Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IB95_LEIDO

TriTrypDb:

LdBPK_110720.1 , LdCL_110012600 , LDHU3_11.0920

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IB95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB95

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.687
CLV_NRD_NRD_1	194	196	PF00675	0.613
CLV_NRD_NRD_1	22	24	PF00675	0.487
CLV_NRD_NRD_1	349	351	PF00675	0.427
CLV_NRD_NRD_1	381	383	PF00675	0.456
CLV_NRD_NRD_1	417	419	PF00675	0.496
CLV_NRD_NRD_1	446	448	PF00675	0.588
CLV_PCSK_KEX2_1	116	118	PF00082	0.719
CLV_PCSK_KEX2_1	194	196	PF00082	0.613
CLV_PCSK_KEX2_1	22	24	PF00082	0.487
CLV_PCSK_KEX2_1	348	350	PF00082	0.426
CLV_PCSK_KEX2_1	381	383	PF00082	0.456
CLV_PCSK_KEX2_1	416	418	PF00082	0.448
CLV_PCSK_KEX2_1	446	448	PF00082	0.475
CLV_PCSK_PC7_1	442	448	PF00082	0.462
CLV_PCSK_SKI1_1	195	199	PF00082	0.606
CLV_PCSK_SKI1_1	290	294	PF00082	0.603
CLV_PCSK_SKI1_1	334	338	PF00082	0.486
CLV_PCSK_SKI1_1	382	386	PF00082	0.497
CLV_PCSK_SKI1_1	398	402	PF00082	0.380
DEG_APCC_DBOX_1	437	445	PF00400	0.530
DEG_APCC_DBOX_1	81	89	PF00400	0.551
DEG_SPOP_SBC_1	110	114	PF00917	0.575
DOC_CKS1_1	227	232	PF01111	0.622
DOC_CYCLIN_yCln2_LP_2	218	224	PF00134	0.607
DOC_MAPK_gen_1	47	57	PF00069	0.558
DOC_MAPK_MEF2A_6	50	57	PF00069	0.561
DOC_MAPK_NFAT4_5	50	58	PF00069	0.561
DOC_PP1_RVXF_1	15	21	PF00149	0.411
DOC_PP2B_LxvP_1	218	221	PF13499	0.593
DOC_PP2B_LxvP_1	224	227	PF13499	0.558
DOC_USP7_MATH_1	124	128	PF00917	0.739
DOC_USP7_MATH_1	179	183	PF00917	0.789
DOC_USP7_MATH_1	189	193	PF00917	0.680
DOC_USP7_MATH_1	411	415	PF00917	0.512
DOC_USP7_UBL2_3	424	428	PF12436	0.526
DOC_WW_Pin1_4	166	171	PF00397	0.694
DOC_WW_Pin1_4	173	178	PF00397	0.675
DOC_WW_Pin1_4	196	201	PF00397	0.753
DOC_WW_Pin1_4	226	231	PF00397	0.764
LIG_14-3-3_CanoR_1	266	270	PF00244	0.523
LIG_14-3-3_CanoR_1	273	283	PF00244	0.562
LIG_14-3-3_CanoR_1	316	323	PF00244	0.524
LIG_14-3-3_CanoR_1	438	442	PF00244	0.484
LIG_Actin_WH2_2	319	336	PF00022	0.516
LIG_BIR_II_1	1	5	PF00653	0.629
LIG_BRCT_BRCA1_1	227	231	PF00533	0.644
LIG_FHA_1	144	150	PF00498	0.615
LIG_FHA_1	244	250	PF00498	0.614
LIG_FHA_1	63	69	PF00498	0.601
LIG_FHA_2	205	211	PF00498	0.686
LIG_FHA_2	276	282	PF00498	0.565
LIG_GBD_Chelix_1	401	409	PF00786	0.471
LIG_LIR_Gen_1	26	35	PF02991	0.528
LIG_LIR_Nem_3	26	32	PF02991	0.595
LIG_LYPXL_yS_3	367	370	PF13949	0.540
LIG_MYND_1	196	200	PF01753	0.602
LIG_PDZ_Class_2	465	470	PF00595	0.494
LIG_PTB_Apo_2	216	223	PF02174	0.600
LIG_PTB_Phospho_1	216	222	PF10480	0.595
LIG_SH2_STAP1	75	79	PF00017	0.451
LIG_SH2_STAT3	222	225	PF00017	0.628
LIG_SH2_STAT3	75	78	PF00017	0.452
