DUF5745 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IB84_LEIDO

TriTrypDb:

LdBPK_211720.1 , LdCL_210023000 , LDHU3_21.2030

Length:

821

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	7
GO:0005813	centrosome	3	7
GO:0005815	microtubule organizing center	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3Q8IB84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IB84

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	531	535	PF00656	0.697
CLV_C14_Caspase3-7	547	551	PF00656	0.616
CLV_NRD_NRD_1	236	238	PF00675	0.536
CLV_NRD_NRD_1	481	483	PF00675	0.770
CLV_NRD_NRD_1	519	521	PF00675	0.842
CLV_NRD_NRD_1	540	542	PF00675	0.566
CLV_NRD_NRD_1	554	556	PF00675	0.696
CLV_NRD_NRD_1	585	587	PF00675	0.782
CLV_NRD_NRD_1	707	709	PF00675	0.569
CLV_NRD_NRD_1	737	739	PF00675	0.520
CLV_NRD_NRD_1	799	801	PF00675	0.538
CLV_NRD_NRD_1	88	90	PF00675	0.806
CLV_PCSK_FUR_1	583	587	PF00082	0.742
CLV_PCSK_FUR_1	66	70	PF00082	0.622
CLV_PCSK_FUR_1	705	709	PF00082	0.556
CLV_PCSK_KEX2_1	235	237	PF00082	0.536
CLV_PCSK_KEX2_1	481	483	PF00082	0.770
CLV_PCSK_KEX2_1	519	521	PF00082	0.791
CLV_PCSK_KEX2_1	540	542	PF00082	0.566
CLV_PCSK_KEX2_1	554	556	PF00082	0.696
CLV_PCSK_KEX2_1	585	587	PF00082	0.782
CLV_PCSK_KEX2_1	610	612	PF00082	0.853
CLV_PCSK_KEX2_1	68	70	PF00082	0.697
CLV_PCSK_KEX2_1	707	709	PF00082	0.574
CLV_PCSK_KEX2_1	737	739	PF00082	0.528
CLV_PCSK_KEX2_1	794	796	PF00082	0.522
CLV_PCSK_KEX2_1	799	801	PF00082	0.544
CLV_PCSK_KEX2_1	87	89	PF00082	0.834
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.564
CLV_PCSK_PC1ET2_1	610	612	PF00082	0.834
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.697
CLV_PCSK_PC1ET2_1	794	796	PF00082	0.505
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.631
CLV_PCSK_PC7_1	703	709	PF00082	0.553
CLV_PCSK_PC7_1	795	801	PF00082	0.508
CLV_PCSK_SKI1_1	611	615	PF00082	0.775
CLV_PCSK_SKI1_1	666	670	PF00082	0.727
CLV_PCSK_SKI1_1	726	730	PF00082	0.507
CLV_Separin_Metazoa	804	808	PF03568	0.638
DEG_SPOP_SBC_1	305	309	PF00917	0.644
DEG_SPOP_SBC_1	336	340	PF00917	0.709
DEG_SPOP_SBC_1	38	42	PF00917	0.801
DEG_SPOP_SBC_1	49	53	PF00917	0.706
DOC_ANK_TNKS_1	518	525	PF00023	0.640
DOC_CKS1_1	44	49	PF01111	0.726
DOC_CKS1_1	648	653	PF01111	0.707
DOC_CYCLIN_yCln2_LP_2	324	330	PF00134	0.738
DOC_MAPK_gen_1	235	244	PF00069	0.479
DOC_MAPK_gen_1	726	735	PF00069	0.537
DOC_MAPK_MEF2A_6	235	244	PF00069	0.483
DOC_MAPK_MEF2A_6	272	280	PF00069	0.490
DOC_MAPK_RevD_3	72	88	PF00069	0.621
DOC_PP4_FxxP_1	374	377	PF00568	0.805
DOC_PP4_MxPP_1	354	357	PF00568	0.701
