DNAJ domain protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ domain protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IB91_LEIDO

TriTrypDb:

LdBPK_240530.1 , LdCL_240010100 , LDHU3_24.0640

Length:

794

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 2
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3Q8IB91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	452	456	PF00656	0.447
CLV_C14_Caspase3-7	775	779	PF00656	0.567
CLV_MEL_PAP_1	342	348	PF00089	0.640
CLV_NRD_NRD_1	151	153	PF00675	0.591
CLV_NRD_NRD_1	219	221	PF00675	0.627
CLV_NRD_NRD_1	405	407	PF00675	0.491
CLV_NRD_NRD_1	480	482	PF00675	0.619
CLV_NRD_NRD_1	583	585	PF00675	0.621
CLV_NRD_NRD_1	631	633	PF00675	0.547
CLV_NRD_NRD_1	659	661	PF00675	0.580
CLV_NRD_NRD_1	7	9	PF00675	0.692
CLV_NRD_NRD_1	753	755	PF00675	0.362
CLV_PCSK_FUR_1	632	636	PF00082	0.546
CLV_PCSK_KEX2_1	151	153	PF00082	0.591
CLV_PCSK_KEX2_1	480	482	PF00082	0.571
CLV_PCSK_KEX2_1	634	636	PF00082	0.549
CLV_PCSK_KEX2_1	658	660	PF00082	0.583
CLV_PCSK_KEX2_1	7	9	PF00082	0.635
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.536
CLV_PCSK_SKI1_1	145	149	PF00082	0.598
CLV_PCSK_SKI1_1	160	164	PF00082	0.463
CLV_PCSK_SKI1_1	2	6	PF00082	0.678
CLV_PCSK_SKI1_1	289	293	PF00082	0.577
CLV_PCSK_SKI1_1	296	300	PF00082	0.505
CLV_PCSK_SKI1_1	325	329	PF00082	0.528
CLV_PCSK_SKI1_1	368	372	PF00082	0.762
CLV_PCSK_SKI1_1	59	63	PF00082	0.491
CLV_PCSK_SKI1_1	617	621	PF00082	0.516
CLV_PCSK_SKI1_1	674	678	PF00082	0.394
CLV_PCSK_SKI1_1	683	687	PF00082	0.323
CLV_PCSK_SKI1_1	703	707	PF00082	0.238
CLV_PCSK_SKI1_1	774	778	PF00082	0.436
DEG_APCC_DBOX_1	159	167	PF00400	0.305
DEG_APCC_DBOX_1	295	303	PF00400	0.356
DEG_Nend_UBRbox_1	1	4	PF02207	0.547
DEG_SPOP_SBC_1	34	38	PF00917	0.442
DOC_CYCLIN_RxL_1	292	301	PF00134	0.373
DOC_CYCLIN_yCln2_LP_2	706	712	PF00134	0.666
DOC_MAPK_gen_1	157	166	PF00069	0.316
DOC_MAPK_gen_1	218	228	PF00069	0.404
DOC_MAPK_gen_1	584	590	PF00069	0.450
DOC_MAPK_gen_1	680	690	PF00069	0.550
DOC_MAPK_gen_1	7	14	PF00069	0.608
DOC_MAPK_MEF2A_6	683	690	PF00069	0.538
DOC_MAPK_MEF2A_6	7	14	PF00069	0.614
DOC_MAPK_NFAT4_5	683	691	PF00069	0.542
DOC_PIKK_1	120	127	PF02985	0.372
DOC_PP2B_LxvP_1	285	288	PF13499	0.384
DOC_PP2B_LxvP_1	363	366	PF13499	0.434
DOC_PP2B_LxvP_1	699	702	PF13499	0.651
DOC_PP4_FxxP_1	598	601	PF00568	0.408
DOC_USP7_MATH_1	251	255	PF00917	0.293
DOC_USP7_MATH_1	388	392	PF00917	0.473