LIG_SH2_STAT5	29	32	PF00017	0.613
LIG_SH2_STAT5	294	297	PF00017	0.462
LIG_SH3_3	164	170	PF00018	0.527
LIG_SH3_3	224	230	PF00018	0.591
LIG_SUMO_SIM_anti_2	299	308	PF11976	0.457
LIG_SUMO_SIM_anti_2	432	438	PF11976	0.481
LIG_SUMO_SIM_par_1	142	150	PF11976	0.579
LIG_SUMO_SIM_par_1	246	254	PF11976	0.557
LIG_TRAF2_1	336	339	PF00917	0.452
LIG_TRAF2_1	457	460	PF00917	0.552
MOD_CK1_1	234	240	PF00069	0.681
MOD_CK1_1	51	57	PF00069	0.543
MOD_CK2_1	147	153	PF00069	0.689
MOD_CK2_1	204	210	PF00069	0.571
MOD_GlcNHglycan	191	194	PF01048	0.658
MOD_GlcNHglycan	233	236	PF01048	0.580
MOD_GSK3_1	100	107	PF00069	0.571
MOD_GSK3_1	124	131	PF00069	0.701
MOD_GSK3_1	143	150	PF00069	0.569
MOD_GSK3_1	173	180	PF00069	0.673
MOD_GSK3_1	239	246	PF00069	0.607
MOD_NEK2_1	147	152	PF00069	0.744
MOD_NEK2_1	437	442	PF00069	0.563
MOD_NEK2_2	179	184	PF00069	0.595
MOD_PIKK_1	33	39	PF00454	0.488
MOD_PKA_2	265	271	PF00069	0.469
MOD_PKA_2	27	33	PF00069	0.490
MOD_PKA_2	275	281	PF00069	0.498
MOD_PKA_2	315	321	PF00069	0.591
MOD_PKA_2	360	366	PF00069	0.544
MOD_PKA_2	437	443	PF00069	0.564
MOD_PKA_2	62	68	PF00069	0.557
MOD_PKB_1	116	124	PF00069	0.635
MOD_PKB_1	98	106	PF00069	0.633
MOD_Plk_1	143	149	PF00069	0.698
MOD_Plk_1	305	311	PF00069	0.515
MOD_Plk_1	51	57	PF00069	0.540
MOD_Plk_1	69	75	PF00069	0.384
MOD_Plk_1	7	13	PF00069	0.425
MOD_Plk_2-3	143	149	PF00069	0.634
MOD_Plk_2-3	455	461	PF00069	0.611
MOD_ProDKin_1	166	172	PF00069	0.693
MOD_ProDKin_1	173	179	PF00069	0.676
MOD_ProDKin_1	196	202	PF00069	0.752
MOD_ProDKin_1	226	232	PF00069	0.765
MOD_SUMO_for_1	32	35	PF00179	0.522
MOD_SUMO_for_1	409	412	PF00179	0.487
MOD_SUMO_rev_2	289	295	PF00179	0.482
MOD_SUMO_rev_2	420	430	PF00179	0.632
TRG_DiLeu_BaEn_1	213	218	PF01217	0.575
TRG_DiLeu_BaEn_4	253	259	PF01217	0.429
TRG_DiLeu_BaEn_4	420	426	PF01217	0.450
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.445
TRG_ENDOCYTIC_2	29	32	PF00928	0.531
TRG_ENDOCYTIC_2	367	370	PF00928	0.540
TRG_ER_diArg_1	116	118	PF00400	0.764
TRG_ER_diArg_1	194	196	PF00400	0.613
TRG_ER_diArg_1	21	23	PF00400	0.482
TRG_ER_diArg_1	348	350	PF00400	0.463
TRG_ER_diArg_1	416	418	PF00400	0.468
TRG_ER_diArg_1	446	448	PF00400	0.588
TRG_NES_CRM1_1	331	347	PF08389	0.453
TRG_NES_CRM1_1	426	439	PF08389	0.473
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P310	Leptomonas seymouri	53%	85%
A0A0S4IYQ0	Bodo saltans	25%	100%
A0A1X0NVG8	Trypanosomatidae	31%	100%
A0A3R7L4W3	Trypanosoma rangeli	33%	100%
A4H6J6	Leishmania braziliensis	80%	100%
A4HUY1	Leishmania infantum	100%	100%
E9ANL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QH07	Leishmania major	95%	100%
V5C199	Trypanosoma cruzi	34%	100%