START domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

START domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBA5_LEIDO

TriTrypDb:

LdBPK_292840.1 , LdCL_110014200 , LDHU3_11.1090

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IBA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBA5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	19
GO:0008289	lipid binding	2	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.364
CLV_PCSK_KEX2_1	5	7	PF00082	0.643
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.643
CLV_PCSK_SKI1_1	27	31	PF00082	0.406
DOC_CKS1_1	28	33	PF01111	0.377
DOC_WW_Pin1_4	107	112	PF00397	0.402
DOC_WW_Pin1_4	150	155	PF00397	0.278
DOC_WW_Pin1_4	16	21	PF00397	0.518
DOC_WW_Pin1_4	27	32	PF00397	0.327
DOC_WW_Pin1_4	289	294	PF00397	0.404
LIG_14-3-3_CanoR_1	136	141	PF00244	0.342
LIG_CtBP_PxDLS_1	246	250	PF00389	0.193
LIG_deltaCOP1_diTrp_1	288	296	PF00928	0.359
LIG_FHA_1	211	217	PF00498	0.229
LIG_FHA_1	248	254	PF00498	0.246
LIG_FHA_2	108	114	PF00498	0.261
LIG_FHA_2	19	25	PF00498	0.488
LIG_FHA_2	235	241	PF00498	0.216
LIG_LIR_Gen_1	113	123	PF02991	0.237
LIG_LIR_Gen_1	175	185	PF02991	0.242
LIG_LIR_Nem_3	113	118	PF02991	0.245
LIG_LIR_Nem_3	125	130	PF02991	0.285
LIG_LIR_Nem_3	175	180	PF02991	0.258
LIG_LIR_Nem_3	53	57	PF02991	0.256
LIG_LYPXL_SIV_4	204	212	PF13949	0.193
LIG_NRBOX	113	119	PF00104	0.384
LIG_Pex14_2	123	127	PF04695	0.262
LIG_PTAP_UEV_1	19	24	PF05743	0.351
LIG_PTB_Apo_2	157	164	PF02174	0.248
LIG_SH2_CRK	115	119	PF00017	0.262
LIG_SH2_CRK	28	32	PF00017	0.339
LIG_SH2_CRK	46	50	PF00017	0.299
LIG_SH2_NCK_1	71	75	PF00017	0.467
LIG_SH2_STAP1	285	289	PF00017	0.322
LIG_SH2_STAP1	55	59	PF00017	0.373
LIG_SH2_STAT3	235	238	PF00017	0.265
LIG_SH2_STAT5	177	180	PF00017	0.297
LIG_SH2_STAT5	205	208	PF00017	0.275
LIG_SH2_STAT5	215	218	PF00017	0.217
LIG_SH2_STAT5	235	238	PF00017	0.328
LIG_SH2_STAT5	252	255	PF00017	0.209
LIG_SH2_STAT5	285	288	PF00017	0.415
LIG_SH2_STAT5	55	58	PF00017	0.419
LIG_SH3_1	82	88	PF00018	0.442
LIG_SH3_3	17	23	PF00018	0.323
LIG_SH3_3	5	11	PF00018	0.459
LIG_SH3_3	82	88	PF00018	0.442
LIG_SUMO_SIM_par_1	245	250	PF11976	0.193
LIG_WRC_WIRS_1	54	59	PF05994	0.358
LIG_WW_1	190	193	PF00397	0.193
MOD_CDK_SPK_2	107	112	PF00069	0.228
MOD_CK1_1	138	144	PF00069	0.342
MOD_CK1_1	16	22	PF00069	0.520
MOD_CK1_1	210	216	PF00069	0.255
MOD_CK1_1	318	324	PF00069	0.489
MOD_CK1_1	35	41	PF00069	0.405
MOD_CK2_1	107	113	PF00069	0.360
MOD_CK2_1	18	24	PF00069	0.503
MOD_GlcNHglycan	105	108	PF01048	0.322
MOD_GlcNHglycan	140	143	PF01048	0.330
MOD_GlcNHglycan	224	227	PF01048	0.419
MOD_GlcNHglycan	319	323	PF01048	0.428
MOD_GlcNHglycan	34	37	PF01048	0.369
MOD_GSK3_1	103	110	PF00069	0.325
MOD_GSK3_1	14	21	PF00069	0.543
MOD_GSK3_1	180	187	PF00069	0.297
MOD_N-GLC_1	180	185	PF02516	0.241
MOD_N-GLC_1	306	311	PF02516	0.343
MOD_NEK2_1	135	140	PF00069	0.384
MOD_NEK2_1	180	185	PF00069	0.235
MOD_NEK2_1	67	72	PF00069	0.324
MOD_PIKK_1	234	240	PF00454	0.248
MOD_PKA_1	315	321	PF00069	0.465
MOD_PKA_2	135	141	PF00069	0.318
MOD_Plk_1	180	186	PF00069	0.199
MOD_Plk_1	306	312	PF00069	0.354
MOD_Plk_1	318	324	PF00069	0.406
MOD_Plk_2-3	298	304	PF00069	0.586
MOD_Plk_4	231	237	PF00069	0.270
MOD_ProDKin_1	107	113	PF00069	0.307
MOD_ProDKin_1	150	156	PF00069	0.278
MOD_ProDKin_1	16	22	PF00069	0.507
MOD_ProDKin_1	27	33	PF00069	0.333
MOD_ProDKin_1	289	295	PF00069	0.402
MOD_SUMO_for_1	305	308	PF00179	0.460
MOD_SUMO_rev_2	76	85	PF00179	0.422
TRG_DiLeu_BaEn_1	113	118	PF01217	0.227
TRG_ENDOCYTIC_2	115	118	PF00928	0.269
TRG_ENDOCYTIC_2	177	180	PF00928	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J9	Leptomonas seymouri	36%	88%
A0A0N1I4D8	Leptomonas seymouri	75%	96%
A0A0S4INS4	Bodo saltans	39%	100%
A0A0S4KH88	Bodo saltans	35%	82%
A0A1X0NV84	Trypanosomatidae	53%	100%
A0A1X0P910	Trypanosomatidae	36%	86%
A0A3Q8IJ21	Leishmania donovani	34%	89%
A0A3R7KCX0	Trypanosoma rangeli	38%	89%
A0A422MZR8	Trypanosoma rangeli	49%	100%
A4H6L4	Leishmania braziliensis	79%	100%
A4HHT0	Leishmania braziliensis	37%	89%
A4HUZ7	Leishmania infantum	100%	100%
A4I4Z0	Leishmania infantum	34%	100%
C9ZKK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	88%
D0A7F2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AED5	Leishmania major	34%	100%
E9ALF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9ANN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QGZ1	Leishmania major	94%	100%
Q9JMD3	Mus musculus	34%	100%
Q9Y365	Homo sapiens	34%	100%
V5BC62	Trypanosoma cruzi	36%	89%
V5DT41	Trypanosoma cruzi	50%	100%