DOC_USP7_MATH_1	501	505	PF00917	0.456
DOC_USP7_MATH_1	51	55	PF00917	0.357
DOC_USP7_MATH_1	547	551	PF00917	0.558
DOC_USP7_MATH_1	562	566	PF00917	0.462
DOC_USP7_MATH_1	570	574	PF00917	0.449
DOC_USP7_MATH_1	601	605	PF00917	0.480
DOC_USP7_UBL2_3	55	59	PF12436	0.284
DOC_USP7_UBL2_3	755	759	PF12436	0.575
DOC_USP7_UBL2_3	80	84	PF12436	0.284
DOC_WW_Pin1_4	132	137	PF00397	0.445
DOC_WW_Pin1_4	138	143	PF00397	0.407
DOC_WW_Pin1_4	206	211	PF00397	0.318
DOC_WW_Pin1_4	384	389	PF00397	0.568
DOC_WW_Pin1_4	499	504	PF00397	0.487
LIG_14-3-3_CanoR_1	176	185	PF00244	0.373
LIG_14-3-3_CanoR_1	2	10	PF00244	0.551
LIG_14-3-3_CanoR_1	250	256	PF00244	0.361
LIG_14-3-3_CanoR_1	286	292	PF00244	0.392
LIG_14-3-3_CanoR_1	39	47	PF00244	0.331
LIG_14-3-3_CanoR_1	746	751	PF00244	0.641
LIG_AP2alpha_1	263	267	PF02296	0.418
LIG_APCC_ABBA_1	164	169	PF00400	0.307
LIG_BRCT_BRCA1_1	134	138	PF00533	0.466
LIG_BRCT_BRCA1_1	605	609	PF00533	0.342
LIG_BRCT_BRCA1_2	134	140	PF00533	0.467
LIG_Clathr_ClatBox_1	687	691	PF01394	0.625
LIG_CtBP_PxDLS_1	528	532	PF00389	0.476
LIG_deltaCOP1_diTrp_1	675	685	PF00928	0.639
LIG_EVH1_1	363	367	PF00568	0.477
LIG_FHA_1	268	274	PF00498	0.384
LIG_FHA_1	29	35	PF00498	0.643
LIG_FHA_1	358	364	PF00498	0.401
LIG_FHA_1	374	380	PF00498	0.547
LIG_FHA_1	430	436	PF00498	0.404
LIG_FHA_1	515	521	PF00498	0.404
LIG_FHA_1	709	715	PF00498	0.597
LIG_FHA_2	121	127	PF00498	0.439
LIG_FHA_2	274	280	PF00498	0.425
LIG_FHA_2	530	536	PF00498	0.443
LIG_FHA_2	74	80	PF00498	0.344
LIG_GBD_Chelix_1	10	18	PF00786	0.662
LIG_LIR_Apic_2	597	601	PF02991	0.447
LIG_LIR_Gen_1	179	190	PF02991	0.371
LIG_LIR_Gen_1	333	342	PF02991	0.431
LIG_LIR_Gen_1	354	363	PF02991	0.347
LIG_LIR_Gen_1	432	440	PF02991	0.408
LIG_LIR_Gen_1	465	473	PF02991	0.398
LIG_LIR_Gen_1	515	525	PF02991	0.476
LIG_LIR_Gen_1	535	544	PF02991	0.227
LIG_LIR_Gen_1	682	690	PF02991	0.609
LIG_LIR_Nem_3	126	131	PF02991	0.429
LIG_LIR_Nem_3	179	185	PF02991	0.300
LIG_LIR_Nem_3	232	237	PF02991	0.402
LIG_LIR_Nem_3	261	267	PF02991	0.335
LIG_LIR_Nem_3	354	358	PF02991	0.332
LIG_LIR_Nem_3	41	47	PF02991	0.273
LIG_LIR_Nem_3	432	437	PF02991	0.354
LIG_LIR_Nem_3	465	469	PF02991	0.361
LIG_LIR_Nem_3	515	521	PF02991	0.416
LIG_LIR_Nem_3	535	540	PF02991	0.218
LIG_LIR_Nem_3	604	610	PF02991	0.382
LIG_LIR_Nem_3	682	688	PF02991	0.613
LIG_NRBOX	13	19	PF00104	0.535
LIG_NRBOX	772	778	PF00104	0.587
LIG_Pex14_1	182	186	PF04695	0.394
LIG_Pex14_2	258	262	PF04695	0.304