DOC_USP7_MATH_1	106	110	PF00917	0.578
DOC_USP7_MATH_1	146	150	PF00917	0.723
DOC_USP7_MATH_1	306	310	PF00917	0.668
DOC_USP7_MATH_1	38	42	PF00917	0.857
DOC_USP7_MATH_1	493	497	PF00917	0.842
DOC_USP7_MATH_1	579	583	PF00917	0.765
DOC_USP7_MATH_1	64	68	PF00917	0.843
DOC_USP7_MATH_1	712	716	PF00917	0.456
DOC_USP7_MATH_1	77	81	PF00917	0.643
DOC_USP7_MATH_1	83	87	PF00917	0.705
DOC_USP7_MATH_1	94	98	PF00917	0.655
DOC_WW_Pin1_4	148	153	PF00397	0.797
DOC_WW_Pin1_4	226	231	PF00397	0.605
DOC_WW_Pin1_4	40	45	PF00397	0.728
DOC_WW_Pin1_4	420	425	PF00397	0.812
DOC_WW_Pin1_4	499	504	PF00397	0.776
DOC_WW_Pin1_4	512	517	PF00397	0.793
DOC_WW_Pin1_4	518	523	PF00397	0.674
DOC_WW_Pin1_4	563	568	PF00397	0.754
DOC_WW_Pin1_4	604	609	PF00397	0.738
DOC_WW_Pin1_4	647	652	PF00397	0.744
LIG_14-3-3_CanoR_1	204	214	PF00244	0.488
LIG_14-3-3_CanoR_1	36	45	PF00244	0.714
LIG_14-3-3_CanoR_1	585	590	PF00244	0.691
LIG_14-3-3_CanoR_1	654	659	PF00244	0.622
LIG_14-3-3_CanoR_1	688	695	PF00244	0.654
LIG_14-3-3_CanoR_1	770	774	PF00244	0.527
LIG_BIR_III_4	363	367	PF00653	0.718
LIG_BIR_III_4	78	82	PF00653	0.624
LIG_BRCT_BRCA1_1	207	211	PF00533	0.423
LIG_CaM_IQ_9	695	710	PF13499	0.545
LIG_FHA_1	436	442	PF00498	0.638
LIG_FHA_1	770	776	PF00498	0.523
LIG_FHA_2	117	123	PF00498	0.582
LIG_FHA_2	167	173	PF00498	0.767
LIG_FHA_2	529	535	PF00498	0.668
LIG_FHA_2	660	666	PF00498	0.622
LIG_FHA_2	725	731	PF00498	0.557
LIG_FHA_2	750	756	PF00498	0.505
LIG_LIR_Apic_2	320	325	PF02991	0.599
LIG_LIR_Gen_1	191	200	PF02991	0.549
LIG_LIR_Gen_1	208	219	PF02991	0.483
LIG_LIR_Nem_3	191	195	PF02991	0.531
LIG_LIR_Nem_3	207	213	PF02991	0.485
LIG_LIR_Nem_3	340	346	PF02991	0.727
LIG_LIR_Nem_3	443	449	PF02991	0.630
LIG_MLH1_MIPbox_1	207	211	PF16413	0.482
LIG_PDZ_Class_2	816	821	PF00595	0.533
LIG_PROFILIN_1	156	162	PF00235	0.566
LIG_PTB_Apo_2	445	452	PF02174	0.615
LIG_PTB_Phospho_1	445	451	PF10480	0.612
LIG_REV1ctd_RIR_1	666	672	PF16727	0.647
LIG_SH2_CRK	215	219	PF00017	0.490
LIG_SH2_CRK	343	347	PF00017	0.794
LIG_SH2_CRK	446	450	PF00017	0.631
LIG_SH2_CRK	636	640	PF00017	0.734
LIG_SH2_CRK	750	754	PF00017	0.527
LIG_SH2_NCK_1	343	347	PF00017	0.714
LIG_SH2_NCK_1	636	640	PF00017	0.734
LIG_SH2_SRC	343	346	PF00017	0.798
LIG_SH2_SRC	430	433	PF00017	0.715
LIG_SH2_STAP1	710	714	PF00017	0.547
LIG_SH2_STAP1	750	754	PF00017	0.527
LIG_SH2_STAP1	779	783	PF00017	0.498
LIG_SH2_STAP1	808	812	PF00017	0.516
LIG_SH2_STAT3	372	375	PF00017	0.640
LIG_SH2_STAT3	4	7	PF00017	0.825
LIG_SH2_STAT3	710	713	PF00017	0.555
LIG_SH2_STAT5	430	433	PF00017	0.715
