF01048	0.718
MOD_GlcNHglycan	79	82	PF01048	0.727
MOD_GlcNHglycan	813	816	PF01048	0.775
MOD_GlcNHglycan	841	844	PF01048	0.749
MOD_GlcNHglycan	847	850	PF01048	0.753
MOD_GlcNHglycan	853	856	PF01048	0.659
MOD_GlcNHglycan	859	862	PF01048	0.575
MOD_GlcNHglycan	867	870	PF01048	0.542
MOD_GlcNHglycan	87	90	PF01048	0.660
MOD_GlcNHglycan	879	883	PF01048	0.495
MOD_GlcNHglycan	915	918	PF01048	0.817
MOD_GlcNHglycan	949	952	PF01048	0.830
MOD_GSK3_1	150	157	PF00069	0.755
MOD_GSK3_1	281	288	PF00069	0.612
MOD_GSK3_1	293	300	PF00069	0.613
MOD_GSK3_1	476	483	PF00069	0.565
MOD_GSK3_1	568	575	PF00069	0.708
MOD_GSK3_1	578	585	PF00069	0.675
MOD_GSK3_1	627	634	PF00069	0.651
MOD_GSK3_1	689	696	PF00069	0.653
MOD_GSK3_1	790	797	PF00069	0.622
MOD_GSK3_1	811	818	PF00069	0.815
MOD_GSK3_1	902	909	PF00069	0.615
MOD_GSK3_1	913	920	PF00069	0.726
MOD_GSK3_1	926	933	PF00069	0.757
MOD_N-GLC_1	144	149	PF02516	0.754
MOD_N-GLC_1	717	722	PF02516	0.682
MOD_N-GLC_1	827	832	PF02516	0.654
MOD_NEK2_1	233	238	PF00069	0.541
MOD_NEK2_1	24	29	PF00069	0.545
MOD_NEK2_1	329	334	PF00069	0.567
MOD_NEK2_1	582	587	PF00069	0.645
MOD_NEK2_1	700	705	PF00069	0.588
MOD_NEK2_2	154	159	PF00069	0.683
MOD_NEK2_2	160	165	PF00069	0.606
MOD_NEK2_2	815	820	PF00069	0.658
MOD_OFUCOSY	886	891	PF10250	0.503
MOD_PIKK_1	346	352	PF00454	0.565
MOD_PIKK_1	487	493	PF00454	0.644
MOD_PIKK_1	517	523	PF00454	0.442
MOD_PIKK_1	646	652	PF00454	0.843
MOD_PIKK_1	693	699	PF00454	0.580
MOD_PIKK_1	775	781	PF00454	0.716
MOD_PIKK_1	923	929	PF00454	0.849
MOD_PIKK_1	941	947	PF00454	0.541
MOD_PK_1	9	15	PF00069	0.494
MOD_PKA_1	143	149	PF00069	0.710
MOD_PKA_1	204	210	PF00069	0.581
MOD_PKA_1	476	482	PF00069	0.567
MOD_PKA_2	204	210	PF00069	0.547
MOD_PKA_2	222	228	PF00069	0.583
MOD_PKA_2	249	255	PF00069	0.493
MOD_PKA_2	27	33	PF00069	0.549
MOD_PKA_2	284	290	PF00069	0.521
MOD_PKA_2	346	352	PF00069	0.565
MOD_PKA_2	475	481	PF00069	0.572
MOD_PKA_2	578	584	PF00069	0.640
MOD_PKA_2	646	652	PF00069	0.629
MOD_PKA_2	748	754	PF00069	0.746
MOD_PKA_2	811	817	PF00069	0.753
MOD_PKA_2	930	936	PF00069	0.815
MOD_PKB_1	796	804	PF00069	0.646
MOD_Plk_1	514	520	PF00069	0.475
MOD_Plk_1	568	574	PF00069	0.663
MOD_Plk_1	717	723	PF00069	0.680
MOD_Plk_2-3	717	723	PF00069	0.609
MOD_Plk_4	160	166	PF00069	0.612
MOD_Plk_4	902	908	PF00069	0.672
MOD_Plk_4	969	975	PF00069	0.680
MOD_ProDKin_1	150	156	PF00069	0.787
MOD_ProDKin_1	301	307	PF00069	0.744
MOD_ProDKin_1	665	671	PF00069	0.726
MOD_ProDKin_1	67	73	PF00069	0.755
MOD_ProDKin_1	885	891	PF00069	0.701
MOD_ProDKin_1	906	912	PF00069	0.729
MOD_ProDKin_1	917	923	PF00069	0.739
MOD_ProDKin_1	926	932	PF00069	0.754
MOD_ProDKin_1	959	965	PF00069	0.718
MOD_SUMO_for_1	528	531	PF00179	0.564
MOD_SUMO_rev_2	236	242	PF00179	0.546
MOD_SUMO_rev_2	758	766	PF00179	0.759
TRG_DiLeu_BaEn_1	710	715	PF01217	0.693
TRG_DiLeu_BaEn_2	14	20	PF01217	0.553
TRG_DiLeu_BaEn_4	15	21	PF01217	0.552
TRG_DiLeu_BaEn_4	409	415	PF01217	0.554
TRG_ENDOCYTIC_2	2	5	PF00928	0.626
TRG_ENDOCYTIC_2	607	610	PF00928	0.580
TRG_ENDOCYTIC_2	979	982	PF00928	0.690
TRG_ER_diArg_1	171	173	PF00400	0.689
TRG_ER_diArg_1	230	232	PF00400	0.597
TRG_ER_diArg_1	396	398	PF00400	0.552
TRG_ER_diArg_1	416	418	PF00400	0.328
TRG_ER_diArg_1	475	477	PF00400	0.584
TRG_ER_diArg_1	509	512	PF00400	0.548
TRG_ER_diArg_1	619	621	PF00400	0.596
TRG_ER_diArg_1	795	798	PF00400	0.624
TRG_ER_diArg_1	966	968	PF00400	0.700
TRG_Pf-PMV_PEXEL_1	3	7	PF00026	0.710
TRG_Pf-PMV_PEXEL_1	619	623	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P545	Leptomonas seymouri	42%	89%
A4HDH0	Leishmania braziliensis	69%	100%
A4I0V1	Leishmania infantum	99%	100%
E9AWV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QAL9	Leishmania major	90%	100%