LIG_Pex14_2	263	267	PF04695	0.315
LIG_Pex14_2	327	331	PF04695	0.362
LIG_RPA_C_Fungi	3	15	PF08784	0.452
LIG_SH2_CRK	518	522	PF00017	0.605
LIG_SH2_CRK	537	541	PF00017	0.333
LIG_SH2_NCK_1	237	241	PF00017	0.563
LIG_SH2_NCK_1	315	319	PF00017	0.516
LIG_SH2_SRC	106	109	PF00017	0.626
LIG_SH2_STAP1	178	182	PF00017	0.493
LIG_SH2_STAP1	596	600	PF00017	0.447
LIG_SH2_STAT3	130	133	PF00017	0.553
LIG_SH2_STAT5	224	227	PF00017	0.498
LIG_SH2_STAT5	335	338	PF00017	0.432
LIG_SH2_STAT5	466	469	PF00017	0.445
LIG_SH2_STAT5	537	540	PF00017	0.595
LIG_SH2_STAT5	589	592	PF00017	0.458
LIG_SH2_STAT5	596	599	PF00017	0.376
LIG_SH2_STAT5	613	616	PF00017	0.378
LIG_SH3_1	667	673	PF00018	0.611
LIG_SH3_3	288	294	PF00018	0.433
LIG_SH3_3	361	367	PF00018	0.550
LIG_SH3_3	556	562	PF00018	0.715
LIG_SH3_3	667	673	PF00018	0.611
LIG_SH3_3	728	734	PF00018	0.584
LIG_SUMO_SIM_par_1	224	230	PF11976	0.510
LIG_SUMO_SIM_par_1	685	692	PF11976	0.544
LIG_TRAF2_1	527	530	PF00917	0.628
LIG_TRAF2_1	54	57	PF00917	0.389
LIG_TRAF2_1	627	630	PF00917	0.707
LIG_TRAF2_1	679	682	PF00917	0.552
LIG_TRAF2_1	76	79	PF00917	0.421
LIG_TRAF2_1	783	786	PF00917	0.492
LIG_TYR_ITIM	516	521	PF00017	0.558
LIG_UBA3_1	520	526	PF00899	0.319
LIG_UBA3_1	750	755	PF00899	0.529
LIG_WRC_WIRS_1	259	264	PF05994	0.446
LIG_WRC_WIRS_1	281	286	PF05994	0.531
LIG_WRC_WIRS_1	466	471	PF05994	0.528
LIG_WRC_WIRS_1	595	600	PF05994	0.456
MOD_CDK_SPxK_1	384	390	PF00069	0.725
MOD_CDK_SPxxK_3	138	145	PF00069	0.513
MOD_CK1_1	3	9	PF00069	0.644
MOD_CK1_1	468	474	PF00069	0.447
MOD_CK2_1	120	126	PF00069	0.533
MOD_CK2_1	186	192	PF00069	0.446
MOD_CK2_1	235	241	PF00069	0.565
MOD_CK2_1	251	257	PF00069	0.386
MOD_CK2_1	273	279	PF00069	0.499
MOD_CK2_1	51	57	PF00069	0.353
MOD_CK2_1	645	651	PF00069	0.758
MOD_CK2_1	73	79	PF00069	0.421
MOD_CMANNOS	722	725	PF00535	0.463
MOD_GlcNHglycan	107	111	PF01048	0.621
MOD_GlcNHglycan	178	181	PF01048	0.530
MOD_GlcNHglycan	503	506	PF01048	0.533
MOD_GlcNHglycan	636	640	PF01048	0.701
MOD_GlcNHglycan	647	650	PF01048	0.658
MOD_GlcNHglycan	651	655	PF01048	0.642
MOD_GSK3_1	132	139	PF00069	0.565
MOD_GSK3_1	202	209	PF00069	0.556
MOD_GSK3_1	269	276	PF00069	0.499
MOD_GSK3_1	34	41	PF00069	0.604
MOD_GSK3_1	380	387	PF00069	0.656
MOD_GSK3_1	495	502	PF00069	0.574
MOD_GSK3_1	535	542	PF00069	0.455
MOD_GSK3_1	547	554	PF00069	0.553
MOD_GSK3_1	570	577	PF00069	0.447
MOD_GSK3_1	761	768	PF00069	0.473
MOD_GSK3_1	777	784	PF00069	0.369
MOD_N-GLC_1	512	517	PF02516	0.487