LIG_SH2_STAT5	667	670	PF00017	0.727
LIG_SH2_STAT5	694	697	PF00017	0.537
LIG_SH3_1	645	651	PF00018	0.623
LIG_SH3_3	129	135	PF00018	0.733
LIG_SH3_3	14	20	PF00018	0.754
LIG_SH3_3	151	157	PF00018	0.828
LIG_SH3_3	350	356	PF00018	0.789
LIG_SH3_3	382	388	PF00018	0.710
LIG_SH3_3	41	47	PF00018	0.736
LIG_SH3_3	447	453	PF00018	0.751
LIG_SH3_3	587	593	PF00018	0.815
LIG_SH3_3	645	651	PF00018	0.741
LIG_SH3_3	653	659	PF00018	0.784
LIG_SH3_3	71	77	PF00018	0.757
LIG_SUMO_SIM_par_1	240	245	PF11976	0.527
LIG_TRAF2_1	169	172	PF00917	0.759
LIG_TRAF2_1	457	460	PF00917	0.811
LIG_TRAF2_1	622	625	PF00917	0.768
LIG_TRAF2_1	662	665	PF00917	0.622
LIG_TYR_ITIM	213	218	PF00017	0.486
LIG_WRC_WIRS_1	189	194	PF05994	0.513
LIG_WW_3	646	650	PF00397	0.685
MOD_CDK_SPxK_1	604	610	PF00069	0.730
MOD_CDK_SPxxK_3	512	519	PF00069	0.840
MOD_CDK_SPxxK_3	604	611	PF00069	0.731
MOD_CDK_SPxxK_3	647	654	PF00069	0.649
MOD_CK1_1	229	235	PF00069	0.595
MOD_CK1_1	39	45	PF00069	0.740
MOD_CK1_1	423	429	PF00069	0.705
MOD_CK1_1	48	54	PF00069	0.750
MOD_CK1_1	496	502	PF00069	0.728
MOD_CK1_1	724	730	PF00069	0.485
MOD_CK1_1	769	775	PF00069	0.525
MOD_CK2_1	116	122	PF00069	0.586
MOD_CK2_1	166	172	PF00069	0.780
MOD_CK2_1	50	56	PF00069	0.755
MOD_CK2_1	512	518	PF00069	0.837
MOD_CK2_1	570	576	PF00069	0.773
MOD_CK2_1	609	615	PF00069	0.763
MOD_CK2_1	659	665	PF00069	0.625
MOD_CK2_1	681	687	PF00069	0.594
MOD_CK2_1	717	723	PF00069	0.551
MOD_CK2_1	724	730	PF00069	0.533
MOD_CK2_1	749	755	PF00069	0.504
MOD_GlcNHglycan	124	127	PF01048	0.761
MOD_GlcNHglycan	148	151	PF01048	0.748
MOD_GlcNHglycan	308	311	PF01048	0.706
MOD_GlcNHglycan	339	342	PF01048	0.699
MOD_GlcNHglycan	368	371	PF01048	0.791
MOD_GlcNHglycan	389	392	PF01048	0.731
MOD_GlcNHglycan	394	397	PF01048	0.746
MOD_GlcNHglycan	412	415	PF01048	0.693
MOD_GlcNHglycan	464	467	PF01048	0.807
MOD_GlcNHglycan	499	502	PF01048	0.730
MOD_GlcNHglycan	512	515	PF01048	0.768
MOD_GlcNHglycan	52	55	PF01048	0.754
MOD_GlcNHglycan	593	596	PF01048	0.770
MOD_GlcNHglycan	611	614	PF01048	0.673
MOD_GlcNHglycan	690	693	PF01048	0.656
MOD_GlcNHglycan	714	717	PF01048	0.542
MOD_GlcNHglycan	78	82	PF01048	0.780
MOD_GlcNHglycan	810	815	PF01048	0.506
MOD_GlcNHglycan	89	92	PF01048	0.821
MOD_GlcNHglycan	94	97	PF01048	0.601
MOD_GSK3_1	116	123	PF00069	0.721
MOD_GSK3_1	148	155	PF00069	0.780
MOD_GSK3_1	163	170	PF00069	0.660
MOD_GSK3_1	195	202	PF00069	0.628
MOD_GSK3_1	36	43	PF00069	0.782
MOD_GSK3_1	431	438	PF00069	0.682
MOD_GSK3_1	45	52	PF00069	0.797
MOD_GSK3_1	458	465	PF00069	0.776
MOD_GSK3_1	493	500	PF00069	0.734
