Archaic_Translocase_of_outer_membrane_14_kDa_subu nit_putative/GeneDB:LmjF.24.0940

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Archaic Translocase of outer membrane 14 kDa subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBB3_LEIDO

TriTrypDb:

LdBPK_240960.1 , LdCL_240014600 , LDHU3_24.1130

Length:

115

Annotations

LeishMANIAdb annotations

Potential organellar protein (an N-terminal mitochondrial transit peptide cannot be excluded). Localization: Mitochondrial (by feature)

Annotations by Jardim et al.

Mitochondrial protein, outer mitochondrial membrane proteome 14 (ATOM14) Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0005742	mitochondrial outer membrane translocase complex	4	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098799	outer mitochondrial membrane protein complex	3	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IBB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBB3

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006626	protein targeting to mitochondrion	5	1
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.576
CLV_PCSK_KEX2_1	105	107	PF00082	0.568
CLV_PCSK_SKI1_1	54	58	PF00082	0.484
CLV_PCSK_SKI1_1	78	82	PF00082	0.554
CLV_Separin_Metazoa	75	79	PF03568	0.308
DEG_APCC_DBOX_1	28	36	PF00400	0.514
DOC_USP7_MATH_1	20	24	PF00917	0.493
DOC_USP7_MATH_1	49	53	PF00917	0.459
DOC_WW_Pin1_4	97	102	PF00397	0.316
LIG_14-3-3_CanoR_1	19	25	PF00244	0.535
LIG_BIR_II_1	1	5	PF00653	0.558
LIG_deltaCOP1_diTrp_1	26	33	PF00928	0.427
LIG_deltaCOP1_diTrp_1	94	104	PF00928	0.346
LIG_HCF-1_HBM_1	59	62	PF13415	0.337
LIG_LIR_Gen_1	43	51	PF02991	0.347
LIG_LIR_Nem_3	30	36	PF02991	0.422
LIG_LIR_Nem_3	43	48	PF02991	0.325
LIG_LIR_Nem_3	59	65	PF02991	0.368
LIG_SH2_STAP1	108	112	PF00017	0.257
LIG_SH2_STAP1	36	40	PF00017	0.312
LIG_SUMO_SIM_par_1	46	53	PF11976	0.338
MOD_GlcNHglycan	1	4	PF01048	0.378
MOD_GlcNHglycan	36	39	PF01048	0.389
MOD_NEK2_1	14	19	PF00069	0.533
MOD_Plk_4	20	26	PF00069	0.533
MOD_ProDKin_1	97	103	PF00069	0.313
MOD_SUMO_rev_2	64	69	PF00179	0.375
MOD_SUMO_rev_2	74	83	PF00179	0.343
TRG_ENDOCYTIC_2	62	65	PF00928	0.382
TRG_ER_diArg_1	104	106	PF00400	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NVH1	Trypanosomatidae	46%	91%
A0A3R7NMN1	Trypanosoma rangeli	44%	97%
A4HDF0	Leishmania braziliensis	87%	100%
A4I0T3	Leishmania infantum	100%	100%
D0A762	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	97%
E9AWT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QAN9	Leishmania major	95%	100%