MOD_NEK2_1	185	190	PF00069	0.409
MOD_NEK2_1	258	263	PF00069	0.408
MOD_NEK2_1	267	272	PF00069	0.403
MOD_NEK2_1	273	278	PF00069	0.374
MOD_NEK2_1	33	38	PF00069	0.724
MOD_NEK2_1	346	351	PF00069	0.585
MOD_NEK2_1	602	607	PF00069	0.192
MOD_NEK2_1	73	78	PF00069	0.402
MOD_NEK2_1	777	782	PF00069	0.578
MOD_NEK2_2	388	393	PF00069	0.655
MOD_PIKK_1	145	151	PF00454	0.557
MOD_PIKK_1	167	173	PF00454	0.560
MOD_PIKK_1	273	279	PF00454	0.535
MOD_PKA_1	406	412	PF00069	0.454
MOD_PKA_2	38	44	PF00069	0.546
MOD_PKA_2	753	759	PF00069	0.522
MOD_Plk_1	273	279	PF00069	0.564
MOD_Plk_1	512	518	PF00069	0.504
MOD_Plk_2-3	202	208	PF00069	0.433
MOD_Plk_2-3	765	771	PF00069	0.476
MOD_Plk_2-3	95	101	PF00069	0.434
MOD_Plk_4	186	192	PF00069	0.418
MOD_Plk_4	251	257	PF00069	0.500
MOD_Plk_4	258	264	PF00069	0.471
MOD_Plk_4	280	286	PF00069	0.507
MOD_Plk_4	539	545	PF00069	0.543
MOD_Plk_4	570	576	PF00069	0.494
MOD_Plk_4	591	597	PF00069	0.376
MOD_ProDKin_1	132	138	PF00069	0.564
MOD_ProDKin_1	206	212	PF00069	0.379
MOD_ProDKin_1	384	390	PF00069	0.725
MOD_ProDKin_1	499	505	PF00069	0.607
MOD_SUMO_for_1	679	682	PF00179	0.554
MOD_SUMO_rev_2	54	61	PF00179	0.352
MOD_SUMO_rev_2	675	685	PF00179	0.502
MOD_SUMO_rev_2	79	86	PF00179	0.347
MOD_SUMO_rev_2	95	104	PF00179	0.310
TRG_DiLeu_BaEn_1	682	687	PF01217	0.524
TRG_DiLeu_BaEn_2	680	686	PF01217	0.547
TRG_DiLeu_BaEn_4	477	483	PF01217	0.490
TRG_DiLeu_LyEn_5	207	212	PF01217	0.467
TRG_ENDOCYTIC_2	264	267	PF00928	0.428
TRG_ENDOCYTIC_2	315	318	PF00928	0.427
TRG_ENDOCYTIC_2	335	338	PF00928	0.524
TRG_ENDOCYTIC_2	44	47	PF00928	0.318
TRG_ENDOCYTIC_2	466	469	PF00928	0.417
TRG_ENDOCYTIC_2	473	476	PF00928	0.374
TRG_ENDOCYTIC_2	518	521	PF00928	0.545
TRG_ENDOCYTIC_2	537	540	PF00928	0.547
TRG_ENDOCYTIC_2	94	97	PF00928	0.335
TRG_ER_diArg_1	150	152	PF00400	0.489
TRG_ER_diArg_1	480	482	PF00400	0.460
TRG_ER_diArg_1	657	660	PF00400	0.755
TRG_NLS_MonoExtN_4	581	588	PF00514	0.508
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	774	778	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILW3	Leptomonas seymouri	66%	99%
A0A1X0NIM6	Trypanosomatidae	35%	100%
A0A422P3X6	Trypanosoma rangeli	38%	100%
A4HDA9	Leishmania braziliensis	82%	100%
A4I0P2	Leishmania infantum	100%	100%
D0A720	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AWP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QAS9	Leishmania major	94%	100%
V5DSK9	Trypanosoma cruzi	37%	100%