Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBB1_LEIDO

TriTrypDb:

LdBPK_191150.1 , LdCL_190016600 , LDHU3_19.1390

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IBB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBB1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.816
CLV_C14_Caspase3-7	191	195	PF00656	0.514
CLV_NRD_NRD_1	108	110	PF00675	0.491
CLV_NRD_NRD_1	131	133	PF00675	0.707
CLV_NRD_NRD_1	247	249	PF00675	0.653
CLV_NRD_NRD_1	305	307	PF00675	0.615
CLV_NRD_NRD_1	79	81	PF00675	0.760
CLV_NRD_NRD_1	85	87	PF00675	0.699
CLV_NRD_NRD_1	92	94	PF00675	0.692
CLV_PCSK_FUR_1	56	60	PF00082	0.738
CLV_PCSK_KEX2_1	107	109	PF00082	0.752
CLV_PCSK_KEX2_1	133	135	PF00082	0.694
CLV_PCSK_KEX2_1	211	213	PF00082	0.539
CLV_PCSK_KEX2_1	299	301	PF00082	0.660
CLV_PCSK_KEX2_1	58	60	PF00082	0.622
CLV_PCSK_KEX2_1	78	80	PF00082	0.462
CLV_PCSK_KEX2_1	84	86	PF00082	0.712
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.748
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.627
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.687
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.627
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.716
CLV_PCSK_PC7_1	80	86	PF00082	0.680
CLV_PCSK_SKI1_1	179	183	PF00082	0.655
DEG_APCC_DBOX_1	247	255	PF00400	0.541
DOC_CKS1_1	274	279	PF01111	0.696
DOC_MAPK_gen_1	53	63	PF00069	0.614
DOC_USP7_MATH_1	126	130	PF00917	0.775
DOC_USP7_MATH_1	313	317	PF00917	0.554
DOC_USP7_MATH_1	363	367	PF00917	0.806
DOC_USP7_UBL2_3	307	311	PF12436	0.511
DOC_WW_Pin1_4	273	278	PF00397	0.671
DOC_WW_Pin1_4	359	364	PF00397	0.863
LIG_14-3-3_CanoR_1	265	274	PF00244	0.687
LIG_BRCT_BRCA1_1	195	199	PF00533	0.684
LIG_FHA_1	176	182	PF00498	0.683
LIG_FHA_1	23	29	PF00498	0.712
LIG_FHA_1	261	267	PF00498	0.720
LIG_FHA_2	161	167	PF00498	0.675
LIG_FHA_2	226	232	PF00498	0.692
LIG_FHA_2	280	286	PF00498	0.626
LIG_LIR_Apic_2	272	277	PF02991	0.733
LIG_SH2_CRK	274	278	PF00017	0.737
LIG_SH2_SRC	192	195	PF00017	0.520
LIG_SH2_STAP1	262	266	PF00017	0.578
LIG_SH2_STAT5	189	192	PF00017	0.508
LIG_SH2_STAT5	262	265	PF00017	0.745
LIG_SH3_3	221	227	PF00018	0.621
LIG_TRAF2_1	120	123	PF00917	0.726
LIG_TRAF2_1	228	231	PF00917	0.656
LIG_TRAF2_1	233	236	PF00917	0.591
LIG_TRAF2_1	331	334	PF00917	0.773
LIG_TRAF2_1	343	346	PF00917	0.672
LIG_TRAF2_1	65	68	PF00917	0.693
LIG_TRAF2_1	71	74	PF00917	0.682
LIG_UBA3_1	47	51	PF00899	0.572
MOD_CK1_1	30	36	PF00069	0.645
MOD_CK1_1	362	368	PF00069	0.766
MOD_CK2_1	117	123	PF00069	0.717
MOD_CK2_1	140	146	PF00069	0.895
MOD_CK2_1	160	166	PF00069	0.591
MOD_CK2_1	207	213	PF00069	0.614
MOD_CK2_1	225	231	PF00069	0.611
MOD_CK2_1	332	338	PF00069	0.799
MOD_GlcNHglycan	119	122	PF01048	0.716
MOD_GlcNHglycan	128	131	PF01048	0.650
MOD_GlcNHglycan	150	156	PF01048	0.775
MOD_GlcNHglycan	168	171	PF01048	0.553
MOD_GlcNHglycan	184	187	PF01048	0.466
MOD_GlcNHglycan	267	270	PF01048	0.621
MOD_GlcNHglycan	287	291	PF01048	0.541
MOD_GlcNHglycan	315	318	PF01048	0.557
MOD_GlcNHglycan	33	36	PF01048	0.749
MOD_GlcNHglycan	365	368	PF01048	0.848
MOD_GSK3_1	136	143	PF00069	0.849
MOD_GSK3_1	193	200	PF00069	0.615
MOD_GSK3_1	27	34	PF00069	0.673
MOD_GSK3_1	357	364	PF00069	0.849
MOD_N-GLC_1	207	212	PF02516	0.634
MOD_N-GLC_2	242	244	PF02516	0.610
MOD_NEK2_1	160	165	PF00069	0.590
MOD_NEK2_1	181	186	PF00069	0.647
MOD_NEK2_1	193	198	PF00069	0.481
MOD_NEK2_1	301	306	PF00069	0.668
MOD_PIKK_1	160	166	PF00454	0.762
MOD_PKA_2	117	123	PF00069	0.767
MOD_Plk_1	230	236	PF00069	0.604
MOD_Plk_1	286	292	PF00069	0.663
MOD_Plk_2-3	140	146	PF00069	0.829
MOD_Plk_2-3	230	236	PF00069	0.696
MOD_Plk_4	153	159	PF00069	0.786
MOD_Plk_4	188	194	PF00069	0.497
MOD_ProDKin_1	273	279	PF00069	0.667
MOD_ProDKin_1	359	365	PF00069	0.862
MOD_SUMO_for_1	202	205	PF00179	0.662
MOD_SUMO_rev_2	296	301	PF00179	0.680
MOD_SUMO_rev_2	345	355	PF00179	0.700
TRG_ENDOCYTIC_2	10	13	PF00928	0.804
TRG_ENDOCYTIC_2	15	18	PF00928	0.805
TRG_ENDOCYTIC_2	38	41	PF00928	0.802
TRG_ER_diArg_1	107	109	PF00400	0.744
TRG_ER_diArg_1	132	135	PF00400	0.707
TRG_ER_diArg_1	78	80	PF00400	0.787
TRG_NES_CRM1_1	52	67	PF08389	0.727
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.749
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P630	Trypanosomatidae	29%	100%
A0A3R7KAD6	Trypanosoma rangeli	31%	100%
A4HYD4	Leishmania infantum	99%	100%
D0A0R5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AS67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QD99	Leishmania major	86%	100%
V5AZ24	Trypanosoma cruzi	32%	100%