Lipoyl synthase, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

lipoic acid synthetase, mitochondrial precursor, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBB7_LEIDO

TriTrypDb:

LdBPK_190350.1 , LdCL_190008500 , LDHU3_19.0400

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	11
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

A0A3Q8IBB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBB7

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006633	fatty acid biosynthetic process	5	1
GO:0006790	sulfur compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009106	lipoate metabolic process	4	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016740	transferase activity	2	11
GO:0016782	transferase activity, transferring sulphur-containing groups	3	11
GO:0016783	sulfurtransferase activity	4	11
GO:0016992	lipoate synthase activity	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051536	iron-sulfur cluster binding	3	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.398
CLV_NRD_NRD_1	115	117	PF00675	0.198
CLV_NRD_NRD_1	172	174	PF00675	0.220
CLV_NRD_NRD_1	273	275	PF00675	0.188
CLV_NRD_NRD_1	52	54	PF00675	0.501
CLV_PCSK_FUR_1	113	117	PF00082	0.214
CLV_PCSK_FUR_1	271	275	PF00082	0.183
CLV_PCSK_KEX2_1	115	117	PF00082	0.227
CLV_PCSK_KEX2_1	172	174	PF00082	0.254
CLV_PCSK_KEX2_1	273	275	PF00082	0.188

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Y2	Leptomonas seymouri	86%	100%
A0A1X0P6C6	Trypanosomatidae	83%	95%
A0A3R7MAZ7	Trypanosoma rangeli	73%	100%
A0KNA3	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	45%	100%
A0M4W4	Gramella forsetii (strain KT0803)	42%	100%
A0Q6Q2	Francisella tularensis subsp. novicida (strain U112)	46%	100%
A0RKF7	Bacillus thuringiensis (strain Al Hakam)	44%	100%
A1A8Q3	Escherichia coli O1:K1 / APEC	46%	100%
A1AWI8	Ruthia magnifica subsp. Calyptogena magnifica	41%	100%
A1B1T3	Paracoccus denitrificans (strain Pd 1222)	41%	100%

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