MOD_GSK3_1	717	724	PF00069	0.520
MOD_GSK3_1	83	90	PF00069	0.832
MOD_N-GLC_1	146	151	PF02516	0.632
MOD_N-GLC_1	315	320	PF02516	0.577
MOD_N-GLC_2	380	382	PF02516	0.615
MOD_NEK2_1	219	224	PF00069	0.563
MOD_NEK2_1	304	309	PF00069	0.731
MOD_NEK2_1	431	436	PF00069	0.695
MOD_NEK2_1	497	502	PF00069	0.737
MOD_NEK2_1	5	10	PF00069	0.726
MOD_NEK2_1	50	55	PF00069	0.754
MOD_NEK2_1	717	722	PF00069	0.552
MOD_NEK2_1	783	788	PF00069	0.504
MOD_NEK2_2	108	113	PF00069	0.713
MOD_NEK2_2	206	211	PF00069	0.479
MOD_NEK2_2	470	475	PF00069	0.830
MOD_PIKK_1	476	482	PF00454	0.841
MOD_PIKK_1	5	11	PF00454	0.723
MOD_PIKK_1	528	534	PF00454	0.698
MOD_PIKK_1	627	633	PF00454	0.828
MOD_PIKK_1	634	640	PF00454	0.759
MOD_PK_1	199	205	PF00069	0.519
MOD_PKA_1	585	591	PF00069	0.680
MOD_PKA_1	87	93	PF00069	0.620
MOD_PKA_2	198	204	PF00069	0.629
MOD_PKA_2	579	585	PF00069	0.683
MOD_PKA_2	681	687	PF00069	0.594
MOD_PKA_2	717	723	PF00069	0.551
MOD_PKA_2	769	775	PF00069	0.525
MOD_PKA_2	87	93	PF00069	0.805
MOD_PKB_1	583	591	PF00069	0.642
MOD_Plk_1	219	225	PF00069	0.570
MOD_Plk_1	431	437	PF00069	0.690
MOD_Plk_1	810	816	PF00069	0.508
MOD_Plk_4	128	134	PF00069	0.768
MOD_Plk_4	206	212	PF00069	0.477
MOD_Plk_4	431	437	PF00069	0.668
MOD_Plk_4	749	755	PF00069	0.504
MOD_Plk_4	783	789	PF00069	0.489
MOD_ProDKin_1	148	154	PF00069	0.796
MOD_ProDKin_1	226	232	PF00069	0.600
MOD_ProDKin_1	40	46	PF00069	0.731
MOD_ProDKin_1	420	426	PF00069	0.809
MOD_ProDKin_1	499	505	PF00069	0.777
MOD_ProDKin_1	512	518	PF00069	0.795
MOD_ProDKin_1	563	569	PF00069	0.754
MOD_ProDKin_1	604	610	PF00069	0.739
MOD_ProDKin_1	647	653	PF00069	0.745
MOD_SUMO_for_1	793	796	PF00179	0.530
MOD_SUMO_rev_2	678	686	PF00179	0.578
MOD_SUMO_rev_2	724	733	PF00179	0.541
TRG_DiLeu_BaEn_4	260	266	PF01217	0.527
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.475
TRG_ENDOCYTIC_2	215	218	PF00928	0.487
TRG_ENDOCYTIC_2	343	346	PF00928	0.696
TRG_ENDOCYTIC_2	446	449	PF00928	0.629
TRG_ENDOCYTIC_2	750	753	PF00928	0.529
TRG_ER_diArg_1	539	541	PF00400	0.540
TRG_ER_diArg_1	554	557	PF00400	0.706
TRG_ER_diArg_1	583	586	PF00400	0.744
TRG_ER_diArg_1	702	705	PF00400	0.548
TRG_ER_diArg_1	706	708	PF00400	0.562
TRG_ER_diArg_1	736	738	PF00400	0.530
TRG_NES_CRM1_1	268	283	PF08389	0.494
TRG_Pf-PMV_PEXEL_1	693	697	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC22	Leptomonas seymouri	52%	87%
A4HBZ6	Leishmania braziliensis	74%	98%
A4HZE5	Leishmania infantum	99%	100%
E9AVD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QC47	Leishmania major	91%	100%