Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IB97_LEIDO

TriTrypDb:

LdBPK_290040.1 , LdCL_290005300 , LDHU3_29.0050

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IB97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB97

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.590
CLV_NRD_NRD_1	135	137	PF00675	0.514
CLV_NRD_NRD_1	148	150	PF00675	0.542
CLV_NRD_NRD_1	154	156	PF00675	0.466
CLV_NRD_NRD_1	204	206	PF00675	0.507
CLV_NRD_NRD_1	22	24	PF00675	0.689
CLV_NRD_NRD_1	282	284	PF00675	0.462
CLV_NRD_NRD_1	31	33	PF00675	0.590
CLV_NRD_NRD_1	59	61	PF00675	0.685
CLV_PCSK_FUR_1	202	206	PF00082	0.513
CLV_PCSK_KEX2_1	120	122	PF00082	0.544
CLV_PCSK_KEX2_1	135	137	PF00082	0.565
CLV_PCSK_KEX2_1	147	149	PF00082	0.566
CLV_PCSK_KEX2_1	204	206	PF00082	0.568
CLV_PCSK_KEX2_1	22	24	PF00082	0.689
CLV_PCSK_KEX2_1	31	33	PF00082	0.590
CLV_PCSK_KEX2_1	58	60	PF00082	0.511
CLV_PCSK_PC7_1	144	150	PF00082	0.607
CLV_PCSK_SKI1_1	115	119	PF00082	0.521
CLV_PCSK_SKI1_1	135	139	PF00082	0.451
CLV_PCSK_SKI1_1	171	175	PF00082	0.356
CLV_PCSK_SKI1_1	183	187	PF00082	0.380
CLV_PCSK_SKI1_1	218	222	PF00082	0.480
CLV_PCSK_SKI1_1	252	256	PF00082	0.388
DEG_Nend_Nbox_1	1	3	PF02207	0.537
DOC_CYCLIN_RxL_1	112	119	PF00134	0.585
DOC_CYCLIN_RxL_1	246	259	PF00134	0.376
DOC_MAPK_gen_1	22	30	PF00069	0.693
DOC_PP4_FxxP_1	126	129	PF00568	0.607
DOC_USP7_MATH_1	113	117	PF00917	0.400
DOC_USP7_MATH_1	51	55	PF00917	0.479
DOC_USP7_UBL2_3	186	190	PF12436	0.604
LIG_14-3-3_CanoR_1	107	111	PF00244	0.401
LIG_14-3-3_CanoR_1	209	213	PF00244	0.480
LIG_14-3-3_CanoR_1	252	258	PF00244	0.367
LIG_14-3-3_CanoR_1	37	46	PF00244	0.584
LIG_Actin_WH2_2	268	285	PF00022	0.492
LIG_Actin_WH2_2	91	109	PF00022	0.383
LIG_AP_GAE_1	82	88	PF02883	0.606
LIG_FHA_1	175	181	PF00498	0.333
LIG_FHA_1	195	201	PF00498	0.349
LIG_FHA_2	107	113	PF00498	0.421
LIG_FHA_2	152	158	PF00498	0.458
LIG_FHA_2	254	260	PF00498	0.403
LIG_FHA_2	71	77	PF00498	0.711
LIG_LIR_Gen_1	82	91	PF02991	0.456
LIG_LIR_Gen_1	97	106	PF02991	0.376
LIG_LIR_Nem_3	132	137	PF02991	0.623
LIG_LIR_Nem_3	211	215	PF02991	0.468
LIG_LIR_Nem_3	276	282	PF02991	0.438
LIG_LIR_Nem_3	82	88	PF02991	0.493
LIG_LIR_Nem_3	97	103	PF02991	0.372
LIG_NRBOX	171	177	PF00104	0.342
LIG_PCNA_yPIPBox_3	171	185	PF02747	0.479
LIG_Pex14_2	215	219	PF04695	0.448
LIG_PTB_Apo_2	238	245	PF02174	0.506
LIG_SH2_CRK	100	104	PF00017	0.452
LIG_SH2_CRK	134	138	PF00017	0.625
LIG_SH2_CRK	279	283	PF00017	0.453
LIG_SH2_NCK_1	100	104	PF00017	0.452
LIG_SH2_STAP1	100	104	PF00017	0.501
LIG_SH2_STAT3	8	11	PF00017	0.488
LIG_SH2_STAT5	165	168	PF00017	0.421
LIG_SH2_STAT5	253	256	PF00017	0.475
LIG_SUMO_SIM_anti_2	170	177	PF11976	0.365
LIG_SUMO_SIM_par_1	170	177	PF11976	0.348
LIG_TRAF2_1	73	76	PF00917	0.685
LIG_TRAF2_1	91	94	PF00917	0.283
LIG_TYR_ITIM	98	103	PF00017	0.433
MOD_CK1_1	40	46	PF00069	0.707
MOD_CK2_1	106	112	PF00069	0.575
MOD_CK2_1	113	119	PF00069	0.496
MOD_CK2_1	253	259	PF00069	0.365
MOD_CK2_1	70	76	PF00069	0.629
MOD_GlcNHglycan	186	189	PF01048	0.441
MOD_GlcNHglycan	236	239	PF01048	0.540
MOD_GlcNHglycan	40	43	PF01048	0.749
MOD_N-GLC_1	113	118	PF02516	0.396
MOD_NEK2_1	174	179	PF00069	0.343
MOD_NEK2_1	184	189	PF00069	0.393
MOD_NEK2_1	273	278	PF00069	0.476
MOD_NEK2_2	113	118	PF00069	0.396
MOD_NEK2_2	142	147	PF00069	0.618
MOD_PIKK_1	174	180	PF00454	0.425
MOD_PIKK_1	273	279	PF00454	0.468
MOD_PIKK_1	7	13	PF00454	0.484
MOD_PIKK_1	89	95	PF00454	0.354
MOD_PKA_2	106	112	PF00069	0.404
MOD_PKA_2	208	214	PF00069	0.456
MOD_PKA_2	70	76	PF00069	0.570
MOD_Plk_1	113	119	PF00069	0.528
MOD_Plk_1	142	148	PF00069	0.684
MOD_Plk_2-3	76	82	PF00069	0.641
MOD_Plk_4	113	119	PF00069	0.402
MOD_SUMO_for_1	129	132	PF00179	0.649
TRG_DiLeu_BaEn_4	75	81	PF01217	0.757
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.559
TRG_ENDOCYTIC_2	100	103	PF00928	0.446
TRG_ENDOCYTIC_2	134	137	PF00928	0.627
TRG_ENDOCYTIC_2	279	282	PF00928	0.447
TRG_ER_diArg_1	120	122	PF00400	0.572
TRG_ER_diArg_1	134	136	PF00400	0.506
TRG_ER_diArg_1	146	149	PF00400	0.536
TRG_ER_diArg_1	152	155	PF00400	0.445
TRG_ER_diArg_1	203	205	PF00400	0.584
TRG_ER_diArg_1	21	23	PF00400	0.706
TRG_ER_diArg_1	30	32	PF00400	0.664
TRG_ER_diArg_1	57	60	PF00400	0.567
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIG8	Leptomonas seymouri	64%	100%
A0A0S4ITL7	Bodo saltans	34%	100%
A0A1X0NZE1	Trypanosomatidae	64%	96%
A0A3R7KKG3	Trypanosoma rangeli	59%	100%
A4HH12	Leishmania braziliensis	76%	100%
A4I441	Leishmania infantum	98%	100%
C9ZKS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9ADK6	Leishmania major	91%	100%
E9AM75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BUH7	Trypanosoma cruzi	58%	81%