Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IB96_LEIDO

TriTrypDb:

LdBPK_181640.1 , LdCL_180021700 , LDHU3_18.2100

Length:

118

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	yes	yes: 10
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A0A3Q8IB96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB96

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.487
CLV_NRD_NRD_1	52	54	PF00675	0.567
CLV_PCSK_SKI1_1	110	114	PF00082	0.493
DOC_PP2B_PxIxI_1	14	20	PF00149	0.443
DOC_USP7_UBL2_3	106	110	PF12436	0.432
DOC_WW_Pin1_4	44	49	PF00397	0.655
LIG_14-3-3_CanoR_1	95	101	PF00244	0.569
LIG_Actin_WH2_2	79	97	PF00022	0.488
LIG_BIR_II_1	1	5	PF00653	0.637
LIG_BRCT_BRCA1_1	75	79	PF00533	0.516
LIG_EVH1_2	57	61	PF00568	0.422
LIG_FHA_1	68	74	PF00498	0.636
LIG_LIR_Gen_1	47	57	PF02991	0.635
LIG_LIR_Gen_1	76	86	PF02991	0.492
LIG_LIR_Nem_3	107	112	PF02991	0.515
LIG_LIR_Nem_3	18	23	PF02991	0.605
LIG_LIR_Nem_3	47	52	PF02991	0.610
LIG_LIR_Nem_3	76	82	PF02991	0.490
LIG_PALB2_WD40_1	56	64	PF16756	0.430
LIG_REV1ctd_RIR_1	109	118	PF16727	0.523
LIG_TRAF2_1	85	88	PF00917	0.530
LIG_UBA3_1	19	24	PF00899	0.544
MOD_CK1_1	38	44	PF00069	0.615
MOD_GSK3_1	31	38	PF00069	0.572
MOD_GSK3_1	63	70	PF00069	0.585
MOD_GSK3_1	94	101	PF00069	0.522
MOD_N-GLC_1	104	109	PF02516	0.656
MOD_N-GLC_1	31	36	PF02516	0.575
MOD_N-GLC_1	8	13	PF02516	0.438
MOD_N-GLC_2	37	39	PF02516	0.688
MOD_NEK2_1	31	36	PF00069	0.603
MOD_NEK2_1	78	83	PF00069	0.506
MOD_NEK2_1	94	99	PF00069	0.531
MOD_NEK2_2	15	20	PF00069	0.583
MOD_PIKK_1	63	69	PF00454	0.524
MOD_PKA_2	94	100	PF00069	0.562
MOD_Plk_1	104	110	PF00069	0.561
MOD_Plk_1	24	30	PF00069	0.511
MOD_Plk_1	31	37	PF00069	0.526
MOD_Plk_4	73	79	PF00069	0.563
MOD_ProDKin_1	44	50	PF00069	0.645
TRG_ENDOCYTIC_2	109	112	PF00928	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C7	Leptomonas seymouri	37%	94%
A0A0N1HW96	Leptomonas seymouri	41%	100%
A0A0N1IHI7	Leptomonas seymouri	87%	100%
A0A0S4IPF2	Bodo saltans	39%	100%
A0A0S4IRP9	Bodo saltans	60%	99%
A0A0S4JBB4	Bodo saltans	44%	99%
A0A0S4JFI1	Bodo saltans	36%	100%
A0A1X0NKC2	Trypanosomatidae	32%	99%
A0A1X0P0Q8	Trypanosomatidae	51%	94%
A0A1X0P259	Trypanosomatidae	37%	100%
A0A1X0P760	Trypanosomatidae	65%	100%
A0A3R7K0R9	Trypanosoma rangeli	37%	100%
A0A3S7X3W3	Leishmania donovani	37%	100%
A0A3S7X6I1	Leishmania donovani	39%	70%
A0A422N867	Trypanosoma rangeli	47%	94%
A0A422NFX4	Trypanosoma rangeli	31%	98%
A0A422NPM1	Trypanosoma rangeli	63%	100%
A4H9R6	Leishmania braziliensis	85%	100%
A4HIL9	Leishmania braziliensis	39%	100%
A4HLA1	Leishmania braziliensis	41%	100%
A4HY35	Leishmania infantum	100%	100%
A4I5W4	Leishmania infantum	37%	100%
A4I8S7	Leishmania infantum	40%	100%
C9ZR85	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A4S3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	94%
E9ARU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B159	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B3P3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
Q4Q707	Leishmania major	37%	100%
Q4QDM4	Leishmania major	97%	100%
V5BMX8	Trypanosoma cruzi	39%	100%